Identifiers and Description

Gene Model Identifier

TTHERM_00564190

Standard Name

None

Aliases

PreTt08957 | 75.m00155 | 3721.m00037 | TPPT1

Description

tyrosine phosphatase; Protein-tyrosine phosphatase containing protein

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• protein tyrosine phosphatase activity (IEA) | GO:0004725

Biological Process

• protein dephosphorylation (IEA) | GO:0006470

Domains

• ( PF00102 ) Protein-tyrosine phosphatase

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.5%

TetraMine Data

TTHERM_00564190

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_14569.1	1.999126889527329e-167	protein-tyrosine phosphatase c ontaining protein (327 aa)
Oxytricha	Contig11522.0.g89	1.0002546821282671e-50	Protein-tyrosine phosphatase
DictyBase	DDB_G0273097	1.000159011384939e-43	ptpA1-1 on chromosome: 2 posit ion 2586710 to 2588480
WormBase	WBGene00004213	5.998886722426197e-42	locus:ptp-1 Tyrosine-protein phosphatase 1 status:Partia lly_confirmed UniProt:P28191 protein_id:CAB54194.1
Stentor Coeruleus	SteCoe_20825	1.7587922024243116e-25
SGD	YDL230W	1.9999391735788327e-19	PTP1 Phosphotyrosine-specific protein phosphatase that depho sphorylates a broad range of s ubstrates in vivo, including F pr3p; localized to the cytopla sm and the mitochondria; propo sed to be a negative regulator of filamentation

General Information

Paragraph No	Gene Name	Paragraph Text
119	TTHERM_00564190	Tetrahymena thermophilia’s TPPT1 protein is homologous with proteins in the Y phosphatase family associated with the removal of phosphate groups from tyrosine residues. It contains 1 domain (E-value= 2.9E-67), which is a Y phosphatase domain. The closest homologs are found in Paramecium tetraurelia, Ichthyopthirius multifiliis, a freshwater fish disease, and Stentor coeruleus, a large ciliate. It is possible that this protein is involved in cell signaling pathways. Paragraph by: Margot Chisholm, Keck Science Center, Pitzer College.

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00564190(coding)
ATGGACACAAAAAATAATTTGTAATAGGAAGAAGCCTTTTATGAAAAATTTGCAGTACCT
CCAGCTCCAATTAAAAAAGAAGAAATTGATTATTCATATACAGAAGAGTTAAAAGCAGAG
ACAAGAAAAATTAAGGATTTGCTGAATTTCAAAATGACTAATTAGTTTTAAGTATTGTAA
ATGATCACTCATACAAATAATCATCATAATAATAGAATCAAAGCAAATGAATTTTTAGAT
TATAATAGATATACTGATATTCTACCATATAAGCATTCAGTTGTTAAAATTAGCGGAAGT
ACCTAAGTTGATTAATACATAAATGCTAATTACATAAATAATCCCTTTAAAGATAAAGCT
TATATTGCTACTCAAGGACCTATTCCAAATACAATCTCTTCTTTTTGGAGAATGATATGG
GAATAAAAAACAAATTTGATTATTATGCTTTGCAAGGAATTCGTTAAATGTGATAAATAT
TGGCCAAGCCAAGGATAGATCTTATAGGAGGGAGATTTGCAAGTCCAATTTTTATCGTAG
TAAAAAAATGCATAATAGAATATTATTGAAAGACAATTCATACTCAAGTATAAAAATGAA
TAACGTTAAGTCTCTTAAGTGCATTGGGAAGGATGGCCAGATCATGGTGTTCCTGAAAGT
AGAGATTATGGAGTTTTAGAAAATTTAGTATAAAGGGTAGTAAATCAAATTGAATAGTCC
AAGATTCCTGTCGTGCATTGCAGTGCTGGAGTTGGTAGAACTGGTACATTGTTAGCCCTC
TCTAATATTTACATGACTTTGAAATATCATTAAGTTAAAAAAACTCCTATAGACTAAATA
GAATTAAACGTCTTAGATATAGTTAGAAGACTTAGAGAGTAAAGAATGATCATGGTATAA
ATGGATAACTAATTAAACTTAGTATATGAAATTACAAAAACTTTTATCAGAAAAATGTTC
AAATTTTGA

>TTHERM_00564190(protein)
MDTKNNLQQEEAFYEKFAVPPAPIKKEEIDYSYTEELKAETRKIKDLLNFKMTNQFQVLQ
MITHTNNHHNNRIKANEFLDYNRYTDILPYKHSVVKISGSTQVDQYINANYINNPFKDKA
YIATQGPIPNTISSFWRMIWEQKTNLIIMLCKEFVKCDKYWPSQGQILQEGDLQVQFLSQ
QKNAQQNIIERQFILKYKNEQRQVSQVHWEGWPDHGVPESRDYGVLENLVQRVVNQIEQS
KIPVVHCSAGVGRTGTLLALSNIYMTLKYHQVKKTPIDQIELNVLDIVRRLREQRMIMVQ
MDNQLNLVYEITKTFIRKMFKF

>TTHERM_00564190(gene)
ATGGACACAAAAAATAATTTGTAATAGGAAGAAGCCTTTTATGAAAAATTTGCAGTACCT
CCAGCTCCAATTAAAAAAGAAGAAATTGATTATTCATATACAGAAGAGTTAAAAGCAGAG
ACAAGAAAAATTAAGGATTTGCTGAATTTCAAAATGACTAATTAGTTTTAAGTAAATATT
TTAAGAATAGTTTAAATAAAATAAATTGTTAAAATAAAAATTTATTTCATCAAGGTATTG
TAAATGATCACTCATACAAATAATCATCATAATAATAGAATCAAAGCAAATGAATTTTTA
GATTATAATAGATATACTGATATTCTACCATGTAATTCTAAAAAAAATATAAAATGAAAA
TTAATCTAAAATTTGTTAAAATAGATAAGCATTCAGTTGTTAAAATTAGCGGAAGTACCT
AAGTTGATTAATACATAAATGCTAATTACATAAATGTATAATAATCAATTTTTTATTTTG
CGAATTATTGAAGTGTTTTGATTGTTTTTTATTTTTTGTTTAGAATCCCTTTAAAGATAA
AGCTTATATTGCTACTCAAGGACCTATTCCAAATACAATCTCTTCTTTTTGGAGAATGAT
ATGGGAATAAAAAACAAATTTGATTATTATGCTTTGCAAGGAATTCGTAAATAGTTTAAA
TTGATAATTAACTTTTTTTAAACTAATCATGTTTTATGAAAACTTAAAATAGGAATAAAA
TAAAGTAAGTTATATATTAGTAGATCTTTAACAGCTATATGTTTTCCATGTTTGACATAA
TACAATTCAGGTTAAATGTGATAAATATTGGCCAAGCCAAGGATAGATCTTATAGGAGGG
AGATTTGCAAGTCCAATTTTTATCGTAGTAAAAAAATGCATAATAGAATATTATTGAAAG
ACAATTCATACTCAAGTATAAAAATGAATAACGTTAAGTCTCTTAAGTGCATGTATAATT
ATCATATTCAGGTTACTAATAAGTTTCATAAAATACATTTTATTTAAAAAAGTGGGAAGG
ATGGCCAGATCATGGTGTTCCTGAAAGTAGAGATTATGGAGTTTTAGAAAATTTAGTATA
AAGGGTAGTAAATCAAATTGAATAGTCCAAGATTCCTGTCGTGCATTGCAGGTAATATTA
GAAAAAAATATAAATAAAATTAGATATGTATACATGTATAAAAAGTGCTGGAGTTGGTAG
AACTGGTACATTGTTAGCCCTCTCTAATATTTACATGACTTTGAAATATCATTAAGTTAA
AAGTAAGATAGATTATTTTTTGTAATTTCTATTCATAATAAGTTTACTTTTTATTTAACG
CACAGAAACTCCTATAGACTAAATAGAATTAAACGTCTTAGATATAGTTAGAAGACTTAG
AGAGTAAAGAATGATCATGGTATAAATGGATAACTAATTAAACTTAGTATATGAAATTAC
AAAAACTTTTATCAGAAAAATGTTCAAATTTTGA