Identifiers and Description
Gene Model Identifier
TTHERM_00627090
Standard Name
SPO11 (Ortholog of budding yeast SPO11)
Aliases
PreTt24634 | 88.m00102 | 3822.m00628
Description
Type IIB DNA topoisomerase family protein
Required for meiotic DNA DSBs. Required for the elongation of meiotic nuclei and full chromosome pairing in Tetrahymena
Genome Browser
Gene Ontology Annotations
Cellular Component
Molecular Function
Biological Process
Domains
No Data fetched for Domains
Gene Expression Profile
Homologs (v.2006 protein sequences)
| Source | Identifier | Score | Description |
| ParameciumDB | GSPATP00009108001 | 3.00129010688343e-24 | Paramecium tetraurelia GSPATP0
0009108001 protein
|
| IPI(HUMAN) | IPI:IPI00181896.1 | 7.99876338514687e-21 | 2|ENSEMBL:ENSP00000316034|REF
SEQ:NP_937998|H- INV:HIT000041
863|VEGA:OTTHUMP00000031361 Ta
x_Id=9606 Splice Isoform 2 of
Meiotic recombination protein
SPO11
|
| WormBase | T05E11.4 | 4.99961789195456e-16 | WBGene00004985 spo-11
|
| ToxoDB | 52.m01591 | 8.00267927440358e-15 | Toxoplasma gondii meiotic reco
mbination protein SPO11, putat
ive
|
| TAIR | AT5G02820 | 8.99596726193887e-15 | DNA topoisomerase VIA (SPO11)
|
| FlyBase | FBgn0002716 | 2.99947124940085e-11 | |
| SGD | YHL022C | 4.00056668739648e-11 | SPO11 SGDID:S000001014, Chr VI
II from 64155-62959, reverse c
omplement, Verified ORF, "Meio
sis-specific protein that init
iates meiotic recombination by
catalyzing the formation of d
ouble-strand breaks in DNA via
a transesterification reactio
n; required for homologous chr
omosome pairing and synaptonem
al complex formation"
|
| CryptoDB | EAK89350 | 1.99906734431412e-08 | Cryptosporidium parvum (Iowa)
protein EAK89350
|
| PlasmoDB | PFL0825c | 4.00086488086642e-06 | Plasmodium falciparum PFL0825c
|
General Information
| Paragraph No | Gene Name | Paragraph Text |
| 15 | SPO11 | Spo11p induces DSBs and at the same time triggers the elongation of meiotic nuclei (crescents) via an ATR-dependent response in Tetrahymena. The crescent resembles the conserved bouquet arrangement and the fission yeast horsetail nucleus. It promotes meiotic chromosome pairing. Thus, by nuclear elongation and the ensuing close juxtapositioning of homologous chromosome regions within the tubular nucleus, Spo11p ensures that DSBs formed by its activity can be repaired by homologous recombination. |
Associated Literature
- Ref:20422424: Lukaszewicz A, Howard-Till RA, Novatchkova M, Mochizuki K, Loidl J (2010) MRE11 and COM1/SAE2 are required for double-strand break repair and efficient chromosome pairing during meiosis of the protist Tetrahymena. Chromosoma 119(5):505-18
- Ref:19297526: Loidl J, Mochizuki K (2009) Tetrahymena meiotic nuclear reorganization is induced by a checkpoint kinase-dependent response to DNA damage. Molecular biology of the cell 20(9):2428-37
- Ref:18522989: Mochizuki K, Novatchkova M, Loidl J (2008) DNA double-strand breaks, but not crossovers, are required for the reorganization of meiotic nuclei in Tetrahymena. Journal of cell science 121(Pt 13):2148-58
Sequences
>TTHERM_00627090(coding)
ATGGATATTTAAAATATCAATTCAAATACATAAACAAAATATTTTATAAAATTATACGAA
AATTTTCCATAATTTTGTAAATAAAAGATTGATTTCTTAAGTATAAAATAATCAATTTTA
AATTAAAATAGATTTATTTTAATCTTATGCTTATTAAATAAATTTCAGTAAATTTCAGTC
TAATTTTTTAAATCTATTGATAAATAATTGGATTAAATAATAAATAAATTTTAGCTAAAT
ATTAAATTTATTAATAATCTGAAAAGTACAAAAAACTTTTAAACCTAAAGAAAAATGAAT
TTCAACCAGTTAAAATCTCTAAATGCTCAAATACTCCAAAGACACTTTGAAGCTCTCAAT
TTTCTTGGAATTTAATATTCAATACATGATTTAGATAAAGAAAGTATCATTAACAGGTTA
AGAGATTTTTTCTTTTAACTTCTGAAAGAGATTATTATTTAGAATTCATGCCTTAAACTT
ATGGAAAAAAAAGATATATAATTTGACTACTTTTATTTTATACATGCAGAGTAGCAATAT
ATCTCCAACTAATCCTTAGAAATAACTAGCTAAAAATATCAAAATTTTTACAGTCAATTC
TAATCATTAAGAAAACTTAACAAAGAAGGAAAAAATAAAACAATGGTTATCCATAAGAAT
AATTTAAAATCATTAGAAAAGTTACTTTTTTGCATAAAATAAATTTTGAATGCCCTTAAA
AATGATTTTTAAATCACAAAAAGAGAAATATTCTACACAAATGTTGAACTTTTTGACTAA
AATTAGTAAAACTTAGAAAAAATTATTCAAATATTGCAAAATTAATTAAGACTGCCAAGA
AATTGTTTAAATATTATTGCTTCAGCTAAAGGTTTAGTAACTGGTAATGTATAATTCTAA
GTTAGTTCTTAAGCTGAATTTATTGATCTTAGTAAAAATTTTGGAGAAGTCAGGCAAATA
TAGCCAAAGGAAGAAATTTTATGGATTGAAACAAACTCTGCATTTATATTGGTTGTAGAG
AAAGAAACTGTTTTTTAAAAAATCATAGCTGAAAAAGACGAATAGCTTTTGAAGAATTGT
ATAATGATTACTGGGAAAGGGTATGGCGATTATAGCACCAAATAATATATAAAGATGCTA
ACTGCTAACAATCCAAACTCGCCTTTATTTTATTTAGGGGATTTCGATCCATTTGGCTTA
GATATACTCTTCAATTACACTTTTGGTTCCGAAAATTCTGTCTACTAACAAGATAACTTG
CCAAATATTCATTTCTTAGGTCTATCAAGCTTTGATATTTTGGATTTTAATTAATAATCT
GATGAAAAAAAATTCAATGTTGAAAACAATTTAAGCAAACAAGATATTTGTAAGCTGGAT
GCCTTAATCGCCAAATTTGAATTTAGTAAATTGAATTAACTTAAAAATAATTATTTATAA
ATACCAAAAGATAAAATAGACTCAAATAAATTAGATGATCTCACTAGTTAAAGAAAAGTA
GAAATGGATAAGCTTTTTGGTAGGGTAATTAGAAGAAATCAAGCTGCAGAAGAGTTCATG
AAAAATGAAGATGCAAAAGCTCATGAAAAGGAAACAGTAAAGTAAAATATGTAAATATAG
ACTGGCATAAAGGTTGCTTTGAGACTGTCTTTTATAGGTTCTGTTGCTTTATTATACAAA
AGAGGATTTTTTGCAAAATAAAGCCCATTTTTCATGAGAGAATTATTATTAATGGTAGGA
GGATATGGAGTTATTTCAATAGGAGATTTCTTTGCATCTGAATATATGTGGTCCAACGCT
GGAACCATTATCAGAAGATATACTAATTATTCCGATTCATATTATGTAGATGATAAAACT
TACAATAAAATGAAGGAAATGTATAAATTAAAGTAGAATTAACCATAGCAAACTGTAGAA
TATTAAGAAAATAATGATAAAATGTATGACTGA
>TTHERM_00627090(protein)
MDIQNINSNTQTKYFIKLYENFPQFCKQKIDFLSIKQSILNQNRFILILCLLNKFQQISV
QFFKSIDKQLDQIINKFQLNIKFINNLKSTKNFQTQRKMNFNQLKSLNAQILQRHFEALN
FLGIQYSIHDLDKESIINRLRDFFFQLLKEIIIQNSCLKLMEKKDIQFDYFYFIHAEQQY
ISNQSLEITSQKYQNFYSQFQSLRKLNKEGKNKTMVIHKNNLKSLEKLLFCIKQILNALK
NDFQITKREIFYTNVELFDQNQQNLEKIIQILQNQLRLPRNCLNIIASAKGLVTGNVQFQ
VSSQAEFIDLSKNFGEVRQIQPKEEILWIETNSAFILVVEKETVFQKIIAEKDEQLLKNC
IMITGKGYGDYSTKQYIKMLTANNPNSPLFYLGDFDPFGLDILFNYTFGSENSVYQQDNL
PNIHFLGLSSFDILDFNQQSDEKKFNVENNLSKQDICKLDALIAKFEFSKLNQLKNNYLQ
IPKDKIDSNKLDDLTSQRKVEMDKLFGRVIRRNQAAEEFMKNEDAKAHEKETVKQNMQIQ
TGIKVALRLSFIGSVALLYKRGFFAKQSPFFMRELLLMVGGYGVISIGDFFASEYMWSNA
GTIIRRYTNYSDSYYVDDKTYNKMKEMYKLKQNQPQQTVEYQENNDKMYD
>TTHERM_00627090(gene)
ATGGATATTTAAAATATCAATTCAAATACATAAACAAAATATTTTATAAAATTATACGAA
AATTTTCCATAATTTTGTAAATAAAAGATTGATTTCTTAAGTATAAAATAATCAATTTTA
AATTAAAATAGATTTATTTTAATCTTATGCTTATTAAATAAATTTCAGTAAATTTCAGTC
TAATTTTTTAAATCTATTGATAAATAATTGGATTAAATAATAAATAAATTTTAGCTAAAT
ATTAAATTTATTAATAATCTGAAAAGTACAAAAAACTTTTAAACCTAAAGAAAAATGAAT
TTCAACCAGTTAAAATCTCTAAATGCTCAAATACTCCAAAGACACTTTGAAGCTCTCAAT
TTTCTTGGAATTTAATATTCAATACATGATTTAGATAAAGAAAGTATCATTAACAGGTTA
AGAGATTTTTTCTTTTAACTTCTGAAAGAGATTATTATTTAGAATTCATGCCTTAAACTT
ATGGAAAAAAAAGATATATAATTTGACTACTTTTATTTTATACATGCAGAGTAGCAATAT
ATCTCCAACTAATCCTTAGAAATAACTAGCTAAAAATATCAAAATTTTTACAGTCAATTC
TAATCATTAAGAAAACTTAACAAAGAAGGAAAAAATAAAACAATGGTTATCCATAAGAAT
AATTTAAAATCATTAGAAAAGTTACTTTTTTGCATAAAATAAATTTTGAATGCCCTTAAA
AATGATTTTTAAATCACAAAAAGAGAAATATTCTACACAAATGTTGAACTTTTTGACTAA
AATTAGTAAAACTTAGAAAAAATTATTCAAATATTGCAAAATTAATTAAGACTGCCAAGA
AATTGTTTAAATATTATTGCTTCAGCTAAAGGTTTAGTAACTGGTAATGTATAATTCTAA
GTTAGTTCTTAAGCTGAAGTAAAATTCCTTTATGTATTTCCTTGATTTAACTCACAAAAA
TTCTTTAATAGTTTATTGATCTTAGTAAAAATTTTGGAGAAGTCAGGCAAATATAGCCAA
AGGAAGAAATTTTATGGATTGAAACAAACTCTGCATTTATATTGGTTGTAGAGAAAGAAA
CTGTTTTTTAAAAAATCATAGCTGAAAAAGACGAGTAAGTTCCTATTAATTTATTTATTA
GTTTTATGATTTTTAATATTTTGATTTATATAATTAGATAGCTTTTGAAGAATTGTATAA
TGATTACTGGGAAAGGGTATGGCGATTATAGCACCAAATAATATATAAAGATGCTAACTG
CTAACAATCCAAACTCGCCTTTATTTTATTTAGGGGATTTCGATCCATTTGGCTTAGATA
TACTCTTCAATTACACTTTTGGTTCCGAAAATTCTGTCTACTAACAAGATAACTTGCCAA
ATATTCATTTCTTAGGTCTATCAAGCTTTGATATTTTGGATTTTAATTAATAATCTGATG
AAAAAAAATTCAATGTTGAAAACAATTTAAGCAAACAAGATATTTGTAAGCTGGATGCCT
TAATCGCCAAATTTGAATTTAGTAAATTGAATTAACTTAAAAATAATTATTTATAAATAC
CAAAAGATAAAATAGACTCAAATAAATTAGATGATCTCACTAGTTATCAGATAAATAGAT
GGAAGAAATGGATTGAAAATGCTGAGTTTATAAGACAAAACAATACAAAATATGAAATCG
AAGACATTTATCCATTCCTTAGCTAAAAAAATTTAACTTTATCATAATTTATTATAAATA
AAATCTAATCAAACAAATATTTATGATATTAATTTCTTATTTTTCTTTTTTGCTTGTGTA
AAGAAATATTTAGAATTAAATTTTATTTTTCACTCAAACTAAAGTTATTTTTAGTATTTT
TAAAACTGTATTTACAAATACCGTAGTTTCTTTAACCTAAATTCTCGGTTTTAAGCATAC
TGAGCCAAGGAAAAGACTATTATATCTAAATTCTGAAAATTGTTTGAAATAAATTATTTA
TTCTTAATTTAATTGATTTTACAATAAATAATATTATTGGGATTTATTTAAATTTTTAAC
AATCTTAAATTATTTTACTTTTATAAATACTAATTTTTATCTCTTAAGTATGATCTTCAT
TCATTGTATGATAAGCCAATCATTTTAAATCTTATTTTAAGCAACCTCTTGCTGAAAAAT
GTAAGATAGTTTAGAATATTAATAATAAAATTCCATTTTGAAAAAAAATATTAAAGGAGC
TTTAAATGGATGAAAACTGTGATTATTTTTATGCTCTTTACAATGAAAAAAATTATTTTG
ATTTATAAATCTGAATATTTTCTACTTATTGGTTTTTGTAAATAATTAATTCTACGATGT
TCATGAATGGATAAAATTTTTTAATTTGATAAATTTGAGAAAGTTCGTAATTATTTATCA
TTTTGCATTTAAAAAAGAAAGATATTTAGCTATGGTTTTTATTATGATGCTTTTTGTATG
GAAGAAATTTCTATTAGAGGAAGCAAGCTTTTTTTGATACTTCAAATTAATTATAAATAT
TCATAAAAATTAATTAATTTTTTTAAGGTTAAAGAAAAGTAGAAATGGATAAGCTTTTTG
GTAGGGTAATTAGAAGAAATCAAGCTGCAGAAGAGTTCATGAAAAATGAAGATGCAAAAG
CTCATGAAAAGGAAACAGTAAAGTAAAATATGTAAATATAGACTGGCATAAAGGTTGCTT
TGAGACTGTCTTTTATAGGTTCTGTTGCTTTATTATACAAAAGAGGATTTTTTGCAAAAT
AAAGCCCATTTTTCATGAGAGAATTATTATTAATGGTAGGAGGATATGGAGTTATTTCAA
TAGGAGATTTCTTTGCATCTGAATATATGTGGTCCAACGCTGGAACCATTATCAGAAGAT
ATACTAATTATTCCGATTCATATTATGTAGATGATAAAACTTACAATAAAATGAAGGAAA
TGTATAAATTAAAGTAGAATTAACCATAGCAAACTGTAGAATATTAAGAAAATAATGATA
AAATGTATGACTGA
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