Identifiers and Description

Gene Model Identifier

TTHERM_00621280

Standard Name

NHX2 (Sodium Hydrogen Exchanger 2)

Aliases

PreTt05125 | 86.m00157

Description

Sodium/hydrogen exchanger family protein

Genome Browser

Gene Ontology Annotations

Cellular Component

• integral to membrane (IEA) | GO:0016021

Molecular Function

• solute:hydrogen antiporter activity (IEA) | GO:0015299

Biological Process

• cation transport (IEA) | GO:0006812

Domains

• ( TIGR00831 ) Na+/H+ antiporter
• ( TIGR03173 ) xanthine permease
• ( PF03647 ) Transmembrane proteins 14C
• ( PF02322 ) cytochrome oxidase subunit II
• ( TIGR00840 ) sodium/hydrogen exchanger 3
• ( TIGR02831 ) stage II sporulation protein M
• ( PF07690 ) transporter, major facilitator family
• ( PF00999 ) transporter, monovalent cation:proton antiporter-2 (CPA2)

Gene Expression Profile

• Tetrahymena Functional Genomics Database: TTHERM_00621280

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
ParameciumDB	GSPATP00016996001	4.9984441578007e-72	Paramecium tetraurelia GSPATP0 0016996001 protein
TAIR	AT5G27150	3.99937413575047e-31	sodium proton exchanger / Na+/ H+ antiporter (NHX1)
SGD	YDR456W	2.99931102462213e-28	NHX1 SGDID:S000002864, Chr IV from 1367476-1369377, Verified ORF, "Endosomal Na+/H+ exchan ger, required for intracellula r sequestration of Na+; requir ed for osmotolerance to acute hypertonic shock"
WormBase	Y18D10A.6b	9.99797531338778e-28	WBGene00003735 nhx-8 Sodium/hy drogen exchanger family
WormBase	Y18D10A.6a	9.99797531338778e-28	WBGene00003735 nhx-8 Sodium/hy drogen exchanger family
IPI(HUMAN)	IPI:IPI00216972.3	9.99797531338778e-28	PROT:Q8IVB4|TREMBL:Q3LIC2;Q5J PI6;Q5WA58|ENSEMBL:ENSP0000 03 20246|REFSEQ:NP_775924|H- INV: HIT000017799;HIT000027216;HIT0 00051508 Tax_Id=9606 Sodium/hy drogen exchanger 9
FlyBase	FBgn0026787	4.0006511639687e-23
DictyBase	DDB0202441	1.99910955692301e-20	nhe1 sodium/hydrogen exchanger Na-H exchanger
DictyBase	DDB0231789	1.99910955692301e-20	nhe1 sodium/hydrogen exchanger Na-H exchanger
ToxoDB	541.m01159	4.00094936373533e-18	Toxoplasma gondii sodium/hydro gen exchanger, putative

General Information

Paragraph No	Gene Name	Paragraph Text
26	NHX2	NHX2 belongs in the family of sodium-hydrogen exchangers that act as antiporrters that maintain the pH of actively metabolizing cells by controlling the balance of sodium. THe antiporters have 10-12 regions on the N-terminus and a large cytoplasmic region on the C-terminus. The 10-12 transmembrane regions contain 2 highly conserved regions and most of the regions share identities within the family , while the large cytoplasmic region is noted to have little similarity with other members in the family. Paragraph by: Chris Fang and Deanna Liou (undergraduates) Keck Science Department, The Claremont Colleges

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00621280(coding)
ATGTTTGGAGTAATCTTTTTAATTGTAGTTGTGCTAATCTTGTTCTATTTGATTGGAGGT
GGGCTCCTTGAGCACTATAAGATACACGTTATTCATGAAACAGGATTAGGTATCATTATG
GGTATGATTGTAGGATTTATTTTCTATCAAGCCGATTACGAATTCTACTCAAGTAGTATG
ATATTTGAAGGTGAGCTCTTCTTTTACTTTATCCTTCCACCCATTATTTTTGCAGGCGGT
TACAACTTGAAAAAGCGTCGTTTTTTCCAAAATTTCTTCTACATTAATATATATGGATTA
CTTGGTACTATAGTCAATTTCATAGTAGTATGGCTCTTAACTTATGCTGTTAACGAAGCA
GGTTTGATTCGTAGATATAGTGATTTTTCTCAGTCTGTAACATTATCAACAAGAGATATC
CTTCTGTTTTCTGCTACTATATGCGCTACAGATAGTGTAGCTGCCTTAGCTATGATTAAA
TCAGAGAAATATCCAAAATTATTTAGTGTTATTTTTGGTGAAGGCATGGTAAATGATTCT
GTATCAATTATTCTATATAAGGCTGTCTTGGATTTAGTTGGCGACTCATCTGAACCTCAG
CCTATAACTTTCACTTTCCTTAACTTCTTAAAGATGATTGGTGAATTCCTTAAAAACTCA
GTATGCAGTTTAGCTATTGGTCTTGGTTGGGGTCTCTTAGCTACTTTAGTCATGAAAAAA
TTTAGGTTTTTGACACATAATCCAGTAGTTGAAACAGTTGTTGTTTTACTATTTGGTTTT
GGTGCTTTCGCTTCTTCAGAAAACCTAGATATGTCTGGTGTCATTTCAATTTTAGTATGT
GGTATTATCATGTCTCATTACCTTTTCTATAACATATCATCAACTGGTAAAGTAACAACA
GGTGTCACTTTTTCAAGTATCTCTATTATTGCAGAATCAGCTCTTTATATCTATTTGGGT
ATCGTCTTCTGGTAAACAAAGGGAGATCCTCACAATCCAAGCTCTTATGCATGGTCATGG
ACTTTCTTACTCATTGAATTGGCTATTGCCTTTTTCGCTCGTTTTGTGAGTGTTTTTGTA
GTTTCTTGGATTTTCATGCTAATTAAGGGCAAATAAAAATGGAGATTAAATAGATATGAA
ATGGGTATTATTTGGTTTGCAGGTATTATTAGAGGAGCTATTGCTTTTGCATTGATTTAG
AATGTACCTTAAGATGATTCAAATCCTTAGGCAACACAAGTTATTTAGAGTACAACTCTC
TTTATTGTTATAATCACAACTATTGTCTTAGGAGGTCTAATGCCTTTTTATATAAATGTC
ATGCTGAAACAAATTTCAAAGAATCCTAAGTATCATGAAAATCATCCTTCTATTCGTGAT
AGTTTGGTTGGAGAATCAAAAGAAAGTAGAGAATTCAAAAGCAAGAGTCAGACAAAGTGG
AAATTATTTGATGAAAACTTTATCAAACCTTTGTTCATTTTCGACTATGAAAATAGAAAA
GAGCAAATTAAGATGGAAAAACAAAAGCTTAAAATGAACAGCTCACAGTTTGATGCTGGA
TATATAAAAGAATAGGAATAGGAAATGGGTCACCAAGAAAACGAAAATGAAGAAAATCAT
CAAGATTAACAAGATCAACAGCAACAAGAATTGCAAATTGGAAATGATAATGGCTAAGAA
GAAAATTTCAAATAAATATCCAGAGCAAACATGAATAAGCAAGCAGTTTAATCAATCAAT
TAAGATCCAGAAAATCATAGTAGTAATGAACATATTTGA

>TTHERM_00621280(protein)
MFGVIFLIVVVLILFYLIGGGLLEHYKIHVIHETGLGIIMGMIVGFIFYQADYEFYSSSM
IFEGELFFYFILPPIIFAGGYNLKKRRFFQNFFYINIYGLLGTIVNFIVVWLLTYAVNEA
GLIRRYSDFSQSVTLSTRDILLFSATICATDSVAALAMIKSEKYPKLFSVIFGEGMVNDS
VSIILYKAVLDLVGDSSEPQPITFTFLNFLKMIGEFLKNSVCSLAIGLGWGLLATLVMKK
FRFLTHNPVVETVVVLLFGFGAFASSENLDMSGVISILVCGIIMSHYLFYNISSTGKVTT
GVTFSSISIIAESALYIYLGIVFWQTKGDPHNPSSYAWSWTFLLIELAIAFFARFVSVFV
VSWIFMLIKGKQKWRLNRYEMGIIWFAGIIRGAIAFALIQNVPQDDSNPQATQVIQSTTL
FIVIITTIVLGGLMPFYINVMLKQISKNPKYHENHPSIRDSLVGESKESREFKSKSQTKW
KLFDENFIKPLFIFDYENRKEQIKMEKQKLKMNSSQFDAGYIKEQEQEMGHQENENEENH
QDQQDQQQQELQIGNDNGQEENFKQISRANMNKQAVQSINQDPENHSSNEHI

>TTHERM_00621280(gene)
ATGTTTGGAGTAATCTTTTTAATTGTAGTTGTGCTAATCTTGTTCTATTTGATTGGAGGT
GGGCTCCTTGAGCACTATAAGGTAATTGATTTTAATTCTCCATATATTTACATCTAAGAC
GAATTGGATAAAACCAGATAAATTTGAATTAATTGTTTACTAATTTAATTTTATAATATA
TTATAGATACACGTTATTCATGAAACAGGATTAGGTATCATTATGGGTATGATTGTAGGA
TTTATTTTCTATCAAGCCGATTACGAATTCTACTCAAGTAGTGTAAACAATAATAAAATT
GATTAAAAATGATTAAATTAGCAATTTAAAAAGAGTAACAACACCAAATTAACTAAAATT
ATTTTTAATTTAAATTAGATGATATTTGAAGGTGAGCTCTTCTTTTACTTTATCCTTCCA
CCCATTATTTTTGCAGGCGGTTACAACTTGAAAAAGCGTCGTTTTTTCCAAAATTTCTTC
TACATTAATATATATGGATTACTTGGTACTATAGTCAATTTCATAGTAGTATGGCTCTTA
ACTTATGCTGTTAACGAAGCAGGTAAAAAATAATTATTATTTAGTAGCATTTTACAGTAG
AAAATCTTAAATAAATTGCACTTAGCAATAAAATTCAATTGAATTATAAATAGCTAGTGG
ATGTTTATTACATTTAAGCATACTTTAAGTACAGAGTAAACAACCTTCAGCAAAGAAAAT
ACAGGCTCAAAAATAAAAATAAAATTTCTATGAATTAAATTTATATTATATTATCAAAAA
CTCAAAAAATGAATTTACAAATTTAATTAACACTATTTTTGTAATAAAAAGGTTTGATTC
GTAGATATAGTGATTTTTCTCAGTCTGTAACATTATCAACAAGAGATATCCTTCTGTTTT
CTGCTACTATATGCGCTACAGATAGTGTAGCTGCCTTAGCTATGATTAAATCAGAGAAAT
ATCCAAAATTATTTAGTGTTATTTTTGGTGAAGGCATGGTAAATGATTCTGTATCAATTA
TTCTATATAAGGCTGTCTTGGATTTAGTTGGCGACTCATCTGAACCTCAGCCTATAACTT
TCACTTTCCTTAACTTCTTAAAGATGATTGGTGAATTCCTTAAAAACTCAGTATGCAGTT
TAGCTATTGGTCTTGGTTGGGGTAAATAAAATTAAATTTAAATGGTTTAATTTACTAACT
ATTTTTTATAATTAAAAATAAATAGGTCTCTTAGCTACTTTAGTCATGAAAAAATTTAGG
TTTTTGACACATAATCCAGTAGTTGAAACAGTTGTTGTTTTACTATTTGGTTTTGGTGCT
TTCGCTTCTTCAGAAAACCTAGATATGTCTGGTGTCATTTCAATTTTAGTATGTGGTATT
ATCATGTCTCATTACCTTTTCTATAACATATCATCAACTGGTAAAGTAACAACAGGGTAA
TTTTTAGAAATTTTATAAAATATTAAGCTTAATTTTTTTGTTACTCTCTAAATTATTTGG
TTATATTCTTTAAAATAAACATAAATTTCTTTATATAAATTAATAGTGTCACTTTTTCAA
GTATCTCTATTATTGCAGAATCAGCTCTTTATATCTATTTGGGTATCGTCTTCTGGTAAA
CAAAGGGAGATCCTCACAATCCAAGCTCTTATGCATGGTCATGGACTTTCTTACTCATTG
AATTGGCTATTGCCTTTTTCGCTCGTTTTGTGAGTGTTTTTGTAGTTTCTTGGATTTTCA
TGCTGTAAAAAATTTTAATATGAATAAAAAAAAATATTTAAAAATTATATATTTTAATAG
AATTAAGGGCAAATAAAAATGGAGATTAAATAGATATGAAATGGGTATTATTTGGTTTGC
AGGTATTATTAGAGGAGCTATTGCTTTTGCATTGATTTAGAATGTACCTTAAGATGATTC
AAATCCTTAGGCAACACAAGTTATTTAGAGTACAACTCTCTTTATTGTTATAATCACAAC
TATTGTCTTAGGAGGTCTAATGCCTTTTTATATAAATGTCATGCTGAAACAAATTTCAAA
GAATCCTAAGTATCATGAAAATCATCCTTCTATTCGTGATAGTTTGGTTGGAGAATCAAA
AGAAAGTAGAGAATTCAAAAGCAAGAGTCAGACAAAGTGGAAATTATTTGATGAAAACTT
TATCAAACCTTTGTTCATTTTCGACTATGAAAATAGAAAAGAGCAAATTAAGATGGAAAA
ACAAAAGCTTAAAATGAACAGCTCACAGTTTGATGCTGGATATATAAAAGAATAGGAATA
GGAAATGGGTCACCAAGAAAACGAAAATGAAGAAAATCATCAAGATTAACAAGATCAACA
GCAACAAGAATTGCAAATTGGAAATGATAATGGCTAAGAAGAAAATTTCAAATAAATATC
CAGAGCAAACATGAATAAGCAAGCAGTTTAATCAATCAATTAAGATCCAGAAAATCATAG
TAGTAATGAACATATTTGA