Saettone A, Ponce M, Nabeel-Shah S, Fillingham J (2019) RACS: rapid analysis of ChIP-Seq data for contig based genomes. BMC bioinformatics 20(1):533 PUBMED:31664892
Tian M, Mochizuki K, Loidl J (2019) Non-coding RNA Transcription in Tetrahymena Meiotic Nuclei Requires Dedicated Mediator Complex-Associated Proteins. Current biology : CB ( ): PUBMED:31280995
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Identifiers and Description
Gene Model Identifier
TTHERM_00794620
Standard Name
HOP2 (HOmologous Pairing 2 homolog)
Aliases
PreTt21461 | 134.m00141 | HOP2A
Description
Homologous pairing protein; involved in chiasmata and meiotic bivalent formation; paralog of TTHERM_01190440 (HOPP2); meiosis-specific homolog of yeast HOP2
HOP2 Meiosis-specific protein
that localizes to chromosomes,
preventing synapsis between n
onhomologous chromosomes and e
nsuring synapsis between homol
ogs; complexes with Mnd1p to p
romote homolog pairing and mei
otic double-strand break repai
r
Hop2 and Mnd1 are meiosis-specific proteins that function in a complex in budding yeast. Their general architecture is strikingly similar, and therefore they are potentially homologous protein families. The Hop2-Mnd1 system seems to have undergone duplication in the evolutionary history of Tetrahymena, because both protein families are represented by two homologs with distinct expression patterns in this species. Just as for HOP2 (meiotic) and HOPP2 (ubiquitous), there is a meiotic (MND1)and a ubiquitously expressed (MNDP1) version, which raises the possibility that a meiotic and a ubiquitous Mnd1p-Hop2p complex exists.
Associated Literature
Ref:18522989: Mochizuki K, Novatchkova M, Loidl J (2008) DNA double-strand breaks, but not crossovers, are required for the reorganization of meiotic nuclei in Tetrahymena. Journal of cell science 121(Pt 13):2148-58