Identifiers and Description

Gene Model Identifier

TTHERM_00554610

Standard Name

UBA4 (UBiquitin-Activating enzyme 4)

Aliases

PreTt29268 | 72.m00191

Description

Ubiquitin-activating enzyme; provides instructions for activating ubiquitin-like proteins for protein degradation; homolog of UBA5 in Mus musculus

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

No Data fetched for Gene Ontology Annotations

Domains

• ( PF00899 ) ThiF family
• ( PF05237 ) MoeZ/MoeB domain
• ( TIGR02354 ) thiamine biosynthesis protein ThiF
• ( TIGR02355 ) molybdopterin synthase sulfurylase MoeB
• ( TIGR02356 ) thiazole biosynthesis adenylyltransferase ThiF

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.1%

TetraMine Data

TTHERM_00554610

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_07308.1	9.997093137033517e-262	ThiF family protein (384 aa)
Oxytricha	Contig3977.0.g98	6.000794656677251e-128	ThiF family
DictyBase	DDB_G0293306	2.0004683842646898e-122	uba5 on chromosome: 6 position 2741328 to 2742563
WormBase	WBGene00020184	9.997006461365152e-115	locus:uba-5 Ubiquitin-like m odifier-activating enzyme 5 status:Confirmed UniProt:P91 430 protein_id:CCD67786.1
Stentor Coeruleus	SteCoe_5601	1.0377033238158346e-53
SGD	YDR390C	0.00000000000003999587784428659	UBA2 Subunit of a heterodimeri c nuclear SUMO activating enzy me (E1) with Aos1p; activates Smt3p (SUMO) before its conjug ation to proteins (sumoylation ), which may play a role in pr otein targeting; essential for viability

General Information

No Data fetched for General Information

Associated Literature

1. Ref:SUPR000213
2. Ref:SUPR000188
3. Ref:SUPR000171
4. Ref:SUPR000248

Sequences

>TTHERM_00554610(coding)
ATGGATAGCGATAAAGAACTACAAAGGCTTTTAGATGAAAGATAAAAGCTAAATGATAAA
ATTAACGAATATGTTAAAGAAAAGTATTAAAAGTATAAAGGTATGAGCGAAGAGGTCAAG
GATGATAACCCATATAGTCGTTTGATGGCATTGAAGAGAATGGGTGTTGTTTAAAATTAC
GAGAAAATTAGAGATTGTTCAGTTTTAGTTGTTGGTGTTGGTGGTGTAGGTTCAGTATTA
GCTGAAATGCTTACTCGTTGTGGCTTAGGCAAATTGATTATCTACGATTATGATAAAGTA
GAGTTAGCAAACATGAATAGATTGTTTTATACTCCTTAATAAGTTGGTTTATCTAAGGTC
GATGCAGCTAAAGGGACTCTTTAATCTATAAATCCTGAAATTACAATCGAAGCTTACAAC
ATGAACATTACCACTAACAGTGGATTTGAGCACTTGTTAGATAGAATAAAGAAAGGAGGT
AAGAATGGCGAAAGAATTAATTTAGTAGTTTCTTGTGTAGATAACTATGCTGCTCGTATG
GCAATTAATACAGGTTGTAACGAACTTGACCAAATATGGTTTGAAAGTGGTGTAAGTGAA
GATGCTATGAGTGCTCATATTTAGATTATGATTCCAGGTGAAACTGCTTGCTTCGCATGT
GCTACACCTCTTGCTGTGGTTGAAAGTAACGAACACACAATAAAAAGAGAAGGCGTTTGT
GCAGCTTCACTTCCTACTACTATGGGTATTACAGCTGGTTTTCTTGCATAAAATGCCTTA
AAATTCCTTCTTGATTTTGGTGACCTTGCTTTTGTTTTAGCTTATAACGCAAAAGCTGAC
TTTTTCACCAACTATATGATTAAGCCAAACTCTGAATGCAAGGAAAACGAATGTAGAAAA
AGACAAGCTGAAAAGGCTGTTAATAAATAAGAAAACATCCTTGAAAGACTTGAATAAAGA
AAGAAGGCTGCCAAGGAAGCCTTCGAAAAGGAAAATAAACCCAGCGAAAACGAGTGGGGA
ATCGAAATAGTTGATGAATCAGGACCACAAAGTGATTCCAATAAAAAAGATGATGATGTA
AAGGAAATTTCAGAATAAGAAATTGAGCAAAATAATTTGGACGATTTGATGGCAAAACTG
TAAAATATGTGA

>TTHERM_00554610(protein)
MDSDKELQRLLDERQKLNDKINEYVKEKYQKYKGMSEEVKDDNPYSRLMALKRMGVVQNY
EKIRDCSVLVVGVGGVGSVLAEMLTRCGLGKLIIYDYDKVELANMNRLFYTPQQVGLSKV
DAAKGTLQSINPEITIEAYNMNITTNSGFEHLLDRIKKGGKNGERINLVVSCVDNYAARM
AINTGCNELDQIWFESGVSEDAMSAHIQIMIPGETACFACATPLAVVESNEHTIKREGVC
AASLPTTMGITAGFLAQNALKFLLDFGDLAFVLAYNAKADFFTNYMIKPNSECKENECRK
RQAEKAVNKQENILERLEQRKKAAKEAFEKENKPSENEWGIEIVDESGPQSDSNKKDDDV
KEISEQEIEQNNLDDLMAKLQNM

>TTHERM_00554610(gene)
ATGGATAGCGATAAAGAACTACAAAGGCTTTTAGATGAAAGATAAAAGCTAAATGATAAA
ATTAACGAATATGTTAAAGAAAAGTATTAAAAGTATAAAGGTATGAGCGAAGAGGTCAAG
GATGATAACCCATATAGGTACTTAGTTAGATACATGAATAAATAAATACATAAATCATAT
CATACATAATATAAATTAAAAGATTAAAAATTGAAATATTTTAACAAATAAACTGAGCAA
TTAAATTAATTAAATTGTTAAAATATAAAATTTATAAGTAAACGCATTATAGAAAATAGT
TCATTTTTATTAAGTTTTTAAGCGATTAGAAATATTTCACTTTCTTCTGTTTTTTATAGA
GAGCAATTACTTTTTTATTTGATAGATTTTAATGGATGAGTAATTAAGCAATTATTTAAT
TTATTTAGTCGTTTGATGGCATTGAAGAGAATGGGTGTTGTTTAAAATTACGAGAAAATT
AGAGATTGTTCAGTTTTAGTTGTTGGTGTTGGTGGTGTAGGTTCAGTATTAGCTGAAATG
CTTACTCGTTGTGGCTTAGGCAAATTGATTATCTACGATTATGATAAAGTAGAGTTAGCA
AACATGAATAGGTAAATAAATAAATCAATTTAAAAATTATTAAAAATGCATAAAATTTTG
TTATAGATTTATAAGAATAAGCATAAAAAAGTTAGAATTTATTTCATATACTTATATCAA
TAGATGATAAAGTAAAAATATAAACATAAATACAGAATAAAATCATAATTTTAAATTATG
TTAAGAAATATTTTTTTTGTTTATCTGTAAAATGTTCAAAAAATTAATAAATTATTAGAT
TAGTTTATATTAATTTTTATTTTAAAAGATTGTTTTATACTCCTTAATAAGTTGGTTTAT
CTAAGGTCGATGCAGCTAAAGGGACTCTTTAATCTATAAATCCTGAAATTACAATCGAAG
CTTACAACATGAACATTACCACTAACAGTAATATATTTTCTTTAAGCTTTTAGATTACTA
TCATCATAATTAAAAAACAGTTAAAATATCAAGATCTTAACATAAAGATATTATTTGTTA
GAAAAATTAATATACTAATAAATAGAAATATAAATAATTTATAAAGATTGTGATCAAAAA
TTAAATTCTATCTAACAATGATAATAAATAAATAAATAAATAAATAAATAAAGCAATTTT
TTATGTATTCATTTTAAATTTATTTAAGAGACTAATTGGAAAGCAAATATTTAAATAGTT
TTCATTTAAACATAAAGGTGGATTTGAGCACTTGTTAGATAGAATAAAGAAAGGAGGTAA
GAATGGCGAAAGAATTAATTTAGTAGTTTCTTGTGTAGATAACTATGCTGCTCGTATGGC
AATTAATACAGGTTGTAACGAACTTGACCAAATATGGTAATTATTTTATATTGATTTTGT
TTTAAAAAAAATGGGAAGTTAAATTTATGAATAAAAAAGTTTTATTAATTAAAAAATAAA
TTGATTTAATCAATCAAGTTAGATCATTATAAAAGCAAAAAATATATTAATAGAAACAAT
TTTGATTTTAGAATAAATAAGGTCTGTAAAAATTAAATAGAAAAAAAATTATGTCAAAAA
TAAGAAGAAAAAAAAAAATCTTTATTATTCTTGAAGACAGATTTAAATTTATTAATTTAG
AATAAATAAATAATCTAAGAGTATGCGTCACTCACTTTTAATAATCAACCATTTTAAATT
TTTATAACAATATTATTATGCAATATTGTTTAATTTATTTGGATCGTCTATTATAAATTA
CAATAGATTTTACGTCATACTTTATAATAAAAATTAACCATTTTTTTATTATTTAAGTTT
TTTAAATTTATAATATAATTCTATCTTGTTGATAACTTTTTGGTGCTCCTTAAAAGATTT
TCAAAAATTTGATTCATTTTTTCAAAAATAAAAATTCATCATCTAAAAACCAAAAATTAT
AATAAAAATTTATTCTATAAAATGTAAGAATATTCTATTTAAAATTTCAAAATCAAACCA
ATAAATATTACAACTTTTGTAGTTTTATAATATGATCTAGCACAATAAACAGCTTATTTG
CATTTTTATTGATACAATTTTTAGAATGCATCAATAAAAAGTTTTATTTCCCCTTTTAGA
TTTTCAAAAAAATGTAAAGCTTCAAAGAAAAAAAATATGATTTTTTAACAAGTTATTGTA
ACATGATATTTTATTGCGTAACAAATTAGTATTGAGTCATTTATCAATCAATTTATTTTT
AAAACTGCCTTTACCCCCTCGTTTGTGAATTAATTTATAGGAGAAGATAGCCTTATAATT
TTTGCTTGTAACCTAACTCTAACTTTAAGATATTTTTTATTATGTATTTTTCAGGTTTGA
AAGTGGTGTAAGTGAAGATGCTATGAGTGCTCATATTTAGATTATGATTCCAGGTGAAAC
TGCTTGCTTCGCATGTGCTACACCTCTTGCTGTGGTTGAAAGTAACGAACACACAATAAA
AAGAGAAGGCGTTTGTGCAGCTTCACTTCCTACTACTATGGGTATTACAGCTGGTTTTCT
TGCATAAAATGCCTTAAAATTCCTTCTTGATTTTGGTGACCTTGCTTTTGTTTTAGCTTA
TAACGCAAAAGCTGACTTTTTCACCAACTATATGATTAAGCCAAACTCTGAATGCAAGGA
AAACGAATGTAGAAAAAGACAAGCTGAAAAGGCTGTTAATAAATAAGAAAACATCCTTGA
AAGACTTGAATAAAGAAAGAAGGCTGCCAAGGAAGCCTTCGAAAAGGAAAATAAACCCAG
CGAAAACGAGTGGGGAATCGAAATAGTTGATGAATCAGGACCACAAAGTGATTCCAATAA
AAAAGATGATGATGTAAAGGAAATTTCAGAATAAGAAATTGAGCAAAATAATTTGGACGA
TTTGATGGCAAAACTGTAAAATATGTGA