Identifiers and Description

Gene Model Identifier

TTHERM_01190440

Standard Name

HOPP2 (HOP2 Paralog)

Aliases

PreTt14763 | 268.m00039 | HOP2B

Description

Ubiquitously expressed paralog of the meiotically expressed gene HOP2 (TTHERM_00794620). Essential for vegetative growth. Tat binding protein 1(TBP-1)-interacting protein (TBPIP)"

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Gene Ontology Annotations

No Data fetched for Gene Ontology Annotations

Domains

  • ( TIGR00019 ) peptide chain release factor 1
  • ( PF07106 ) Tat binding protein 1(TBP-1)-interacting protein

Gene Expression Profile

Homologs (v.2006 protein sequences)

SourceIdentifierScoreDescription
ParameciumDBGSPATP000054450013.00071600924832e-10Paramecium tetraurelia GSPATP0
0005445001 protein
PlasmoDBPFL0325w2.00023732685282e-09Plasmodium falciparum PFL0325w
TAIRAT1G133306.99839434845872e-08expressed protein
CryptoDBEAK888784.00086488086642e-06Cryptosporidium parvum (Iowa)
protein EAK88878
ToxoDB55.m001606.99720342114394e-06Toxoplasma gondii tat binding
protein 1(TBP-1)-interacting p
rotein (TBPIP) family
DictyBaseDDB02039413.99852468753662e-05JC3V2_0_01567

General Information

Paragraph NoGene NameParagraph Text
16HOPP2HOP2B is a homolog of budding yeast HOmologous Pairing 2. It is essential for vegetative growth. HOP2B has a meiosis-specific paralog in Tetrahymena (HOP2, HOP2A, TTHERM_00794620) which is the yeast HOP2 ortholog.
55HOPP2Hop2 and Mnd1 are meiosis-specific proteins that function in a complex in budding yeast. Their general architecture is strikingly similar, and therefore they are potentially homologous protein families. The Hop2-Mnd1 system seems to have undergone duplication in the evolutionary history of Tetrahymena, because both protein families are represented by two homologs with distinct expression patterns in this species. Just as for HOP2 (meiotic) and HOPP2 (ubiquitous), there is a meiotic (MND1)and a ubiquitously expressed (MNDP1) version, which raises the possibility that a meiotic and a ubiquitous Mnd1p-Hop2p complex exists.

Associated Literature

  1. Ref:18522989: Mochizuki K, Novatchkova M, Loidl J (2008) DNA double-strand breaks, but not crossovers, are required for the reorganization of meiotic nuclei in Tetrahymena. Journal of cell science 121(Pt 13):2148-58

Sequences 

>TTHERM_01190440(coding)
ATGAGTTAAGTTGAAGAAAAAGTTGATGTTGAAGAGGGTGCTCAAGAAAACGATCAAGCT
GAAGATACAGGAAGAAGAAGATCTACAAGAGCAAGAGCTCCTCCTGCACCTACTGCTCCT
GCTGCTAAGAAAGATCCTAAGGCAGCAAAGGGAGCTAAGAAGGGCGCAGCTAAAAAAGAT
CCTAAATAGAAAAAAGGAGCAAAAAAGAAAGGATCTGATGATGAAGATTCAGACATTGAA
ATTATTGAAGACAAGCCAGAAAATATGGATGACGAAGAAGAAGAAATTAAAGAAAAAAAA
GAAACAAAAGAAAAAAAAGATGATGAATTAGATGAAGAAGATGAAATTGAAGAAGAACCT
TCTGAAGATGACGATGATGAGGAAGATGAATTTGATGAAAAGCCAAAAAAGAAAGGAAAA
GGTGCTGCTAAATCTGCACCCGCTGCTAAAAAAGGTAAGGCAGCTGAAAAGCCTGAAAAG
AAGGCTCCTGCTACTAAAGCTCCTGCAGCCAAAGGCAAAAAGAAATCTAAAGAAAGCGAT
GATGAAGACGACTTTAATGATGATAGTGAAGAGGCTAAACCAAAGGGAAAAGGTGGAGCT
GCTAAAAAGGGTGCTCCTGCTAAGAAGGGAAAAAAAGATGAAGATGATGGAGGCACTGTT
GATGATGATACTGTACTTGAATATATGAAGAAAGCTAATAGACCATATTCTTTGATTAAT
ATTTGTGATAATTTACATGGAAAAATTAAGAAGACCGCTTTATAGAAAATGCTCGATGGG
TTGGTCAGTAAGAATAAATTGACTTGCAAAGAGTTTGGTAAAGCTAAAATTTATCTCATG
AATTAAGATTTGTTGCCATAGGTTGATAAATCAGAGCTAGAATAAATGCAAAATGATTTG
AATGAAAAAAGAGTTTACTTGAGAGAAATTGGTGAAGAAATCAAAGAACTTACTAAAAAA
ATAGCCACTTATAATAAATAATTAACCAATGCTTAAATTTAAGAAGAAATTGTAAAGAAC
GAAAAAATGATTAAGTAACTAGAAGATAAAATGCATTTCTATTAAAGTGATAAATTCGTT
TAAGCATCAGAATCCGATGTTAAGAAGCACGAAGAAGCATATCAAAAAATGGAGAAAGAA
TACAAGAGACGTAGAAGAATGTGTAAGGATGGTATTGGTCAAATAGCTGAAGGTATGAAT
AAAAAGCTATCAGAAGTATAAGAATTGATTGGAATAGAAGAGGAAGATGAGTGA



>TTHERM_01190440(protein)
MSQVEEKVDVEEGAQENDQAEDTGRRRSTRARAPPAPTAPAAKKDPKAAKGAKKGAAKKD
PKQKKGAKKKGSDDEDSDIEIIEDKPENMDDEEEEIKEKKETKEKKDDELDEEDEIEEEP
SEDDDDEEDEFDEKPKKKGKGAAKSAPAAKKGKAAEKPEKKAPATKAPAAKGKKKSKESD
DEDDFNDDSEEAKPKGKGGAAKKGAPAKKGKKDEDDGGTVDDDTVLEYMKKANRPYSLIN
ICDNLHGKIKKTALQKMLDGLVSKNKLTCKEFGKAKIYLMNQDLLPQVDKSELEQMQNDL
NEKRVYLREIGEEIKELTKKIATYNKQLTNAQIQEEIVKNEKMIKQLEDKMHFYQSDKFV
QASESDVKKHEEAYQKMEKEYKRRRRMCKDGIGQIAEGMNKKLSEVQELIGIEEEDE



>TTHERM_01190440(gene)
GTGCTAATTACAAGCAATACATAAATAGCTACATAATCTATAATTAATAAATAAATCAAC
AAATAATATCAAACATAACCAACTAATTATTCCATAGTTTGAATTGTTAATACAAAGATG
AGTTAAGTTGAAGAAAAAGTTGATGTTGAAGAGGGTGCTCAAGAAAACGATCAAGCTGAA
GATACAGGAAGAAGAAGATCTACAAGAGCAAGAGCTCCTCCTGCACCTACTGCTCCTGCT
GCTAAGAAAGATCCTAAGGCAGCAAAGGGAGCTAAGAAGGGCGCAGCTAAAAAAGATCCT
AAATAGAAAAAAGGAGCAAAAAAGAAAGGATCTGATGATGAAGATTCAGACATTGTAATC
AAAATTTTGAGAAATCAATCATTTTTGAATTGAAATTAATTATCAAATTTCAAATAATTA
ATTGGTAGGAAATTATTGAAGACAAGCCAGAAAATATGGATGACGAAGAAGAAGAAATTA
AAGAAAAAAAAGAAACAAAAGAAAAAAAAGATGATGAATTAGATGAAGAAGATGAAATTG
AAGAAGAACCTTCTGAAGATGACGATGATGAGGAAGATGAATTTGATGAAAAGCCAAAAA
AGAAAGGAAAAGGTGCTGCTAAATCTGCACCCGCTGCTAAAAAAGTAGAAATACTCCATT
TTTAGAAATATTTATTTATTTCAATTTATCTTTTTATTAGGGTAAGGCAGCTGAAAAGCC
TGAAAAGAAGGCTCCTGCTACTAAAGCTCCTGCAGCCAAAGGCAAAAAGAAATCTAAAGA
AAGCGATGATGAAGACGACTTTAATGATGATAGTGAAGAGGCTAAACCAAAGGGAAAAGG
TGGAGCTGCTAAAAAGGGTGCTCCTGCTAAGAAGGGAAAAAAAGATGAAGATGATGGAGG
CACTGTTGATGGTAATTTAACTTCAAGTGAAATTTAAAGCTAATAAATTTGATTGATTTT
TATATTAGATGATACTGTACTTGAATATATGAAGAAAGCTAATAGACCATATTCTTTGAT
TAATATTTGTGATAATTTACATGGAAAAATTAAGAAGACCGCTTTATAGAAAATGCTCGA
TGGGTTGGTCAGTAAGGTAAGCTATTTAATTTTGTAATAAAAATAACATAGATCATTTTA
CTTAAACCATTAAAATAGAATAAATTGACTTGCAAAGAGTTTGGTAAAGCTAAAATTTAT
CTCATGAATTAAGATTTGTTGCCATAGGTTGATAAATCAGAGCTAGAATAAATGCAAAAT
GATTTGAATGAAAAAAGAGTTTACTTGAGAGAAATTGGTGAAGAAATCAAAGAACTTACT
AAAAAAATAGCCACTTATAATAAATAATTAACCAATGCTTAAATTTAAGAAGAAATTGTA
AAGAACGAAAAAATGGTAAAATATTTTATTATTTATTTATTTATTTACTCTCTTCTTTTT
ATTCTTTTCTAAATATTCTTTAAATTAAATATCAGATTAAGTAACTAGAAGATAAAATGC
ATTTCTATTAAAGTGATAAATTCGTTTAAGCATCAGAATCCGATGTTAAGAAGCACGAAG
AAGCATATCAAAAAATGGAGGTAAATTAATTTAATTTAAACTTTTTAATTCAAATTTTTT
ATTTATTTATTTATTTATTTATTTATTTATTTATAATTAAATTACAGAAAGAATACAAGA
GACGTAGAAGAATGTGTAAGGATGGTATTGGTCAAATAGCTGAAGGTATGAATAAAAAGC
TATCAGAAGTATAAGAATTGATTGGAATAGAAGAGGAAGATGAGTGAGCGAGAAAAAGCT
TTATTACTCTAAAATGTTAAAAAATAAACAAATTAGGCAAATTGATGAATTGAATATAAA
ATACTCTATTAATAATTAAGTTACACACTATTATAATATTACAAATTTAACTAACATATA
ATCAATACATCATATAAATTTCATTGTATGGTTGATTTATATATCTGTCCTTAATTTCTT
TTGTTCATTTTTCCTTAAGCGATT