TGD | Gene Details

Identifiers and Description

Gene Model Identifier
TTHERM_01035740

Standard Name
MYO2 (MYOsin )

Aliases
PreTt09585 | 206.m00058

Description
Myosin heavy chain; member of proposed myosin Class XX, distinct from previously defined myosin classes; contains predicted coiled-coil, myosin tail homology (MyTH4), and FERM domains

Genome Browser

Gene Ontology Annotations

Cellular Component
myosin complex (IEA) | GO:0016459
myosin complex (ISS) | GO:0016459 | Ref:15988740
Molecular Function
ATP binding (IEA) | GO:0005524
motor activity (IEA) | GO:0003774
motor activity (ISS) | GO:0003774 | Ref:15988740
ATP binding (ISS) | GO:0005524 | Ref:15988740

Domains

( PF00784 ) MyTH4 domain
( TIGR01612 ) rhoptry protein
( PF00063 ) Myosin head (motor domain)
( PF00612 ) IQ calmodulin-binding motif
( TIGR00088 ) tRNA (guanine-N1)-methyltransferase

Gene Expression Profile

Tetrahymena Functional Genomics Database: TTHERM_01035740

Homologs (v.2006 protein sequences)

Source Identifier Score Description

ParameciumDB GSPATP00024180001 1.00049823623892e-141 Paramecium tetraurelia GSPATP0
0024180001 protein

IPI(HUMAN) IPI:IPI00738806.1 2.00087349844317e-95 34496|H-INV:HIT000014963 Tax_
Id=9606 PREDICTED: myosin VIIB

DictyBase DDB0216200 2.9994041385174e-93 myoE myosin IE

DictyBase DDB0188056 2.9994041385174e-93 myoE myosin IE

TAIR AT2G31900 2.9994041385174e-93 myosin family protein

WormBase T10H10.1 2.99962770752593e-88 WBGene00002039 hum-6 myosin

SGD YAL029C 2.00034166303604e-86 MYO4 SGDID:S000000027, Chr I f
rom 92271-87856, reverse compl
ement, Verified ORF, "One of t
wo type V myosins; required fo
r mother-specific HO expressio
n, for the bud tip localizatio
n of ASH1 and IST2 mRNA; facil
itates growth and orientation
of ER tubules along with She3p
"

FlyBase FBgn0040299 7.9990117075148e-86

FlyBase FBgn0040299 7.9990117075148e-86

ToxoDB 65.m01195 7.00166383481934e-84 Toxoplasma gondii WD-40 repeat
myosin-like protein, putative

CryptoDB EAK90169 2.99883040163713e-79 Cryptosporidium parvum (Iowa)
protein EAK90169

PlasmoDB MAL13P1.148 1.99980996899167e-77 Plasmodium falciparum 148

Source	Identifier	Score	Description
ParameciumDB	GSPATP00024180001	1.00049823623892e-141	Paramecium tetraurelia GSPATP0 0024180001 protein
IPI(HUMAN)	IPI:IPI00738806.1	2.00087349844317e-95	34496\|H-INV:HIT000014963 Tax_ Id=9606 PREDICTED: myosin VIIB
DictyBase	DDB0216200	2.9994041385174e-93	myoE myosin IE
DictyBase	DDB0188056	2.9994041385174e-93	myoE myosin IE
TAIR	AT2G31900	2.9994041385174e-93	myosin family protein
WormBase	T10H10.1	2.99962770752593e-88	WBGene00002039 hum-6 myosin
SGD	YAL029C	2.00034166303604e-86	MYO4 SGDID:S000000027, Chr I f rom 92271-87856, reverse compl ement, Verified ORF, "One of t wo type V myosins; required fo r mother-specific HO expressio n, for the bud tip localizatio n of ASH1 and IST2 mRNA; facil itates growth and orientation of ER tubules along with She3p "
FlyBase	FBgn0040299	7.9990117075148e-86
FlyBase	FBgn0040299	7.9990117075148e-86
ToxoDB	65.m01195	7.00166383481934e-84	Toxoplasma gondii WD-40 repeat myosin-like protein, putative
CryptoDB	EAK90169	2.99883040163713e-79	Cryptosporidium parvum (Iowa) protein EAK90169
PlasmoDB	MAL13P1.148	1.99980996899167e-77	Plasmodium falciparum 148

General Information

Paragraph No Gene Name Paragraph Text
10 MYO1,
MYO12,
MYO11,
MYO10,
MYO9,
MYO8,
MYO5,
MYO4,
MYO3,
MYO2,
MYO13 Proteins of the myosin superfamily are ATP-dependent molecular motors that travel unidirectionally along actin filaments. The myosin heavy chain proteins are comprised of three domains: a head (motor) domain responsible for ATP hydrolysis at the N-terminus, a neck (lever arm) region, and a C-terminal tail region. Thirteen predicted myosin heavy chain genes have been identified in the Tetrahymena genome and named MYO1-MYO13. A phylogenetic analysis comparing these predicted proteins with the 19 previously identified myosin classes suggests that Myo1p-Myo12p belong to a previously undescribed class of myosins. This new family, designated Class XX, does not include Myo13p, which did not branch with this class or any of the other classes in the analysis. The neck and tail regions of the Tetrahymena myosins include a variety of domains characterized in other myosin classes, with each protein containing one or more of the following domains: coiled-coil (which may support dimerization); IQ motif (binding sites for calmodulin or calmodulin-like proteins); FERM domain (Four-point-one protein, Ezrin, Radixin, Moesin homology); and MyTH4 domain (Myosin Tail Homology 4).

Associated Literature

Ref:16505385: Foth BJ, Goedecke MC, Soldati D (2006) New insights into myosin evolution and classification. Proceedings of the National Academy of Sciences of the United States of America 103(10):3681-6
Ref:15988740: Williams SA, Gavin RH (2005) Myosin genes in Tetrahymena. Cell motility and the cytoskeleton 61(4):237-43
Ref:17821280: Harrison JA, Fowler EH (1945) AN ANTIGEN-ANTIBODY REACTION WITH TETRAHYMENA WHICH RESULTS IN DYSTOMY. Science (New York, N.Y.) 102(2638):65-6

Sequences

>TTHERM_01035740(coding)
ATGAGTATTGATTCACATTAAATAGAAAGAATTAAGACATCATGGATGCTTAATGGAGTT
TAATGCTGGGCTAAAGTAGCACCAGAGGAAAACTCCGAGCTTATGTTTCGTAGGGCTATT
ATTACAGGTTTAGATAATAAGCGTGAGCATGCATTCTTAAAATATGAGTTTCATCTTATC
TAAATTTAACAGCAAAAAGAAAAAGGTCCAGAAAAAGTACATGTTAGAGACTTAATAGAA
TGCAATTAGAATGCAGATAGTGAAAAATTTAAAGAAGGTTTTCCTGATATGGTTTCGATG
AATGTATTAAATGAAGCAGAAATTTTGAATAATGTTTGGTTGCGATATTCTAAAGACCTA
ATTTTTTCCTACATAGGACCTACATTAATTGTAATGAATCCCTACAAGAATGTAGAAAAG
CTTTTTAATGAAAAGGTTTTATAAGAATTTTAGAAACCTGCAATAAATAACAATTTCGAT
ATAAAGTAGCATTAGCCTCATGTCTATGCAGTAACTACATTAGCTTATTAGTAGCTATTT
ATGAATTAAAAGAACCAGGCAATAGTAATTAGTGGAGAATCAGGAGCTGGTAAGACTGAA
AATGCTAAATATTGTATGGCTTTTTTAACTTCTTTAAGTAATGAAACAACTAAGCAGTAA
CGCCCAAAAAAGAAAACTTAATTGGCGAACTAATTAAATAGATATTCTACAATGAGATAT
TCTTCAGTAGTAGCTAGCAACATCTCAGATTCTTAATATACTGAAGACTCTATACTTTAA
TTAAAGGATACATCGATTGAAGAGCGTATTCTTAGATGCAACCCAATTTTGGAAGCGTTT
GGTAATGCTAAAACAGTGAGAAATGATAATTCAAGTAGATTTGGTAAATATGTTCGTATT
TGGATTGGAAAGCATGATAAAAGAATTAAAGGAGCCTCAATTACAAATTACTTATTAGAA
AAAAGTAGAGTGACTCTACTATCATAAGGTGAAAGAAACTATCACATATTCTATCATTTT
TTATAAGGATTAGAAACTTCACAACTTAAAACTTATAAACTTGTGGAAAAAAATGGTAAT
AGAATAGATTTAAAAAATTTTAATTATTTAAATTAAACTAATGTGTACGAAATAAGCTCC
TTTCCTAGTGATAAAATAATGATTGATTAGATTATTGAATCCTTTGAGAAAATGGAGATT
GATTCATACTAGTAAGTAGCTATTTTTAAAGTTTTATCAGCTATTCTTTATATTGGAAAT
ATTGAGTTTGATAGCTCAACATATACAGATAATACTCCTTGTAGTATAAAAAACTAAGAT
ATCATATAAACTGTTTCTGAACTTTTAGAAATAAATTAGTAAGATAAAATTTTGAAGTCA
ATTATATTTAAAATACGTTAAGTTGGTAGCTAGGTTATGGAAACTCCAGTGAATGTTGAA
GAGTGCAAAATTAATAGGGATTCATTAGCGAGAGCTCTTTATGATAAAATGTTTACATGG
ATAGTTTAATCATTAAATATGGAAATTTTACCTTAGAATAGTAATCCTAACGAATGTTTA
AGTCTCGGATTGCTAGATATTTTTGGGTTTGAGAACTTTAAGGTCAATTCTTTTGAATAA
TTATGCATCAACTTCACAAATGAGCGCTTGCAATAGCTATATATTGTATATGTGTTTAAA
GCTGAAGAAGAAGAGTTTAAAAAAGAAGGTCTTAAAGTCCATAGCTTAGAACTTTCTTAT
TAAGATAATTAAGTTATTATAGATACAATGGATAAGCCACCTAATGGTATTTTTGATCTT
CTAGATGAAAGTTGTTCTTTAGGAAATTCAACAGATGAAAAGTTTTACTAAAAAATTGTT
TCAACCTACTCTAAAAATGATTAAATTAAGATACCAAAAATTTAAAACATGAAATTCTCA
ATTGTACATACTGCAAAAGAAGTTGAATACACAGCTGATGGCTTTAGAAATAAAAATAAA
GATGAGATTTCTACTTTTCTAGATTAATGCATATCGTCATCTAGTAGTTCTGAAATATGT
TCTATATGGTAAGGAATTGGAGAAGTTAATATGACAGATATGGAGGTTTCTTCAAAAACA
GTGCAGGATATGTCAATTTCAGTGAGAAATACTTAGAAAAAATTAGAAAATAAGGGAAAA
GCTCAAAAATTTTTAGGAGCAAAATTCAGGGCTTAAATGAAAGATCTTATGGGAGAACTT
AATTCTTGTGATGTACATTTTATTAGATGTATTAAGCCTAATGAAGATAAAGTAAAAGAA
AAATTTGTTAGTCAATATGTACTCTTGCAGATAAGATATTTAGGTATTTTGGAAAGTATT
AAGGTGAGAAGAGAAGGATTTCCATGTAGAATGAGCTATGAAGAATTTTACACTAAATAT
CATGAGCTTGATGTTTTTAATAGAAAAATAACATTATAGAGGCACTTAGATATGAAACAA
GATATGCCAGGATTGTGTAGAGAATTGTTATTTAGAGTTGTAAAAGATGTTAACAAAAAA
GAAGTTCTATTTGGTTAAACTAAGTTGTACTTAAAAGTTTAGCCATCAACAGAGTTAGAT
AATAGATTAATTAAATGGTGGTAGTTTAAAAATGATTAGGCTGGTAAAATCTAAGGATAG
TGGGAAGTTTACAATAACAGAAAAGTTATTAAAGAAAATTTAAAGATTATAAAAAATGCT
GTTAAAAGTTTTGTTAAACTTTAAGCTATTTATAAAATGAAAGTCTAAAAAAAAGCATAT
CTTAAGACATTATAATAGAAAAAGGGAATAGAAATACTTTAGAAAATACAAAAAAAAATG
CAACAAGCTAAATTAAAAGAAGTACTAAAACTATGGGTGGATAAAATAAAAACATAAAAA
AAGGGAGATAAATGGTCTAATGCAGTATCGAAAGTTTGTAATATAAGTAAAAGAAACCAT
GTGAGAGATATCAAAGAATACTGGCTTAGATGGAAGAATTTTATCAAATCTGAATAAGAA
AAAGAATTACAAAACAAAATAAAAGAATAGGAAGCAAAAGCTATTGAACAAAATAAAGCA
ATAGAAGAATAAAAGCAAATAGAAAAAGAAGTAGAGGAAGAGGAAGAAAAAAAAGATGAT
GTTAAGGAATTAGAATAAGTAAAACCTTAAGAACCTGTAGTTTAAAAGAAGATTAACCCT
AATGGACTTGAAATGGAAAGAGAAGATATAAAGTCAGACGAGTTTACTTCTTAGGGTCTA
AAAATTTGGCCTAACTTTTCAAACTTTACTAAGCCTTATAATTTATAAAATAAATTCTCT
ATCCCTAATGATATTTTAGACAATAATTAAAAATACTAAAATCCTAAGGAGCCAGAATAA
AAAGACTTATAAAATTTAGAGTTTAGTGATTAGTTTCTTTAATTAGTTCAATAATCATCA
TTCTTAGAATATTGCAATAATAATGTAAAAAGAGCTAAGAATTTCAGTAAAAAAATGTAA
ATTGCTAAAATAATGCAATACTAATCAAATAATCTAAGTGAATCTCTACTCTAACAATCA
GATTCATTCAATGAAGATGCTACTAAGATTTTTAGATCTTTATTAAAAATCTCTGGAAAT
AGAAATTCTCGTTTCTCTCCTAGATACCATTCTGATCTGATATTAAATCTATGTTATGGA
AGGGATTCGGAATTAGATCCTAACTGCTATGTGATAGGTAAAAAAGTGGAAAATCCAGAA
GATTAAAAAAAATAAAATAATAGAAGAGAATCTAAAGAAAATAAAGATCTTGATTAGAGA
AGAGGAAGCTATTTAAAAAATTACTCATCATAGGTATGCTAAAAATAATAAGGGAAAAAT
GGTGATTCAAATCAAGAAGAGGATGATTTAAGCCATGAAAACAAATTAGAATTAATGGCT
AACTAAATCCTTCATGGTAATTTAAATCATATAAGGGATGAAGTCTACTTTTAAATATGC
AAATAGATTGCTGGAAACAAATCCTAAGAGGCTAAAAAAAATTTATACAAATTTGCAGCT
GAAATGTCCAATTTATTCGCACCTTCTTAGGATGCCCTCTATCCATTAATAAATTTCTTC
ATGGATTAATCATTACAAGATCCAAATGCTTAAAATAAAGAAGATGCTAAGTATATCGTC
AGTAAACTTTCTGAATTTGCTAGAGGATATGCAGTAGTTAAATTAATGAACCCTGATCAG
TTAAAAAAATAAAGTATTTTAAAGGTATTAAAGAATAATGATCCCCTTGAATTACAACTT
TAAAAAAATAATAATTAGTAAGTCTTGATTAACTATATAAACAAGATGTAACCCAGATAA
TTAATTCCTTCACATCAAGAAGTCTCAAAAATTCATAATAGATAGTAAATATGCATAAAA
ATATATTTATTTGATGGTACCTATATTTGGGTTCCTGCTGAATCATTAGAAACTGTTAAA
AGCATAGTAGAAAAAGCATGTAGCCAAATCGATATGAAAGAACGTTATTAATTTTTTAGC
CTCTATGAAGTTCTTTATGAGTAAGGAAAGGTTATGAAAGAAGCTTTTTTATTTGACAGA
GTTAAAATAATGGATATTTTTAATTCCCATCAAATTACAACAGAGCTATAACAGAAAAAA
CATTCTAAAAATATTGAATTCAGAATTTATCTTAGGATAAGAGTTTATTACAAGCTTTTT
AAAGATGATATAGATTCGATAAATATGTTTTATATGCAAAATATATATGAAGTAAACTAA
GGAAGGCTACCCTTAACTGAAAACTAAATAACTTAATTAGCTGCTCATTACTGCTATTCA
TCTCTAAAAACTTAACAGGGAAATGAGAAGAATATAGAAAATATGATAAATAAAGCTGTG
CCTTAGTACGCAATTCAAAAGTATCATAATAGACAATGGGGTAATGAAGTAAGTGAAATT
TATAAAAAACTTGAATACTAAAATGCTTTAGAAGCAAGATGGATGTATCTTGAAATAATC
AGACCTCATGATCTCTTTTTAAGCTACTAATTTGAATGCAGAATGTTTGTCTAATAAAAA
ACCGATTAGGGTTATAAGCTAGTTTAAAATTAATAGATAATTTTAGGTATTAGACCTTTG
TAAATAGTTATTTCTGATTTAGAACGTAAAACTATGTTGATAATTGATTTTTCTGAAATG
ACTAAATGGGGATAAAGCATAAGTAGTAACTCCTACTTTCTAATATAGCATGAAAATTCA
AACCTTTATGTGTTTGAAGTGTAAGATGTGGAGTTGGCTGATTATCTAATTAATGCATAT
GTAAATTGGAAACTCGAAAGAAATCTTGATGATGCTTCGAACCCCACTTACAGTGATGTT
ATTACTTTCTTAGTTTCTGATAATGATCAAGCAAATTAAATTAAATGA

>TTHERM_01035740(protein)
MSIDSHQIERIKTSWMLNGVQCWAKVAPEENSELMFRRAIITGLDNKREHAFLKYEFHLI
QIQQQKEKGPEKVHVRDLIECNQNADSEKFKEGFPDMVSMNVLNEAEILNNVWLRYSKDL
IFSYIGPTLIVMNPYKNVEKLFNEKVLQEFQKPAINNNFDIKQHQPHVYAVTTLAYQQLF
MNQKNQAIVISGESGAGKTENAKYCMAFLTSLSNETTKQQRPKKKTQLANQLNRYSTMRY
SSVVASNISDSQYTEDSILQLKDTSIEERILRCNPILEAFGNAKTVRNDNSSRFGKYVRI
WIGKHDKRIKGASITNYLLEKSRVTLLSQGERNYHIFYHFLQGLETSQLKTYKLVEKNGN
RIDLKNFNYLNQTNVYEISSFPSDKIMIDQIIESFEKMEIDSYQQVAIFKVLSAILYIGN
IEFDSSTYTDNTPCSIKNQDIIQTVSELLEINQQDKILKSIIFKIRQVGSQVMETPVNVE
ECKINRDSLARALYDKMFTWIVQSLNMEILPQNSNPNECLSLGLLDIFGFENFKVNSFEQ
LCINFTNERLQQLYIVYVFKAEEEEFKKEGLKVHSLELSYQDNQVIIDTMDKPPNGIFDL
LDESCSLGNSTDEKFYQKIVSTYSKNDQIKIPKIQNMKFSIVHTAKEVEYTADGFRNKNK
DEISTFLDQCISSSSSSEICSIWQGIGEVNMTDMEVSSKTVQDMSISVRNTQKKLENKGK
AQKFLGAKFRAQMKDLMGELNSCDVHFIRCIKPNEDKVKEKFVSQYVLLQIRYLGILESI
KVRREGFPCRMSYEEFYTKYHELDVFNRKITLQRHLDMKQDMPGLCRELLFRVVKDVNKK
EVLFGQTKLYLKVQPSTELDNRLIKWWQFKNDQAGKIQGQWEVYNNRKVIKENLKIIKNA
VKSFVKLQAIYKMKVQKKAYLKTLQQKKGIEILQKIQKKMQQAKLKEVLKLWVDKIKTQK
KGDKWSNAVSKVCNISKRNHVRDIKEYWLRWKNFIKSEQEKELQNKIKEQEAKAIEQNKA
IEEQKQIEKEVEEEEEKKDDVKELEQVKPQEPVVQKKINPNGLEMEREDIKSDEFTSQGL
KIWPNFSNFTKPYNLQNKFSIPNDILDNNQKYQNPKEPEQKDLQNLEFSDQFLQLVQQSS
FLEYCNNNVKRAKNFSKKMQIAKIMQYQSNNLSESLLQQSDSFNEDATKIFRSLLKISGN
RNSRFSPRYHSDLILNLCYGRDSELDPNCYVIGKKVENPEDQKKQNNRRESKENKDLDQR
RGSYLKNYSSQVCQKQQGKNGDSNQEEDDLSHENKLELMANQILHGNLNHIRDEVYFQIC
KQIAGNKSQEAKKNLYKFAAEMSNLFAPSQDALYPLINFFMDQSLQDPNAQNKEDAKYIV
SKLSEFARGYAVVKLMNPDQLKKQSILKVLKNNDPLELQLQKNNNQQVLINYINKMQPRQ
LIPSHQEVSKIHNRQQICIKIYLFDGTYIWVPAESLETVKSIVEKACSQIDMKERYQFFS
LYEVLYEQGKVMKEAFLFDRVKIMDIFNSHQITTELQQKKHSKNIEFRIYLRIRVYYKLF
KDDIDSINMFYMQNIYEVNQGRLPLTENQITQLAAHYCYSSLKTQQGNEKNIENMINKAV
PQYAIQKYHNRQWGNEVSEIYKKLEYQNALEARWMYLEIIRPHDLFLSYQFECRMFVQQK
TDQGYKLVQNQQIILGIRPLQIVISDLERKTMLIIDFSEMTKWGQSISSNSYFLIQHENS
NLYVFEVQDVELADYLINAYVNWKLERNLDDASNPTYSDVITFLVSDNDQANQIK

>TTHERM_01035740(gene)
ATGAGTATTGATTCACATTAAATAGAAAGAATTAAGACATCATGGATGCTTAATGGAGTT
TAATGCTGGGCTAAAGTAGCACCAGAGGAAAACTCCGAGCTTATGTTTCGTAGGGCTATT
ATTACAGGTTTAGATAATAAGCGTGAGCATGCATTCTTAAAATATGAGTTTCATCTTATC
TAAATTTAACAGCAAAAAGAAAAAGGTCCAGAAAAAGTACATGTTAGAGACTTAATAGAA
TGCAATTAGAATGCAGATAGTGAAAAATTTAAAGAAGGTTTTCCTGATATGGTTTCGATG
AATGTATTAAATGAAGCAGAAATTTTGAATAATGTTTGGTTGCGATATTCTAAAGACCTA
ATTTTTTCCTACATAGGACCTACATTAATTGTAATGAATCCCTACAAGAATGTAGAAAAG
CTTTTTAATGAAAAGGTTTTATAAGAATTTTAGAAACCTGCAATAAATAACAATTTCGAT
ATAAAGTAGCATTAGCCTCATGTCTATGCAGTAACTACATTAGCTTATTAGTAGCTATTT
ATGAATTAAAAGAACCAGGCAATAGTAATTAGTGGAGAATCAGGAGCTGGTAAGACTGAA
AATGCTAAATATTGTATGGCTTTTTTAACTTCTTTAAGTAATGAAACAACTAAGCAGTAA
CGCCCAAAAAAGAAAACTTAATTGGCGAACTAATTAAATAGATATTCTACAATGAGATAT
TCTTCAGTAGTAGCTAGCAACATCTCAGATTCTTAATATACTGAAGACTCTATACTTTAA
TTAAAGGATACATCGATTGAAGAGCGTATTCTTAGATGCAACCCAATTTTGGAAGCGTTT
GGTAATGCTAAAACAGTGAGAAATGATAATTCAAGTAGATTTGGTAAATATGTTCGTATT
TGGATTGGAAAGCATGATAAAAGAATTAAAGGAGCCTCAATTACAAATTACTTATTAGAA
AAAAGTAGAGTGACTCTACTATCATAAGGTGAAAGAAACTATCACATATTCTATCATTTT
TTATAAGGTAATTATTGAATCTTTCATTATTTTCAAAACATTTTGATTAAAAAGAAATGC
ATACAGTATTATTCATATAAATAGATTACTTAACATTTAGATTTTTAATTAAATTAGCTA
CATTTAATTCCAAAAGAATTTATCAATCTATATTAATTATAATTAAAATTTGATCCTTGA
GAATTAATATTGGTGTAACTATTTTAAATTAAAAAATTCAATAAATTTTTAGGAAATTTG
TTTCCCATAAAATTGACAAAAAATTAAATCATAAGATAGTTATGAATAAATAAATTATAA
CTAAAATACTCAAATAATTTTATTTATTTTAGATCAAAATATTTATTTTAAGTAAAGCAA
ATTAAGAAATTTACTAAGTAAAATAATTTCAACGAAATTAAATTTTTTATTCATATTTTT
AACAAATTTACTGAAGAAATATGTAGGAATTGTTTATATAAAGCTAAGATTAAGCAAGAA
ATAAAATTAGATTTTATTTTTTATATTTTTCCTTATCTATTAAAATATAAAATTTCATAA
AAATATATAAAAAGTAATAGTTTTGAATTTGGTATAATTTATTTATTTAAAATAGGATTA
GAAACTTCACAACTTAAAACTTATAAACTTGTGGAAAAAAATGGTAATAGAATAGATTTA
AAAAATTTTAATTATTTAAATTAAACTAATGTGTACGAAATAAGCTCCTTTCCTAGTGAT
AAAATAATGATTGATTAGATTATTGAATCCTTTGAGAAAATGGAGATTGATTCATACTAG
TAAGTAGCTATTTTTAAAGTTTTATCAGCTATTCTTTATATTGGAAATATTGAGTTTGAT
AGCTCAACATATACAGATAATACTCCTTGTAGTATAAAAAACTAAGATATCATATAAACT
GTTTCTGAACTTTTAGAAATAAATTAGTAAGATAAAATTTTGAAGTCAATTATATTTAAA
ATACGTTAAGTTGGTAGCTAGGTAAATTATTACTTTTAAAATGACTTTATATTGAAAATA
TAATCTAAAAATAAGGTTATGGAAACTCCAGTGAATGTTGAAGAGTGCAAAATTAATAGG
GATTCATTAGCGAGAGCTCTTTATGATAAAATGTTTACATGGATAGTTTAATCATTAAAT
ATGGAAATTTTACCTTAGAATAGTAATCCTAACGAATGTTTAAGTCTCGGATTGCTAGAT
ATTTTTGGGTTTGAGAACTTTAAGGTCAATTCTTTTGAATAATTATGCATCAACTTCACA
AATGAGCGCTTGCAATAGCTATATATTGTATATGTGTTTAAAGCTGAAGAAGAAGAGTTT
AAAAAAGAAGGTCTTAAAGTCCATAGCTTAGAACTTTCTTATTAAGATAATTAAGTTATT
ATAGATACAATGGATAAGCCACCTAATGGTATTTTTGATCTTCTAGATGAAAGTTGTTCT
TTAGGAAATTCAACAGATGAAAAGTTTTACTAAAAAATTGTTTCAACCTACTCTAAAAAT
GATTAAATTAAGGTACTATTTGATTTTTCTTATTTAAATCTTTAAAAAAATTTGTTTAAT
TTGAAAAATAAAACCAATAAAATTTAGCCTTAAATATTTAATTTTTAAAAAATAAAATTA
TTTAAGATACCAAAAATTTAAAACATGAAATTCTCAATTGTACATACTGCAAAAGAAGTT
GAATACACAGCTGATGGCTTTAGAAATAAAAATAAAGATGAGATTTCTACTTTTCTAGAT
TAATGCATATCGTCATCTAGTAGTTCTGAAATATGTTCTATATGGTAAGGAATTGGAGAA
GTTAATATGACAGATATGGAGGTTTCTTCAAAAACAGTGCAGGATATGTCAATTTCAGTG
AGAAATACTTAGAAAAAATTAGAAAATAAGGGAAAAGCTCAAAAATTTTTAGGAGCAAAA
TTCAGGGCTTAAATGAAAGATCTTATGGGAGAACTTAATTCTTGTGATGTACATTTTATT
AGATGTATTAAGCCTAATGAAGATAAAGTAAAAGAAAAATTTGTTAGTCAATATGTACTC
TTGCAGATAAGATATTTAGGTATTTTGGAAAGTATTAAGGTGAGAAGAGAAGGATTTCCA
TGTAGAATGAGCTATGAAGAATTTTACACTAAATATCATGAGCTTGATGTTTTTAATAGG
TAAATTAATAGGACAAGAATCTTTTAATAACTTTTTTTTTAGAAAAATAACATTATAGAG
GCACTTAGATATGAAACAAGATATGCCAGGATTGTGTAGAGAATTGTTATTTAGAGTTGT
AAAAGATGTTAACAAAAAAGAAGTTCTATTTGGTTAAACTAAGTTGTACTTAAAAGTTTA
GCCATCAACAGAGTTAGATAATAGATTAATTAAATGGTGGTAGTTTAAAAATGATTAGGC
TGGTAAAATCTAAGGATAGTGGGAAGTTTACAATAACAGAAAAGTTATTAAAGAAAATTT
AAAGATTATAAAAAATGCTGTTAAAAGTTTTGTTAAACTTTAAGCTATTTATAAAATGAA
AGTCTAAAAAAAAGCATATCTTAAGACATTATAATAGAAAAAGGGAATAGAAATACTTTA
GAAAATACAAAAAAAAATGCAACAAGCTAAATTAAAAGAAGTACTAAAACTATGGGTGGA
TAAAATAAAAACATAAAAAAAGGGAGATAAATGGTCTAATGCAGTATCGAAAGTTTGTAA
TATAAGTAAAAGAAACCATGTGAGAGATATCAAAGAATACTGGCTTAGATGGAAGAATTT
TATCAAATCTGAATAAGAAAAAGAATTACAAAACAAAATAAAAGAATAGGAAGCAAAAGC
TATTGAACAAAATAAAGCAATAGAAGAATAAAAGCAAATAGAAAAAGAAGTAGAGGAAGA
GGAAGAAAAAAAAGATGATGTTAAGGAATTAGAATAAGTAAAACCTTAAGAACCTGTAGT
TTAAAAGAAGTAAGTTTAAAGTTAAATAGTTATTTAAATTTTATAAAAAACTTTAATTTA
TCAATCAGGATTAACCCTAATGGACTTGAAATGGAAAGAGAAGATATAAAGTCAGACGAG
TTTACTTCTTAGGGTCTAAAAATTTGGCCTAACTTTTCAAACTTTACTAAGCCTTATAAT
TTATAAAATAAATTCTCTATCCCTAATGATATTTTAGACAATAATTAAAAATACTAAAAT
CCTAAGGAGCCAGAATAAAAAGACTTATAAAATTTAGAGTTTAGTGATTAGTTTCTTTAA
TTAGTTCAATAATCATCATTCTTAGAATATTGCAATAATAATGTAAAAAGAGCTAAGAAT
TTCAGTAAAAAAATGTAAATTGCTAAAATAATGCAATACTAATCAAATAATCTAAGTGAA
TCTCTACTCTAACAATCAGATTCATTCAATGAAGATGCTACTAAGATTTTTAGATCTTTA
TTAAAAATCTCTGGAAATAGAAATTCTCGTTTCTCTCCTAGATACCATTCTGATCTGATA
TTAAATCTATGTTATGGAAGGTTGATAATACTCTTTTTTATATTTTGAATTTTACATTTA
AATTTTATTTTATTCTATTTATAGGGATTCGGAATTAGATCCTAACTGCTATGTGATAGG
TAAAAAAGTGGAAAATCCAGAAGATTAAAAAAAATAAAATAATAGAAGAGAATCTAAAGA
AAATAAAGATCTTGATTAGAGAAGAGGAAGCTATTTAAAAAATTACTCATCATAGGTATG
CTAAAAATAATAAGGGAAAAATGGTGATTCAAATCAAGAAGAGGATGATTTAAGCCATGA
AAACAAATTAGAATTAATGGCTAACTAAATCCTTCATGGTAATTTAAATCATATAAGGGA
TGAAGTCTACTTTTAAATATGCAAATAGATTGCTGGAAACAAATCCTAAGAGGCTAAAAA
AAATTTATACAAATTTGCAGCTGAAATGTCCAATTTATTCGCACCTTCTTAGGATGCCCT
CTATCCATTAATAAATTTCTTCATGGATTAATCATTACAAGATCCAAATGCTTAAAATAA
AGAAGATGCTAAGTATATCGTCAGTAAACTTTCTGAATTTGCTAGAGGATATGCAGTAGT
TAAATTAATGAACCCTGATCAGTTAAAAAAATAAAGTATTTTAAAGGTATTAAAGAATAA
TGATCCCCTTGAATTACAACTTTAAAAAAATAATAATTAGTAAGTCTTGATTAACTATAT
AAACAAGATGTAACCCAGATAATTAATTCCTTCACATCAAGAAGTCTCAAAAATTCATAA
TAGATAGTAAATATGCATAAAAATATATTTATTTGATGGTACCTATATTTGGGTTCCTGC
TGAATCATTAGAAACTGTTAAAAGCATAGTAGAAAAAGCATGTAGCCAAATCGATATGAA
AGAACGTTATTAATTTTTTAGCCTCTATGAAGTTCTTTATGAGTAAGGAAAGGTTATGAA
AGAAGCTTTTTTATTTGACAGAGTTAAAATAATGGATATTTTTAATTCCCATCAAATTAC
AACAGAGCTATAACAGAAAAAACATTCTAAAAATATTGAATTCAGAATTTATCTTAGGAT
AAGAGTTTATTACAAGCTTTTTAAAGATGATATAGATTCGATAAATATGTTTTATATGCA
AAATATATATGAAGTAAACTAAGGAAGGCTACCCTTAACTGAAAACTAAATAACTTAATT
AGCTGCTCATTACTGCTATTCATCTCTAAGTAATTAATCATTTTTTAAAAAAATATTAAA
CTTTAATCTATTAAATTAAAAAACTGTTTTAAAAGTACCAATTAAATTTATTCTACCTCA
AACAAACATAATTTAATGTAATAAATTTTTCCTAATTAAAAAAGTGCTTAAGCTTAAAAA
TTGGTTATAATTATTTTTTTTTTCCATAAAATATTATGAATTTTATTTACTTACTATATT
CCCTTATTTCTCAAATCTTGTAATTAGCAAAAAGAAGTGAAGTATATGAAAAATTTTTTC
TTAATAGTATCAAAAAATAGTCAAAAATAATGTTTTTTTTTTGTAGGGAATATGGTATTT
AGTAAAATTTAATCTAAAAATAAAAAATATTTTAATTTAAAATTAGAAACTTAACAGGGA
AATGAGAAGAATATAGAAAATATGATAAATAAAGCTGTGCCTTAGTACGCAATTCAAAAG
TATCATAATAGACAATGGGGTAATGAAGTAAGTGAAATTTATAAAAAACTTGAATACTAA
AATGCTTTAGAAGCAAGATGGATGTATCTTGAAATAATCAGACCTCATGATCTCTTTTTA
AGCTACTAATTTGAATGCAGAATGTTTGTCTAATAAAAAACCGATTAGGGTTATAAGCTA
GTTTAAAATTAATAGATAATTTTAGGTATTAGACCTTTGTAAATAGTTATTTCTGATTTA
GAACGTAAAACTATGTTGATAATTGATTTTTCTGAAATGACTAAATGGGGATAAAGCATA
AGTAGTAACTCCTACTTTCTAATATAGCATGAAAATTCAAACCTTTATGTGTTTGAAGTG
TAAGATGTGGAGTTGGCTGATTATCTAATTAATGCATATGTAAATTGGAAACTCGAAAGA
AATCTTGATGATGCTTCGAACCCCACTTACAGTGATGTTATTACTTTCTTAGTTTCTGAT
AATGATCAAGCAAATTAAATTAAATGATTTTAAGACAGTTTTCAAAAATAAAAAAAACTT
AAATTAACTAAAAACTTTACTACCTATCTAAAAATTATTTTAAATTTAAATATATATTCA
TTTTATAAAACTTTATTTTAATAAATACTAAATC

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Paragraph No	Gene Name	Paragraph Text
10	MYO1, MYO12, MYO11, MYO10, MYO9, MYO8, MYO5, MYO4, MYO3, MYO2, MYO13	Proteins of the myosin superfamily are ATP-dependent molecular motors that travel unidirectionally along actin filaments. The myosin heavy chain proteins are comprised of three domains: a head (motor) domain responsible for ATP hydrolysis at the N-terminus, a neck (lever arm) region, and a C-terminal tail region. Thirteen predicted myosin heavy chain genes have been identified in the Tetrahymena genome and named MYO1-MYO13. A phylogenetic analysis comparing these predicted proteins with the 19 previously identified myosin classes suggests that Myo1p-Myo12p belong to a previously undescribed class of myosins. This new family, designated Class XX, does not include Myo13p, which did not branch with this class or any of the other classes in the analysis. The neck and tail regions of the Tetrahymena myosins include a variety of domains characterized in other myosin classes, with each protein containing one or more of the following domains: coiled-coil (which may support dimerization); IQ motif (binding sites for calmodulin or calmodulin-like proteins); FERM domain (Four-point-one protein, Ezrin, Radixin, Moesin homology); and MyTH4 domain (Myosin Tail Homology 4).