Identifiers and Description

Gene Model Identifier

TTHERM_00391590

Standard Name

UBA2 (Ubiquitin Activating enzyme 2 )

Aliases

PreTt23486 | 42.m00220 | 3813.m01445

Description

Ubiquitin activating enzyme

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• ubiquitin-like modifier activating enzyme activity (IEA) | GO:0008641
• ATP binding (IEA) | GO:0005524
• catalytic activity (IEA) | GO:0003824

Biological Process

• cellular protein modification process (IEA) | GO:0006464

Domains

No Data fetched for Domains

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 13.4%

TetraMine Data

TTHERM_00391590

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_11464.1	9.997093137033517e-262	ubiquitin-activating enzyme e1 (684 aa)
Oxytricha	Contig20101.0.g96	4.0006908853687255e-76	ThiF family
DictyBase	DDB_G0286919	1.9999590304423412e-72	uba2 on chromosome: 4 position 5077667 to 5079750
WormBase	WBGene00006700	4.000989088096131e-71	locus:uba-2 SUMO-activating enzyme subunit uba-2 status: Partially_confirmed UniProt: Q9NAN1 protein_id:CAB54319.4
SGD	YDR390C	6.9972728945133496e-59	UBA2 Subunit of a heterodimeri c nuclear SUMO activating enzy me (E1) with Aos1p; activates Smt3p (SUMO) before its conjug ation to proteins (sumoylation ), which may play a role in pr otein targeting; essential for viability
Stentor Coeruleus	SteCoe_19993	0.000000000000004658886145103398

General Information

No Data fetched for General Information

Associated Literature

1. Ref:25527524: Nasir AM, Yang Q, Chalker DL, Forney JD (2015) SUMOylation is developmentally regulated and required for cell pairing during conjugation in Tetrahymena thermophila. Eukaryotic cell 14(2):170-81
2. Ref:16682458: Matsuda A, Forney JD (2006) The SUMO pathway is developmentally regulated and required for programmed DNA elimination in Paramecium tetraurelia. Eukaryotic cell 5(5):806-15

Sequences

>TTHERM_00391590(coding)
ATGAGTTTAGGAAGAATAAATCAGCTTTTATTTGGCAAGGAATTTTTAAACTATTTAAAT
GAAATAAACATTCTTCTTATTGGTGTAGGAGGCATTGGTTGCGAAGTTTTAAAAGTGTTG
TAATAGTTTAAAGTGAAGTCTTTACATATTTTGGATTTAGATACAATTGAAGTTTCAAAT
CTCAATCGTCAGTTTTTGTTTCGTAAACATCACAGAGGACATTTTAAAGCACACGTAGCT
AGAGATGTTTTGAAGCAAGAATATCCTGATATGAATATTATTTCATATAACAGCAATATT
AAGGATGCTTAATTTGGGTTAAAGTTCTTTAAAAACTTCTAGCTTGTCATTATGGCTCTT
GATAATTAAGAAACCAGGTCTTTTGTAAACAAATAATGCATGATATTGAATATTCCTTTG
ATAGATGCAGGAACAACTGGATATAAAGGATAGAGCTTTATATTGAAGAGAGGAGAGACT
AGATGCTACGACTGCTTCCCTAGATCTGAAAATAAGAAAACCTACCCTGCTTGCACTATC
AGAACTCTTCCTGAGAAGCCAGTTCACTGCATCATCTGGGCTAAATATCTTTACACTGTA
CTTTTTAATGAGAAATTAGAAGATGACGATGATTCCAACCTTCTTTAGGATATTGCTAAA
TACATTGAAGGAGAAAACCATACCGACCTTGAGAAAGGACAATACCTTTTTAAGGCTATA
TTTGAAACTGATGTTAATAGGTAGAAGGAAGGAGAAGATAATTAAAAATTTTAGCATTTG
AAAGTGCTAGTTAGAGAGGAGTTAGAGGGTAAGTTAGATAAATCTCAAGATTATTTGCAT
AGATAAGACTTAAAATTCTTGCAAAGCACCCATACTGAAGAAGTTTATATGGATATTTTT
ATTAAGAGCTTTGAGCATTTGATCAAGGAAAAAAGATAAAAAAGTTGTGTTCCCTTTGAA
AAAGATGACAATTTGTGTATGAAGTTTATTACTGCTGCATGTAATTTACGTTGCATAGTT
TTTTCCATTCCTCTCTAAACTTAATTTTAGGTTAAGGAAGTTGCTGGTAATATTGTGCCT
GCTATTGCAAGCACTAATTCAATAGTAAGTGCTATTGAAATTACTGAAACTATTAAATTA
TTATAAAGACAGTTTTACAACAACCCTTAAAAATACAAAAATAGAGAATTATACATTTAA
AATGACATTAAAACTAAAATCCTTGATGCAAAACCTGGTAACTTCAATCCTAATTGCATG
TCTTGCAACTAGAATTTGCTTCCTCATATTATTTATTGTGATTTTAACAAAGTCACTCTT
GGAGAGTTTATTAATTCTGAGCTTCGTAGCAAAGCTATGTAGGATGAAGATGATGATGAG
GGAAACGATGATAATAAATTAGTTAACTTTAGTATTTCAAGTGGTTAATTTATTATATAT
GAAGAGGATGAGTATCAAGAAGAAGATGAATAAGAGCAAAACGAAGCAAAGCGCCAAAAA
TTAATCAGTGAAATATTCAAAGACTTTTCTGATAGTAGAGTTGTAGTTACAAATGAGGAT
AACAACAGCATCCATTAAACTTATCTCTTCTGTCATATCGAGAACCACAAAATCCCTGGT
CTTGACATAGTTCGCTAAGAAAAGAATCCTAACAATACAGTCACATGGAAAACAGTGATT
GCTTAATCAGACACTGTAAACAAAGATGAGGAATAAAAAAAGCAAGAAGAAGAAGAACAA
AATAAAAAGAACTATAAGGAAGTTAAAGGAGATGACAAAAACAATAACACTTTAGAAATA
TTAGATTCCGATTCAGAAGATGATTTAGTTATTTGCGAAGATAATGATAATCCATCTCAA
GGCGCCGCAGAAAAAGAAAAGAGTAAATAATCAAATGGAAAATAACCTCATTCTGAAACT
GATGTATCTTCTTTAAACCAAAAGAGAAAGGCAGTATAGGAAATTTCTGATGGTGGAGCT
ATGTAAATAATTGATGACAGTGATGATGAAATAATTTTTGAAGATTAATAAGACAACAAA
AAGTTAAAAGTGGATTGA

>TTHERM_00391590(protein)
MSLGRINQLLFGKEFLNYLNEINILLIGVGGIGCEVLKVLQQFKVKSLHILDLDTIEVSN
LNRQFLFRKHHRGHFKAHVARDVLKQEYPDMNIISYNSNIKDAQFGLKFFKNFQLVIMAL
DNQETRSFVNKQCMILNIPLIDAGTTGYKGQSFILKRGETRCYDCFPRSENKKTYPACTI
RTLPEKPVHCIIWAKYLYTVLFNEKLEDDDDSNLLQDIAKYIEGENHTDLEKGQYLFKAI
FETDVNRQKEGEDNQKFQHLKVLVREELEGKLDKSQDYLHRQDLKFLQSTHTEEVYMDIF
IKSFEHLIKEKRQKSCVPFEKDDNLCMKFITAACNLRCIVFSIPLQTQFQVKEVAGNIVP
AIASTNSIVSAIEITETIKLLQRQFYNNPQKYKNRELYIQNDIKTKILDAKPGNFNPNCM
SCNQNLLPHIIYCDFNKVTLGEFINSELRSKAMQDEDDDEGNDDNKLVNFSISSGQFIIY
EEDEYQEEDEQEQNEAKRQKLISEIFKDFSDSRVVVTNEDNNSIHQTYLFCHIENHKIPG
LDIVRQEKNPNNTVTWKTVIAQSDTVNKDEEQKKQEEEEQNKKNYKEVKGDDKNNNTLEI
LDSDSEDDLVICEDNDNPSQGAAEKEKSKQSNGKQPHSETDVSSLNQKRKAVQEISDGGA
MQIIDDSDDEIIFEDQQDNKKLKVD

>TTHERM_00391590(gene)
ATGAGTTTAGGAAGAATAAATCAGCTTTTATTTGGCAAGGAATTTTTAAACTATTTAAAT
GAAATAAACATTCTTCTTATTGGTGTAGGAGGCATTGGTTGCGAAGTTTTAAAAGTGTTG
TAATAGTTTAAAGTGAAGTCTTTACATATTTTGGATTTAGATACAATTGAAGTTTCAAAT
CTCAATCGTCAGTTTTTGTTTCGTAAACATCACAGAGGACATTTTAAAGTAATTGAAATT
TACTTTTGGGCGGATTAATAATTTATTCCTGAAAAATTATCTAGGCACACGTAGCTAGAG
ATGTTTTGAAGCAAGAATATCCTGATATGAATATTATTTCATATAACAGCAATATTAAGG
ATGCTTAATTTGGGTTAAAGTTCTTTAAAAACTTCTAGCTTGTCATTATGGCTCTTGATA
ATTAAGAAACCAGGTCTTTTGTAAACAAATAATGCATGATATTGAATATTCCTTTGATAG
ATGCAGGAACAACTGGATATAAAGGATAGAGCTTTATATTGAAGAGAGGAGAGACTAGAT
GCTACGACTGCTTCCCTAGATCTGAAAATAAGAAAACCTACCCTGCTTGCACTATCAGAA
CTCTTCCTGAGAAGCCAGTTCACTGCATCATCTGGGCTAAATATCTTTACACTGTACTTT
TTAATGAGAAATTAGAAGATGACGATGATTCCAACCTTCTTTAGGATATTGCTAAATACA
TTGAAGGAGAAAACCATACCGACCTTGAGAAAGGACAATACCTTTTTAAGGCTATATTTG
AAACTGATGTTAATAGGTAAAAAGATATCTTTTATAAAATAAAATCCAATATAAATTATT
AGAAGACACTTAAATTATACATTCAATCTTTAATTAATTAATTAATTAATTATTATATTT
TGTGTAGACAGAGATAGATAGAACTTTAATTTTTATCTTTTATTACAGGTAGAAGGAAGG
AGAAGATAATTAAAAATTTTAGCATTTGAAAGTGCTAGTTAGAGAGGAGTTAGAGGGTAA
GTTAGATAAATCTCAAGATTATTTGCATAGATAAGACTTAAAATTCTTGCAAAGCACCCA
TACTGAAGAAGTTTATATGGATATTTTTATTAAGAGCTTTGAGCATTTGATCAAGGAAAA
AAGATAAAAAAGTTGTGTTCCCTTTGAAAAAGATGACAATTTGTGTATGAAGTTTATTAC
TGCTGCATGTAATTTACGTTGCATAGTTTTTTCCATTCCTCTCTAAACTTAATTTTAGGT
TAAGGAAGTTGCTGGTAATATTGTGCCTGCTATTGCAAGCACTAATTCAATAGTAAGTGC
TATTGAAATTACTGAAACTATTAAATTATTATAAAGACAGTTTTACAACAACCCTTAAAA
ATACAAAAATAGAGAATTATACATTTAAAATGACATTAAAACTAAAATCCTTGATGCAAA
ACCTGGTAACTTCAATCCTAATTGCATGTCTTGCAACTAGAATTTGCTTCCTCATATTAT
TTATTGTGATTTTAACAAAGTCACTCTTGGAGAGTTTATTAATTCTGAGCTTCGTAGCAA
AGCTATGTAGGATGAAGATGATGATGAGGGAAACGATGATAATAAATTAGTTAACTTTAG
TATTTCAAGTGGTTAATTTATTATATATGAAGAGGATGAGTATCAAGAAGAAGATGAATA
AGAGCAAAACGAAGCAAAGCGCCAAAAATTAATCAGTGAAATATTCAAAGACTTTTCTGA
TAGTAGAGTTGTAGTTACAAATGAGGATAACAACAGCATCCATTAAACTTATCTCTTCTG
TCATATCGAGAACCACAAAATCCCTGGTCTTGACATAGTTCGCTAAGAAAAGAATCCTAA
CAATACAGTCACATGGAAAACAGTGATTGCTTAATCAGACACTGTAAACAAAGATGAGGA
ATAAAAAAAGCAAGAAGAAGAAGAACAAAATAAAAAGAACTATAAGGAAGTTAAAGGAGA
TGACAAAAACAATAACACTTTAGAAATATTAGATTCCGATTCAGAAGATGATTTAGTTAT
TTGCGAAGATAATGATAATCCATCTCAAGGCGCCGCAGAAAAAGAAAAGAGTAAATAATC
AAATGGAAAATAACCTCATTCTGAAACTGATGTATCTTCTTTAAACCAAAAGAGAAAGGC
AGTATAGGAAATTTCTGATGGTGGAGCTATGTAAATAATTGATGACAGTGATGATGAAAT
AATTTTTGAAGATTAATAAGACAACAAAAAGTTAAAAGTGGATTGA