TGD | Gene Details

Identifiers and Description

Gene Model Identifier
TTHERM_00423370

Standard Name
MYO5 (MYOsin )

Aliases
PreTt13970 | 47.m00165

Description
Myosin heavy chain; member of proposed myosin Class XX, distinct from previously defined myosin classes; contains predicted coiled-coil, myosin tail homology (MyTH4), and FERM domains

Genome Browser

Gene Ontology Annotations

Cellular Component
myosin complex (IEA) | GO:0016459
Molecular Function
ATP binding (IEA) | GO:0005524
motor activity (IEA) | GO:0003774

Domains

( PF00784 ) MyTH4 domain
( PF03998 ) Utp11 protein
( PF07453 ) NUMOD1 domain
( TIGR01612 ) rhoptry protein
( PF00063 ) Myosin head (motor domain)
( TIGR00864 ) polycystin cation channel protein
( PF00788 ) Ras association (RalGDS/AF-6) domain
( PF05866 ) crossover junction endodeoxyribonuclease RusA

Gene Expression Profile

Tetrahymena Functional Genomics Database: TTHERM_00423370

Homologs (v.2006 protein sequences)

Source Identifier Score Description

ParameciumDB GSPATP00024180001 9.99838497179609e-146 Paramecium tetraurelia GSPATP0
0024180001 protein

IPI(HUMAN) IPI:IPI00742240.1 1.00036029423542e-110 Tax_Id=9606 PREDICTED: similar
to myosin VIIb

FlyBase FBgn0040299 9.99849682679538e-105

FlyBase FBgn0040299 9.99849682679538e-105

DictyBase DDB0167337 9.99679536751975e-103 myoD myosin ID heavy chain

DictyBase DDB0202969 9.99679536751975e-103 myoC myosin IC

DictyBase DDB0191347 9.99679536751975e-103 myoD myosin ID heavy chain

DictyBase DDB0215355 9.99679536751975e-103 myoC myosin IC

WormBase T10H10.1 9.9950941977843e-101 WBGene00002039 hum-6 myosin

ToxoDB 49.m03333 9.9950941977843e-101 Toxoplasma gondii myosin, puta
tive

TAIR AT1G54560 3.99851965515777e-99 myosin, putative

SGD YMR109W 1.00024349209755e-91 MYO5 SGDID:S000004715, Chr XII
I from 486586-490245, Verified
ORF, "One of two type I myosi
ns; contains proline-rich tail
homology 2 (TH2) and SH3 doma
ins; MYO5 deletion has little
effect on growth, but myo3 myo
5 double deletion causes sever
e defects in growth and actin
cytoskeleton organization"

PlasmoDB PF13_0233 4.99940046121664e-86 Plasmodium falciparum 0233

CryptoDB EAK90414 7.99628953139498e-82 Cryptosporidium parvum (Iowa)
protein EAK90414

Source	Identifier	Score	Description
ParameciumDB	GSPATP00024180001	9.99838497179609e-146	Paramecium tetraurelia GSPATP0 0024180001 protein
IPI(HUMAN)	IPI:IPI00742240.1	1.00036029423542e-110	Tax_Id=9606 PREDICTED: similar to myosin VIIb
FlyBase	FBgn0040299	9.99849682679538e-105
FlyBase	FBgn0040299	9.99849682679538e-105
DictyBase	DDB0167337	9.99679536751975e-103	myoD myosin ID heavy chain
DictyBase	DDB0202969	9.99679536751975e-103	myoC myosin IC
DictyBase	DDB0191347	9.99679536751975e-103	myoD myosin ID heavy chain
DictyBase	DDB0215355	9.99679536751975e-103	myoC myosin IC
WormBase	T10H10.1	9.9950941977843e-101	WBGene00002039 hum-6 myosin
ToxoDB	49.m03333	9.9950941977843e-101	Toxoplasma gondii myosin, puta tive
TAIR	AT1G54560	3.99851965515777e-99	myosin, putative
SGD	YMR109W	1.00024349209755e-91	MYO5 SGDID:S000004715, Chr XII I from 486586-490245, Verified ORF, "One of two type I myosi ns; contains proline-rich tail homology 2 (TH2) and SH3 doma ins; MYO5 deletion has little effect on growth, but myo3 myo 5 double deletion causes sever e defects in growth and actin cytoskeleton organization"
PlasmoDB	PF13_0233	4.99940046121664e-86	Plasmodium falciparum 0233
CryptoDB	EAK90414	7.99628953139498e-82	Cryptosporidium parvum (Iowa) protein EAK90414

General Information

Paragraph No Gene Name Paragraph Text
10 MYO1,
MYO12,
MYO11,
MYO10,
MYO9,
MYO8,
MYO5,
MYO4,
MYO3,
MYO2,
MYO13 Proteins of the myosin superfamily are ATP-dependent molecular motors that travel unidirectionally along actin filaments. The myosin heavy chain proteins are comprised of three domains: a head (motor) domain responsible for ATP hydrolysis at the N-terminus, a neck (lever arm) region, and a C-terminal tail region. Thirteen predicted myosin heavy chain genes have been identified in the Tetrahymena genome and named MYO1-MYO13. A phylogenetic analysis comparing these predicted proteins with the 19 previously identified myosin classes suggests that Myo1p-Myo12p belong to a previously undescribed class of myosins. This new family, designated Class XX, does not include Myo13p, which did not branch with this class or any of the other classes in the analysis. The neck and tail regions of the Tetrahymena myosins include a variety of domains characterized in other myosin classes, with each protein containing one or more of the following domains: coiled-coil (which may support dimerization); IQ motif (binding sites for calmodulin or calmodulin-like proteins); FERM domain (Four-point-one protein, Ezrin, Radixin, Moesin homology); and MyTH4 domain (Myosin Tail Homology 4).

Associated Literature

Ref:16505385: Foth BJ, Goedecke MC, Soldati D (2006) New insights into myosin evolution and classification. Proceedings of the National Academy of Sciences of the United States of America 103(10):3681-6
Ref:15988740: Williams SA, Gavin RH (2005) Myosin genes in Tetrahymena. Cell motility and the cytoskeleton 61(4):237-43

Sequences

>TTHERM_00423370(coding)
ATGTTTGATAAGAATTCATAAATTGATCTTAATTAGAAAGAAAAATTAATGGGTGTGAAA
GCATCAGGTAAAAAGATCAACCAACAAAATAAATATATGATTAGCAAGCAATGCCTTAAT
GACTTGGGCTTAATATAAACTCCTTGCAAATTAGTGTAATAGAGTGAGGTAGAGTTTTAT
TTTAGAGCAAACAAAAAATAACTAACTATAAAGCATATGGCAGCAAAAGCTAATTAAAAA
AGCAAGGTTAATACTACTTGGATGGTTCCAGATACTCCAGCTTGGATAGAAGTTGGAAAG
GAAGAACCAGAGACGAAGAAAGTTTTTATGAAAGCGACAATTATTGATATAAATAAGGAT
AAAACATAAGTAAAATTAACAAAAAAAGAAGATAATGAGGCTATTCCTGATGAAGTAAGT
GTCGAGAAGGTATATCAAGTAAATTAATTGCCTGAAACCGGATTTTCGGATATGGTAAGA
ATGGATAACCTGAATGAAGCAGAAATTATAAACAATTTGGAATTAAGATATTCTAAAGAT
ATTATTTATACTTATATTGGGCCAACATTAATCGTGATGAATCCATATAAATATATAGAA
AGTGCTATGAGCGAACAACTTTTACTTATGTATTAAAATGAGCTTATTAGTAAAGGATTT
ATTGATTAAAGGGAAACTCCTCCTCATACATATGCAGTAGCTGGATAAGCTTTTAGTAAA
CTGTTTGAGAATATGAAAAATCAAGCAATAGTAATTAGTGGAGAGTCAGGTGCAGGAAAA
ACAGAAAATGCAAAATTAGCGATGAAATTTTTAACTACAATGAGTCATCATGATTCAAAT
ACAGTGATTAGGATTTCAAAAGGAGAGTCTTCCATAGAAGATAAAATATTGAGTTGTAAT
CCTATCCTAGAAGCGTTTGGAAATGCTAAAACTGTTAGAAATGACAATTCAAGTAGATTT
GGTAAATATGTCAGTATCTTAGTTGATAAAAAGTCGCATAAAATTCAGGGAGCTTCCATA
ACTAATTACTTACTTGAAAAAAGTAGAGTTACTGTTTAGGGATAAAATGAAAGAAATTAT
CATATTTTCTACCACTTACTCAAGGGTTGTTCTGCTGCTGACAAGAAAAAATTAGGTTTA
GTGGATCCAAACAATGGATTACCTTTTGATCCAGAACAATTTTAATATTTAAAAGATGGC
GGATGCTATGAAGTTAGCACAATTGATGATTATGCACTATACAATGAAGTTTAAGATTCT
TTTACTAGGATGAATTTTTCTTAACACGAGAGAAACACTATTTGGAGGATTTTGTGTGCT
ATTTTACTTTTGGGAAACATCAGATTTGATAAAACAACTCTCACTGATTCAAAGCCCTGC
AGTATTATTGGGATTGACTTCTCTAAAAAAGTAGCAGATTTACTTGATATGTAATATAAT
ATATTGGAGAGATGTCTTCTTATTAAAAGGCGTAAAGTTGGTAATGATATTACTGAGTCA
CCACTTAATGAATAAGATATTTATGCAAATAGAGATAGCTTGGCTAGAACTTTATATGAT
AACCTTTTTACATGGTTAGTTAAGAGATTAAATCTTACTGTTCTCCCATCAGAATTGTCT
GAAAAATAGCTTCAAGAATAATGTCTCTCAATAGGATTACTCGATATTTTTGGTTTCGAA
GTGTTTAAAGTGAACAGTTTTGAGCAATTGTGCATCAATTATACTAATGAGAAGCTATAG
CAGCTATATATTTCTTACGTCTTCAAATCCGAAGAGTAGGAGTTTATCAATGAGGGACTA
AAAGATCATATTGGATAGCTAAGCTACACTGATAATTAAGAAGTTATTGATTTGATGGAT
AAATATCCGAAAGGTATATTTGATCTCCTTGATGAGAGCTCCTCTCTCGGATCTTCGACT
GACTAGCAACTATTTTAAAAAATATGTTCTACCCATAAATCTTCTCAATTCTTTATCCTT
AATAAGTCAAGCGCAGATTCTTTTGTAATCAAGCACACAGCTAAAAATGTTGAGTATTGC
ATAAATAATTTTAGAACAAAAAATAAAGCTGAAATTAGCTAAGATATTATTGATACTGTA
CTGTCATCAACTAATGAGTTACTTGGAGATATATTTTTAGGTCTTGTTGGTGAAGAGGTT
AAACAAAAATAATTTATTATTAGTTAGCCTAAAAAGCCTTCAAAAAATGATAAATTTTTA
GGAGCAAAGTTCAGATTTTAAATGAAGTAGCTTATGGATGAATTGATGAATGCTGATTGT
CATTTTATTAGATGCATTAAACCAAACGAAGTTAAGAAAAAAGATTACTTTTTACAAGGA
TATGCTTTTATATAAATAAGATATTTAGGTGTCCTAGAAGCTATTTATGTTAGAAAAGAA
GGATTTCCTTATAGAAAAAATTTTAAAGACTTGTACACTTAATATGGAGATATGGTCAAA
AAATTTAGAGGAGTTTCTCTGAAGAAATAAATAGAATAGAAAGCTAACTTTAATTAAATA
AGTGAAGATATAATAGCTTAGCTTTTGCCAAACGTAGATAAGAAGAAATTACTTTATGGT
AAGACTAAGATTTTTACTAAGGATGATGTTGGTAGAGAATTAGATGAATTACTTCACGTG
TGGTTCCAAAAGAAAAATGATTTTGCTAAGCACATTCAACACTAATTTAAAGTTTTTAAG
TTTAAAAAAAATATTCTGGCAAATTTGAAGAGATTATCTAAAATTGTTAAATGCTTCAGA
CGCTTAGCTGCGATGTATAAAATGAAAAAGCAAAGAAAGAAATTCTTATGCATGAAGGCA
TCTGTGTTTAGAGTCAAAGTTATTAGAGTAAAATTATTTAAGAAAATGGCTTTTGGAATT
TGGAAAGATTTGATAATTGAATAACTGAGAAAAGAAAGAAAGAAAAAGAGCTTAGCTTTA
ATGATGAAATTATTTGACTATCATATTAAGAAGAAAAACTTTAATAACTACAAGGCTAAA
GTATAATCAAAGAAAAAGTAAATTTAGGATTAGCTTGAAAGAGAAGCAGAGATTAAATAA
AAATAGTTATAAGAGCAATAAAGGTTGGAAAAGAAAAAGAGAGAATAAGAAGAAAAGCAA
TAAATATAACTCTAGCAATATCAGACTCAAGGAATGGAAATGTGTGTCAGTCCTGATACT
ACAAAAGAAATGACTATGAACACTGAAAACTCTAATGAATATTCAAATGAAAAAAAATCT
AATGAGGAAAACTCATTCTAGATGGATTCTCTAAATTAATCATTAAATATGTCATTTGTT
GACTAAATTCCTAATCACGATAAAATGATCCATGAAAATCTAAAAAGAGGTACACTAGCT
CATCGAATGACTAATTTAATTAACCAGAAGAAAATAGACCAAAGAAATATGCAATCAAGT
GATACTTTTGATGATGACAATGACGATAAAGAAACTTCCGTTATTGACAACTATCTAAAC
CCAGAATAAACACCTGAAGAATTATAAGGATAAGTTAACATTGACAAAGTTTATCTTTCA
CAAGACTGCATGTTCAATATATAAAATATACAAGAATCTCTTAAATAAAGAATATTAGAA
AACGACTACATCCAATTTTGTAAAGACATTTACAAAAAGAGAAGTAGTTGGGGAAGGACT
ATTCCTTTTGAAAAGTAGGGTTTCCATTAAAAAGAACCTCTGAAAAAGCCTTTAACCAAT
ATATCACCTCTCTTAGAACCAATTGCAATAAAAGCATTCACGAGAATACTAAAATATTCA
GAAGTTCTAAAATCTAAAAGAGATTCAAGGATGCAAGCTTATAAGCTTTTAGAATTGTGC
TTTGATTAAGATAGCTCTCTGCAAGATGAGGTTTTCTTATAAATTGCTAAACAATTGCAA
ACTGATGATCTAAGCTTAAAGAAAAAATACTATTCGTTAATGGCTATTTATTCTAGCTTC
ATTAGTACTAGCTCAAACACTATATATCCCCTATTAAACTGCTTCTATAATTTAACATTA
ACTGAGAAAGATGAAATTAATAAATAAAGATGTAAATTTATTTTCACAAGAATAAGAAAA
TGCTTTTAATCTCCAAGAGTTTACTTGCCTACTAAACAAGAAATATAAATGATTGAAAAC
AGAAAGAGTATTATGGTTCCTATTTATATTTATATTAATCGCTGTATTTTTATTGCTGTA
GAAAGCTATACTGATATTAGTAGCGCTATTAGTTTTGCATTAAGAGAATTAGAAATAGAA
ACAAATTAGCGAAACTACTGCCTGATTGAATAAATTACTATTGAGAATTTAGACTCATAA
GATGAGAATAATAAAGTAATAATTGAAGAGAATATTTTAGGAGATGACGAAAAAATTATG
GATATTTATAGCTGTTGGGAGAATGAAAAAGACTTAATTAAAAAGAAAAAATTAAAGCAA
AGCTTTTCTGCAAAAATTATATTTAAAATAAAAAACTTTTTTAAATTCAATAAATACGAC
ATAGATTCAATATTCATGTATTTCGCTCACTGCTGTTAAGATTATTTAAATGGCAGATTT
GTTTTGTAAGATAATGTAATTGTTAGATTGGCTTTACTTAAGCTCATTAATGATTATAAC
AGTATCTAAGAGGCTTAAAAAATCCTTAAAAACGTTAAACTGAAACTTCATGAATATATT
CCTATCAACGAAAAGTCTGAGTCTTTGATAAATAACTGGCAAACTGCTGCACTTTCACTT
TGCAATAAGATACCTTAATGTGATTCTTCTTAAGCTAGGACTCTATTTTTAAATACACTT
AAAAAGCATAGCTTTCTTTTTATGTCTCACCAATTTGAATGTCATTTTTACACATCAGAT
TCTTATTAAAGAAATTCCTTTGCTTAAAATAGCACAGTAGAAGAAGCTATAGTTGCAATT
AAGCCTTTTGAAATTCTAATTTTAGAAAAGTAATCTAAAGACATAATTGACTAATTTAAA
TTGAGTGAAATTGTTAAATTTGGAAAACAATCTTAAAATAGAATAACTATTATTTTAGGA
GATACAAAAACATTCCATTTTCAATTAAAAGATGCTGACCCATATATTTAAATCATTAAT
TAATATATTAAAATGGCTCTAAGTCCTGTAAAATAAATTAGAAAGGGTAAAAAAAAAAAG
AAGATGATTGTTAACAAAATTGAGGAGCTCTAAAATTGCTTAAATTGCTAAATATTATAA
ATTGATCTGGAGAGAAATAGAATTTTTGATGAAGGAGTTATTACCTTAGGTTCTCAATTA
TCAAAATTAACTAATTTGGTTAATTTAAAACTTACATTAGAGGAGCAGCATATTTAGTAT
AAGGATTATCTAAATTGCCTAATATCTAAATATTAAATCTTTAACTAAGGCTCTGAATTA
TGTAAATTACCAAATCTGTTAGCTTTGAGTATTTACTTAAGCTCCAATTATATTGATGGT
GAAGGTGCTACTGCTTTAAGCTCTGAGTTAGCAAAACTAACTAACCTCTAATCTTTGATA
GTTTACTTATCGTATAACTAAATCTAATAGCAATATAAGAAACAACTAAAAAGAAAGGCT
TTTAAGCTTAAGAATTTAGTCTAGTGTGTTTTTTACTTTTGA

>TTHERM_00423370(protein)
MFDKNSQIDLNQKEKLMGVKASGKKINQQNKYMISKQCLNDLGLIQTPCKLVQQSEVEFY
FRANKKQLTIKHMAAKANQKSKVNTTWMVPDTPAWIEVGKEEPETKKVFMKATIIDINKD
KTQVKLTKKEDNEAIPDEVSVEKVYQVNQLPETGFSDMVRMDNLNEAEIINNLELRYSKD
IIYTYIGPTLIVMNPYKYIESAMSEQLLLMYQNELISKGFIDQRETPPHTYAVAGQAFSK
LFENMKNQAIVISGESGAGKTENAKLAMKFLTTMSHHDSNTVIRISKGESSIEDKILSCN
PILEAFGNAKTVRNDNSSRFGKYVSILVDKKSHKIQGASITNYLLEKSRVTVQGQNERNY
HIFYHLLKGCSAADKKKLGLVDPNNGLPFDPEQFQYLKDGGCYEVSTIDDYALYNEVQDS
FTRMNFSQHERNTIWRILCAILLLGNIRFDKTTLTDSKPCSIIGIDFSKKVADLLDMQYN
ILERCLLIKRRKVGNDITESPLNEQDIYANRDSLARTLYDNLFTWLVKRLNLTVLPSELS
EKQLQEQCLSIGLLDIFGFEVFKVNSFEQLCINYTNEKLQQLYISYVFKSEEQEFINEGL
KDHIGQLSYTDNQEVIDLMDKYPKGIFDLLDESSSLGSSTDQQLFQKICSTHKSSQFFIL
NKSSADSFVIKHTAKNVEYCINNFRTKNKAEISQDIIDTVLSSTNELLGDIFLGLVGEEV
KQKQFIISQPKKPSKNDKFLGAKFRFQMKQLMDELMNADCHFIRCIKPNEVKKKDYFLQG
YAFIQIRYLGVLEAIYVRKEGFPYRKNFKDLYTQYGDMVKKFRGVSLKKQIEQKANFNQI
SEDIIAQLLPNVDKKKLLYGKTKIFTKDDVGRELDELLHVWFQKKNDFAKHIQHQFKVFK
FKKNILANLKRLSKIVKCFRRLAAMYKMKKQRKKFLCMKASVFRVKVIRVKLFKKMAFGI
WKDLIIEQLRKERKKKSLALMMKLFDYHIKKKNFNNYKAKVQSKKKQIQDQLEREAEIKQ
KQLQEQQRLEKKKREQEEKQQIQLQQYQTQGMEMCVSPDTTKEMTMNTENSNEYSNEKKS
NEENSFQMDSLNQSLNMSFVDQIPNHDKMIHENLKRGTLAHRMTNLINQKKIDQRNMQSS
DTFDDDNDDKETSVIDNYLNPEQTPEELQGQVNIDKVYLSQDCMFNIQNIQESLKQRILE
NDYIQFCKDIYKKRSSWGRTIPFEKQGFHQKEPLKKPLTNISPLLEPIAIKAFTRILKYS
EVLKSKRDSRMQAYKLLELCFDQDSSLQDEVFLQIAKQLQTDDLSLKKKYYSLMAIYSSF
ISTSSNTIYPLLNCFYNLTLTEKDEINKQRCKFIFTRIRKCFQSPRVYLPTKQEIQMIEN
RKSIMVPIYIYINRCIFIAVESYTDISSAISFALRELEIETNQRNYCLIEQITIENLDSQ
DENNKVIIEENILGDDEKIMDIYSCWENEKDLIKKKKLKQSFSAKIIFKIKNFFKFNKYD
IDSIFMYFAHCCQDYLNGRFVLQDNVIVRLALLKLINDYNSIQEAQKILKNVKLKLHEYI
PINEKSESLINNWQTAALSLCNKIPQCDSSQARTLFLNTLKKHSFLFMSHQFECHFYTSD
SYQRNSFAQNSTVEEAIVAIKPFEILILEKQSKDIIDQFKLSEIVKFGKQSQNRITIILG
DTKTFHFQLKDADPYIQIINQYIKMALSPVKQIRKGKKKKKMIVNKIEELQNCLNCQILQ
IDLERNRIFDEGVITLGSQLSKLTNLVNLKLTLEEQHIQYKDYLNCLISKYQIFNQGSEL
CKLPNLLALSIYLSSNYIDGEGATALSSELAKLTNLQSLIVYLSYNQIQQQYKKQLKRKA
FKLKNLVQCVFYF

>TTHERM_00423370(gene)
ATGTTTGATAAGAATTCATAAATTGATCTTAATTAGAAAGAAAAATTAATGGGTGTGAAA
GCATCAGGTAAAAAGATCAACCAACAAAATAAATATATGATTAGCAAGCAATGCCTTAAT
GACTTGGGCTTGTATATAATTACATTGTGCCTTAAAATTTATAATTAACAAATGTGTTTG
AGATGATAATTTTAATATATTATTATTATTATTATATATTTATAATAATTTCGCAAAGAT
ATTTACATCAAATAATTTTAAAGAATATAAACTCCTTGCAAATTAGTGTAATAGAGTGAG
GTAGAGTTTTATTTTAGAGCAAACAAAAAATAACTAACTATAAAGCATATGGCAGCAAAA
GCTAATTAAAAAAGCAAGGTTAATACTACTTGGATGGTTCCAGATACTCCAGCTTGGATA
GAAGTTGGAAAGGAAGAACCAGAGACGAAGAAAGTTTTTATGAAAGCGACAATTATTGAT
ATAAATAAGGATAAAACATAAGTAAAATTAACAAAAAAAGAAGATAATGAGGCTATTCCT
GATGAAGTAAGTGTCGAGAAGGTATATCAAGTAAATTAATTGCCTGAAACCGGATTTTCG
GATATGGTAAGAATGGATAACCTGAATGAAGCAGAAATTATAAACAATTTGGAATTAAGA
TATTCTAAAGATATTATTTATACTTATATTGGGCCAACATTAATCGTGATGAATCCATAT
AAATATATAGAAAGTGCTATGAGCGAACAACTTTTACTTATGTATTAAAATGAGCTTATT
AGTAAAGGATTTATTGATTAAAGGGAAACTCCTCCTCATACATATGCAGTAGCTGGATAA
GCTTTTAGTAAACTGTTTGAGAATATGAAAAATCAAGCAATAGTAATTAGTGGAGAGTCA
GGTGCAGGAAAAACAGAAAATGCAAAATTAGCGATGAAATTTTTAACTACAATGAGTCAT
CATGATTCAAATACAGTGATTAGGATTTCAAAAGGAGGTAATTAATTTTAAAATAAATTT
GAGTAAATTTCTTAAAACTTTAATGGAATTTACAAAATATATTTCTCTGCTGCTTATTAT
TGAGAAATAATGAATGAAGTCTTAACTACATATTACATACGATTAATTTTCCAATTCAGA
AAGAAGTTTATTAAAAGTCATTCTATAAATTAAAAACTATTACTTTATAACAAATTATTC
CTACCACTATTTAATATTTTTATTGCTTATTAATATATATATATATATTAATAGAGTCTT
CCATAGAAGATAAAATATTGAGTTGTAATCCTATCCTAGAAGCGTTTGGAAATGCTAAAA
CTGTTAGAAATGACAATTCAAGTAGATTTGGTAAATATGTCAGTATCTTAGTTGATAAAA
AGTCGCATAAAATTCAGGGAGCTTCCATAACTAATTACTTACTTGAAAAAAGTAGAGTTA
CTGTTTAGGGATAAAGTAAAATAAAATTCATTTCTCAATTTATTTAATTATATAGCCATG
GATTATTTTTTATGATCTTAAATCGAATATATTCACTTTATACCTAATTTATGCAAATAA
AATATTTAACTTAATCATTCTCACAATAAATTTGATTATTTCTTAACTTAAATATTGATA
AATTTCATTGTTTGTTTTTGAATCAATTTATTGTTTTTTTTATTCTTATAATAGATGAAA
GAAATTATCATATTTTCTACCACTTACTCAAGGGTTGTTCTGCTGCTGACAAGAAAAAAT
TAGGTTTAGTGGATCCAAACAATGGATTACCTTTTGATCCAGAACAATTTTAATATTTAA
AAGATGGCGGATGCTATGAAGTTAGCACAATTGATGATTATGCACTATACAATGAAGTTT
AAGATTCTTTTACTAGGATGAATTTTTCTTAACACGAGAGAAACACTATTTGGAGGATTT
TGTGTGCTATTTTACTTTTGGGAAACATCAGATTTGATAAAACAACTCTCACTGATTCAA
AGCCCTGCAGTATTATTGGGATTGACTTCTCTAAAAAAGTAGCAGATTTACTTGATATGT
AATATAATATATTGGAGAGATGTCTTCTTATTAAAAGGCGTAAAGTTGGTAATGATATTA
CTGAGTCACCACTTAATGAATAAGATATTTATGCAAATAGAGATAGCTTGGCTAGAACTT
TATATGATAACCTTTTTACATGGTTAGTTAAGAGATTAAATCTTACTGTTCTCCCATCAG
AATTGTCTGAAAAATAGCTTCAAGAATAATGTCTCTCAATAGGATTACTCGATATTTTTG
GTTTCGAAGTGTTTAAAGTGAACAGTTTTGAGCAATTGTGCATCAATTATACTAATGAGA
AGCTATAGCAGCTATATATTTCTTACGTCTTCAAATCCGAAGAGTAGGAGTTTATCAATG
AGGGACTAAAAGATCATATTGGATAGCTAAGCTACACTGATAATTAAGAAGTTATTGATT
TGATGGATAAATATCCGAAAGGTATATTTGATCTCCTTGATGAGAGCTCCTCTCTCGGAT
CTTCGACTGACTAGCAACTATTTTAAAAAATATGTTCTACCCATAAATCTTCTCAATTCT
TTATCCTTAATAAGTCAAGCGCAGTAAAAAAACTAAATATTTTAATGTAAATAGTAAATG
ATATTTCTTTTATTTAAAGGATTCTTTTGTAATCAAGCACACAGCTAAAAATGTTGAGTA
TTGCATAAATAATTTTAGAACAAAAAATAAAGCTGAAATTAGCTAAGATATTATTGATAC
TGTACTGTCATCAACTAATGAGTTACTTGGAGATATATTTTTAGGTATTTTTTAAAATTT
ATTTTTATAATAAAAATAAAAATTATTTCGATTTTTTTAAAAAAAAGGTCTTGTTGGTGA
AGAGGTTAAACAAAAATAATTTATTATTAGTTAGCCTAAAAAGCCTTCAAAAAATGATAA
ATTTTTAGGAGCAAAGTTCAGATTTTAAATGAAGTAGCTTATGGATGAATTGATGAATGC
TGATTGTCATTTTATTAGATGCATTAAACCAAACGAAGTTAAGAAAAAAGATTACTTTTT
ACAAGGATATGCTTTTATATAAATAAGATATTTAGGTGTCCTAGAAGCTATTTATGTTAG
AAAAGAAGGATTTCCTTATAGGTAAAATTATTTAATTTAATAATATCTTTGACAACCAAC
ATATTGTTTATTAAAAATAAGAAAAAATTTTAAAGACTTGTACACTTAATATGGAGATAT
GGTCAAAAAATTTAGAGGAGTTTCTCTGAAGAAATAAATAGAATAGAAAGCTAACTTTAA
TTAAATAAGTGAAGATATAATAGCTTAGCTTTTGCCAAACGTAGATAAGAAGAAATTACT
TTATGGTAAGACTAAGATTTTTACTAAGGATGATGTTGGTAGAGAATTAGATGAATTACT
TCACGTGTGGTTCCAAAAGAAAAATGATTTTGCTAAGCACATTCAACACTAATTTAAAGT
TTTTAAGTTTAAAAAAAATATTCTGGCAAATTTGAAGAGATTATCTAAAATTGTTAAATG
CTTCAGACGCTTAGCTGCGATGTATAAAATGAAAAAGCAAAGAAAGAAATTCTTATGCAT
GAAGGCATCTGTGTTTAGAGTCAAAGTTATTAGAGTAAAATTATTTAAGAAAATGGCTTT
TGGAATTTGGAAAGATTTGATAATTGAATAACTGAGAAAAGAAAGAAAGAAAAAGAGCTT
AGCTTTAATGATGAAATTATTTGACTATCATATTAAGAAGAAAAACTTTAATAACTACAA
GGCTAAAGTATAATCAAAGAAAAAGTAAATTTAGGATTAGCTTGAAAGAGAAGCAGAGAT
TAAATAAAAATAGTTATAAGAGCAATAAAGGTTGGAAAAGAAAAAGAGAGAATAAGAAGA
AAAGCAATAAATATAACTCTAGCAATATCAGACTCAAGGAATGGAAATGTGTGTCAGTCC
TGATACTACAAAAGAAATGACTATGAACACTGAAAACTCTAATGAATATTCAAATGAAAA
AAAATCTAATGAGGAAAACTCATTCTAGATGGATTCTCTAAATTAATCATTAAATATGTC
ATTTGTTGACTAAATTCCTAATCACGATAAAATGATCCATGAAAATCTAAAAAGAGGTAC
ACTAGCTCATCGAATGACTAATTTAATTAACCAGAAGAAAATAGACCAAAGAAATATGCA
ATCAAGTGATACTTTTGATGATGACAATGACGATAAAGAAACTTCCGTTATTGACAACTA
TCTAAACCCAGAGTAATTAATTAATTAATTCATTTATTTTTTTAATAATTTAATTTGGAG
TTTATATTTTTTTATTAATACTATTATTATTTAAATATCAAAAACCTAAATAAACGTTTT
ATGTTTAAAATAGATAAACACCTGAAGAATTATAAGGATAAGTTAACATTGACAAAGTTT
ATCTTTCACAAGACTGCATGTTCAATATATAAAATATACAAGAATCTCTTAAATAAAGAA
TATTAGAAAACGACTACATCCAATTTTGTAAAGACATTTACAAAAAGAGAAGTAGTTGGG
GAAGGACTATTCCTTTTGAAAAGTAGGGTTTCCATTAAAAAGAACCTCTGAAAAAGCCTT
TAACCAATATATCACCTCTCTTAGAACCAATTGCAATAAAAGCATTCACGAGAATACTAA
AATATTCAGAAGTTCTAAAATCTAAAAGAGATTCAAGGGTATAATAAATATATAAAAAAG
AAAGTATTTTTTATAATTTTTATTAATAAAATAGATGCAAGCTTATAAGCTTTTAGAATT
GTGCTTTGATTAAGATAGCTCTCTGCAAGATGAGGTTTTCTTATAAATTGCTAAACAATT
GCAAACTGATGATCTAAGCTTAAAGAAAAAATACTATTCGTTAATGGCTATTTATTCTAG
CTTCATTAGTACTAGCTCAAACACTATATATCCCCTATTAAACTGCTTCTATAATTTAAC
ATTAACTGAGAAAGATGAAATTAATAAATAAAGATGTAAATTTATTTTCACAAGAATAAG
AAAATGCTTTTAATCTCCAAGGTAATTAATTTATTAACTCATTCAAAAAAGCATCTTCTT
ATAACATAAATCAATTAATGTCATATTGAAAAAAGATTTAATTTTAAAAAAAATTTTAAT
TTAACTTAAACAATTTATTCTTTTTAATATAAAATCTAAAAAAATGTTTTAAATGCTTAA
AAATAAACAAAAATTAAAAAAATTTAATCAATTAAAAAAATATTTTTATTTTTTAATGAA
TTTTATAAAAAAAACAGAGTTTACTTGCCTACTAAACAAGAAATATAAATGATTGAAAAC
AGAAAGAGTATTATGGTTCCTATTTATATTTATATTAATCGCTGTATTTTTATTGCTGTA
GAAAGCTATACTGATATTAGTAGCGCTATTAGTTTTGCATTAAGAGAATTAGAAATAGAA
ACAAATTAGCGAAACTACTGCCTGATTGAATAAATTACTATTGAGAATTTAGACTCATAA
GATGAGAATAATAAAGTAATAATTGAAGAGAATATTTTAGGAGATGACGAAAAAATTATG
GATATTTATAGCTGTTGGGAGAATGAAAAAGACTTAATTAAAAAGAAAAAATTAAAGCAA
AGCTTTTCTGCAAAAATTATATTTAAAATAAAAAACTTTTTTAAATTCAATAAATACGAC
ATAGATTCAATATTCATGTATTTCGCTCACTGCTGTTAAGATTATTTAAATGGCAGATTT
GTTTTGTAAGATAATGTAATTGTTAGATTGGCTTTACTTAAGCTCATTAATGATTATAAC
AGTATCTAAGAGGCTTAAAAAATCCTTAAAAACGTTAAACTGAAACTTCATGAATATATT
CCTATCAACGAAAAGTCTGAGTCTTTGATAAATAACTGGCAAACTGCTGCACTTTCACTT
TGCAATAAGATACCTTAATGTGATTCTTCTTAAGCTAGGACTCTATTTTTAAATACACTT
AAAAAGCATAGCTTTCTTTTTATGTCTCACCAATTTGAATGTCATTTTTACACATCAGAT
TCTTATTAAAGAAATTCCTTTGCTTAAAATAGCACAGTAGAAGAAGCTATAGTTGCAATT
AAGCCTTTTGAAATTCTAATTTTAGAAAAGTAATCTAAAGACATAATTGACTAATTTAAA
TTGAGTGAAATTGTTAAATTTGGAAAACAATCTTAAAATAGAATAACTATTATTTTAGGA
GATACAAAAACATTCCATTTTCAATTAAAAGATGCTGACCCATATATTTAAATCATTAAT
TAATATATTAAAATGGCTCTAAGTCCTGTGTGAAATTAATACTCAAATAAATCTATAAAA
ATATTTCCTTAATAATATTGTAATTTATGTAAATAATTTAAATTTTGTCTCTATTTGTTC
ATTTAAAAATTAAATTAAATAAGAAAATTAATTTAATAAATAAATTAAAGAATAAAATAA
TTACCAATCAAAAATTTAGATTTCACTAAAAACTTAATTGGAATATTTTTAAAAATAATA
AGGTAAATCAGAAAATAATTTTTTAATACATACATAATCTTTAATTTAATTATGTTTATT
TAATTATTATTTAAATAATTGCTAATAAATAGCGACGATTATTTTTTAATATTGCAAAGT
ACTATAGTAGCAAGCACAAAATAAATTAATTTATGCTTATAGAAAAATTAGAAATATCAA
ATAATTTTCTTTGAATAAAATATTTATTTTGTGATTAATTACATTACTTTACATATTTAA
TTCAGAAAAGATTTTGGATCGATTTTTAGATTATATTAAAAGTATGTTTTAGTTGCAAAA
AGATTTTGAAAAAATAAATAAATAAGTAACTATCACAGACTACAAAACTATAAAATCAAA
AAATAAAAAATAATATTTATTAATTTATTTATATCTATAATTTTAATCTAATTCATTAAT
TTTTATTTTTTAGGAAAATATTTTTATTTAGTTTTTAAATATTATTTTTTTCAAATACAA
AGAAAGAAAGATTAATTAACTCAATCTTAATTATAAAAGCTTATATAAAATAAGTATAAA
AGATTATTATCGTTCAATTATTTTTTTTAGAAAATAAATTAGAAAGGGTAAAAAAAAAAA
GAAGATGATTGTTAACAAAATTGAGGAGCTCTAAAATTGCTTAAATTGCTAAATATTATA
AATTGATCTGGAGTAAACCTTTATCAAAAATTTCTAAAATAAAAATATTCTCTTTTAAAA
TATTTTTTATTAAAACTCAATAATTTATTTAAATCATATTTATTTATTGAAACTTTTGTT
AAAGATTAAATTTAAATATAAATTAATTATAAATTGAATGGCTAACTTTATTAATTTATT
TATTTATATAAATAAATTTGCAGTAGAAAGTAAAATATTTTTATAAATAATTTAAAATTT
TTATTTTGAGAGATAACTTATTCAGCTTAGATTCTGAATTAGCTAAACTAACAAAGCTCA
CTAATTTAATTCTCTATTAACAGTTATAAACATAAAAATGAAAATTAAGAAATGATTTTA
AGATATTGTTTAGCTTATATTTTATACTAAAATATAATTTTTTTTCCTTCTTTTTATTTT
ATTTGTTTTTAATTTTCTTATATTTTACTTTTTCTTTATAATTTATAAAATTATTTTCTT
AAAACTAAAAGGAGAAATAGAATTTTTGATGAAGGAGTTATTACCTTAGGTTCTCAATTA
TCAAAATTAACTAATTTGGTTAATTTAAAACTTACATTAGAGTAATATATATAATCAATT
TATTTATTATTTTCTTAAACATATCTAAGAAAAACTTAATCAATAAAAAACTAAATAAAT
ATATAAAAATGTCCTTAATAAATTTTAGAAACATATTTTAGGAGGAATTTTTTTCAAAAA
TTAAAAAAAAATATTGCAAATTGTAGAAATAGGTATTTAATCAATGTGTGTGTGTTTATA
GATTATTAATATCTCCATAAAAAATAATTTAAATTGCTAAAAAATATATTAATTAATTAT
AATAAATCTGAATAACTACATAAACAAATGTTTTCTCATTAAGTTATTCTATTACTAATT
ATTTATTACTGATTATTTTCTATCAATAAGATACTATTCTTTCAAATATTTTTAATTTAT
CAAACTCTCTTAATTCTTATAAAATTTTATTTTATTAAACAAAGGAGAAACAATATTAGT
GAAAGGAGCATTTATGAATTAAGTAATGACTTAACAAAATTAACTAATCTCTCAACTTTA
TCACTAAATTTCAAGTAAATTAATTTAAAATCTATTTAGTTTTTCAAAAAAAAAAATTAT
ATAAAAATTAAATAAATATTTCGAAAAAACTAAAAAAAAAAAACAATAAAAAATAAATAT
TTTAACTCTGAATAAAATTTTTTTAATTAATAATATAATGAATCATTGCTTTAAATTGAG
CTGATATTTTATTAATTAATAAAGTGAAAATAATATAACTTGTAAGGGAGCAGCATATTT
AGTATAAGGATTATCTAAATTGCCTAATATCTAAATATTAAATCTTTAACTAAGGTAAAT
AAATCAAACCAATTTATTTCATTTTTATTTATCTAAATAAAATCAAAATTTAAAAAAATA
CAAAAAATTAATTAATGATGATTTCAAAATTAAATCAAAAAGAAACTAAAATTTTATTGT
TAATTAATGAATAAATTAAAATTTTTTATTAAACTTTATTTTATTCTATTGGTAAACTCT
TATTGTTAAATCTATTGAATTTTTTTAAATTAAATACTAAATTTTTTTAAAATTAAATTA
AATACTATTTTTTATTCATAAAATTTAACCTTTTTTTATAATTATAAGAAAAATTAATTT
GCGTAATGAGGGAGCATTTGTTATAGGCTCTGAATTATGTAAATTACCAAATCTGTTAGC
TTTGAGTATTTACTTAAGGTAATATACTATTTAAATTTAATTCAAGTTTTCAATTGTTAA
ATATAGCTTAAATTAAAATTAATTAATTTAATTCTTATTCTCTTTTTTTACTTTATTATC
TAATTTTCATTTTTAATTCATTTTCTATTTTTATGTATTCTATATTTATATTTCAATAAT
TGGCAACTTAAATAATAAAGCTCCAATTATATTGATGGTGAAGGTGCTACTGCTTTAAGC
TCTGAGTTAGCAAAACTAACTAACCTCTAATCTTTGATAGTTTACTTATCGTAAGAAAAT
ATTACTTACTTATTTATTTATTTAATTTTTTGAGGAAAAAGAAGCACATAATTCAAAGTT
TATAAAGTTTATGAAAAAAAATGTTTATTAGAGAGATTAATAATTATTGAATAAAATATA
TAAATTTTCATTTAAAAACATAATAAATTGCTCGAATTTTAATATTTTATTTGATTAACA
TAATAAAAATGTATTTAAATTTAATTTAGAGTGTTTCTATTTTAAGAATAAAAATTAAAA
ATTTTGAATATTTAATAATAGGTATAACTAAATCTAATAGCAATATAAGAAACAACTAAA
AAGAAAGGCTTTTAAGCTTAAGAATTTAGTCTAGTGTGTTTTTTACTTTTGA

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Paragraph No	Gene Name	Paragraph Text
10	MYO1, MYO12, MYO11, MYO10, MYO9, MYO8, MYO5, MYO4, MYO3, MYO2, MYO13	Proteins of the myosin superfamily are ATP-dependent molecular motors that travel unidirectionally along actin filaments. The myosin heavy chain proteins are comprised of three domains: a head (motor) domain responsible for ATP hydrolysis at the N-terminus, a neck (lever arm) region, and a C-terminal tail region. Thirteen predicted myosin heavy chain genes have been identified in the Tetrahymena genome and named MYO1-MYO13. A phylogenetic analysis comparing these predicted proteins with the 19 previously identified myosin classes suggests that Myo1p-Myo12p belong to a previously undescribed class of myosins. This new family, designated Class XX, does not include Myo13p, which did not branch with this class or any of the other classes in the analysis. The neck and tail regions of the Tetrahymena myosins include a variety of domains characterized in other myosin classes, with each protein containing one or more of the following domains: coiled-coil (which may support dimerization); IQ motif (binding sites for calmodulin or calmodulin-like proteins); FERM domain (Four-point-one protein, Ezrin, Radixin, Moesin homology); and MyTH4 domain (Myosin Tail Homology 4).