Gene Model Identifier
TTHERM_00647330
Standard Name
THD1
Aliases
PreTt15839 | 93.m00135 | 3727.m00055
Description
Histone deacetylase; homolog of yeast Rpd3p; localized to the macronucleus during vegetative growth; deacetylates all four core histones in vitro; knockdown cells exhibit extrusion bodies and reduced phosphorylation of histone H1
Genome Browser (Macronucleus)
Genome Browser (Micronucleus)
Cellular Component Biological Process
( PF04702 ) Vicilin N terminal region
( PF00850 ) Histone deacetylase family
( PF02134 ) Repeat in ubiquitin-activating (UBA) protein
Tetrahymena Functional Genomics Database:
Signal Peptide Present?: No
TTHERM_00647330
Fullscreen View
No Data fetched for StockID
(v.2006 protein sequences)
Source Identifier Score Description
Stentor Coeruleus SteCoe_7527 0
Tetrahymena borealis EI9_18837.1 9.997093137033517e-262 histone deacetylase (730 aa)
Oxytricha Contig1672.0.g15 0.000000005997038937208364 Myb-like DNA-binding domain
Paragraph No Gene Name Paragraph Text 12 THD1 THD1, a homolog of the Saccharomyces cerevisiae Rpd3p, a class I histone deacetylase (HDAC), is localized to the macronucleus during vegetative growth, and distributed to developing new macronuclei early in their differentiation. Thd1p deacetylates all four core histones in vitro. Thd1p is a 52kDa polypeptide in an HDAC complex of approximately 160 kDa. 13 THD1 Tetrahymena cells with reduced Thd1p expression exhibited phenotypes indicative of loss of chromatin integrity, such as DNA fragmentation and extrusion of chromatin from the macronucleus, variable macronuclear size and shape, enlarged nucleoli, and reduced phosphorylation of histone H1 from bulk chromatin. Macronuclei in THD1 knockdown cells also contained more DNA, suggesting Thd1p may play a role in regulating macronuclear DNA content. The THD1 gene could not be completely replaced by a disruption construct, suggesting that THD1 is an essential gene.
Ref:18178773 : Smith JJ, Torigoe SE, Maxson J, Fish LC, Wiley EA (2008) A class II histone deacetylase acts on newly synthesized histones in Tetrahymena. Eukaryotic cell 7(3):471-82Ref:17715364 : Parker K, Maxson J, Mooney A, Wiley EA (2007) Class I histone deacetylase Thd1p promotes global chromatin condensation in Tetrahymena thermophila. Eukaryotic cell 6(10):1913-24Ref:15879532 : Wiley EA, Myers T, Parker K, Braun T, Yao MC (2005) Class I histone deacetylase Thd1p affects nuclear integrity in Tetrahymena thermophila. Eukaryotic cell 4(5):981-90Ref:11046129 : Wiley EA, Ohba R, Yao MC, Allis CD (2000) Developmentally regulated rpd3p homolog specific to the transcriptionally active macronucleus of vegetative Tetrahymena thermophila. Molecular and cellular biology 20(22):8319-28
>TTHERM_00647330(coding)ATG AAT TAA AAT ACT CAT ACT TAT GAA GAG AGT CCA TCT TTT TAG GAT TCT TTT ATA GAT TAA CAA TAA TAA ATT AAG AGT AAT TTA TCT CTT CAT ACA TTG CAA CCA AAC GAT ACT TTT CAT GCT GAA TAC TAA ACT CAG AAT CCT CCC TCT TTT CAG GAA AAG AAT CTA TTT ATT AAC TAG TTA AAT ACC AAT GAA TAC AGT CAT GAT AAC TTT GAA GTT GAT TAA GTA ACA GGA GAG TAA GAC TAT TTA AAT GAT GGT GAA AAT AAC ACT AGA AAT TAT ACT ATA AAT TAC AAT CAT GTA GAA AAT AAT TAA GAT GAA GAT GAT GAA ATA TAC GCT GAT TAC TTG CCT GAA AAT TTC TTT GAG CAA TTA AAA CCG AAC CCA AGC TAA TTT ACA ATG AAT TTT AAT TAG AAC ACT AAA AAA AAG GAA GAA AGA AAA TCC ATA AAT AAT CGT TCA ACT TCT CTT AAA AAA AGA ATA GAA TAA AAA AAT GAT GAG ATG TTA TAC ACT AGA GCC GCC AAG TAG TAA ATA TGC CAA AAC CTC GTT TAG CAA TAG ATT GAT AAA GAA ATC AAA TAC ATG TCT AAT GCA AAA AAA ATG AGC CAA AAT AGC TAT AGA ATA GTG GCA AAA AAA TTA GAA AAT GTA ATA TCT TCA AAA ATG GCA GAA ATT GAC CCC TCT TTG AGT AAA ATA TTG ACA TTT TCT CAA GTA GGC AGA TTA TTC TAG CTG CTT GAT TTA TTC ACT GTA GTT AAA TTT GAT GAA AAC TCA TAA ATC ATC ATC GAA TAA AAT ATA GAT CCT CAT AAA AAA CTT AGA TTT GCC CAA GAA ACA ATG TTT CAC CAA TAA TTT TGG TTT TTT GTT GTG AAT TAT ATC AAT AAA GAG ACT GTA TTG GGA GAA ATA GTT TTT TCT ACT CTG AGA ATA TTG ATG GAT CCA ATG CAA TTA ACG ATT AAA GAA ACT AAA GAT TTC TTA GCT TAG TAT ATG GGT AGG ACA CTT ACA TAT TTA GAA GAA GAT AGA AAA GCT GCT TAA GAG AGA ACA TAA GGA TTT TAG CTC TGG AGC GTT GAC GAA ATT ATC AAG GCA TTT CGC TAG ATT AAT GAA TAA AGA ATT TTA AGG GAA AAG TCT TAA AAC ATA AAT AAT ATT AAT AAT GTA AAT AAA AAT AAA GCA AGC AAT AAA GAT TTA GAT AAA AAT ATT TAT ACT TTC AAA CCA ACA ATT GAT AAA AAC TCT TAA TTA ATT GAT GAA ATG CAT AGG AAA AAA TTT GCT ATG GCA TCT AGT GGA CTA AAT ATC ACT CCT ATT AGA CAT TCA AAT GCA ACA CAA AAC ACA AAG AGT ATA CAA AGT ACT AAT AAA CTT ATA AAT TTA CTC TAA TCT TCC TAA AGT AAC TAG AAT CTG CAT TCT TAA GCT AGT ATT TTA CTC TAA CAG TAA ATG AAT TAA ACT CTG ATC AAT AAT TAA AGC AAT ACA AAT AAT TTG AAT CAC AAC AGC AGC TCT TTG AGT TTT TTA AAT AAT ACA AAT AAT TAA GTT AAT TAA CAC CCT AAC ATG AAT TAC AAC GAA AAT AAT TCT ACA ACT ACT AAT GCT ACA AGT GAC TAT AGA AGC ACT ACT ATG AAT ACT GAT GTG GCT AAT AAT AGC TCT GAA AAT TCA TAA AGA AAC AGT GAT AAA TTT CTT TCT TAA AAA GTT AAA TCT CTA CTT TCT CAG CAT TAG CAT CCT TCT AGA ACG AAT TTA AAT ACA AAC AAT TAA AAT TTT AAC ACT TTG TAG CAC AAT AGT CAT AAT AAT AAC AAC CAA AAT GGC TAA ATT GGA ATG AGT GAA TAT GAT CAT GAA GAT CCT TAG AGC TAC TTC TCA AAA ATT AAA AGA TGT GCT ACA TTA AGC AGT TTC TAA ATT CCA GAG GAA GAT TAT ATA GAA GAT ATT AGC CAC ATT CCT TCA AAT AAT TTT GAA AAA CCA ATA GAT AGA GTC AAC ATG ATG CTA TAG AAG TAG CAG CAA ACC TAG AGA AAA ATC AGT TAA AAA AAG GAA CAA ATA ATT TAG GAA CAA ATG AAG GAA TGT ACT TTT AAA CCA TAA CTT CAA AGA AGT GTT TCT CCT TAA TAC TCT GCA TAT TCT AGA AAT CAA AAA GAA TTA TTA CAA AGA CAG TAG CAT GAT ATA AAC AAA AGA TAG TAA GCA GCA GAA TAA AGA AAT AGA TAA AAG TAA GAA TAT GAA GAA AAA CTA TTA AAT GAA TGT ACA TTC TAA CCT TCG TTA TCT CCT TCT TAA AGG CTC ATT AAC AAA ACA AGT AAA TCA CCA GTT TCA CCT AAA GGG TTT GAA TAA ACT GTT CAT AGA ATG AGA GCT GCT TAG GAT ATT TAG CGT TAA AGC AGA AAA GCT TTT GAT TAA GGA TCA TAT AGC TCG AAT GCC TAA ATA GTA AGA AAT TCT GTT GTT AGA AAT TCA TTA AGT CCA AAT GTT GAA ATT AAT AAA TAA ATT TAG ATA TAA TAA AGC TTT TAG AAG CAA AAT CCT TCT TAA TAG CAA GAA CAA TAC TTA TAA TAA GTA AAT TAA CAA AAA TAA ATT TAA TAA GAT TTT TCA GAA GAT TTA GAA GGA GAT ATG CTA CAA TAA TAA CCA TAA TAA GAA AAA TAA TAA TTT TAC TAG ATA TAT GAA AAC TAA AAT TAA AGT GCA AAT CAA ATG CAT TAA TAA AAA TAA AGC ATA GTT GAA AAA GAA AAC GAA CAA AGA TTA GAT TTA GAA AAC TAA TTC ATT AAT GAC TAA TAA AGT TTT GTA GAG AAA ATA ACA AAT AAA TAA AAA CCT AAT TTT TAA GAT TAA ACA TTT GGA GAT TCA TAA AAG AAA AAC CAA TAA TTA GAA ATT TAT TAA AAA CCA AAA GCT AAG CCA TTT TTT GTG CTA GAT ATT ATT ACA CCA AAA GGA GAG AAA GCA GCT TTA GAA CTA TTT AAG GAT GAT GAT ATT TAC CAA AAA GCT GAA GTA TTC TCT TAA CAA TAT TAA TTA GAC GAA ATT ACA TAA AGT AAA ATA GAA TAG ATC CTA GAT TAG CAA ATG CAA AAA TAT CTC TTA AAA AAA TAA AAC ACT GTA AAA AAT AAT TGA >TTHERM_00647330(protein)M N Q N T H T Y E E S P S F Q D S F I D Q Q Q Q I K S N L S L H T L Q P N D T F H A E Y Q T Q N P P S F Q E K N L F I N Q L N T N E Y S H D N F E V D Q V T G E Q D Y L N D G E N N T R N Y T I N Y N H V E N N Q D E D D E I Y A D Y L P E N F F E Q L K P N P S Q F T M N F N Q N T K K K E E R K S I N N R S T S L K K R I E Q K N D E M L Y T R A A K Q Q I C Q N L V Q Q Q I D K E I K Y M S N A K K M S Q N S Y R I V A K K L E N V I S S K M A E I D P S L S K I L T F S Q V G R L F Q L L D L F T V V K F D E N S Q I I I E Q N I D P H K K L R F A Q E T M F H Q Q F W F F V V N Y I N K E T V L G E I V F S T L R I L M D P M Q L T I K E T K D F L A Q Y M G R T L T Y L E E D R K A A Q E R T Q G F Q L W S V D E I I K A F R Q I N E Q R I L R E K S Q N I N N I N N V N K N K A S N K D L D K N I Y T F K P T I D K N S Q L I D E M H R K K F A M A S S G L N I T P I R H S N A T Q N T K S I Q S T N K L I N L L Q S S Q S N Q N L H S Q A S I L L Q Q Q M N Q T L I N N Q S N T N N L N H N S S S L S F L N N T N N Q V N Q H P N M N Y N E N N S T T T N A T S D Y R S T T M N T D V A N N S S E N S Q R N S D K F L S Q K V K S L L S Q H Q H P S R T N L N T N N Q N F N T L Q H N S H N N N N Q N G Q I G M S E Y D H E D P Q S Y F S K I K R C A T L S S F Q I P E E D Y I E D I S H I P S N N F E K P I D R V N M M L Q K Q Q Q T Q R K I S Q K K E Q I I Q E Q M K E C T F K P Q L Q R S V S P Q Y S A Y S R N Q K E L L Q R Q Q H D I N K R Q Q A A E Q R N R Q K Q E Y E E K L L N E C T F Q P S L S P S Q R L I N K T S K S P V S P K G F E Q T V H R M R A A Q D I Q R Q S R K A F D Q G S Y S S N A Q I V R N S V V R N S L S P N V E I N K Q I Q I Q Q S F Q K Q N P S Q Q Q E Q Y L Q Q V N Q Q K Q I Q Q D F S E D L E G D M L Q Q Q P Q Q E K Q Q F Y Q I Y E N Q N Q S A N Q M H Q Q K Q S I V E K E N E Q R L D L E N Q F I N D Q Q S F V E K I T N K Q K P N F Q D Q T F G D S Q K K N Q Q L E I Y Q K P K A K P F F V L D I I T P K G E K A A L E L F K D D D I Y Q K A E V F S Q Q Y Q L D E I T Q S K I E Q I L D Q Q M Q K Y L L K K Q N T V K N N >TTHERM_00647330(gene)ATG AAT TAA AGT AAC TTC ATT TTT GGA AGA AAA AGC TTT ATT TAA TCT TTA ATC ATT TAA ACT ATT TGA AAG ATA CTC ATA CTT ATG AAG AGA GTC CAT CTT TTT AGG ATT CTT TTA TAG ATT AAC AAT AAT AAA TTA AGA GTA ATT TAT CTC TTC ATA CAT TGC AAC CAA ACG ATA CTT TTC ATG CTG AAT ACT AAA CTC AGA ATC CTC CCT CTT TTC AGG AAA AGA ATC TAT TTA TTA ACT AGT TAA ATA CCA ATG AAT ACA GTC ATG ATA ACT TTG AAG TTG ATT AAG TAA CAG GAG AGT AAG ACT ATT TAA ATG ATG GTG AAA ATA ACA CTA GAA ATT ATA CTA TAA ATT ACA ATC ATG TAG AAA ATA ATT AAG ATG AAG ATG ATG AAA TAT ACG CTG ATT ACT TGC CTG AAA ATT TCT TTG AGC AAT TAA AAC CGA ACC CAA GCT AAT TTA CAA TGA ATT TTA ATT AGA ACA CTA AAA AAA AGG AAG AAA GAA AAT CCA TAA ATA ATC GTT CAA CTT CTC TTA AAA AAA GAA TAG AAT AAA AAA ATG TAA ACT GAT ACT TTT GTG TTT TAA ACC TCT ATC AAA TCG CAA TTT TAA TAT AAT TTT TGA TTA ATA ATA TCT CAC TTT TAC TAA CAT AAA ATA AGG ATG AGA TGT TAT ACA CTA GAG CCG CCA AGT AGT AAA TAT GCC AAA ACC TCG TTT AGC AAT AGG TAA TGA AAA TTT TTA TAA TTT CAT TGA CAT ATA AAA TAT TAT TTG AAG CTC TAT TTT TAG TTA CTG ATT TTC ATT TTA TAA AAG ATT GAT AAA GAA ATC AAA TAC ATG TCT AAT GCA AAA AAA ATG AGC CAA AAT AGC TAT AGA ATA GTG GCA AAA AAA TTA GAA AAT GTA ATA TCT TCA AAA ATG GCA GAA ATT GAC CCC TCT TTG AGT AAA ATA TTG ACA TTT TCT CAA GTA GGC AGA TTA TTC TAG CTG CTT GAT TTA TTC ACT GTA GTT AAA TTT GAT GAA AAC TCA TAA AGT ATT AAT TTA ATT GAT TTA TTT TTA TTA TTA TTA TAA TTA TTC ATT TGC ATC TTT TGC ATA AAT ATC AAC AAC CAC CAA AAC CCT TTA ATT AAG TTT TTA ACG AAT TTC TTA ATT TTG CGA AAA TAT CTT CAT TTA TTC TTT CAT TGA TAA ATT CGT TTG CAT TTT CTT TTG CGC AAT GTT AAA TAC AGA TAA CTA CAA TTT ATT AAT ATT TCA AAC TGA AAT TGT GCT AAA AAA TCA CAT TTT TTA TTT CAA TTA TTC TAT CAG TTA AAT TAG AAT ACT TCA AAG TAA ATA TTT TTA ATT TAT ATT TAA AAA ATT AGT CAT CAT CGA ATA AAA TAT AGA TCC TCA TAA AAA ACT TAG ATT TGC CCA AGA AGT AAG AAT AAT TTT TAA TTA TTT TAT TTT TTC TAA TCA ATT TAT TTT CAT TTT TTG ACA AAA ATT TTT CAT TTA TTT TGG TTT AAT CTT TTA ATT AAA TAT TAA ATT TAT TTT AAA TAA CTT CCA TTC AAT TAT TTA GAT AAA TAA CTA AAT AAA AAC TAA AAA ATC TTT TTA TTT TTT CTT TTA AGA TAG ATT ATT TAG ATT AAT TTT TTA TTT CTT TCA AAA AAA ATT GTT AAA TAT GAA AGA TAT TTT TGT TTA ATT TAA AAA ACA AAT TTA TTA AAT TAT TTT CAA TAT CTT TAC TTA ATT TAA CAA AAT GAA TAA AAT TTT TTA TTT TAA TTT TGA TTG AAA AAT ATT TTT TCA TTG ATT TTT AAT AAA ATT AAT TAT TTG CTA TTT TAA TTT TAT AGA CAA TGT TTC ACC AAT AAT TTT GGT TTT TTG TTG TGA ATT ATA TCA ATA AAG AGA CTG TAT TGG GAG AAA TAG TTT TTT CTA CTC TGA GAA TAT TGA TGG ATC CAA TGC AAT TAA CGA TTA AAG AAA CTA AAG ATT TCT TAG CTT AGT ATA TGG GTA GGA CAC TTA CAT ATT TAG AAG AAG ATA GAA AAG CTG CTT AAG AGA GAA CAT AAG GAT TTT AGC TCT GGA GCG TTG ACG AAA TTA TCA AGG CAT TTC GCT AGA TTA ATG AAT AAA GAA TTT TAA GGG AAA AGT CTT AAA ACA TAA ATA ATA TTA ATA ATG TAA ATA AAA ATA AAG CAA GCA ATA AAG ATT TAG ATA AAA ATA TTT ATA CTT TCA AAC CAA CAA TTG ATA AAA ACT CTT AAT TAA TTG ATG AAA TGC ATA GGA AAA AAT TTG CTA TGG CAT CTA GTG GAC TAA ATA TCA CTC CTA TTA GAC ATT CAA ATG CAA CAC AAA ACA CAA AGA GTA TAC AAA GTA CTA ATA AAC TTA TAA ATT TAC TCT AAT CTT CCT AAA GTA ACT AGA ATC TGC ATT CTT AAG CTA GTA TTT TAC TCT AAC AGT AAA TGA ATT AAA CTC TGA TCA ATA ATT AAA GCA ATA CAA ATA ATT TGA ATC ACA ACA GCA GCT CTT TGA GTT TTT TAA ATA ATA CAA ATA ATT AAG TTA ATT AAC ACC CTA ACA TGA ATT ACA ACG AAA ATA ATT CTA CAA CTA CTA ATG CTA CAA GTG ACT ATA GAA GCA CTA CTA TGA ATA CTG ATG TGG CTA ATA ATA GCT CTG AAA ATT CAT AAA GAA ACA GTG ATA AAT TTC TTT CTT AAA AAG TTA AAT CTC TAC TTT CTC AGC ATT AGC ATC CTT CTA GAA CGA ATT TAA ATA CAA ACA ATT AAA ATT TTA ACA CTT TGT AGC ACA ATA GTC ATA ATA ATA ACA ACC AAA ATG GCT AAA TTG GAA TGA GTG AAT ATG ATC ATG AAG ATC CTT AGA GCT ACT TCT CAA AAA TTA AAA GAT GTG CTA CAT TAA GCA GTT TCT AAA TTC CAG AGG AAG ATT ATA TAG AAG ATA TTA GCC ACA TTC CTT CAA ATA ATT TTG AAA AAC CAA TAG ATA GAG TCA ACA TGA TGC TAT AGA AGT AGC AGC AAA CCT AGA GAA AAA TCA GTT AAA AAA AGG AAC AAA TAA TTT AGG AAG TAA ATT AAT TTA CTA ATA ATT AAT TAA TTA TTT ACT AAT TAA ATA TTT TAA AGC AAA TGA AGG AAT GTA CTT TTA AAC CAT AAC TTC AAA GAA GTG TTT CTC CTT AAT ACT CTG CAT ATT CTA GAA ATC AAA AAG AAT TAT TAC AAA GAC AGT AGC ATG ATA TAA ACA AAA GAT AGT AAG CAG CAG AAT AAA GAA ATA GAT AAA AGT AAG AAT ATG AAG AAA AAC TAT TAA ATG AAT GTA CAT TCT AAC CTT CGT TAT CTC CTT CTT AAA GGT TTT TCA TTG ATT TTT TTC TGA ATT TTT AAA ATT AAA ATG AAA TAA ATG TGA ATT TAT TTA TTT ATG TAT AGG CTC ATT AAC AAA ACA AGT AAA TCA CCA GTT TCA CCT AAA GGG TTT GAA TAA ACT GTT CAT AGA ATG AGA GCT GCT TAG GAT ATT TAG CGT TAA AGC AGA AAA GCT TTT GAT TAA GGA TCG TAA TTA AAA AAT TTA GAT TTA TTA AAA TGA ATA AAT TGT TTA TTA TTA TTT ATT TAT ATT TAA TTT TTA ATA AAT TTA CTT AAT TTA AAC TCA AAT TAA ATT TTA GAT ATA GCT CGA ATG CCT AAA TAG TAA GAA ATT CTG TTG TTA GAA ATT CAT TAA GTC CAA ATG TTG AAA TTA ATA AAT AAA TTT AGA TAT AAT AAA GCT TTT AGA AGC AAA ATC CTT CTT AAT AGC AAG AAC AAT ACT TAT AAT AAG TAA ATT AAC AAA AAT AAA TTT AAT AAG ATT TTT CAG AAG ATT TAG AAG GAG ATA TGC TAC AAT AAT AAC CAT AAT AAG AAA AAT AAT AAT TTT ACT AGA TAT ATG AAA ACT AAA ATT AAA GTG CAA ATC AAA TGC ATT AAT AAA AAT AAA GCA TAG TTG AAA AAG AAA ACG AAC AAA GAT TAG ATT TAG AAA ACT AAT TCA TTA ATG ACT AAT AAA GTT TTG TAG AGA AAA TAA CAA ATA AAT AAA AAC CTA ATT TTT AAG ATT AAA CAT TTG GAG ATT CAT AAA AGA AAA ACC AAT AAT TAG AAA TTT ATT AAA AAC CAA AAG CTA AGC CAT TTT TTG TGC TAG ATA TTA TTA CAC CAA AAG GAG AGT AAT TTA AAA AAA CCA TTT CAA ATA AAA CAA ATA AGT TAT TTA ATT ATT TAA AAA TAG GAA AGC AGC TTT AGA ACT ATT TAA GGA TGA TGA TAT TTA CCA AAA AGC TGA AGT ATT CTC TTA ACA ATA TTA ATT AGA CGA AAT TAC ATA AAG TAA AAT AGA ATA GAT CCT AGA TTA GCA AAT GCA AAA ATA TCT CTT AAA AAA ATA AAA CAC TGT AAA AAA TAA TTG A
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