Identifiers and Description

Gene Model Identifier

TTHERM_00092840

Standard Name

UBA22 (UBA2 Paralog)

Aliases

PreTt16538 | 6.m00612 | 3836.m02198

Description

Ubiquitin activating protein; involved in SUMOylation

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• ubiquitin-like modifier activating enzyme activity (IEA) | GO:0008641
• ATP binding (IEA) | GO:0005524
• catalytic activity (IEA) | GO:0003824

Biological Process

• cellular protein modification process (IEA) | GO:0006464

Domains

• ( PF00899 ) ThiF family
• ( PF05237 ) MoeZ/MoeB domain
• ( TIGR02354 ) thiamine biosynthesis protein ThiF
• ( TIGR02355 ) molybdopterin synthase sulfurylase MoeB
• ( PF02134 ) Repeat in ubiquitin-activating (UBA) protein
• ( TIGR02356 ) thiazole biosynthesis adenylyltransferase ThiF
• ( TIGR00136 ) tRNA uridine 5-carboxymethylaminomethyl modification enzyme

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.3%

TetraMine Data

TTHERM_00092840

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_02543.1	9.997093137033517e-262	hypothetical protein (578 aa)
Oxytricha	Contig20101.0.g96	2.998830401637127e-79	ThiF family
DictyBase	DDB_G0286919	3.999627495270728e-67	uba2 on chromosome: 4 position 5077667 to 5079750
WormBase	WBGene00006700	1.0000310450948521e-65	locus:uba-2 SUMO-activating enzyme subunit uba-2 status: Partially_confirmed UniProt: Q9NAN1 protein_id:CAB54319.4
SGD	YDR390C	1.0003503620230312e-57	UBA2 Subunit of a heterodimeri c nuclear SUMO activating enzy me (E1) with Aos1p; activates Smt3p (SUMO) before its conjug ation to proteins (sumoylation ), which may play a role in pr otein targeting; essential for viability
Stentor Coeruleus	SteCoe_19993	0.0000000000002543665647376923

General Information

No Data fetched for General Information

Associated Literature

1. Ref:SUPR000183
2. Ref:SUPR000161

Sequences

>TTHERM_00092840(coding)
ATGGAAATAGAGGCTTAAAGGTCTGACAGAAGCTTGAAGCTAATTTATGGTGAAGAAGTT
TACAATAAAATTATCTAATCAAATGTTTTAATTGGAGGAGCAGGTGGTGTTGGATGTGAA
ATAATTAAATCATTAAGTAAAACAGGATTTAGGAAATTTACAATGATCGATTTAGATACA
ATAGAGCTAACCAATTTAAATAGGCAATTCTATTTCAGAAAACATCATGTAGGAAAAGCT
AAATCTGCTTGCGCTAAAGAAGGAGTACTATTAATTGAACCAAATATCTTGTAAGTAGAT
GCTATTTTAGGAAATATTTATGATCCAAAGTTTGATGATTTATTTTATAAATAATTTGAT
ATTGCATTTTGTGCTTTTGATAACTAAGGAGCTAGAAGGCACTTTGGTAAGATGTGTACA
GTGAATAACATTCCTATGGTAGAGGCTGGAACTTCTGCATTTAATGGATAGACATAGACT
AGAATAAAAGATTTATTTGAATGCAGAAATTGCACTCCAGAAGTCAAACAATAAACTAGC
TTTAATGTTTGCTCAATTAGAACTAGACCTTCTGAACCTATTCACTGCATAGTTTGGGCT
TCTAATATGTTTAATTTGATATTTGGGAACCAAGATGATTCAAATTTGTTGGAAAACTAT
ATTTAAGATATTTTCAAAGAGGGAATCAAGAATGTCTAAGACCCAAAAGAAAAAGCTCTT
CAGTTATTTGAAAAGATTTTCAACGAAGACATTTAAAAATGTGATGAAAAAGAAAGATTC
CCAATTTCTTTTGAGCAATCTTTATAAATTGACAACAAAGAAGATGCTGTTTACTTTGAT
GAAAGAAATAATCGCAAATTGTTAGAAGACGAAAAAATCTTCACTATTAAGGAGTATGCA
CAGAAATTTATTTAAGCGTTTTTAGATGTATTTCATCATAGAAAAGAAGCTTTAGGAGAA
CTAAAATTTGATAAAGATGATTAACTGGCTTTGAAATTTGTCGCTGCAATCACTAATTTG
CGTACATTTAATTTCCTTAATAAGGAAAATGAAAAGAATAAGTTGAGATATCTCTCAGAG
CATAAAATAAAATAAATGGTTGGAAATATTATCCCTGCAATAGCATCAACAAACGCTATC
GTTTCTGCTATCCAAGTAAATGAAGCAATTAAAATAATGAAAGGTTATGCCAAAACTAAG
CCTTAACTATTCAGCGAGTATTTAGTCCAAAATGGTGATCAAAGCAAAATAACTCCAGCA
CAGTTATCTCTTCCACAATTATCTTGTCCTGTTTGCTCTCCAGCTAATTGCTACATAAAC
ATAAAAGCAAATTGCACTCAAATAACTTTTGGATAGCTCAAATAAATTTTTGAAGAATAG
TACTTAGCATATAATTAAATTATCAAAATAGATGATAAAGTATATTATGACCCTCATTAG
ATTAGTTTGAGAAAGATATTTGACAACTTACTACTAAAGAAAATTAGCGAACTTCCAAAT
TATAATTAAGACTACACTAAATTTAAGCTATTTAGCATTGATAATTAGATCACTTGGGAG
TTCAATTTAATGCATGATAGCTCTTTATAAGGATAACAAGTAGTTTGTGATCAAAATAGT
GACCCTACTAGAATAAAGTAGCAACAAATTCAATATATAAAACTAAAGCATGAGCAAACT
TTTAAAGAAAAAATAGATATATTTAAGAGATATAAGTATATTTGA

>TTHERM_00092840(protein)
MEIEAQRSDRSLKLIYGEEVYNKIIQSNVLIGGAGGVGCEIIKSLSKTGFRKFTMIDLDT
IELTNLNRQFYFRKHHVGKAKSACAKEGVLLIEPNILQVDAILGNIYDPKFDDLFYKQFD
IAFCAFDNQGARRHFGKMCTVNNIPMVEAGTSAFNGQTQTRIKDLFECRNCTPEVKQQTS
FNVCSIRTRPSEPIHCIVWASNMFNLIFGNQDDSNLLENYIQDIFKEGIKNVQDPKEKAL
QLFEKIFNEDIQKCDEKERFPISFEQSLQIDNKEDAVYFDERNNRKLLEDEKIFTIKEYA
QKFIQAFLDVFHHRKEALGELKFDKDDQLALKFVAAITNLRTFNFLNKENEKNKLRYLSE
HKIKQMVGNIIPAIASTNAIVSAIQVNEAIKIMKGYAKTKPQLFSEYLVQNGDQSKITPA
QLSLPQLSCPVCSPANCYINIKANCTQITFGQLKQIFEEQYLAYNQIIKIDDKVYYDPHQ
ISLRKIFDNLLLKKISELPNYNQDYTKFKLFSIDNQITWEFNLMHDSSLQGQQVVCDQNS
DPTRIKQQQIQYIKLKHEQTFKEKIDIFKRYKYI

>TTHERM_00092840(gene)
ATGGAAATAGAGGCTTAAAGGTCTGACAGAAGCTTGAAGCTAATTTATGGTGAAGAAGTT
TACAATAAAATTATCTAATCAAATGTTTTAATTGGAGGAGCAGGTGGTGTTGGATGTGAA
ATAATTAAATCATTAAGTAAAACAGGATTTAGGAAATTTACAATGATCGATTTAGATACA
ATAGAGCTAACCAATTTAAATAGGCAATTCTATTTCAGAAAACATCATGTAGGAAAAGCT
AAATCTGCTTGCGCTAAAGAAGGAGTACTATTAATTGAACCAAATATCTTGTAAGTAGAT
GCTATTTTAGGAAATATTTATGATCCAAAGTTTGATGATTTATTTTATAAATAATTTGAT
ATTGCATTTTGTGCTTTTGATAACTAAGGAGCTAGAAGGCACTTTGGTAAGATGTGTACA
GTGAATAACATTCCTATGGTAGAGGCTGGAACTTCTGCATTTAATGGTAATAATTAATTT
TAACAATAAATTGAAAATTATTGTATTTTTCAAAGTCTACTCAATATTTTAACCCTTAAA
AATTTAAAGAATATATTTTTCAAGTAAATTAGGAGTAAAATATAATTTTATTGCTTTGAA
AATTTCAAATAAAATAAGAATTTTAATGTTTTAAAAAATTTATTCAAACAGGATAGACAT
AGACTAGAATAAAAGATTTATTTGAATGCAGAAATTGCACTCCAGAAGTCAAACAATAAA
CTAGCTTTAATGTTTGCTCAATTAGAACTAGACCTTCTGAACCTATTCACTGCATAGTTT
GGGCTTCTAATATGTTTAATTTGATATTTGGGAACCAAGATGATTCAAATTTGTTGGAAA
ACTATATTTAAGATATTTTCAAAGAGGGAATCAAGAATGTCTAAGACCCAAAAGAAAAAG
CTCTTCAGTTATTTGAAAAGATTTTCAACGAAGACATTTAAAAATGTGATGAAAAAGAAA
GATTCCCAATTTCTTTTGAGCAATCTTTATAAATTGACAACAAAGAAGATGCTGTTTACT
TTGATGAAAGAAATAATCGCAAATTGTTAGAAGACGAAAAAATCTTCACTATTAAGGAGT
ATGCACAGAAATTTATTTAAGCGTTTTTAGATGTATTTCATCATAGAAAAGAAGCTTTAG
GAGAACTAAAATTTGATAAAGATGATTAACTGGCTTTGAAATTTGTCGCTGCAATCACTA
ATTTGCGTACATTTAATTTCCTTAATAAGGAAAATGAAAAGAATAAGTTGAGATATCTCT
CAGAGCATAAAATAAAATAAATGGTTGGAAATATTATCCCTGCAATAGGTATTTATTTAA
TTTAAAAATATAAATAAATTATTAAATATCAATTAAACTATAGCATCAACAAACGCTATC
GTTTCTGCTATCCAAGTAAATGAAGCAATTAAAATAATGAAAGGTTATGCCAAAACTAAG
CCTTAACTATTCAGCGAGTATTTAGTCCAAAATGGTGATCAAAGCAAAATAACTCCAGCA
CAGTTATCTGTAAATTATCCATATTAAATAAGCACATTTTTTTAAACTATAAATTTAATT
TAAAAGCTTCCACAATTATCTTGTCCTGTTTGCTCTCCAGCTAATTGCTACATAAACATA
AAAGCAAATTGCACTCAAATAACTTTTGGATAGCTCAAATAAATTTTTGAAGAATAGTAC
TTAGCATATAATTAAATTATCAAAATAGATGATAAAGTATATTATGACCCTCATTAGATT
AGTTTGAGAAAGATATTTGACAACTTACTACTAAAGAAAATTAGCGAACTTCCAAATTAT
AATTAAGACTACACTAAATTTAAGCTATTTAGCATTGATAATTAGATCACTTGGGAGTTC
AATTTAATGCATGATAGCTCTTTATAAGGATAACAAGTAGTTTGTGATCAAAATAGTGAC
CCTACTAGAATAAAGTAGCAACAAATTCAATATATAAAACTAAAGCATGAGCAAACTTTT
AAAGAAAAAATAGATATATTTAAGAGATATAAGTATATTTGA