Identifiers and Description

Gene Model Identifier

TTHERM_00989490

Standard Name

VPS42 (Vacuolar Protein Sorting 4-2)

Aliases

PreTt07839 | 185.m00060 | VPS4B

Description

AAA-type ATPase; ATPase- AAA family protein; associated with membrane vesicle trafficking; putative function in programmed nuclear death

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• macronucleus (IDA) | GO:0031039 | Ref:SUPR000328
• cytoplasmic vesicle (IDA) | GO:0031410 | Ref:SUPR000328
• vacuole (IDA) | GO:0005773 | Ref:SUPR000328

Molecular Function

• ATP binding (IEA) | GO:0005524
• ATPase activity (IEA) | GO:0016887

Domains

• ( PF04212 ) MIT domain
• ( TIGR02880 ) CbbX protein
• ( PF00004 ) ATPase, AAA family
• ( TIGR01242 ) 26S proteasome subunit P45 family
• ( TIGR01241 ) ATP-dependent metallopeptidase HflB
• ( PF09336 ) Vps4 C terminal oligomerisation domain
• ( TIGR02237 ) DNA repair and recombination protein
• ( PF02189 ) Immunoreceptor tyrosine-based activation motif
• ( PF07724 ) ATPase family associated with various
• ( PF07726 ) ATPase family associated with various
• ( PF07728 ) ATPase family associated with various

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 11.4%

TetraMine Data

TTHERM_00989490

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_02920.1	9.997093137033517e-262	ATPase, AAA family protein (49 3 aa)
Oxytricha	Contig13722.0.g102	3.998176907651524e-145	ATPase family associated with various cellular activities (A AA)
SGD	YPR173C	1.000157752625888e-137	VPS4 AAA-ATPase involved in mu ltivesicular body (MVB) protei n sorting, ATP-bound Vps4p loc alizes to endosomes and cataly zes ESCRT-III disassembly and membrane release; ATPase activ ity is activated by Vta1p; reg ulates cellular sterol metabol ism
DictyBase	DDB_G0284347	1.0001366335892501e-125	vps4 on chromosome: 4 position 1865073 to 1866634
WormBase	WBGene00021334	3.9996672065071595e-120	locus:vps-4 status:Confirmed UniProt:Q9BL83 protein_id :CCD68056.1
Stentor Coeruleus	SteCoe_15482	1.580420060273613e-61

General Information

No Data fetched for General Information

Associated Literature

1. Ref:SUPR000328

Sequences

>TTHERM_00989490(coding)
ATGAGCAATAACCCTATGATGTAATTTAGAGACATCGCTCTCTAAAAAATTACTCAAGGT
ATTAACATCTTTAATACCAAGAAGGATAACATTAATGAAAGAGATTAAGGTTATAGGTTG
ATGGTTTCTGGTCTTGAAGACTTAATCAAGTATAGAAAGCAAGAAACAAATGTTGATATT
TAAAATATTTTAAAGCCAAAGATAGATGAATATTTAAAGCAAGCAGCTGCCATGAAAGCT
GAAATTTCTGCCTAATAACAGAACATTAATCAATAGATTCAAAAGCAATCTTAATTTAGC
TATCAAGCAAACAATTAAAATTTGAATAATATTAACACTAATATGAATAATAATAATAAT
CAAAATTAATATAAGCCTCCAGTTAACAACAACAACAACAACAATAATAGCAATAACACC
AATAACAATAATGGTGGAAATAACTAAAACAATAACTAAGGAAAAAGTTAAATCAAGGAA
GGTGATAAAGATAATGCTAAGTTTGAACAAGCATTAGGTGAAGCAATTGTTACTGAAAAG
CCAAATGTTCACTGGTCTGATGTTGCTGGTTTAGAAAATGCTAAGAAAGCACTTAATGAA
GCAGTTATCCTACCCATCAGATTCCCTCATATATTCTAAGGTATGATCAAGCCTTGGAGA
GGTATTTTGTTATATGGACCTCCAGGTACTGGTAAAACATTCTTGGCTAAGGCTTGTGCA
ACAGAATGTGATGCTACCTTCTTCTCTATTTCCTCCTCTGATTTAATTTCTAAGTGGGTT
GGTGAATCTGAAAAGTTAATTAAGACTTTGTTTAAAATGGCCAGAGAGAAAAAACCTTCT
ATTATATTTATTGACGAAATAGATTCAATGACTGGAAATAGATCTGAAGGTGAGAATGAA
GCATCCAGAAGAGTCAAAACTGAATTTTTAGTTTAAATGCAAGGTGTTGGCAATGATGAC
ACTGGTGTTCTTGTCCTTGGTGCTACAAACGTTCCTTGGGGTTTAGATCCTGCTATTAGA
AGAAGATTTGAAAAAAGAATTATGATTCCTTTACCAGAAAAGGAAGCTAGATTCTAATTG
ATTGACAATCTCTTGAATAAAACTCCCAACTGCATTACATAAGAAGAAAGATTATACATT
GCAGAAAGAACTGAAGGTTTTTCAGGTTCTGATATATCTATTTTAGTTAGAGAAGCTTCA
TATGAGCCTCTGAGAATAGCATAAAGAGCCACTAAATTCAAAAAGATTTAAGACAAAGAT
GGCTAACCTAAGTATGTTGCTTGTGCTCCTAGTGATCCCTAAGGTGAATCAAAAGTATTA
ATGGATATATAAGGTAGTATGTTAAAATTGTAAGATGTCAGTATAGATCACTTCGAATTA
GCCTTGTAATCTTGTAAACCCTCAGTCTCTGAAAAAGATATAGAGAGACAAATTGAATTC
ACTAAAGAATTCGGCCAAGATGGTTGA

>TTHERM_00989490(protein)
MSNNPMMQFRDIALQKITQGINIFNTKKDNINERDQGYRLMVSGLEDLIKYRKQETNVDI
QNILKPKIDEYLKQAAAMKAEISAQQQNINQQIQKQSQFSYQANNQNLNNINTNMNNNNN
QNQYKPPVNNNNNNNNSNNTNNNNGGNNQNNNQGKSQIKEGDKDNAKFEQALGEAIVTEK
PNVHWSDVAGLENAKKALNEAVILPIRFPHIFQGMIKPWRGILLYGPPGTGKTFLAKACA
TECDATFFSISSSDLISKWVGESEKLIKTLFKMAREKKPSIIFIDEIDSMTGNRSEGENE
ASRRVKTEFLVQMQGVGNDDTGVLVLGATNVPWGLDPAIRRRFEKRIMIPLPEKEARFQL
IDNLLNKTPNCITQEERLYIAERTEGFSGSDISILVREASYEPLRIAQRATKFKKIQDKD
GQPKYVACAPSDPQGESKVLMDIQGSMLKLQDVSIDHFELALQSCKPSVSEKDIERQIEF
TKEFGQDG

>TTHERM_00989490(gene)
ATGAGCAATAACCCTATGATGTAATTTAGAGACATCGCTCTCTAAAAAATTACTCAAGGT
ATTAACATCTTTAATACCAAGAAGGATAACATTAATGAAAGAGATTAAGGTTATAGGTTG
ATGGTTTCTGGTCTTGAAGACTTAATCAAGTATAGAAAGCAAGAAACAAATGTTGATATT
TAAAATATTTTAAAGCCAAAGATAGATGAATATTTAAAGCAAGCAGCTGCCATGAAAGCT
GAAATTTCTGCCTAATAACAGAACATTAATCAATAGATTCAAAAGCAATCTTAATTTAGC
TATCAAGCAAACAATTAAAATTTGAATAATATTAACACTAATATGAATAATAATAATAAT
CAAAATTAATATAAGCCTCCAGTTAACAACAACAACAACAACAATAATAGCAATAACACC
AATAACAATAATGGTGGAAATAACTAAAACAATAACTAAGGAAAAAGTTAAATCAAGTAA
AAAGTTAATTTTGTTAGGATGATTTTTTTTAATTGTTTTTTATATCGATAGGGAAGGTGA
TAAAGATAATGCTAAGTTTGAACAAGCATTAGGTGAAGCAATTGTTACTGAAAAGCCAAA
TGTTCACTGGTCTGATGTTGCTGGTTTAGAAAATGCTAAGAAAGCACTTAATGAAGCAGT
TATCCTACCCATCAGATTCCCTCATATATTCTAAGGTATGATCAAGCCTTGGAGAGGTAT
TTTGTTATATGGACCTCCAGGTACTGGTAAAACATTCTTGGCTAAGGCTTGTGCAACAGA
ATGTGATGCTACCTTCTTCTCTATTTCCTCCTCTGATTTAATTTCTAAGTGGGTTGGTGA
ATCTGAAAAGTTAATTAAGACTTTGTTTAAAATGGCCAGAGAGAAAAAACCTTCTATTAT
ATTTATTGACGAAATAGATTCAATGACTGGAAATAGGTAAAAATATTACTTATGAAAATT
GTGACAATTTCTTGATTCATTCATAGATTATTTTTTTTTTAAATGTTCATTTTTTTTATT
GACAGTTCAAATCAAATATTTGAAATATGTTGATGATTGCTTGAAAAAATATATCATTTT
TTAACTAAAAAATTGAATTTGCTTATGATTTATTGTAATAAAAAGATCTGAAGGTGAGAA
TGAAGCATCCAGAAGAGTCAAAACTGAATTTTTAGTTTAAATGCAAGGTGTTGGCAATGA
TGACACTGGTGTTCTTGTCCTTGGTGCTACAAACGTTCCTTGGGGTTTAGATCCTGCTAT
TAGAAGAAGGTAAAAACAATTATTGAAGTTAGTGAATGTGTTTTTTATTTATAAATTTTC
AAAAAATAATTAGATTTGAAAAAAGAATTATGATTCCTTTACCAGAAAAGGAAGCTAGAT
TCTAATTGATTGACAATCTCTTGAATAAAACTCCCAACTGCATTACATAAGAAGAAAGAT
TATACATTGCAGAAAGAACTGAAGGGTATTTATCCATTTTATATTATATTAATTTTTAAA
CTTGTTTATTAAAAATAGTTTTTCAGGTTCTGATATATCTATTTTAGTTAGAGAAGCTTC
ATATGAGCCTCTGAGAATAGCATAAAGAGCCACTAAATTCAAAAAGATTTAAGACAAAGA
TGGCTAACCTAAGTATGTTGCTTGTGCTCCTAGTGATCCCTAAGGTGAATCAAAAGTATT
AATGGATATATAAGGTAGTATGTTAAAATTGTAAGATGTCAGTATAGATCACTTCGAATT
AGCCTTGTAATCTTGTAAACCCTCAGTCTCTGAAAAAGATATAGAGAGACAAATTGAATT
CACTAAAGAATTCGGCCAAGATGGTTGA