Nabeel-Shah S, Ashraf K, Saettone A, Garg J, Derynck J, Lambert JP, Pearlman RE, Fillingham J (2020) Nucleus-specific linker histones Hho1 and Mlh1 form distinct protein interactions during growth, starvation and development in Tetrahymena thermophila. Scientific reports 10(1):168 PUBMED:31932604
Akematsu T, Sánchez-Fernández R, Kosta F, Holzer E, Loidl J (2019) The Transmembrane Protein Semi1 Positions Gamete Nuclei for Reciprocal Fertilization in Tetrahymena. iScience 23(1):100749 PUBMED:31884169
Tian M, Loidl J (2019) An MCM family protein promotes interhomolog recombination by preventing precocious intersister repair of meiotic DSBs. PLoS genetics 15(12):e1008514 PUBMED:31815942
Identifiers and Description
Gene Model Identifier
TTHERM_00429730
Standard Name
TTP80 (Tetrahymena Thermophila Protein)
Aliases
PreTt26414 | 48.m00177 | 3831.m01522
Description
Protein that complexes with p95, initially isolated by telomerase association, but deletion results in telomere lengthening without affecting telomerase stability or activity
Ref:15701761: Poderycki MJ, Rome LH, Harrington L, Kickhoefer VA (2005) The p80 homology region of TEP1 is sufficient for its association with the telomerase and vault RNAs, and the vault particle. Nucleic acids research 33(3):893-902
Ref:14563212: Bateman A, Kickhoefer V (2003) The TROVE module: a common element in Telomerase, Ro and Vault ribonucleoproteins. BMC bioinformatics 4( ):49
Ref:11592988: Mason DX, Autexier C, Greider CW (2001) Tetrahymena proteins p80 and p95 are not core telomerase components. Proceedings of the National Academy of Sciences of the United States of America 98(22):12368-73
Ref:11027287: Liu Y, Snow BE, Hande MP, Baerlocher G, Kickhoefer VA, Yeung D, Wakeham A, Itie A, Siderovski DP, Lansdorp PM, Robinson MO, Harrington L (2000) Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo. Molecular and cellular biology 20(21):8178-84
Ref:11090621: Miller MC, Collins K (2000) The Tetrahymena p80/p95 complex is required for proper telomere length maintenance and micronuclear genome stability. Molecular cell 6(4):827-37
Ref:10551828: Kickhoefer VA, Stephen AG, Harrington L, Robinson MO, Rome LH (1999) Vaults and telomerase share a common subunit, TEP1. The Journal of biological chemistry 274(46):32712-7
Ref:9485011: Ramakrishnan S, Eppenberger U, Mueller H, Shinkai Y, Narayanan R (1998) Expression profile of the putative catalytic subunit of the telomerase gene. Cancer research 58(4):622-5
Ref:9671704: Collins K, Gandhi L (1998) The reverse transcriptase component of the Tetrahymena telomerase ribonucleoprotein complex. Proceedings of the National Academy of Sciences of the United States of America 95(15):8485-90
Ref:9499406: Gandhi L, Collins K (1998) Interaction of recombinant Tetrahymena telomerase proteins p80 and p95 with telomerase RNA and telomeric DNA substrates. Genes & development 12(5):721-33
Ref:9398860: Weinrich SL, Pruzan R, Ma L, Ouellette M, Tesmer VM, Holt SE, Bodnar AG, Lichtsteiner S, Kim NW, Trager JB, Taylor RD, Carlos R, Andrews WH, Wright WE, Shay JW, Harley CB, Morin GB (1997) Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nature genetics 17(4):498-502
Ref:9328462: Kipling D (1997) Mammalian telomerase: catalytic subunit and knockout mice. Human molecular genetics 6(12):1999-2004
Ref:9294165: Ramakrishnan S, Sharma HW, Farris AD, Kaufman KM, Harley JB, Collins K, Pruijn GJ, van Venrooij WJ, Martin ML, Narayanan R (1997) Characterization of human telomerase complex. Proceedings of the National Academy of Sciences of the United States of America 94(19):10075-9
Ref:9255061: Shore D (1997) Telomerase and telomere-binding proteins: controlling the endgame. Trends in biochemical sciences 22(7):233-5
Ref:9118230: Nakayama J, Saito M, Nakamura H, Matsuura A, Ishikawa F (1997) TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family. Cell 88(6):875-84
Ref:9020079: Harrington L, McPhail T, Mar V, Zhou W, Oulton R, Bass MB, Arruda I, Robinson MO (1997) A mammalian telomerase-associated protein. Science (New York, N.Y.) 275(5302):973-7
Ref:7774009: Collins K, Kobayashi R, Greider CW (1995) Purification of Tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme. Cell 81(5):677-86
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