Gene Model Identifier
TTHERM_01276320
Standard Name
GIW1
Aliases
PreTt28295 | 304.m00015 | COI1
Description
GIW1 hypothetical protein; Twi1p-associated protein
Genome Browser (Macronucleus)
Genome Browser (Micronucleus)
Cellular Component Biological Process
Tetrahymena Functional Genomics Database:
Signal Peptide Present?: No
TTHERM_01276320
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( SD01824 ) Macronucleus: All GIW1 genes replaced by c-terminal V5 tagged version with neo3 in 3' flanking region ( SD01820 ) Macronucleus: KO of GIW1 with neo3 ( SD01821 ) Macronucleus: KO of GIW1 with neo3 ( SD01822 ) Macronucleus: KO of GIW1 with neo3 ( SD01823 ) Macronucleus: KO of GIW1 with neo3 ( SD01819 ) Macronucleus: All GIW1 genes replaced by c-terminal HA tagged version with neo3 in 3’ flanking region ( SD01825 ) Macronucleus: All GIW1 genes replaced by c-terminal V5tagged version with neo3 in 3’ flanking region ( SD01826 ) Macronucleus: All GIW1 genes replaced by c-terminal V5 tagged version with neo3 in 3’ flanking region ( SD01827 ) Macronucleus: All GIW1 genes replaced by c-terminal V5 tagged version with neo3 in 3’ flanking region ( SD01818 ) Macronucleus: All GIW1 genes replaced by c-terminal HA tagged version with neo3 in 3’ flanking region
(v.2006 protein sequences)
Source Identifier Score Description
Tetrahymena borealis EI9_21071.1 4.998338612125368e-60 hypothetical protein (376 aa)
Paragraph No Gene Name Paragraph Text 104 GIW1 ,TWI1 Giw1p binds to Twi1p complexed with single-stranded, but not double-stranded, scnRNAs and that this interaction selectively promotes the MAC localization of the mature Twi1p-scnRNA complex (Noto et al. 2010). 105 GIW1 ,COI12 ,TWI1 ATP-dependent and ATP-independent activities of Coi12p facilitate scnRNA loading by counteracting the Twi1p-binding protein Giw1p, which is important for sorting scnRNAs to Twi1p (Woehrer et al. 2015).
Ref:29021213 : Noto T, Mochizuki K (2017) Whats, hows and whys of programmed DNA elimination in Tetrahymena. Open biology 7(10): Ref:25588944 : Woehrer SL, Aronica L, Suhren JH, Busch CJ, Noto T, Mochizuki K (2015) A Tetrahymena Hsp90 co-chaperone promotes siRNA loading by ATP-dependent and ATP-independent mechanisms. The EMBO journal 34(4):559-77Ref:26688337 : Kataoka K, Mochizuki K (2015) Phosphorylation of an HP1-like Protein Regulates Heterochromatin Body Assembly for DNA Elimination. Developmental cell 35(6):775-88Ref:22103557 : Mochizuki K (2012) Developmentally programmed, RNA-directed genome rearrangement in Tetrahymena. Development, growth & differentiation 54(1):108-19Ref:21915788 : Kataoka K, Mochizuki K (2011) Programmed DNA elimination in Tetrahymena: a small RNA-mediated genome surveillance mechanism. Advances in experimental medicine and biology 722( ):156-73Ref:20211138 : Noto T, Kurth HM, Kataoka K, Aronica L, DeSouza LV, Siu KW, Pearlman RE, Gorovsky MA, Mochizuki K (2010) The Tetrahymena argonaute-binding protein Giw1p directs a mature argonaute-siRNA complex to the nucleus. Cell 140(5):692-703
>TTHERM_01276320(coding)ATG TAA AGT TTT GTA AAT CTT ATC TAA CTG GAA GAG AAC TAT AAC TTA AGT CTT TTG TCT TAT TCA AAC TCT ATA AGG TAG TAT CTA TTA GAT AAC AAA GTG CAC GAA GAT AAA TAC ATA TAG CTC ATG AAA GAC ATC AAA GAT TTG TTT TCG TCT CCT ACT TTT TTG ATG CCA AAT TTC TCT GAC AAA AGA AAA TAA TTT TTC TCA TAA TTA TGC TTA ATT GCT TTT GAT TTT GCT AAT AAT TAA GTT ACT GAA TAA TAA TCT TTG AGT GAA TTT AGA AAA AAA TTC AAA TTT CCT TTT GTA ATA ATT GCT ATT ATT TAC ACT AAA CTT TTA GAG ATA AAA GAA GCC TTA CCT GAA GAT TTC TTA ACT CTA GTG GAT TGT CAC TTC AAA AAT AAA GGT CCT TAA AGT ATA TTT GCC TCT TTG ACA TTG ATT TCT TTA TTT TTG AAT GAA GTA GAT TAA TAT GAA ATA GAT TGT GAC CAT ATT GAA TCT TCA AAT ACA TTA AGT AGT TGT AGC GAG GCT GCA GAG TCT AAT ATT CCT AAA AAG GTC AAT ATA ACT GTA AAG ACA GTC TAA AAT TTC TTT GAT AAA TAA GGA TTA TAG ATG ATA GCA TTT CCC TTA AAT GTT ATC AAA AAT ATT CAC TGT GTA GCA CAT GAT CAA TAG AGT ATT ATC CAG CTA TTG CTA AAA ATA GTT GTG ATA ATA ATT AAA AAC ATG AGT AAC AAA ATC AAA TAA GAG TTT TTT TAT TTT CAT TAG AAG GAT TTA AAT GTG ATT CTT TCA TGT TTT ATA GGC TTT TTG TAG TAA AAT AAC TAG GCT AGA GAA GAT CGC GAT GTA GCT TTA GCA AAT ATT TTT GAA TTT TGC GAA TTG CTA GCT AAA TCT ACT TCA CCT GCT TAA TTA TAC GTT GCG TTT AAA GAT TTT TTA GTT TAT ATT TCA TAG AAT TTT TCA TTT GCT AAT GAT AGT ATA GAA TAC TTT GAC TTC AAT TCT AAG TGT GTG GAT TTT TTA GTT TCT ATT ACT CCA TGC TTT ATT TAA TAG TCT GAG AAT TTA TCT GCA TAT CCT TTA ATA ATA TAG TTA TTG AAG TAA TCT GCT AAA ATA AAT CTT GTG AAT TTA GAG GAT TAG ATA GGC TGC TTG CAT ATA TGG AGC CAT TAT TCT GAC TAG TTC ATT CAG GCT TAC GAT AAT AAT AAT AAT TCA ATA AAA GCT GAA ACA ATT AAT AAC TTA GCT ATT CTG AAT TCT ACT TTT ATT GAA TCT CTA CAA TTT GAT ATA GAG CTA TTA TTT AAT TTG TAG ATA AAA GAT CAT GAT TCT GAA GAT GTT AAT TAA TTT GTG GAC CAA CTA TCC CGC TTA GTT ATT CAT TCT AAT CTC ATT GAT AAC CAA TTA TTT GTA GAA GTA ATA AAA TCT TTG AGT CTA CTT TAT TAG AAA AAT ATG CTC CTT TAT TAT ACT TTC CAA AAA TGT TTG ATG AAG TAG TAC CTT AAT TCT AAA GAT ACT CTC AGC TAA ATT TAC TAA GTT TTT GGC AAG AGT AAT GAT TTT CTT TAG ATT ACA GAA TTG TTA TTT GAA TCT TTT AGT TAA GCA CAA AAA TAA TTT GCA AAT TTA GAT CTA AAT ACC ATA GCT GCT ATT GAA AAA TTT ACA TAG TTC ATG TCT TAA ATA GGT GCA AAG CTG TTT AAT ACT TAA ATA TCT CAT CTT GAG TAG TCT TAA ATT TTG GGA ATA TTT CAA AAA TAT ATT TTG AAC CCA ATT AAA ATG TTT AAT TTA AAT ATA TTT TCT TAA TTA CCT GAA AAT TTT ATA CAG CTT AAT GAA GTT TAA TTT AGT CAA GTC TGC ACA ATG ATG GAG TCA GTT CAT TAC TTT ATT TTC TCT GAC AAT AAA AGC AAT TCA GAT TAA GTT TTT GAG ACA GAG GTT GAT GTT TCT ATG ATA AAA AAG ATA TTG TTA TTC AAT TAA TCA GTT AAC TAA GAC ATG GCC TAC TGG ATT AAC CCA CAA TTA AAG AAT GAA AGA AAA AAA ATA AAA TAA TTC TAC CAA AGT ACA ATT TAT TGG GTA ATA TTT GCT TCA ATT AAT CTT GAA AAT GCT GCT AAC ATA TTT GAA AGC TAT TTC TTT TAG AAA GAG TTC AAT ATT TGG GTA TTG AAT TCT ACT ATC AAA AAG CTC AAA GGT AGG ATA TTA CCA AAC ACA TTT CTG CTT TAC TTG TGT TAC TAT TTA AAA TCC CTC ACT GAC TCT GAT AGT TTT AGC AAA ATT CCT AAG TAA GAG CTA TTA GAA AAC TCT CAG ATC TAT AAA ACT ATT TCT CTT TAC TTA AAT CTG GCA ATT AGA TTT AAA ATG GAT TTT CTT GAG AAA GAA GAA ACT TAG TCA GAA AAT TCT CAC TAT TTT AAT TTC ATT CTA GAG ATA TTA GAC CAC ATG TAT TTT ACT AAT AAA AAA ATT GTG CTT GAT TTT TGT TAA AAG ATA TTG AAT TAT TTT GAT TAA GAT TGC TAT AAT TAA AAC ATT ATT TAA TTA GCT TAA TCT AGC CAA ACT TTT TAA AAC ATC ACT CTT TAG CTT TTT ACT AAT ATT TGG GAG TAA ATC TTC AAT TTT TGT TCT AGT AGC AAT GAA AAG GCA GAA GAG TTT AAA GAA AAA GAT ATT AGC TAA TCT ATT GAT TTT ATT TTA AAA TTC TCT AAG TGT TTA TAA GGT AAC TTG TCA ATA ATT TAA GAC CGT ATT ATG CTT GTT ATA AAA GCC CAT CCT ATT TAT AGT TCG AAT TCT CAA ATT ATT TAT TCC ACT ATC ATA GAA AAT TTG GTA ATT AAA GAA ATA GAT GGA GTT AAG GTT CTT TAA AAT GTT TTT TTA AAA TCT ATA ATT AAA GAC TTA CAG ATT TGG GCT AAA TCT ATA TGT CCT TAG AGA TTA CAA AGC TGA >TTHERM_01276320(protein)M Q S F V N L I Q L E E N Y N L S L L S Y S N S I R Q Y L L D N K V H E D K Y I Q L M K D I K D L F S S P T F L M P N F S D K R K Q F F S Q L C L I A F D F A N N Q V T E Q Q S L S E F R K K F K F P F V I I A I I Y T K L L E I K E A L P E D F L T L V D C H F K N K G P Q S I F A S L T L I S L F L N E V D Q Y E I D C D H I E S S N T L S S C S E A A E S N I P K K V N I T V K T V Q N F F D K Q G L Q M I A F P L N V I K N I H C V A H D Q Q S I I Q L L L K I V V I I I K N M S N K I K Q E F F Y F H Q K D L N V I L S C F I G F L Q Q N N Q A R E D R D V A L A N I F E F C E L L A K S T S P A Q L Y V A F K D F L V Y I S Q N F S F A N D S I E Y F D F N S K C V D F L V S I T P C F I Q Q S E N L S A Y P L I I Q L L K Q S A K I N L V N L E D Q I G C L H I W S H Y S D Q F I Q A Y D N N N N S I K A E T I N N L A I L N S T F I E S L Q F D I E L L F N L Q I K D H D S E D V N Q F V D Q L S R L V I H S N L I D N Q L F V E V I K S L S L L Y Q K N M L L Y Y T F Q K C L M K Q Y L N S K D T L S Q I Y Q V F G K S N D F L Q I T E L L F E S F S Q A Q K Q F A N L D L N T I A A I E K F T Q F M S Q I G A K L F N T Q I S H L E Q S Q I L G I F Q K Y I L N P I K M F N L N I F S Q L P E N F I Q L N E V Q F S Q V C T M M E S V H Y F I F S D N K S N S D Q V F E T E V D V S M I K K I L L F N Q S V N Q D M A Y W I N P Q L K N E R K K I K Q F Y Q S T I Y W V I F A S I N L E N A A N I F E S Y F F Q K E F N I W V L N S T I K K L K G R I L P N T F L L Y L C Y Y L K S L T D S D S F S K I P K Q E L L E N S Q I Y K T I S L Y L N L A I R F K M D F L E K E E T Q S E N S H Y F N F I L E I L D H M Y F T N K K I V L D F C Q K I L N Y F D Q D C Y N Q N I I Q L A Q S S Q T F Q N I T L Q L F T N I W E Q I F N F C S S S N E K A E E F K E K D I S Q S I D F I L K F S K C L Q G N L S I I Q D R I M L V I K A H P I Y S S N S Q I I Y S T I I E N L V I K E I D G V K V L Q N V F L K S I I K D L Q I W A K S I C P Q R L Q S >TTHERM_01276320(gene)ATG TAA AGT TTT GTA AAT CTT ATC TAA CTG GAA GAG AAC TAT AAC TTA AGT CTT TTG TCT TAT TCA AAC TCT ATA AGG TAG TAT CTA TTA GAT AAC AAA GTG CAC GAA GAT AAA TAC ATA TAG CTC ATG AAA GAC ATC AAA GAT TTG TTT TCG TCT CCT ACT TTT TTG ATG CCA AAT TTC TCT GAC AAA AGA AAA TAA TTT TTC TCA TAA TTA TGC TTA ATT GCT TTT GAT TTT GCT AAT AAT TAA GTT ACT GAA TAA TAA TCT TTG AGT GAA TTT AGA AAA AAA TTC AAA TTT CCT TTT GTA ATA ATT GCT ATT ATT TAC ACT AAA CTT TTA GAG ATA AAA GAA GCC TTA CCT GAA GAT TTC TTA ACT CTA GTG GAT TGT CAC TTC AAA AAT AAA GGT CCT TAA AGT ATA TTT GCC TCT TTG ACA TTG ATT TCT TTA TTT TTG AAT GAA GTA GAT TAA TAT GAA ATA GAT TGT GAC CAT ATT GAA TCT TCA AAT ACA TTA AGT AGT TGT AGC GAG GCT GCA GAG TCT AAT ATT CCT AAA AAG GTC AAT ATA ACT GTA AAG ACA GTC TAA AAT TTC TTT GAT AAA TAA GGA TTA TAG ATG ATA GCA TTT CCC TTA AAT GTT ATC AAA AAT ATT CAC TGT GTA GCA CAT GAT CAA TAG AGT ATT ATC CAG CTA TTG CTA AAA ATA GTT GTG ATA ATA ATT AAA AAC ATG AGT AAC AGT ATA GAT TTC ACT TAA ATT TAC TTT TAA AAT ATA TTA AAT TAT TTT TTT AAT TAA TTT AGA AAT CAA ATA AGA GTT TTT TTA TTT TCA TTA GAA GGA TTT AAA TGT GAT TCT TTC ATG TTT TAT AGG CTT TTT GTA GTA AAA TAA CTA GGC TAG AGA AGA TCG CGA TGT AGC TTT AGC AAA TAT TTT TGA ATT TTG CGA ATT GCT AGC TAA ATC TAC TTC ACC TGC TTA ATT ATA CGT TGC GTT TAA AGA TTT TTT AGT TTA TAT TTC ATA GAA TTT TTC ATT TGC TAA TGA TAG TAT AGA ATA CTT TGA CTT CAA TTC TAA GTG TGT GGA TTT TTT AGT TTC TAT TAC TCC ATG CTT TAT TTA ATA GTC TGA GAA TTT ATC TGC ATA TCC TTT AAT AAT ATA GTT ATT GAA GTA ATC TGC TAA AAT AAA TCT TGT GAA TTT AGA GGA TTA GAT AGG CTG CTT GCA TAT ATG GAG CCA TTA TTC TGA CTA GTT CAT TCA GGC TTA CGA TAA TAA TAA TAA TTC AAT AAA AGC TGA AAC AAT TAA TAA CTT AGC TAT TCT GAA TTC TAC TTT TAT TGA ATC TCT ACA ATT TGA TAT AGA GCT ATT ATT TAA TTT GTA GAT AAA AGA TCA TGA TTC TGA AGA TGT TAA TTA ATT TGT GGA CCA ACT ATC CCG CTT AGT TAT TCA TTC TAA TCT CAT TGA TAA CCA ATT GTA ATT TTT TAG TTT ACT TTA AAA TAT AGT AAT GTT TAA TTA TCT TTT TTG TTT ATT TAT AAA AAT ATT AAT TAG ATT TGT AGA AGT AAT AAA ATC TTT GAG TCT ACT TTA TTA GAA AAA TAT GCT CCT TTA TTA TAC TTT CCA AAA ATG TTT GAT GAA GTA GTA CCT TAA TTC TAA AGA TAC TCT CAG CTA AAT TTA CTA AGT TTT TGG CAA GAG TAA TGA TTT TCT TTA GAT TAC AGA ATT GTT ATT TGA ATC TTT TAG TTA AGC ACA AAA ATA ATT TGC AAA TTT AGA TCT AAA TAC CAT AGC TGC TAT TGA AAA ATT TAC ATA GTT CAT GTC TTA AAT AGG TGC AAA GCT GTT TAA TAC TTA AAT ATC TCA TCT TGA GTA GTC TTA AAT TTT GGG AAT ATT TCA AAA ATA TAT TTT GAA CCC AAT TAA AAT GTT TAA TTT AAA TAT ATT TTC TTA ATT ACC TGA AAA TTT TAT ACA GCT TAA TGA AGT TTA ATT TAG TCA AGT CTG CAC AAT GAT GGA GTC AGT TCA TTA CTT TAT TTT CTC TGA CAA TAA AAG CAA TTC AGA TTA AGT AAT AAC TTT TAA ATT AAA AAT ACT TTT AAA AAT TCC TTT TTA AAT AAA ATT TAA AGG TTT TTG AGA CAG AGG TTG ATG TTT CTA TGA TAA AAA AGA TAT TGT TAT TCA ATT AAT CAG TTA ACT AAG ACA TGG CCT ACT GGA TTA ACC CAC AAT TAA AGA ATG AAA GAA AAA AAA TAA AAT AAT TCT ACC AAA GTA CAA TTT ATT GGG TAA TAT TTG CTT CAA TTA ATC TTG AAA ATG CTG CTA ACA TAT TTG AAA GCT ATT TCT TTT AGA AAG AGT TCA ATA TTT GGG TAT TGA ATT CTA CTA TCA AAA AGC TCA AAG GTA GGA TAT TAC CAA ACA CAT TTC TGC TTT ACT TGT GTT ACT ATT TAA AAT CCC TCA CTG ACT CTG ATA GTT TTA GCA AAA GTA AAT TAA TTT TAT TCA TTT ATT TAT TTC ACA AAT TTT TTA GTT GTT TAA AAG AGT GAA TAT GAA GAA AAA TTT AGA AAA TTA ATG GTA AAT ATT TCT AAA TCT GTA CCT TCT GAG ATA TAT GTA GAT TAC TCT AAA ATT TAG TAC TAT CTT TAA TTA TAC ATT AAT GAA GAG TGT TAA ATG TTT AGA TTT TAA ATA TTA AGT GAC TAG ACA GTC AGC TTA CTG ACA TTA GAA AAC AGA TTT TCT CAT GTT TAT AAA GTA TTT ATA ATA TTA GAA GAT CTC TTT ACA ATT GTT TAG AGA TTT CCT AAG TTT TAT TAT GAA AAT ACA TTT ATG GGT CTA AAA AGG AAT TTC TTT TTA AAT CGT GTT TTT TGG ATT ATT GTT AAA TGC TTT ACA ATA GTT CCT AAG TAA GAG CTA TTA GAA AAC TCT CAG ATC TAT AAA ACT ATT TCT CTT TAC TTA AAT CTG GCA ATT AGA TTT AAA ATG GAT TTT CTT GAG AAA GAA GAA ACT TAG TCA GAA AAT TCT CAC TAT TTT AAT TTC ATT CTA GAG GTA TTT AAT TTA TTT TAA TCT AAA TTA TTT TTA TTT AAA TTT ATT TTT TAA AAA GAT ATT AGA CCA CAT GTA TTT TAC TAA TAA AAA AAT TGT GCT TGA TTT TTG TTA AAA GAT ATT GAA TTA TTT TGA TTA AGA TTG CTA TAA TTA AAA CAT TAT TTA ATT AGC TTA ATC TAG CCA AAC TTT TTA AAA CAT CAC TCT TTA GCT TTT TAC TAA TAT TTG GGA GTA AAT CTT CAA TTT TTG TTC TAG TAG CAA TGA AAA GGC AGA AGA GTT TAA AGA AAA AGA TAT TAG CTA ATC TAT TGA TTT TAT TTT AAA ATT CTC TAA GTG TTT ATA AGG TAA CTT GTC AAT AAT TTA AGA CCG TAT TAT GCT TGT TAT AAA AGC CCA TCC TAT TTA TAG TTC GAA TTC TCA AAT TAT TTA TTC CAC TAT CAT AGA AAA TTT GGT AAT TAA AGA AAT AGA TGG AGT TAA GGT TCT TTA AAA TGT TTT TTT AAA ATC TAT AAT TAA AGA CTT ACA GAT TTG GGC TAA ATC TAT ATG TCC TTA GAG ATT ACA AAG CTG A
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