Identifiers and Description

Gene Model Identifier

TTHERM_01243450

Standard Name

OGL1 (OGG1-Like)

Aliases

PreTt01756 | 287.m00027

Description

OGL1 HhH-GPD family base excision DNA repair protein; HhH-GPD superfamily base excision DNA repair protein

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• oxidized purine nucleobase lesion DNA N-glycosylase activity (IEA) | GO:0008534
• damaged DNA binding (IEA) | GO:0003684

Biological Process

• nucleotide-excision repair (IEA) | GO:0006289
• base-excision repair (IEA) | GO:0006284

Domains

• ( PF00633 ) Helix-hairpin-helix motif
• ( TIGR00588 ) 8-oxoguanine DNA-glycosylase (ogg)
• ( TIGR00161 ) conserved hypothetical protein TIGR00161
• ( PF07934 ) 8-oxoguanine DNA glycosylase, N-terminal domain
• ( PF00730 ) base excision DNA repair protein,

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.5%

TetraMine Data

TTHERM_01243450

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_10178.1	9.997093137033517e-262	HhH-GPD superfamily base excis ion DNA repair protein (378 aa )
Oxytricha	Contig9033.0.g113	1.0004671766404936e-76	8-oxoguanine DNA glycosylase, N-terminal domain
DictyBase	DDB_G0292618	5.001636743996964e-56	ogg1 on chromosome: 6 position 1847428 to 1848747
SGD	YML060W	1.000159011384939e-43	OGG1 Mitochondrial glycosylase /lyase that specifically excis es 7,8-dihydro-8-oxoguanine re sidues located opposite cytosi ne or thymine residues in DNA, repairs oxidative damage to m itochondrial DNA, contributes to UVA resistance

General Information

Paragraph No	Gene Name	Paragraph Text
88	OGL1	Tetrahymena thermophila’s OGL1 protein is homologous to proteins from the HhH-GPD and OGG-N superfamilies, which are associated with DNA repair. It contains two domains; the first domain (E-value= 3.0 -17), in the HhH-GPD family, is a Helix-hairpin-helix and Gly/Pro rich loop, found on proteins that remove base lesions. The second domain (E-value=6.9-13), is common to oxoguanine gylcosylases, also known as OGG1, which removes 8-oxoG lesions. The closest homologs are in Scheffersomyces stipitis, a negative Crabtree yeast, and in Taphrina deformans, a fungi/plant pathogen, with 46% identical residues. OGL1 may be an essential protein in preventing mutations in DNA that lead to a short lifespan, early aging, and cancer. Paragraph by: Lillian Horin, Maite Cortes Garcia, Francis Ryu, Forrest Fulgenzi, Keck Science Center, Pitzer College

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_01243450(coding)
ATGAAGTCTCTAATAAACCCCTTAACTAAAAAGCCAATAACATAGATAGAATTCAATTTA
AAGAATACCTTGGTCAACGGCCAAGCATTTAATTGGATAAACAAAGATGTAACTTATAAC
AAAGAGTTTAGAGGGATTCTAGGTAAAAATGTAGTAGATTTTAAAGTTAATGAAAATAAT
GAAGTAATGTACAAAGAAATACCAGAAAATTCAAAAATTGAGGAGATTATTAATGATTAC
TTGCAATTAAATGTAGATTTAGTCAAGCTTACTGTTGAGTGGTCAGAAAAAGATAACTAT
TATGCTAAAGTCAAAGAATAGTTAAAAGGAGTTCGTATCTTGAGATAGTTTCCATTTGAG
TGCATGATTAGCTTTATATGTTCCTAAAACAATAATATTCCAAGAATTACTAAAATTTTA
AAAAGTTTGAGATAGAATTTTGGAGAGGAAATTTATAGAGAAAAATTAGAAGATGGTAGC
GAAGAAATTTATTATAGTTTTCCATCTGTAGCATCATTGAGGAAAGCAACAGAACAAAAT
CTCAGAGATTTGGGATTGGGTTATAGAGCTAATTATATTGTCTCAGCAGTTTAGCTACTT
GAGGAGAAAGGAGGAGAAGAATATTTGCACAAATTGCGCTAGCTGAAAGATTCACATGAG
AAAAGAGAAGCCCTGCTTGAATTCAAAGGAATAGGAAATAAAGTAGCAGATTGTATATCT
CTCTTTAGCTTAGATGCAAAAGATTTAATCCCTGTAGATACTCATGTTTTTCAAATATAT
AATAGAGTTTACAAAAAAAATAAAAACAAAGATAAAAAAATGACAAAAGATCAGTATTCA
GAAATAGAAAATTTCTTTAAAGATCTATATGGAGATTATGCAGGATGGGCCCATCAAGCT
ATTTTTGCGGCTGAACTCGTCTCTTTTTAGTCAGAAATTAACTCAAACGAAAACTCTTCA
GTAAAAAAAACAAAATCATCAAAATTACAAGAGGAAAAAGAATAAGAAAAAGAATAAACT
ACAGAGGAGTAAAAAATTATTTCTAAAAGTAAAATTAGCGAATAAACATCTTCAGAGAAA
AATAAAAGAAATTAAAACAAAAAAATAAAGTGA

>TTHERM_01243450(protein)
MKSLINPLTKKPITQIEFNLKNTLVNGQAFNWINKDVTYNKEFRGILGKNVVDFKVNENN
EVMYKEIPENSKIEEIINDYLQLNVDLVKLTVEWSEKDNYYAKVKEQLKGVRILRQFPFE
CMISFICSQNNNIPRITKILKSLRQNFGEEIYREKLEDGSEEIYYSFPSVASLRKATEQN
LRDLGLGYRANYIVSAVQLLEEKGGEEYLHKLRQLKDSHEKREALLEFKGIGNKVADCIS
LFSLDAKDLIPVDTHVFQIYNRVYKKNKNKDKKMTKDQYSEIENFFKDLYGDYAGWAHQA
IFAAELVSFQSEINSNENSSVKKTKSSKLQEEKEQEKEQTTEEQKIISKSKISEQTSSEK
NKRNQNKKIK

>TTHERM_01243450(gene)
ATGAAGTCTCTAATAAACCCCTTAACTAAAAAGCCAATAACATAGATAGAATTCAATTTA
AAGAATACCTTGGTCAACGGCCAAGCATTTAATTGGATAAACAAAGATGTAACTTATAAC
AAAGAGTTTAGAGGGATTCTAGGTAAAAATGTAGTAGATTTTAAAGTAAAATTAAATGAA
AATTATTTTCATAATAAACATAATTAAAATCAAAAATTTAATGAAAGGTTAATGAAAATA
ATGAAGTAATGTACAAAGAAATACCAGAAAATTCAAAAATTGAGGAGATTATTAATGATT
ACTTGCAATTAAATGTAGATTTAGTCAAGCTTACTGTTGAGTGGTCAGAAAAAGATAACT
ATTATGCTAAAGTCAAAGAATAGTTAAAAGGAGTTCGTATCTTGAGATAGTTTCCATTTG
AGTGCATGATTAGCTTTATATGTTCCTAAAACAATAATATTCCAAGAATTACTAAAATTT
TAAAAAGTTTGAGATAGAATTTTGGAGAGGAAATTTATAGAGAAAAATTAGAAGATGGTA
GCGAAGAAATTTATTATAGTTTTCCATCTGTAGCATCATTGAGGAAAGCAACAGAACAAA
ATCTCAGAGATTTGGGATTGGGTTATAGAGCTAATTATATTGTCTCAGCAGTTTAGCTAC
TTGAGGAGAAAGGAGGAGAAGAATATTTGCACAAATTGCGCTAGCTGAAAGATTCACATG
AGAAAAGAGAAGCCCTGCTTGAATTCAAAGGAATAGGAAATAAAGTAGCAGATTGTATAT
CTCTCTTTAGCTTAGATGCAAAAGATTTAATCCCTGTAGATACTCATGTTTTTCAAATAT
ATAATAGAGTTTACAAAAAAAATAAAAACAAAGATAAAAAAATGACAAAAGATCAGTATT
CAGAAATAGAAAATTTCTTTAAAGATCTATATGGAGATTATGCAGGATGGGCCCATCAAG
CTATTTTTGCGGCTGAACTCGTCTCTTTTTAGTCAGAAATTAACTCAAACGAAAACTCTT
CAGTAAAAAAAACAAAATCATCAAAATTACAAGAGGAAAAAGAATAAGAAAAAGAATAAA
CTACAGAGGAGTAAAAAATTATTTCTAAAAGTAAAATTAGCGAATAAACATCTTCAGAGA
AAAATAAAAGAAATTAAAACAAAAAAATAAAGTGA