TGD | Gene Details

Identifiers and Description

Gene Model Identifier
TTHERM_00718040

Standard Name
PKC2 (Protein Kinase C related protein)

Aliases
PreTt10899 | 114.m00134 | 3827.m00977

Description
Protein kinase domain containing protein. Sequence similarity to a protein kinase family unique to Tetrahymena thermophila (Eisen et al., 2006)."

Genome Browser

Gene Ontology Annotations

Molecular Function
ATP binding (IEA) | GO:0005524
protein tyrosine kinase activity (IEA) | GO:0004713
protein kinase activity (IEA) | GO:0004672
Biological Process
protein phosphorylation (IEA) | GO:0006468

Domains

No Data fetched for Domains

Gene Expression Profile

Tetrahymena Functional Genomics Database: TTHERM_00718040

Homologs (v.2006 protein sequences)

Source Identifier Score Description

IPI(HUMAN) IPI:IPI00028196.5 1.00011677370438e-19 47355;XP_945705|H-INV:HIT0000
01481;HIT000042861 Tax_Id=9606
PREDICTED: doublecortin and C
aM kinase-like 3

TAIR AT3G53930 7.00144647424944e-19 protein kinase family protein

ParameciumDB GSPATP00002585001 9.99531783540373e-19 Paramecium tetraurelia GSPATP0
0002585001 protein

WormBase Y60A3A.12 9.99946582325553e-18 WBGene00000499 chk-2

DictyBase DDB0201878 1.00036155324936e-16 gdt2 GDT family protein kinase
tyrosine kinase-like protein
protein kinase, TKL group puta
tive transmembrane protein

DictyBase DDB0220631 1.00036155324936e-16 gdt2 GDT family protein kinase
tyrosine kinase-like protein
protein kinase, TKL group puta
tive transmembrane protein

FlyBase FBgn0046689 1.99925856616649e-15

ToxoDB 57.m01866 6.99906378360039e-15 Toxoplasma gondii cAMP-depende
nt protein kinase, putative /
serine/threonine protein kinas
e, putative

PlasmoDB PF13_0211 2.00091826746458e-13 Plasmodium falciparum 0211

SGD YPL150W 2.00091826746458e-13 YPL150W SGDID:S000006071, Chr
XVI from 268187-270892, Unchar
acterized ORF, "Hypothetical p
rotein"

CryptoDB EAK90093 2.00057776818706e-11 Cryptosporidium parvum (Iowa)
protein EAK90093

Source	Identifier	Score	Description
IPI(HUMAN)	IPI:IPI00028196.5	1.00011677370438e-19	47355;XP_945705\|H-INV:HIT0000 01481;HIT000042861 Tax_Id=9606 PREDICTED: doublecortin and C aM kinase-like 3
TAIR	AT3G53930	7.00144647424944e-19	protein kinase family protein
ParameciumDB	GSPATP00002585001	9.99531783540373e-19	Paramecium tetraurelia GSPATP0 0002585001 protein
WormBase	Y60A3A.12	9.99946582325553e-18	WBGene00000499 chk-2
DictyBase	DDB0201878	1.00036155324936e-16	gdt2 GDT family protein kinase tyrosine kinase-like protein protein kinase, TKL group puta tive transmembrane protein
DictyBase	DDB0220631	1.00036155324936e-16	gdt2 GDT family protein kinase tyrosine kinase-like protein protein kinase, TKL group puta tive transmembrane protein
FlyBase	FBgn0046689	1.99925856616649e-15
ToxoDB	57.m01866	6.99906378360039e-15	Toxoplasma gondii cAMP-depende nt protein kinase, putative / serine/threonine protein kinas e, putative
PlasmoDB	PF13_0211	2.00091826746458e-13	Plasmodium falciparum 0211
SGD	YPL150W	2.00091826746458e-13	YPL150W SGDID:S000006071, Chr XVI from 268187-270892, Unchar acterized ORF, "Hypothetical p rotein"
CryptoDB	EAK90093	2.00057776818706e-11	Cryptosporidium parvum (Iowa) protein EAK90093

General Information

Paragraph No Gene Name Paragraph Text
30 PKC2 PKC2 shares homology with a number of Protein Kinase C related proteins in other ciliated prokaryotes. PKC2 contains only one single domain across its entire 517 amino acids. It conserves most of the protein kinase domain, and contains a 241 amino acid region with unknown function. PKC2 appears to play a role in amplifying the message of signal transduction pathways by phosphorylating serine and threonine. This induces a conformational change in a targeted protein and subsequently leads to a cellular response. Paragraph by: Jacqueline Kroll and Rachel Brunetti (undergraduates), Keck Science Department, The Claremont Colleges.

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00718040(coding)
ATGTAAAATAGAATTTTCGTAGGATAAAAGAGTAAATACTAACAAAATAAAAATACTATA
ATATAAGGAGGATAGGCCTAAATATATTTTGCGATTGATTCAAAAAATTATTAGCAGGTA
GTAATTAAAGAATACTTTAAGGATTCAAGCTTTTAAGTAGATTATGAAGTCTTAAAAAAG
ATTTAAGATAAATATTCTGAAAACTTAGAAAATTTAGTCAAAATATATGACTAAAGTAGT
GAAAAGGAAAAAATGAAATTTATAGTAATTGAATACTGCAATGAAGGGGATCTCTATACT
TATCACATTAAAAAATAATAAGAAGTTTAGACATTTGAATAAGCACTAGAAGTTATAGAT
ATTGCAATTTAAATTACTAAAGGAATGATGATATTAAAAGAACTAAACCTAGCGCATAGA
GATTTAAAGCCTGAAAATATATTGATCCATAATGATGGAGAAAAAATTATAGCTAAAATA
TCAGATTATGGACTAACTAAAGAGGTATAAAGAGATTTGAAATCAATTGTAGGAACACCA
AATTATATGGCTCCTGAAATACTATCTGCTTATAAGAAAGGCTCAGTATATGACGATAAA
ATAGACGTTTGGTCTTTTGGATTAATTTTATATGAAATGTTTACTTGCAAGTAAATATTT
AAAGGTGATTAAAAATAGATCTTTAATTAACTCATTCACTACAATGACATAATTGATTAA
CTTTTATTTTAAGATAAATTTTAAGATGTTAGTAAATTGGTTATAAGATGCCTTTAAAAA
GATCCTAAAAATAGACCTGATTTTAAATAAATATAAACTGAATTAATATAAATATAAAAT
AATTTTTCATTTTCAGTAATTGATTCTTAAGCAAAAGAATTAGATTATTCTTAATAGTCA
ATCATTTAAAATGAATAGAAAGATCAATTCAATAATTAATAAATTTATTTTGCTGGGTAA
AACAAAAATTAGAATCAACTAAATATCACAAAGGATAATGATCAAATTAAAATGCAAAAT
TAATTAAAAAACTGTCAAAATCAAAGGCAGTTTGTAAATGATCAATATTCTAACAAATAA
TTTTAAGTCCATAACAATAAAATAGAAAAAAAATAAAACAACTAAATGCATAAGTAATAA
AATAACATTTGTTCATATATGAACAACGTAAACTAAGAAAAAAATATACAAATATAAAGC
GAAATACAAAAGTACAATTTTAAGTCAATAGAATTAAGGAAAATCGAAAAAATTATTAAC
ATAAAAAAACTTTTGATAAAATATGGATATATAAATGGCGTTTGTGATGTGGACTAATCA
ATGTATAAATGTATTGTTATAGGTGATAGTATTGTTGAAATCCTTTCACCTTTAATATTA
TAATTTATTTTACAATTTAATAGAGATTGTCTATAAGATATTAAAAATTTAGTAGAAAAA
GAATAATTTGAATAGAAGTAGTTAGAAAAATAAATCGATATATTGATTGATCTGTTTAAG
GAGAACTCTTAAATACCTGTTTCAAAAATCGGTTTCTGCATAAAATATATTTGA

>TTHERM_00718040(protein)
MQNRIFVGQKSKYQQNKNTIIQGGQAQIYFAIDSKNYQQVVIKEYFKDSSFQVDYEVLKK
IQDKYSENLENLVKIYDQSSEKEKMKFIVIEYCNEGDLYTYHIKKQQEVQTFEQALEVID
IAIQITKGMMILKELNLAHRDLKPENILIHNDGEKIIAKISDYGLTKEVQRDLKSIVGTP
NYMAPEILSAYKKGSVYDDKIDVWSFGLILYEMFTCKQIFKGDQKQIFNQLIHYNDIIDQ
LLFQDKFQDVSKLVIRCLQKDPKNRPDFKQIQTELIQIQNNFSFSVIDSQAKELDYSQQS
IIQNEQKDQFNNQQIYFAGQNKNQNQLNITKDNDQIKMQNQLKNCQNQRQFVNDQYSNKQ
FQVHNNKIEKKQNNQMHKQQNNICSYMNNVNQEKNIQIQSEIQKYNFKSIELRKIEKIIN
IKKLLIKYGYINGVCDVDQSMYKCIVIGDSIVEILSPLILQFILQFNRDCLQDIKNLVEK
EQFEQKQLEKQIDILIDLFKENSQIPVSKIGFCIKYI

>TTHERM_00718040(gene)
ATGTAAAATAGAATTTTCGTAGGATAAAAGAGTAAATACTAACAAAATAAAAATACTATA
ATATAAGGAGGATAGGCCTAAATATATTTTGCGATTGATTCAAAAAATTATTAGCAGGTA
GTAATTAAAGAATACTTTAAGGATTCAAGTAATACATCATTTTTTATACTTTTTGGTAGC
TTGATTTATGGTAAACGCTAAAATTATTCTTTTAAATAAAAGGCTTTTAAGTAGATTATG
AAGTCTTAAAAAAGATTTAAGATAAATATTCTGAAAACTTAGAAAATTTAGTCAAAATAT
ATGACTAAAGTAGTGAAAAGGAAAAAATGAAATTTATAGTAATTGAATACTGCAATGAAG
GGGATCTCTATACTTATCACATTAAAAAATAATAAGAAGTTTAGACATTTGAATAAGCAC
TAGAAGTTATAGATATTGCAATTTAAATTACTAAAGGAATGATGATATTAAAAGAACTAA
ACCTAGCGCATAGAGATTTAAAGCCTGAAAATATATTGATCCATAATGATGGAGAAAAAA
TTATAGCTAAAATATCAGATTATGGACTAACTAAAGAGGTATAAAGAGATTTGAAATCAA
TTGTAGGAACACCAAATTATATGGCTCCTGAAATACTATCTGCTTATAAGAAAGGCTCAG
TATATGACGATAAAATAGACGTTTGGTCTTTTGGATTAATTTTATATGAAATGTTTACTT
GCAAGTAAATATTTAAAGGTGATTAAAAATAGATCTTTAATTAACTCATTCACTACAATG
ACATAATTGATTAACTTTTATTTTAAGATAAATTTTAAGATGTTAGTAAATTGGTTATAA
GATGCCTTTAAAAAGATCCTAAAAATAGACCTGATTTTAAATAAATATAAACTGAATTAA
TATAAATATAAAATAATTTTTCATTTTCAGTAATTGATTCTTAAGCAAAAGAATTAGATT
ATTCTTAATAGTCAATCATTTAAAATGAATAGAAAGATCAATTCAATAATTAATAAATTT
ATTTTGCTGGGTAAAACAAAAATTAGAATCAACTAAATATCACAAAGGATAATGATCAAA
TTAAAATGCAAAATTAATTAAAAAACTGTCAAAATCAAAGGCAGTTTGTAAATGATCAAT
ATTCTAACAAATAATTTTAAGTCCATAACAATAAAATAGAAAAAAAATAAAACAACTAAA
TGCATAAGTAATAAAATAACATTTGTTCATATATGAACAACGTAAACTAAGAAAAAAATA
TACAAATATAAAGCGAAATACAAAAGTACAATTTTAAGTCAATAGAATTAAGGAAAATCG
AAAAAATTATTAACATAAAAAAACTTTTGATAAAATATGGATATATAAATGGCGTTTGTG
ATGTGGACTAATCAATGTATAAATGTATTGTTATAGGTGATAGTATTGTTGAAATCCTTT
CACCTTTAATATTATAATTTATTTTACAATTTAATAGAGATTGTCTATAAGATATTAAAA
ATTTAGTAGAAAAAGAATAATTTGAATAGAAGTAGTTAGAAAAATAAATCGATATATTGA
TTGATCTGTTTAAGGAGAACTCTTAAATGTAAAATAATTTAGTTAGAAATGTTATACAAG
ACCTGTTTCAAAAATCGGTTTCTGCATAAAATATATTTGA

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Identifiers and Description

Gene Model Identifier

Standard Name

Aliases

Description

Genome Browser

Gene Ontology Annotations

Molecular Function

Biological Process

Domains

Gene Expression Profile

Homologs (v.2006 protein sequences)

General Information

Associated Literature

Sequences

Wiki Links

External Links

Paragraph No	Gene Name	Paragraph Text
30	PKC2	PKC2 shares homology with a number of Protein Kinase C related proteins in other ciliated prokaryotes. PKC2 contains only one single domain across its entire 517 amino acids. It conserves most of the protein kinase domain, and contains a 241 amino acid region with unknown function. PKC2 appears to play a role in amplifying the message of signal transduction pathways by phosphorylating serine and threonine. This induces a conformational change in a targeted protein and subsequently leads to a cellular response. Paragraph by: Jacqueline Kroll and Rachel Brunetti (undergraduates), Keck Science Department, The Claremont Colleges.