Gene Model Identifier
TTHERM_00144830
Standard Name
TWI11
Aliases
PreTt26691 | 11.m00388 | 3702.m00110
Description
TWI11 piwi domain protein; Argonaute/Piwi family protein
Genome Browser (Macronucleus)
Genome Browser (Micronucleus)
Cellular Component Molecular Function Biological Process
Tetrahymena Functional Genomics Database:
Signal Peptide Present?: No
TTHERM_00144830
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( SD02064 ) ( SD02065 ) ( SD02066 ) Macronucleus: N-terminal HA tag on Twi 11 ( SD02067 ) Macronucleus: N-terminal HA tag on Twi 11 ( SD02114 ) ( SD02797 ) Micronucleus: HA tagged TWI11 ( SD02798 ) Micronucleus: HA tagged TWI11 ( SD02799 ) Micronucleus: Neo3 upstream of HA tagged TWI11 ( SD02800 ) Micronucleus: Neo3 upstream of HA tagged TWI11 ( SD02801 ) Micronucleus: TWI11-HA with neo3 in 5’ region Macronucleus: TWI11-HA with neo3 in 5’ region ( SD02802 ) Micronucleus: TWI11-HA with neo3 in 5’ region Macronucleus: TWI11-HA with neo3 in 5’ region ( SD02803 ) Micronucleus: TWI11-HA with neo3 in 5’ region Macronucleus: TWI11-HA with neo3 in 5’ region ( SD02804 ) Micronucleus: TWI11-HA with neo3 in 5’ region Macronucleus: TWI11-HA with neo3 in 5’ region ( SD02805 ) Micronucleus: TWI11-HA with neo3 in 5’ region Macronucleus: TWI11-HA with neo3 in 5’ region ( SD02853 ) Macronucleus: TWI11 with neo3 ( SD02854 ) Micronucleus: Part of TWI11 coding replaced with neo3 cassette. ( SD02855 ) Micronucleus: Part of TWI11 coding replaced with neo3 cassette, homozygous ( SD02856 ) Micronucleus: Part of TWI11 coding replaced with neo3 cassette, heterozygous ( SD02857 ) Micronucleus: Part of TWI11 coding replaced with neo3 cassette, homozygous ( SD02858 ) Micronucleus: Neo 3 cassette replaces part of TWI11 coding region Macronucleus: Neo 3 cassette replaces part of TWI11 coding region ( SD02860 ) Micronucleus: Neo3 replaces part of TWI11 Macronucleus: Neo3 replaces part of TWI11 ( SD02861 ) Micronucleus: Original ΔTWI11 mic replaced by the WT mic of a CU427 cell Macronucleus: Still has ΔTWI11 with neo3 replacing part of coding ( SD02862 ) Micronucleus: neo3 in coding Macronucleus: neo3 in coding ( SD02863 ) Macronucleus: TWI11 with neo3 ( SD02864 ) Macronucleus: TWI11 with neo3 ( SD02865 ) Macronucleus: TWI11 with neo3 ( SD02866 ) Macronucleus: neo3 replaces part of coding region
(v.2006 protein sequences)
Source Identifier Score Description
Tetrahymena borealis EI9_04784.1 9.997093137033517e-262 piwi domain-containing protein
Oxytricha Contig1484.1.g65 8.002927718340724e-80 Piwi domain
DictyBase DDB_G0271870 2.0008536325002377e-42 agnC on chromosome: 2 position
WormBase WBGene00004178 1.9994920269952867e-34 locus:prg-1 status:Confirmed
Stentor Coeruleus SteCoe_687 5.380186160021138e-32
Paragraph No Gene Name Paragraph Text 108 TWI1 ,TWI11 Maternally-expressed Twi1p is loaded with Early-scnRNAs expressed from the MIC at early conjugation stages while zygotically-expressed Twi1p and Twi11p are loaded with Late-scnRNAs expressed from the new MAC at late conjugation stages (Noto et al. 2015).
Ref:29887308 : Noto T, Mochizuki K (2018) Small RNA-Mediated trans-Nuclear and trans-Element Communications in Tetrahymena DNA Elimination. Current biology : CB 28(12):1938-1949.e5Ref:29920263 : Chalker DL (2018) Transgenerational Inheritance: Parental Guidance Suggested. Current biology : CB 28(12):R702-R704Ref:29021213 : Noto T, Mochizuki K (2017) Whats, hows and whys of programmed DNA elimination in Tetrahymena. Open biology 7(10): Ref:27892853 : Hamilton EP, Kapusta A, Huvos PE, Bidwell SL, Zafar N, Tang H, Hadjithomas M, Krishnakumar V, Badger JH, Caler EV, Russ C, Zeng Q, Fan L, Levin JZ, Shea T, Young SK, Hegarty R, Daza R, Gujja S, Wortman JR, Birren BW, Nusbaum C, Thomas J, Carey CM, Pritham EJ, Feschotte C, Noto T, Mochizuki K, Papazyan R, Taverna SD, Dear PH, Cassidy-Hanley DM, Xiong J, Miao W, Orias E, Coyne RS (2016) Structure of the germline genome of Tetrahymena thermophila and relationship to the massivelRef:26095658 : Noto T, Kataoka K, Suhren JH, Hayashi A, Woolcock KJ, Gorovsky MA, Mochizuki K (2015) Small-RNA-Mediated Genome-wide trans-Recognition Network in Tetrahymena DNA Elimination. Molecular cell 59(2):229-42Ref:19656801 : Couvillion MT, Lee SR, Hogstad B, Malone CD, Tonkin LA, Sachidanandam R, Hannon GJ, Collins K (2009) Sequence, biogenesis, and function of diverse small RNA classes bound to the Piwi family proteins of Tetrahymena thermophila. Genes & development 23(17):2016-32
>TTHERM_00144830(coding)ATG AGT TTT AAC GAT AAT AGT AAT ACT TTG GTT ACT AAT CAT TAC AAA ATT AAA ATT AAT AAT ATA AAG ATT AAT TGC TAT GAA TTT TAG ACT TAG CCT CCT ATT GAT CCT CTT TTG CTT AAC CGT AAG TCA AGA TAC ATC TCA AGA GTT TTC AAC AAA AAG ATA AAA GAA ATA TTT AGT ACC TTT ATT ATT GGG TCT TAA CTT ATT TAC TCT CCT ATT GAT TTG CAT AAT AAA GTC AGT CTT GGA ACC TTT GAT TTT GTA TCC CCT AAG ACT GAT GGG TGT GAG TCC TTC ACT TAA GAG CTT GAA GTT TTC TTA GTA AAG AAA AAA GAT ATT GTT GGA TAA TAG CTT GAA GAG GAA AAT AAA GAA CTT CAA AAT ATA TTG GGA TAG CTA ATG AGA AAC TTC TAA AAT AAC ACT AAA GGG TTT TAA TAG CTT GGT GCT ACT AAG AGG TTT GCT ATG AAT GTT ATA AAA AAT ATC TCT AAT GGC CTT GAA GCA GTT CTC GGA GTT GAA ACT TTC TTC AAA TTT AGT CCT CAA ACA GGA TTT TAA CTT TCA GTA GAT TAC TGT ATC AAA GTT ATT AAC AAC ACA TCT GTT TAT GAT TTC TTA AAA AAA TCT ATG TCT TAA GGA GCA GAT AGT ATC CAA GAA AAA ATG TAA AAC TGT GTA GTT ATT AGT AAT TAT GGA GAT AAA AAA TTG TAC AAG GTT AAT GGA GTA GCG TTT GAT TTA AAT CCT AAT TCT TTC TTT GAA ATG AGG GAT CCT AAT GAA TCT ACT GGT AAA AAG AAA ATA TCA TTC GTT TAA TAC TAT GAG CTC GTC CAT AAC ATC AGA ATT AGA GAT AAT AGA TAG CCT CTT CTT ATA GTT GAA AAG AAA AGA AGA TAA AAT AAA AGA GCT AAT TAA GAA GGA AAA CCA TAA TAA GAA ACT CCT AAA ATC TAT TTA ATA CCA GAG TTA TGC TAA ATG ACT GGC ATT CCT GAT GAA CTT CAA AAT GAC TTT ATG CTC AAG AAA GCT ATA ACA CAA GTT TCC TAG CCC AAA CCT TAA GAG AGA TCT TAG CAC TGT GGA AAT TAT GTC TCA GCT CTA ATA CAC TAA AAC TAA AAG GCT CTA AGT GAA TGG GGC ATT TAA CTA AGC TAA AAT GAC CCT GTT AAA GCT CGT TAT CAA GTT ATC CAA CCA GGA TGT ATT CTT ATG AAT TAA AAT AGA GAA ATT AAC ATT TAT GGA GAA AAA TAA CTA GAT AGA AAA ATT TAA GAT AGA ATG TAC CAG CCT TGC TAC CTC AAG AAG TGG TGT GCC ATT TGT CAC AAA TCT GAT CAA TAA TTG GCT GGC TAG TTC ATG TCA ACA CTG AAG AAT AGA ATG CAA GCT CAT GGG ATA GGA TAT AAT GAA CCT AAT TAT TTT ACT GTT GAA GGT TAA TCA CAA GAT GAA CTC AAA AGG CTT ATC GAT TCA TTC CCA CCT GAT GTT GAT TTT ATT GTA TTT ATA TTG CAA GGA GCC AAA GGA AAA GGC AAA AAT TAT TAG TAC CTA AAA TCT TTT TTG TTA AAA GAA AAA CCT ATT CCT AGC TAG ATG ATT CTT TAA GGT ACT ATC AAG AGC AGT AAA GAT GGT TGC TAA GTT ATT TGT AAC AAG ATA TGC AAT CAA ATA TGT ATT AAA GTT GGA GGA ATA CCT TAC ATC ATC AAA GAT CTT CCA TTT AGT AAT CTT CCT ACT ATG CTT GTT GGT ATA GAT TAC ATC CGC AAA GAA AAC TAA AAA TCA GTT TAT TCA TTT GTT GCT TCA GTT GAC AGT ACA TTC TGT AAA TTT TTT TCA GGT GCT TAA CTT TTA GAC GCT TAA GAC TAA AAT AAC AAA TTT GTT GAC AAG CTT TTG CAA GCA AGT CTT ACT TAA TTT AAA TAA AAA AAT GGA ATA CTG CCT TAA CGT GTT ATA ATT TAT AGA TAA GCT GCT AAC AAT ATA TTG AAC GAG CCT CTA AAG GAA GAA ATT GCA ATC ATG AAA AAA TGC CTA TCA GAA ATG GAA ATG TCT TAA TGC AAG ATC CAC ATA GTT GGT GTT AAC AGT AGT GAT AAG ACT AAA TTT TTC AAT GAA GAT TAC TCT AAT CCA GCT TAA GGA ACT GTC ATT AGT TAA GAT GTA GTA TCA TCG TAA GGA GAT TTC TTC TTG GTG TCT CAA AGA TCT ATG CAA GGA ACT GCA TAA CCT ATG ATG TAC AAA GAG ATT TAC AGT GAT TAT GAA GGT ATG GAA TTA GAA TAA ATA AGG ACT TAA CTT CAT ACC TTG ACC TAT AGG ATG AGT TAT CTT TTC TAC AAT TTC ACT GGA GCA ATC AAG ATA CCA AGC ATC TTG AAG TAT GCT GAA TAG TAA ACT AAA TTC ATG AAA AAC AAC TTT GAG AAC TTG AAT AAG ATG GAC CCT CAA ACA CTC CTC AGC TAG AAG ATG TGT GAT AAG AAT TCT ACA TTC TAT ATT TGA >TTHERM_00144830(protein)M S F N D N S N T L V T N H Y K I K I N N I K I N C Y E F Q T Q P P I D P L L L N R K S R Y I S R V F N K K I K E I F S T F I I G S Q L I Y S P I D L H N K V S L G T F D F V S P K T D G C E S F T Q E L E V F L V K K K D I V G Q Q L E E E N K E L Q N I L G Q L M R N F Q N N T K G F Q Q L G A T K R F A M N V I K N I S N G L E A V L G V E T F F K F S P Q T G F Q L S V D Y C I K V I N N T S V Y D F L K K S M S Q G A D S I Q E K M Q N C V V I S N Y G D K K L Y K V N G V A F D L N P N S F F E M R D P N E S T G K K K I S F V Q Y Y E L V H N I R I R D N R Q P L L I V E K K R R Q N K R A N Q E G K P Q Q E T P K I Y L I P E L C Q M T G I P D E L Q N D F M L K K A I T Q V S Q P K P Q E R S Q H C G N Y V S A L I H Q N Q K A L S E W G I Q L S Q N D P V K A R Y Q V I Q P G C I L M N Q N R E I N I Y G E K Q L D R K I Q D R M Y Q P C Y L K K W C A I C H K S D Q Q L A G Q F M S T L K N R M Q A H G I G Y N E P N Y F T V E G Q S Q D E L K R L I D S F P P D V D F I V F I L Q G A K G K G K N Y Q Y L K S F L L K E K P I P S Q M I L Q G T I K S S K D G C Q V I C N K I C N Q I C I K V G G I P Y I I K D L P F S N L P T M L V G I D Y I R K E N Q K S V Y S F V A S V D S T F C K F F S G A Q L L D A Q D Q N N K F V D K L L Q A S L T Q F K Q K N G I L P Q R V I I Y R Q A A N N I L N E P L K E E I A I M K K C L S E M E M S Q C K I H I V G V N S S D K T K F F N E D Y S N P A Q G T V I S Q D V V S S Q G D F F L V S Q R S M Q G T A Q P M M Y K E I Y S D Y E G M E L E Q I R T Q L H T L T Y R M S Y L F Y N F T G A I K I P S I L K Y A E Q Q T K F M K N N F E N L N K M D P Q T L L S Q K M C D K N S T F Y I >TTHERM_00144830(gene)ATG AGT TTT AAC GAT AAT AGT AAT ACT TTG GTT ACT AAT CAT TAC AAA ATT AAA ATT AAT AAT ATA AAG ATT AAT TGC TAT GAA TTT TAG ACT TAG CCT CCT ATT GAT CCT CTT TTG CTT AAC CGT AAG TCA AGA TAC ATC TCA AGA GTT TTC AAC AAA AAG ATA AAA GAA ATA TTT AGT ACC TTT ATT ATT GGG TCT TAA CTT ATT TAC TCT CCT ATT GAT TTG CAT AAT AAA GTC AGT CTT GGA ACC TTT GAT TTT GTA TCC CCT AAG ACT GAT GGG TGT GAG TCC TTC ACT TAA GAG CTT GAA GTT TTC TTA GTA AAG AAA AAA GAT ATT GTT GGA TAA TAG CTT GAA GAG GAA AAT AAA GAA CTT CAA AAT ATA TTG GGA TAG CTA ATG AGA AAC TTC TAA AAT AAC ACT AAA GGG TTT TAA TAG CTT GGT GCT ACT AAG AGG TTT GCT ATG AAT GTT ATA AAA AAT ATC TCT AAT GGC CTT GAA GCA GTT CTC GGA GTT GAA ACT TTC TTC AAA TTT AGT CCT CAA ACA GGA TTT TAA CTT TCA GTA GAT TAC TGT ATC AAA GTT ATT AAC AAC ACA TCT GTT TAT GAT TTC TTA AAA AAA TCT ATG TCT TAA GGA GCA GAT AGT ATC CAA GAA AAA ATG TAA AAC TGT GTA ATC AAT TAT TAT TTC TTG ATT TTA TTT TTT ACA TTA ATT AAA AAT TTT ATT TAA ACA GGT AGT TAT TAG TAA TTA TGG AGA TAA AAA ATT GTA CAA GGT TAA TGG AGT AGC GTT TGA TTT AAA TCC TAA TTC TTT CTT TGA AAT GAG GGA TCC TAA TGA ATC TAC TGG TAA AAA GAA AAT ATC ATT CGT TTA ATA CTA TGA GCT CGT CCA TAA CAT CAG AAT TAG AGA TAA TAG ATA GCC TCT TCT TAT AGT TGA AAA GAA AAG AAG ATA AAA TAA AAG AGC TAA TTA AGA AGG AAA ACC ATA ATA AGA AAC TCC TAA AAT CTA TTT AAT ACC AGA GTT ATG CTA AAT GAC TGG CAT TCC TGA TGA ACT TCA AAA TGA CTT TAT GCT CAA GAA AGC TAT AAC ACA AGT TTC CTA GCC CAA ACC TTA AGA GAG ATC TTA GCA CTG TGG AAA TTA TGT CTC AGC TCT AAT ACA CTA AAA CTA AAA GGC TCT AAG TGA ATG GGG CAT TTA ACT AAG CTA AAA TGA CCC TGT TAA AGC TCG TTA TCA AGT TAT CCA ACC AGG ATG TAT TCT TAT GAA TTA AAA TAG AGA AAT TAA CAT TTA TGG AGA AAA ATA ACT AGA TAG AAA AAT TTA AGA TAG AAT GTA CCA GCC TTG CTA CCT CAA GAA GGT ATT TTT TAT TTT TAA TTT TTT TTA ATA ATT TTT CAA ACA CAA GAA AAT TTT TTA TTT ATT TTT TAC ATT TTA TTT ATA ATA ATA TTA TTT AAA AGT GGT GTG CCA TTT GTC ACA AAT CTG ATC AAT AAT TGG CTG GCT AGT TCA TGT CAA CAC TGA AGA ATA GAA TGC AAG CTC ATG GGA TAG GAT ATA ATG AAC CTA ATT ATT TTA CTG TTG AAG GTT AAT CAC AAG ATG AAC TCA AAA GGC TTA TCG ATT CAT TCC CAC CTG ATG TTG ATT TTA TTG TAT TTA TAT TGC AAG GAG CCA AAG GAA AAG GCA AAA ATT ATT AGT ACC TAA AAT CTT TTT TGT TAA AAG AAA AAC CTA TTC CTA GCT AGA TGA TTC TTT AAG GTA CTA TCA AGA GCA GTA AAG ATG GTT GCT AAG TTA TTT GTA ACA AGA TAT GCA ATC AAA TAT GTA TTA AAG TTG GAG GAA TAC CTT ACA TCA TCA AAG ATC TTC CAT TTA GTA ATC TTC CTA CTA TGC TTG TTG GTA TAG ATT ACA TCC GCA AAG AAA ACT AAA AAT CAG TTT ATT CAT TTG TAA AAT TTT TTT TTT CAT CTA TTC ATT AAA AGA AAA AAA TAA ATT ATT AAT TAA TTA CTT TAA CTT TAC TAA TTA AGG TTG CTT CAG TTG ACA GTA CAT TCT GTA AAT TTT TTT CAG GTG CTT AAC TTT TAG ACG CTT AAG ACT AAA ATA ACA AAT TTG TTG ACA AGC TTT TGC AAG CAA GTC TTA CTT AAT TTA AAT AAA AAA ATG GAA TAC TGC CTT AAC GTG TTA TAA TTT ATA GAT AAG CTG CTA ACA ATA TAT TGA ACG AGC CTC TAA AGG AAG AAA TTG CAA TCA TGA AAA AAT GCC TAT CAG AAA TGG AAA TGT CTT AAT GCA AGA TCC ACA TAG TTG GTG TTA ACA GTA GTG ATA AGA CTA AAT TTT TCA ATG AAG ATT ACT CTA ATC CAG CTT AAG GAA CTG TCA TTA GTT AAG ATG TAG TAT CAT CGT AAG GAG ATT TCT TCT TGG TGT CTC AAA GAT CTA TGC AAG GAA CTG CAT AAC CTA TGA TGT ACA AAG AGA TTT ACA GTG ATT ATG AAG GTA TGG AAT TAG AAT AAA TAA GGA CTT AAC TTC ATA CCT TGA CCT ATA GGA TGA GTT ATC TTT TCT ACA ATT TCA CTG GAG CAA TCA AGA TAC CAA GCA TCT TGA AGT ATG CTG AAT AGT AAA CTA AAT TCA TGA AAA ACA ACT TTG AGA ACT TGA ATA AGA TGG ACC CTC AAA CAC TCC TCA GCT AGA AGA TGT GTG ATA AGA ATT CTA CAT TCT ATA TTT GA
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