Identifiers and Description

Gene Model Identifier

TTHERM_00429890

Standard Name

CNPL1 (Conserved nucleoplasmin like 1)

Aliases

PreTt26429 | 48.m00192 | 3831.m01535 | GTE3

Description

Interacts with histone H2A and localizes to MAC. Homolog of human nucleoplasmin 1 (NPM1).

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• macronucleus (IDA) | GO:0031039 | Ref:SUPR000075

Domains

No Data fetched for Domains

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 13%

TetraMine Data

TTHERM_00429890

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_04130.1	3.999244945363787e-60	hypothetical protein (351 aa)

General Information

Paragraph No	Gene Name	Paragraph Text
131	CNPL1	NPM-family proteins are H2A/H2B chaperones with important roles in various cellular processes. Vertebrates have three NPM proteins (NPM 1-3) whereas invertebrates contain only a single Npm-like protein. Human NPM1 functions in many processes, including histone chaperoning, chromatin remodeling, transcription regulation, genome stability, apoptosis, and embryogenesis. Tetrahymena CNPL1 shares conserved domain architecture with NPM-family members and is an ortholog of NPM1 protein. CNPL1 co-purified with histone H2A as a high-confidence interacting partner. CNPL1 localizes to MAC during vegetative growth.

Associated Literature

1. Ref:30796450: Ashraf K, Nabeel-Shah S, Garg J, Saettone A, Derynck J, Gingras AC, Lambert JP, Pearlman RE, Fillingham J (2019) Proteomic analysis of histones H2A/H2B and variant Hv1 in Tetrahymena thermophila reveals an ancient network of chaperones. Molecular biology and evolution ( ):
2. Ref:SUPR000076
3. Ref:SUPR000075

Sequences

>TTHERM_00429890(coding)
ATGTTCTGGGGTTGCACTGTTAAGAAAGGTAACGATCACAAGTTCGAATCTGAAGACCAC
GCTATTTTGCATCTTTCCAATGTTGCTTTGGGTTTAAATACTAAGGCCGGAGCTCAAGCT
TCCGTCTTTGCCAAAGTTGATGGAAAGGAATTCGTCATTACTCACTTGACCTAGGGTAAA
GTTGAACACACTACTCTCGATCTCTATTTTAGAAACGACCAAGAAGTCACTTTCGGTGTT
AAAGGAGAAGCTGAAGTTCACTTGAGTGGTTATTTCGAACCTGATCATGATGAAGAAGAT
CTTTATGATGATTATCCTTATGGCGAAGAAGAATTCGACGACGAAGAAGATGAAGAACTC
GAAGGAGAAGATGATGAAGATGACGATGAAGAGGAAGAAGAAGAAAAGCCTAAGCAACAA
CTCCAAAAGGAAGCTGCTAAGAAGCCAGCTGCCTAACAATAAGCTGCTGCTGCCACTAAA
AAGCCAGCTGAAGTTCAAAAGAAGGCTGAACCTGCTGCCAAGGCTGCTGAAGCAAAGAAG
CAACCTTCCCTTCAAGAAACTTTAGCCTTAAAGGCTGCTGCTGCTGCCAAGGCTAAGGAA
GCTTTGTAAAGTGATGAAGATGATGAAGACGATGATGATATGGATATTGATATGGAAGAT
GATGATGAAGAAGACGATGACGAAGAAGATTTCGATGATGAAGAAGAAGGTAATGATATC
GATGACGATGTTTCTGACTCTGACAATGAAAATGGAACTTTATCTTAAATGTTAAAGAGA
ACTGGTGCTGAATAACACTAAGACTTGAATAAGAAGGCCAAGGCCAACAACAACTAAGCT
GTTAACAAGCCTTAAAACTAAAACTAAAAGCCTTAATAATAAAACTAAAACCAAAAGCAA
AACAACCAACAATAAGGAAAGCCCCAACAATAACAATAAAACCAAAACAAGCAACAACAC
AATAACTAAAACAAGCAAAATCACTAATAACATCAAAACAAGCAAAACTAACATCAAAAC
AAGCAACACAACAACAACTAATAACATCACAACAAGAATTAACACCATCAAAATAAAAAT
CAACACAACAAAAATGCTCACAAAAAGAACTGA

>TTHERM_00429890(protein)
MFWGCTVKKGNDHKFESEDHAILHLSNVALGLNTKAGAQASVFAKVDGKEFVITHLTQGK
VEHTTLDLYFRNDQEVTFGVKGEAEVHLSGYFEPDHDEEDLYDDYPYGEEEFDDEEDEEL
EGEDDEDDDEEEEEEKPKQQLQKEAAKKPAAQQQAAAATKKPAEVQKKAEPAAKAAEAKK
QPSLQETLALKAAAAAKAKEALQSDEDDEDDDDMDIDMEDDDEEDDDEEDFDDEEEGNDI
DDDVSDSDNENGTLSQMLKRTGAEQHQDLNKKAKANNNQAVNKPQNQNQKPQQQNQNQKQ
NNQQQGKPQQQQQNQNKQQHNNQNKQNHQQHQNKQNQHQNKQHNNNQQHHNKNQHHQNKN
QHNKNAHKKN

>TTHERM_00429890(gene)
ATGTTCTGGGGTTGCACTGTTAAGAAAGGTAACGATCACAAGTTCGAATCTGAAGACCAC
GCTATTTTGCATCTTTCCAATGTTGCTTTGGGTTTAAATACTAAGGCCGGAGCTCAAGCT
TCCGTCTTTGCCAAAGTTGATGGAAAGGAATTCGTCATTACTCACTTGACCTAGGGTAAA
GTTGAACACACTACTCTCGATCTCTATTTTAGAAACGACCAAGAAGTCACTTTCGGTGTT
AAAGGAGAAGCTGAAGTTCACTTGAGTGGTTATTTCGAACCTGATCATGATGAAGAAGAT
CTTTATGATGATTATCCTTATGGCGAAGAAGAATTCGACGACGAAGAAGATGAAGAACTC
GAAGGAGAAGATGATGAAGATGACGATGAAGAGGAAGAAGAAGAAAAGCCTAAGCAACAA
CTCCAAAAGGAAGCTGCTAAGAAGCCAGCTGCCTAACAATAAGCTGCTGCTGCCACTAAA
AAGCCAGCTGAAGTTCAAAAGAAGGCTGAACCTGCTGCCAAGGCTGCTGAAGCAAAGAAG
CAACCTTCCCTTCAAGAAACTTTAGCCTTAAAGGCTGCTGCTGCTGCCAAGGCTAAGGAA
GCTTTGTAAAGTGATGAAGATGATGAAGACGATGATGATATGGATATTGATATGGAAGAT
GATGATGAAGAAGACGATGACGAAGAAGATTTCGATGATGAAGAAGAAGGTAATGATATC
GATGACGATGTTTCTGACTCTGACAATGAAAATGGAACTTTATCTTAAATGTTAAAGAGA
ACTGGTGCTGAATAACACTAAGACTTGAATAAGAAGGCCAAGGCCAACAACAACTAAGCT
GTTAACAAGCCTTAAAACTAAAACTAAAAGCCTTAATAATAAAACTAAAACCAAAAGCAA
AACAACCAACAATAAGGAAAGCCCCAACAATAACAATAAAACCAAAACAAGCAACAACAC
AATAACTAAAACAAGCAAAATCACTAATAACATCAAAACAAGCAAAACTAACATCAAAAC
AAGCAACACAACAACAACTAATAACATCACAACAAGAATTAACACCATCAAAATAAAAAT
CAACACAACAAAAATGCTCACAAAAAGAACTGA