Tian M, Mochizuki K, Loidl J (2022) Arrested crossover precursor structures form stable homologous bonds in a Tetrahymena meiotic mutant. PloS one 17(2):e0263691 PUBMED:35171923
Nabeel-Shah S, Garg J, Saettone A, Ashraf K, Lee H, Wahab S, Ahmed N, Fine J, Derynck J, Pu S, Ponce M, Marcon E, Zhang Z, Greenblatt JF, Pearlman RE, Lambert JP, Fillingham J (2021) Functional characterization of RebL1 highlights the evolutionary conservation of oncogenic activities of the RBBP4/7 orthologue in Tetrahymena thermophila. Nucleic acids research ( ): PUBMED:34086947
Nabeel-Shah S, Garg J, Kougnassoukou Tchara PE, Pearlman RE, Lambert JP, Fillingham J (2021) Functional proteomics protocol for the identification of interaction partners in Tetrahymena thermophila. STAR protocols 2(1):100362 PUBMED:33786459
Identifiers and Description
Gene Model Identifier
TTHERM_00429890
Standard Name
CNPL1 (Conserved nucleoplasmin like 1)
Aliases
PreTt26429 | 48.m00192 | 3831.m01535 | GTE3
Description
nucleoplasmin protein; Interacts with histone H2A and localizes to MAC. Homolog of human nucleoplasmin 1 (NPM1) (Ashraf et al. 2019).
NPM-family proteins are H2A/H2B chaperones with important roles in various cellular processes. Vertebrates have three NPM proteins (NPM 1-3) whereas invertebrates contain only a single Npm-like protein.
Human NPM1 functions in many processes, including histone chaperoning, chromatin remodeling, transcription regulation, genome stability, apoptosis, and embryogenesis. Tetrahymena CNPL1 shares conserved domain architecture with NPM-family members and is an ortholog of NPM1 protein. CNPL1 co-purified with histone H2A as a high-confidence interacting partner. CNPL1 localizes to MAC during vegetative growth (Ashraf et al. 2019).
Associated Literature
Ref:30796450: Ashraf K, Nabeel-Shah S, Garg J, Saettone A, Derynck J, Gingras AC, Lambert JP, Pearlman RE, Fillingham J (2019) Proteomic analysis of histones H2A/H2B and variant Hv1 in Tetrahymena thermophila reveals an ancient network of chaperones. Molecular biology and evolution ( ):