Identifiers and Description

Gene Model Identifier

TTHERM_00550720

Standard Name

UBC2 (E2 UBiquitin-Conjugating enzyme)

Aliases

PreTt29180 | 72.m00103 | RAD6

Description

E2 ubiquitin-conjugating enzyme; promotes post replication repair; ortholog of yeast RAD6

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• ubiquitin-like protein transferase activity (IEA) | GO:0019787

Biological Process

• post-translational protein modification (IEA) | GO:0043687
• regulation of protein metabolic process (IEA) | GO:0051246

Domains

• ( PF05773 ) RWD domain
• ( PF00179 ) Ubiquitin-conjugating enzyme

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.1%

TetraMine Data

TTHERM_00550720

WebApollo

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Tetrahymena Stock Center

• ( SD02536 ) Micronucleus: Neo2 KO of UBC2
• ( SD02537 ) Micronucleus: Neo2 KO of UBC2
• ( SD02538 ) Micronucleus: Neo2 KO of UBC2
• ( SD01328 ) Micronucleus: Neo2 KO of UBC2
• ( SD01329 ) Micronucleus: Neo2 KO of UBC2

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_07360.1	2.0004261429631518e-110	ubiquitin-conjugating enzyme f amily protein (152 aa)
DictyBase	DDB_G0275787	7.000472351131044e-82	rad6 on chromosome: 2 position 5646909 to 5648070
WormBase	WBGene00006701	7.002185723491005e-79	locus:ubc-1 Ubiquitin-conjug ating enzyme E2 1 status:Con firmed UniProt:P52478 prot ein_id:CCD66736.1
Oxytricha	Contig16539.0.g115	6.002203762674495e-72	Ubiquitin-conjugating enzyme
SGD	YGL058W	1.99927841627239e-68	RAD6 Ubiquitin-conjugating enz yme (E2), involved in postrepl ication repair (as a heterodim er with Rad18p), DSBR and chec kpoint control (as a heterodim er with Bre1p), ubiquitin-medi ated N-end rule protein degrad ation (as a heterodimer with U br1p
Stentor Coeruleus	SteCoe_15965	1.8048513878454153e-35

General Information

No Data fetched for General Information

Associated Literature

1. Ref:19822522: Wang Z, Cui B, Gorovsky MA (2009) Histone H2B ubiquitylation is not required for histone H3 methylation at lysine 4 in tetrahymena. The Journal of biological chemistry 284(50):34870-9
2. Ref:SUPR000207
3. Ref:SUPR000159

Sequences

>TTHERM_00550720(coding)
ATGACAACAGCTGCTAAGAGAAGATTACTTAGAGATTTCAAGAAATTGCAAGATGATCCA
CCAAATGGATTAACTGCTACTCCTATGGAAGATAATATAATGAACTGGGATGCAGTAATT
TTTGGTCCAGAAGACACACCTTGGGAAGGTGCAACATTCAGATTAACATTAGAGTTCACT
GAGGATTATCCCAATAAGCCACCTACTGTTAGATTTAAAACTACCATATTCCACCCTAAT
GTATACAACGATGGATCTATATGTTTAGACATTCTTTAAAACTAATGGAGTCCTATTTAC
GATGTTTGGGCCATCCTCACATCTATACGTTCACTTCTTTGTGATCCAAATCCAAATAGT
CCTGCCAATAGCGAAGCAGCCAAATTGTATTAAGAAGATCGCAAAGAATATATTCGTAGA
GTAAAGGAAATAGTAGAAATGAGCTGGAATTACTGA

>TTHERM_00550720(protein)
MTTAAKRRLLRDFKKLQDDPPNGLTATPMEDNIMNWDAVIFGPEDTPWEGATFRLTLEFT
EDYPNKPPTVRFKTTIFHPNVYNDGSICLDILQNQWSPIYDVWAILTSIRSLLCDPNPNS
PANSEAAKLYQEDRKEYIRRVKEIVEMSWNY

>TTHERM_00550720(gene)
ATGACAACAGCTGCTAAGAGAAGATTACTTAGAGATTTCAAGAAATTGCAAGATGATCCA
CCAAATGGATTAACTGCTACTCCTATGGAAGATAATATAATGAACTGGGATGCAGTAATT
TTTGGTCCAGAAGACACACCTTGGGAAGGTGCAACATTCAGATTAACATTAGAGTTCACT
GAGGATTATCCCAATAAGCCACCTACTGTTAGATTTAAAACTACCATATTCCACCCTAAT
GTATACAACGATGGATCTATATGTTTAGACATTCTTTAAAACTAATGGAGTCCTATTTAC
GATGTTTGGGCCATCCTCACATCTATACGTTCACTTCTTTGTGATCCAAATCCAAATAGT
CCTGCCAATAGCGAAGCAGCCAAATTGTATTAAGAAGATCGCAAAGAATATATTCGTAGA
GTAAAGGAAATAGTAGAAATGAGCTGGAATTACTGA