TGD | Gene Details

Identifiers and Description

Gene Model Identifier
TTHERM_00600310

Standard Name
FLP14 (FLiPpase)

Aliases
PreTt22094 | 83.m00163 | 3685.m00055

Description
phospholipid-translocating P-type ATPase, flippase family protein

Genome Browser

Gene Ontology Annotations

Molecular Function
catalytic activity (IEA) | GO:0003824
Biological Process
metabolic process (IEA) | GO:0008152

Domains

( TIGR00099 ) Cof-like hydrolase
( TIGR01487 ) SPP-like hydrolase, Archaeal
( TIGR00338 ) phosphoserine phosphatase SerB
( PF00702 ) haloacid dehalogenase-like hydrolase
( PF08282 ) haloacid dehalogenase-like hydrolase
( TIGR01517 ) calcium-translocating P-type ATPase, PMCA-type
( TIGR01116 ) calcium-translocating P-type ATPase, SERCA-type
( TIGR01652 ) phospholipid-translocating P-type ATPase, flippase
( TIGR01494 ) ATPase, P-type (transporting), HAD superfamily,

Gene Expression Profile

Tetrahymena Functional Genomics Database: TTHERM_00600310

Homologs (v.2006 protein sequences)

Source Identifier Score Description

ParameciumDB GSPATP00003854001 9.99593845621775e-149 Paramecium tetraurelia GSPATP0
0003854001 protein

IPI(HUMAN) IPI:IPI00221038.1 9.99530525570754e-113 2|TREMBL:Q32M36;Q4G1C1;Q4W5J7
;Q4W5P2|ENSEMBL:ENSP00000264 4
49|H-INV:HIT000057322 Tax_Id=9
606 Splice Isoform Short of Pr
obable phospholipid-transporti
ng ATPase IA

WormBase Y49E10.11a 1.00036029423542e-110 WBGene00013034 tat-1 P-type AT
Pase

FlyBase FBgn0033837 9.99775161630916e-110

SGD YAL026C 9.99605028384712e-108 DRS2 SGDID:S000000024, Chr I f
rom 99698-95631, reverse compl
ement, Verified ORF, "Integral
membrane Ca(2+)-ATPase involv
ed in aminophospholipid transl
ocation; required to form a sp
ecific class of secretory vesi
cles that accumulate upon acti
n cytoskeleton disruption; mut
ation affects maturation of th
e 18S rRNA"

DictyBase DDB0190219 9.99605028384712e-108 JC1V2_0_01058 Q9Y2Q0 Potential
phospholipid-transporting ATP
ase IA (EC 3.6.3.1) (Chromaffi
n granule ATPase II) (ATPase c
lass I type 8A member 1).

TAIR AT1G26130 2.00004349420983e-96 haloacid dehalogenase-like hyd
rolase family protein

CryptoDB EAK89054 3.00036186930044e-85 Cryptosporidium parvum (Iowa)
protein EAK89054

ToxoDB 50.m03192 2.00055538736037e-52 Toxoplasma gondii ATPase 2, pu
tative

PlasmoDB PFL0950c 3.00141685961481e-48 Plasmodium falciparum PFL0950c

Source	Identifier	Score	Description
ParameciumDB	GSPATP00003854001	9.99593845621775e-149	Paramecium tetraurelia GSPATP0 0003854001 protein
IPI(HUMAN)	IPI:IPI00221038.1	9.99530525570754e-113	2\|TREMBL:Q32M36;Q4G1C1;Q4W5J7 ;Q4W5P2\|ENSEMBL:ENSP00000264 4 49\|H-INV:HIT000057322 Tax_Id=9 606 Splice Isoform Short of Pr obable phospholipid-transporti ng ATPase IA
WormBase	Y49E10.11a	1.00036029423542e-110	WBGene00013034 tat-1 P-type AT Pase
FlyBase	FBgn0033837	9.99775161630916e-110
SGD	YAL026C	9.99605028384712e-108	DRS2 SGDID:S000000024, Chr I f rom 99698-95631, reverse compl ement, Verified ORF, "Integral membrane Ca(2+)-ATPase involv ed in aminophospholipid transl ocation; required to form a sp ecific class of secretory vesi cles that accumulate upon acti n cytoskeleton disruption; mut ation affects maturation of th e 18S rRNA"
DictyBase	DDB0190219	9.99605028384712e-108	JC1V2_0_01058 Q9Y2Q0 Potential phospholipid-transporting ATP ase IA (EC 3.6.3.1) (Chromaffi n granule ATPase II) (ATPase c lass I type 8A member 1).
TAIR	AT1G26130	2.00004349420983e-96	haloacid dehalogenase-like hyd rolase family protein
CryptoDB	EAK89054	3.00036186930044e-85	Cryptosporidium parvum (Iowa) protein EAK89054
ToxoDB	50.m03192	2.00055538736037e-52	Toxoplasma gondii ATPase 2, pu tative
PlasmoDB	PFL0950c	3.00141685961481e-48	Plasmodium falciparum PFL0950c

General Information

Paragraph No Gene Name Paragraph Text
19 FLP11,
FLP18,
FLP17,
FLP8,
FLP16,
FLP15,
FLP14,
FLP6,
FLP13,
FLP10,
FLP2,
FLP1,
FLP3,
FLP9,
FLP12,
FLP4,
FLP7,
FLP5,
FLP19 The phospholipid flippase family of genes in Tetrahymena contains 20 members, FLP1-FLP20. Preliminary studies show that many of these genes are differentially regulated in response to temperature and/or the presence of a polycyclic aromatic hydrocarbon (pyrene).

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00600310(coding)
ATGACTGATCAGCAAATTTTGAAAAAAATAAAAAAAATCAGAAACAAAAGGAAAGTGATT
TAAACAAATATGCAATAAGACATGCAAAACACGGACAATATTGTTGATGAAATTTAAAAA
TCCTACCAAAATTAAATAGAAGAATCTTATTTTTTTTGCTTAAGGAGATAGAAAGTTAGA
GATCAAGATAAAAGAGCTATCTACTTAGGAGTTCCAGATAATTAAGTTTGTGATAATAGA
ATTTAAACATCAAAATACAATTATATTACATTTATACCTAAAAATTTACTTGTATAGTTT
AGCAAACTTGCAAATATCTACTTTTTAATTATTGGAATATTTTAAATACTTCCTTCAATT
ACAACGACTGAGGGAAAGCCTATTGTTTATACACCTTTAACAATTATAGTTGTTATTAGT
ATGATAAAGGATTTTATTGAGGATAGAAAAAGGAGAAAATAAGATTAGTTTGAAAATCAG
TCTGATACTAAGAAGCTCAATGTAAAAACAGGCTAATTTGAGAAAGTAAAATGGTAAGAT
CTAAGGATAGGCGATATAATATAAGGAATTTGTTACATAGAAACAAAAAACTTAGACGGT
GAAGTCAATTTAAAGCAAAGATAGAGTTGTGCTCCTAATTTATTTCAAGATGAATAGTTT
ACATAAAATATAAATAATATTGGAAGATTTTAATTCATATATGAAGACCCTAATATTCGT
ATTCACAGTTTTAATGGAATAATGATTGACAAGCAGGATACAGACAGTTAATAAAATCAG
TATCTTCTATCTTTATAAAACATTTGCTTAAGAGGTTGTACTCTCAAGCGTACTAAATCT
CTAATTGGGATTGTTATTTATTCTGGACATGATTGCAAATCTCTAAAATATGCAAATAGA
GGACAGTACAAGTTTGGCACAGTTGAAAAATTAATGAATAAGATGGTGCTTTATGTATTT
ATTATATTGGTTTTAATAAGTATTTTCTGTGCATCATACTACACTATTTGGTACAAATAG
AAAAAAGATGAGCTTCCATATTTAGTTATCGGAAAAAGTGATATAGAATCTCACCTAGTC
GTTAGCTTTTTTATTAGAATTCCAATGTGGATTTTATTACTTAATCCCTTTGTTCCTATA
TCTTTAATGGTAACACTTGAAATTGTAAAATACCTTTAAGGCTAGTTGCTGAGTAAAGAC
AAAAATTTTGTGAACAGCATTAGTGATGAATTAGTAGAAGTAAATGGTAGTAATTTAATA
GATTAGCTTGGACAAGTAAAGTACATTCTAACTGACAAAACAGGGACTCTAACAGCTAAT
ATTATGAAATTTAAGGCTCTATCATTAAACAGTGTTTGTTATGAATATAATTATTAACAA
GATGATCATGGAATTTTAATGAGCTAGAAACTTATTGATCTTTTAAAAAATGCTTAAGAG
AATTAAATAGAGTACGAAGCACTTATGTGTATGAATTTATGCCATGAGCTGTTAATAGAA
TAATAAGAGGGAAAAAGATTGTATCTTGGAACAAGTCCTGATGAAGAATGCATCATGGAC
TTTTGTGTTTAAACAGGTATTTATTTAGAGAGCGTAGACGAGCATAAAGTGATGACTATT
TATGATTCTATCAACGATAAGAGGCTTTAATTTAAGATAATAGCCTTGCATGAATATCGT
TCGGATATTAGAAAAATGTCGATTTTGGTTTAAAATTTATAGACAAAATAATATAAAATT
TACTAGAAAGGAGCTATGAACACAATATTTCAATGCTGTAGATAAGATTAAAAAAATAAA
ATGATAGCTGTTGAAGAGCATTTAAATAATTTCGCTAGCAACATGCTTAGGACTCTTTGT
CTCTCATATAGAAACTTGAGTGAAAATGAAATCACAAAATTCTTTGATAAGAGGAGCAAA
GATCTAGAAGGTGGAAATTTAAATATTCAAGAAATGAATGATGGTCTGTTTGCAGAAATC
GAAAATGAACAAATTTTGATAGGCGGTACCGGAGTTAATGATGAATTTGCAGACTAAGTT
GTTCAAACTCTTTCTAATTTAAAGTAAGCTGGAATTAAAATTTGGATGATTACTGGAGAT
AAAAGAGAAACAGCTTTGAGTATTGGTATCAAATCAAATATAGTAGAGTAAGGTGTTGAA
TTAAAAGTTATTTAAGATGCTACTGAAAGCATCATTAATGAATAATTAGTAATTAATGAG
CTTAAGATGTTCGAAGATTAATTAAAGTAATAATAAAAGTTAAGCATAGGTATCTCTGGA
TTAACTTTTTATGGAATTAATATATCAACAAATACTGAAATAAAACAAACATTTAGCTAC
ATAATGAAGCATGCTGATTCAGTCATAGCATATCATTTCACTCCCAATTAAAAAAAATAA
CTTGTAGATTTAGTTCATAACATAAGTCCAGGTCAATGTGTATTAGCAATAGGAGATGGA
GCTAATGATATTAATATGTTATAGGTTGCTGATGTCGGCATAGGAATACGTGGAAAAGAA
GTAATTTTAATAGTAAAAAGCAACTATTTAATTAGATAAGAGGCTTATAGAAAAAACAGT
CATCTAATTTTATTCAATTTTTATAAAAATCAAGCTTGGATACTTGTTTATTTTTGGATC
AATTTTTATTCTGGTTAAAGTGGTTAGTATGTTTACGATTAATGGATTTCTCAATTTTTC
AATTTATTCTACTCATCTCTTCCTATCATAATTTATGCTTTGTTTGATGAAATCCACCCT
TCAAATTAATTCTTTAAAGCTATACAAACTGATAAAAATATTTTAGAATCAAGACCTCAA
GATTACAAAAAATTTACCAACAATCTCATATTTTAACAAAAAAATTTTTGGAAATGGTTT
TTCTATGGTTCTTTCCATGCACTGATAATAACTTTTATCTCGTAAAACAATCAATTCTAT
TGA

>TTHERM_00600310(protein)
MTDQQILKKIKKIRNKRKVIQTNMQQDMQNTDNIVDEIQKSYQNQIEESYFFCLRRQKVR
DQDKRAIYLGVPDNQVCDNRIQTSKYNYITFIPKNLLVQFSKLANIYFLIIGIFQILPSI
TTTEGKPIVYTPLTIIVVISMIKDFIEDRKRRKQDQFENQSDTKKLNVKTGQFEKVKWQD
LRIGDIIQGICYIETKNLDGEVNLKQRQSCAPNLFQDEQFTQNINNIGRFQFIYEDPNIR
IHSFNGIMIDKQDTDSQQNQYLLSLQNICLRGCTLKRTKSLIGIVIYSGHDCKSLKYANR
GQYKFGTVEKLMNKMVLYVFIILVLISIFCASYYTIWYKQKKDELPYLVIGKSDIESHLV
VSFFIRIPMWILLLNPFVPISLMVTLEIVKYLQGQLLSKDKNFVNSISDELVEVNGSNLI
DQLGQVKYILTDKTGTLTANIMKFKALSLNSVCYEYNYQQDDHGILMSQKLIDLLKNAQE
NQIEYEALMCMNLCHELLIEQQEGKRLYLGTSPDEECIMDFCVQTGIYLESVDEHKVMTI
YDSINDKRLQFKIIALHEYRSDIRKMSILVQNLQTKQYKIYQKGAMNTIFQCCRQDQKNK
MIAVEEHLNNFASNMLRTLCLSYRNLSENEITKFFDKRSKDLEGGNLNIQEMNDGLFAEI
ENEQILIGGTGVNDEFADQVVQTLSNLKQAGIKIWMITGDKRETALSIGIKSNIVEQGVE
LKVIQDATESIINEQLVINELKMFEDQLKQQQKLSIGISGLTFYGINISTNTEIKQTFSY
IMKHADSVIAYHFTPNQKKQLVDLVHNISPGQCVLAIGDGANDINMLQVADVGIGIRGKE
VILIVKSNYLIRQEAYRKNSHLILFNFYKNQAWILVYFWINFYSGQSGQYVYDQWISQFF
NLFYSSLPIIIYALFDEIHPSNQFFKAIQTDKNILESRPQDYKKFTNNLIFQQKNFWKWF
FYGSFHALIITFISQNNQFY

>TTHERM_00600310(gene)
ATGACTGATCAGCAAATTTTGAAAAAAATAAAAAAAATCAGAAACAAAGTAAGAAAATAA
TTAAATAAATAAATTTGGGATGAATTGAATTTAAATATTTTCTTATTTTTATTAAAAATA
GCAAATATTTAAAAAAGGATTACATTTTTCTTAATAGATATGTGTAAAAAATATATTTAT
GTAAAAAGGATATTTATTATTATTTAAATATTTTGATTGCTTTGTTATATGTCAGTATAA
ACAATTAATAAGAGAAACATTTCTAATAGGTAAGAAAAAATAATTTATAAATAGTTATTT
AAGATTAAATCTTACTTGTAAAGAAATATCTTTAATTTTAGCTTAATACTTATAAAAATT
CTATAAGATAAAGCAGCAATCAATCAATTATCAAAAATTGGATTTACAGTAAAACTTATT
CTTGTATTAATTTGGATAATAATTTTTGCAAAAGTTAATTAATTAAAATTAGTATTTTGA
ATAAATAATTTGCTAATCTAGAGGAAAGTGATTTAAACAAATATGCAATAAGACATGCAA
AACACGGACAATATTGTTGATGAAATTTAAAAATCCTACCAAAATTAAATAGAAGAATCT
TATTTTTTTTGCTTAAGGAGATAGAAAGTTAGAGATCAAGATAAAAGAGCTATCTACTTA
GGAGTTCCAGATAATTAAGTTTGTGATAATAGAATTTAAACATCAAAATACAATTATATT
ACATTTATACCTAAAAATTTACTTGTATAGTTTAGCAAACTTGCAAATATCTACTTTTTA
ATTATTGGAATATTTTAAATACTTCCTTCAATTACAACGACTGAGGGAAAGCCTATTGTT
TATACACCTTTAACAATTATAGTTGTTATTAGTATGATAAAGGATTTTATTGAGGATAGA
AAAAGGAGAAAATAAGATTAGTTTGAAAATCAGTCTGATACTAAGAAGCTCAATGTAAAA
ACAGGCTAATTTGAGAAAGTAAAATGGTAAGATCTAAGGATAGGCGATATAATATAAGTA
AATTTAAATGAGAGATTTCCAGCAGATATTTTGGTGTTATCTAGTACTAATCAATATGTA
ATTTCTTTATAGACTTATTAATTAAAAAGTTAATCAAATTATTAGTGATTATCATGTGTA
AAAGCATTGATTTTTTTATTTAATTATTTTGTAAACTGGATAAAAATCTTATAAAATCTT
ATAATCCATTTATTTTCTTTTATTATTTATAAAGGGAATTTGTTACATAGAAACAAAAAA
CTTAGACGGTGAAGTCAATTTAAAGCAAAGATAGAGTTGTGCTCCTAATTTATTTCAAGA
TGAATAGTTTACATAAAATATAAATAATATTGGAAGATTTTAATTCATATATGAAGACCC
TAATATTCGTATTCACAGTTTTAATGGAATAATGATTGACAAGCAGGATACAGACAGTTA
ATAAAATCAGTATCTTCTATCTTTATAAAACATTTGCTTAAGAGGTTGTACTCTCAAGCG
TACTAAATCTCTAATTGGGATTGTTATTTATTCTGGACATGATTGCAAATCTCTAAAATA
TGCAAATAGAGGACAGTAAAATTAAAATTTATTTATTTATTTATTAAAATAAAAATAAAA
AATATTTATTTTCATAGGTACAAGTTTGGCACAGTTGAAAAATTAATGAATAAGATGGTG
CTTTATGTATTTATTATATTGGTTTTAATAAGTATTTTCTGTGCATCATACTACACTATT
TGGTACAAATAGAAAAAAGATGAGCTTCCATATTTAGTTATCGGAAAAAGTGATATAGAA
TCTCACCTAGTCGTTAGCTTTTTTATTAGAATTCCAATGTGGATTTTATTACTTAATCCC
TTTGTTCCTATATCTTTAATGGTAACACTTGAAATTGTAAAATACCTTTAAGGCTAGTTG
CTGAGTAAAGACAAAAATTTTGTGAACAGCATTAGTGATGAATTAGTAGAAGTAAATGGT
AGTAATTTAATAGATTAGCTTGGACAAGTAAAGTACATTCTAACTGACAAAACAGGGACT
CTAACAGCTAATATTATGAAATTTAAGGCTCTATCATTAAACAGTGTTTGTTATGAATAT
AATTATTAACAAGATGATCATGGAATTTTAATGAGCTAGAAACTTATTGATCTTTTAAAA
AATGCTTAAGAGAATTAAGTATTTTATTAATTATGATTTATCACTGAAATGCATATTTTA
TTTATTTATTATTAAATTTTAGATAGAGTACGAAGCACTTATGTGTATGAATTTATGCCA
TGAGCTGTTAATAGAATAATAAGAGGGAAAAAGATTGTATCTTGGAACAAGTCCTGATGA
AGAATGCATCATGGACTTTTGTGTTTAAACAGGTATTTATTTAGAGAGCGTAGACGAGCA
TAAAGTGATGACTATTTATGATTCTATCAACGATAAGAGGCTTTAATTTAAGATAATAGC
CTTGCATGAATATCGTTCGGATATTAGAAAAATGTCGATTTTGGTTTAAAATTTATAGAC
AAAATAATATAAAATTTACTAGAAAGGAGCTATGAACACAATATTTCAATGCTGTAGATA
AGATTAAAAAAATAAAATGATAGCTGTTGAAGAGCATTTAAATAATTTCGCTAGCAACAT
GCTTAGGACTCTTTGTCTCTCATATAGAAACTTGAGTGAAAATGAAATCACAAAATTCTT
TGATAAGTATTTATCTATTAATAGCTATAAAGCAAATCATTTATTTTTAAAAATATTTAA
GGAGGAGCAAAGATCTAGAAGGTGGAAATTTAAATATTCAAGAAATGAATGATGGTCTGT
TTGCAGAAATCGAAAATGAACAAATTTTGATAGGCGGTACCGGAGTTAATGATGAATTTG
CAGACTAAGTTGTTCAAACTCTTTCTAATTTAAAGTAAGCTGGAATTAAAATTTGGATGA
TTACTGGAGATAAAAGAGAAACAGCTTTGAGTATTGGTATCAAATCAAATATAGTAGAGT
AAGGTGTTGAATTAAAAGTTATTTAAGATGCTACTGAAAGCATCATTAATGAATAATTAG
TAATTAATGAGCTTAAGATGTTCGAAGATTAATTAAAGTAATAATAAAAGTTAAGCATAG
GTATCTCTGGATTAACTTTTTATGGAATTAATATATCAACAAATACTGAAATAAAACAAA
CATTTAGCTACATAATGAAGCATGCTGATTCAGTCATAGCATATCATTTCACTCCCAATT
AAAAAAAATAACTTGTAGATTTAGTTCATAACATAAGTCCAGGTCAATGTGTATTAGCAA
TAGGAGATGGAGCTAATGATATTAATATGTTATAGGTTGCTGATGTCGGCATAGGAATAC
GTGGAAAAGAAGTAATTTTAATAGTAAAAAGCAACTATTTAATTAGTATTTTATAAAAAT
AAATTAGGGTAGAGAGGCAGCAAAAGCTTCAGATTTTTCAATTGCAGAATTTAAACATTT
AAACAGGCTAATACTTTATGTAGGATAAGAGGCTTATAGAAAAAACAGTCATCTAATTTT
ATTCAATTTTTATAAAAATCAAGCTTGGATACTTGTTTATTTTTGGATCAATTTTTATTC
TGGTTAAAGTGGTTAGTATGTTTACGATTAATGGATTTCTCAATTTTTCAATTTATTCTA
CTCATCTCTTCCTATCATAATTTATGCTTTGTTTGATGAAATCCACCCTTCAAATTAATT
CTTTAAAGCTATACAAACTGATAAAAATATTTTAGAATCAAGACCTCAAGATTACAAAAA
ATTTACCAACAATCTCATATTTTAACAAAAAAATTTTTGGAAATGGTTTTTCTATGGTTC
TTTCCATGCACTGATAATAACTTTTATCTCGTAAAACAATCAATTCTATTGA

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Identifiers and Description

Gene Model Identifier

Standard Name

Aliases

Description

Genome Browser

Gene Ontology Annotations

Molecular Function

Biological Process

Domains

Gene Expression Profile

Homologs (v.2006 protein sequences)

General Information

Associated Literature

Sequences

Wiki Links

External Links

Paragraph No	Gene Name	Paragraph Text
19	FLP11, FLP18, FLP17, FLP8, FLP16, FLP15, FLP14, FLP6, FLP13, FLP10, FLP2, FLP1, FLP3, FLP9, FLP12, FLP4, FLP7, FLP5, FLP19	The phospholipid flippase family of genes in Tetrahymena contains 20 members, FLP1-FLP20. Preliminary studies show that many of these genes are differentially regulated in response to temperature and/or the presence of a polycyclic aromatic hydrocarbon (pyrene).