Zhao X, Xiong J, Mao F, Sheng Y, Chen X, Feng L, Dui W, Yang W, Kapusta A, Feschotte C, Coyne RS, Miao W, Gao S, Liu Y (2019) RNAi-dependent Polycomb repression controls transposable elements in Tetrahymena. Genes & development 33(5-6):348-364 PUBMED:30808657
Ashraf K, Nabeel-Shah S, Garg J, Saettone A, Derynck J, Gingras AC, Lambert JP, Pearlman RE, Fillingham J (2019) Proteomic analysis of histones H2A/H2B and variant Hv1 in Tetrahymena thermophila reveals an ancient network of chaperones. Molecular biology and evolution ( ): PUBMED:30796450
Tian M, Loidl J (2018) A chromatin-associated protein required for inducing and limiting meiotic DNA double-strand break formation. Nucleic acids research ( ): PUBMED:30357385
Identifiers and Description
Gene Model Identifier
TTHERM_00429730
Standard Name
TTP80 (Tetrahymena Thermophila Protein)
Aliases
PreTt26414 | 48.m00177 | 3831.m01522
Description
Protein that complexes with p95, initially isolated by telomerase association, but deletion results in telomere lengthening without affecting telomerase stability or activity
Ref:15701761: Poderycki MJ, Rome LH, Harrington L, Kickhoefer VA (2005) The p80 homology region of TEP1 is sufficient for its association with the telomerase and vault RNAs, and the vault particle. Nucleic acids research 33(3):893-902
Ref:14563212: Bateman A, Kickhoefer V (2003) The TROVE module: a common element in Telomerase, Ro and Vault ribonucleoproteins. BMC bioinformatics 4( ):49
Ref:11592988: Mason DX, Autexier C, Greider CW (2001) Tetrahymena proteins p80 and p95 are not core telomerase components. Proceedings of the National Academy of Sciences of the United States of America 98(22):12368-73
Ref:11090621: Miller MC, Collins K (2000) The Tetrahymena p80/p95 complex is required for proper telomere length maintenance and micronuclear genome stability. Molecular cell 6(4):827-37
Ref:11027287: Liu Y, Snow BE, Hande MP, Baerlocher G, Kickhoefer VA, Yeung D, Wakeham A, Itie A, Siderovski DP, Lansdorp PM, Robinson MO, Harrington L (2000) Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo. Molecular and cellular biology 20(21):8178-84
Ref:10551828: Kickhoefer VA, Stephen AG, Harrington L, Robinson MO, Rome LH (1999) Vaults and telomerase share a common subunit, TEP1. The Journal of biological chemistry 274(46):32712-7
Ref:9499406: Gandhi L, Collins K (1998) Interaction of recombinant Tetrahymena telomerase proteins p80 and p95 with telomerase RNA and telomeric DNA substrates. Genes & development 12(5):721-33
Ref:9485011: Ramakrishnan S, Eppenberger U, Mueller H, Shinkai Y, Narayanan R (1998) Expression profile of the putative catalytic subunit of the telomerase gene. Cancer research 58(4):622-5
Ref:9671704: Collins K, Gandhi L (1998) The reverse transcriptase component of the Tetrahymena telomerase ribonucleoprotein complex. Proceedings of the National Academy of Sciences of the United States of America 95(15):8485-90
Ref:9118230: Nakayama J, Saito M, Nakamura H, Matsuura A, Ishikawa F (1997) TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family. Cell 88(6):875-84
Ref:9020079: Harrington L, McPhail T, Mar V, Zhou W, Oulton R, Bass MB, Arruda I, Robinson MO (1997) A mammalian telomerase-associated protein. Science (New York, N.Y.) 275(5302):973-7
Ref:9398860: Weinrich SL, Pruzan R, Ma L, Ouellette M, Tesmer VM, Holt SE, Bodnar AG, Lichtsteiner S, Kim NW, Trager JB, Taylor RD, Carlos R, Andrews WH, Wright WE, Shay JW, Harley CB, Morin GB (1997) Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nature genetics 17(4):498-502
Ref:9328462: Kipling D (1997) Mammalian telomerase: catalytic subunit and knockout mice. Human molecular genetics 6(12):1999-2004
Ref:9294165: Ramakrishnan S, Sharma HW, Farris AD, Kaufman KM, Harley JB, Collins K, Pruijn GJ, van Venrooij WJ, Martin ML, Narayanan R (1997) Characterization of human telomerase complex. Proceedings of the National Academy of Sciences of the United States of America 94(19):10075-9
Ref:9255061: Shore D (1997) Telomerase and telomere-binding proteins: controlling the endgame. Trends in biochemical sciences 22(7):233-5
Ref:7774009: Collins K, Kobayashi R, Greider CW (1995) Purification of Tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme. Cell 81(5):677-86
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