TGD | Gene Details

Identifiers and Description

Gene Model Identifier
TTHERM_00411810

Standard Name
CDK1 (Cyclin-Dependent protein Kinase)

Aliases
PreTt21599 | 44.m00266 | 3714.m00112

Description
Cyclin-dependent protein kinase; localizes to domains associated with mature basal bodies of ciliary rows and to both the polykineties and haplokinety of the oral apparatus; partial knockout implicates this CDK in chromatin condensation

Genome Browser

Gene Ontology Annotations

Cellular Component
cell cortex (IDA) | GO:0005938 | Ref:12183062
Molecular Function
cyclin binding (ISS) | GO:0030332 | Ref:12183062
protein tyrosine kinase activity (IEA) | GO:0004713
cyclin-dependent protein serine/threonine kinase activity (ISS) | GO:0004693 | Ref:12183062
protein kinase activity (IEA) | GO:0004672
ATP binding (IEA) | GO:0005524
Biological Process
histone phosphorylation (IDA) | GO:0016572 | Ref:12183062
cortical cytoskeleton organization (IMP) | GO:0030865 | Ref:12183062
protein phosphorylation (IEA) | GO:0006468
cell cycle (IEP) | GO:0007049 | Ref:12183062

Domains

( PF01163 ) RIO1 family
( PF00069 ) protein kinase domain
( PF07714 ) protein tyrosine kinase

Gene Expression Profile

Tetrahymena Functional Genomics Database: TTHERM_00411810

Homologs (v.2006 protein sequences)

Source Identifier Score Description

ParameciumDB GSPATP00025245001 4.99892228664091e-79 Paramecium tetraurelia GSPATP0
0025245001 protein

IPI(HUMAN) IPI:IPI00031681.1 2.99972460658281e-59 PROT:P24941|ENSEMBL:ENSP00000
266970|REFSEQ:NP_001789|H- INV
:HIT000031399 Tax_Id=9606 Cell
division protein kinase 2

TAIR AT3G48750 2.99921413892506e-57 CDKA;1; A-type cyclin-dependen
t kinase. Together with its sp
ecific inhibitor, the Kip-rela
ted protein, KRP2 they regulat
e the mitosis-to-endocycle tra
nsition during leaf developmen
t.

FlyBase FBgn0004107 1.00018013089414e-55

SGD YBR160W 2.99870375813441e-55 CDC28 SGDID:S000000364, Chr II
from 560072-560968, Verified
ORF, "Catalytic subunit of the
main cell cycle cyclin-depend
ent kinase (CDK); alternately
associates with G1 cyclins (CL
Ns) and G2/M cyclins (CLBs) wh
ich direct the CDK to specific
substrates"

WormBase T05G5.3 3.00119315725674e-53 WBGene00000405 cdk-1 serine/th
reonine kinase (CDC2/CDKX subf
amily)

DictyBase DDB0191155 2.00055538736037e-52 cdk5 protein kinase, CMGC grou
p cyclin-dependent kinase CDK
family protein kinase protein
serine/threonine kinase

PlasmoDB MAL13P1.279 2.00055538736037e-52 Plasmodium falciparum 279

DictyBase DDB0188077 2.00055538736037e-52 cdk5 protein kinase, CMGC grou
p cyclin-dependent kinase CDK
family protein kinase protein
serine/threonine kinase

CryptoDB EAK88218 4.99993461670888e-52 Cryptosporidium parvum (Iowa)
protein EAK88218

ToxoDB 38.m00005 2.00070450437286e-47 Toxoplasma gondii cell divisio
n control 2-like protein kinas
e, putative

Source	Identifier	Score	Description
ParameciumDB	GSPATP00025245001	4.99892228664091e-79	Paramecium tetraurelia GSPATP0 0025245001 protein
IPI(HUMAN)	IPI:IPI00031681.1	2.99972460658281e-59	PROT:P24941\|ENSEMBL:ENSP00000 266970\|REFSEQ:NP_001789\|H- INV :HIT000031399 Tax_Id=9606 Cell division protein kinase 2
TAIR	AT3G48750	2.99921413892506e-57	CDKA;1; A-type cyclin-dependen t kinase. Together with its sp ecific inhibitor, the Kip-rela ted protein, KRP2 they regulat e the mitosis-to-endocycle tra nsition during leaf developmen t.
FlyBase	FBgn0004107	1.00018013089414e-55
SGD	YBR160W	2.99870375813441e-55	CDC28 SGDID:S000000364, Chr II from 560072-560968, Verified ORF, "Catalytic subunit of the main cell cycle cyclin-depend ent kinase (CDK); alternately associates with G1 cyclins (CL Ns) and G2/M cyclins (CLBs) wh ich direct the CDK to specific substrates"
WormBase	T05G5.3	3.00119315725674e-53	WBGene00000405 cdk-1 serine/th reonine kinase (CDC2/CDKX subf amily)
DictyBase	DDB0191155	2.00055538736037e-52	cdk5 protein kinase, CMGC grou p cyclin-dependent kinase CDK family protein kinase protein serine/threonine kinase
PlasmoDB	MAL13P1.279	2.00055538736037e-52	Plasmodium falciparum 279
DictyBase	DDB0188077	2.00055538736037e-52	cdk5 protein kinase, CMGC grou p cyclin-dependent kinase CDK family protein kinase protein serine/threonine kinase
CryptoDB	EAK88218	4.99993461670888e-52	Cryptosporidium parvum (Iowa) protein EAK88218
ToxoDB	38.m00005	2.00070450437286e-47	Toxoplasma gondii cell divisio n control 2-like protein kinas e, putative

General Information

Paragraph No Gene Name Paragraph Text
3 CDK1 Cyclin-dependent kinases (cdks) are a family of serine-threonine kinases that are involved in cell cycle control and cell division in eukaryotes. Cdks are catalytic subunits that are activated by association with proteins called cyclins, forming cyclin-cdk complexes. Cdk kinase activity is regulated by cyclin binding, phosphorylation and dephosphorylation, protein degradation, protein-protein interactions with cdk inhibitors, and subcellular localization.
4 CDK1 Tetrahymena thermophila Cdk1p shares homology with cdk homologs from other eukaryotes. It contains 11 catalytic domains characteristic of protein kinases, conserves all of the regulatory phosphorylation sites found in cdks, and has a slightly modified cyclin-binding PSTAIRE motif that is a hallmark of cdks. The Tetrahymena thermophila Cdk1p was also found to bind Saccharomyces cerevisiae p13suc1, a yeast cyclin.
5 CDK1 The level of Cdk1p fluctuates over the vegetative cell cycle, correlating with its histone H1 kinase activity. Cdk1p is associated with the basal bodies of the ciliary rows of the cell cortex and the oral apparatus. This localization, along with the phenotype of a partial CDK1 knockout phenotype of bent and buckled ciliary rows, suggests that Cdk1p is involved in cortical morphogenesis.

Associated Literature

Ref:12045216: Doree M and Hunt T (2002) From Cdc2 to Cdk1: when did the cell cycle kinase join its cyclin partner? J Cell Sci 115(Pt 12):2461-4
Ref:12183062: Zhang H, Huang X, Tang L, Zhang QJ, Frankel J, Berger JD (2002) A cyclin-dependent protein kinase homologue associated with the basal body domains in the ciliate Tetrahymena thermophila. Biochimica et biophysica acta 1591(1-3):119-128
Ref:10329641: Mizzen CA, Dou Y, Liu Y, Cook RG, Gorovsky MA, Allis CD (1999) Identification and mutation of phosphorylation sites in a linker histone. Phosphorylation of macronuclear H1 is not essential for viability in tetrahymena. The Journal of biological chemistry 274(21):14533-6
Ref:8995382: Sweet MT, Carlson G, Cook RG, Nelson D, Allis CD (1997) Phosphorylation of linker histones by a protein kinase A-like activity in mitotic nuclei. The Journal of biological chemistry 272(2):916-23
Ref:9442875: Morgan DO (1997) Cyclin-dependent kinases: engines, clocks, and microprocessors. Annu Rev Cell Dev Biol 13:261-91
Ref:7958616: Doree M and Galas S (1994) The cyclin-dependent protein kinases and the control of cell division. FASEB J 8(14):1114-21
Ref:2065655: Roth SY, Collini MP, Draetta G, Beach D, Allis CD (1991) A cdc2-like kinase phosphorylates histone H1 in the amitotic macronucleus of Tetrahymena. The EMBO journal 10(8):2069-75

Sequences

>TTHERM_00411810(coding)
ATGAACAATAATACATTTGGCTCAGACAGATATGAAAAGCTACTTAAAGTAGGTGAAGGA
ACATATGGTGAAGTTTACAAGGCTAAAGACATTCAAAGCTCTGAAATTGTTGCTTTGAAG
AAGATTAAATTAGAAAATGAAGATGAAGGTGTCCCTTCAACTGCTCTAAGAGAAATTTCA
ATACTTAAAGAGTTACAACCACATCCCAACATCGTTTGCATGCATGAAGTTATTTATCAA
CCCTAAGAGAAGAAGTTATACCTTGTATTTGAATTTGTTGACTAAGACCTTAAAAAATTC
TTAGACTAATACCGCAAAGATAAAAAACTTTAACTTCGTCCTTACCAAATCAAACTCATG
ATGTATCAAATTTTGAATGGATTGAATTTCTGCCACAGCCGTAGAATTATTCATAGAGAT
TTAAAACCCTAAAACATTTTAATTGATGCTAAGGGAAATATTAAGATTGCTGATTTTGGT
TTGGCTAGAGCATTTGGTGTTCCTATCAAGACTCTTACTCATGAAGTTGAAACTCTTTGG
TACAGAGCTCCCGAAATTCTTTTAGGCTAAAAGGCTTATAGTCTCGGAGTTGATATTTGG
AGTTTGGGTTGCATCTTCCACGAAATGGTTGAAAAGAGAGCTCTCTTCATGGGTGACTCT
GAAATTGATTAAATATTTAAAATATTCTAATACCATGGTACTCCTACTGAGTAGACATGG
CCTGCTTTGAAGGAATGTCCTTACTTTAAACCTATATATCCTCGTTTCAAAACTGCTGAT
CCTAAGACTTACTTTAAGAATTTCTGCGATAAAGGATTTGACCTTATTTAATAGATGATT
GCTCTTGACCCTGCTAAAAGAATATCAGTAAAGGATGCTCTCAGACATCCCTACTTTGAA
GATCTTAGCAGAGAAGATATAGCTAAATTTGAGCCTAATTAAGTTCATATGTACTGA

>TTHERM_00411810(protein)
MNNNTFGSDRYEKLLKVGEGTYGEVYKAKDIQSSEIVALKKIKLENEDEGVPSTALREIS
ILKELQPHPNIVCMHEVIYQPQEKKLYLVFEFVDQDLKKFLDQYRKDKKLQLRPYQIKLM
MYQILNGLNFCHSRRIIHRDLKPQNILIDAKGNIKIADFGLARAFGVPIKTLTHEVETLW
YRAPEILLGQKAYSLGVDIWSLGCIFHEMVEKRALFMGDSEIDQIFKIFQYHGTPTEQTW
PALKECPYFKPIYPRFKTADPKTYFKNFCDKGFDLIQQMIALDPAKRISVKDALRHPYFE
DLSREDIAKFEPNQVHMY

>TTHERM_00411810(gene)
GTATCAACTCTCATAAGAAAAATTATTGCTATCAAATATTCGAATTTAAGCAAATAAATC
AATCAATCAGTCAGTCATACATACATAATAGGATGAACAATAATACATTTGGCTCAGACA
GATATGAAAAGCTACTTAAAGTAGGTGAAGGAACATATGGTGAAGTTTACAAGGCTAAAG
ACATTCAAAGCTCTGAAATTGTTGCTTTGAAGAAGATTAAATTAGAAAATGAAGATGAAG
GTGTCCCTTCAACTGCTCTAAGAGAAATTTCAATACTTAAAGAGTTACAACCACATCCCA
ACATCGTTTGGTAAAATTTTATTTCTCATAACTAAAGCGATTATTTATATTTTGTTCCTG
CAATTCTCTTCAATCTTCAATTAGTACCACACTTTGTTTGCTACCAAATTAGTTAGTTAA
AAATAATTCAAAATTTTAATGAATCCATTTTGAAAAGATAAACTTTTGAGTTTAACAAAA
TTGACTGTATTTTTTATAAGATAATAGCAATTTAGAAAAAGAGAAGAATTTATTTATTTG
CCATGTTTTAATTATTTTATTTATATAATAATAGCATGCATGAAGTTATTTATCAACCCT
AAGAGAAGAAGTTATACCTTGTATTTGAATTTGTTGACTAAGACCTTAAAAAATTCTTAG
ACTAATACCGCAAAGATAAAAAACTTTAACTTCGTCCTTACCAAATCAAAGTAAACAAAT
AAACTACATTCAAAAATAGTTTTTTTTTTTAATTTCAAAAATACCTTCTATATAATCTAC
CATAGAACACATGCATTCAAGCACGCAAATTAATTAGAAATTAGATGATCTTAATTCAAT
TAGCTTAAAAAAATATTATTTAAATAATTCGAATTCAAATAAACAGATTATCTTATTGTT
TGATATTTTTATTCAATTTGAAAAAAAAGCAACAAAAGATTTTCAAATTAATTATCAATA
TATTTTGAAACATAACAATCCTTCACTCACTCACTCACTTTCTAACATACGCGTTAAATA
AATGAATCATAGATCAATCAACTATTAAACTTTCAATACTAAATTGGTGCAATTCTCCAT
TTTATTTAGTATTAAATTTAAAGTAAATGCCAAAAATAAATAATGAGAATTTATTCTTTG
ATACTAAAATGAATTTATTACAAAAAAATTAGATAGAAATGATTTTGAAATACTTTGAAA
TGTTAATAAAATAAAAACTAATTTCGGTTAAAAAATAATATATTTTATAATAATAGCTCA
TGATGTATCAAATTTTGAATGGATTGAATTTCTGCCACAGCCGTAGAATTATTCATAGAG
ATTTAAAACCCTAAAACATTTTAATTGATGCTAAGGGAAATATTAAGATTGCTGATTTTG
GTTTGGCTAGAGCATTTGGTGTTCCTATCAAGACTCTTACTCATGAAGTTGAAACTCTTT
GGTACAGAGCTCCCGAAATTCTTTTAGGCTAAAAGGCTTATAGTCTCGGAGTTGATATTT
GGAGTTTGGGTTGCATCTTCCACGAAATGGTTGAAAAGAGAGCTCTCTTCATGGGTGACT
CTGAAATTGATTAAATATTTAAAATATTCTAATACCATGGTACTCCTACTGAGTAGACAT
GGCCTGCTTTGAAGGAATGTCCTTACTTTAAACCTATATATCCTCGTTTCAAAACTGCTG
ATCCTAAGACTTACTTTAAGAATTTCTGCGATAAAGGATTTGACCTTATTTAATAGATGA
TTGCTCTTGACCCTGCTAAAAGAATATCAGTAAAGGATGCTCTCAGACATCCCTACTTTG
AAGATCTTAGCAGAGAAGATATAGCTAAATTTGAGCCTAATTAAGTTCATATGTACTGAA
TATGAAAACAAACAACAACTAATTAATTAATTAACAAACAAATTAATTGCAAATAAATTT
TTATTTAAGAATTGATAATGAATGAATGAAACAACCATATTATTAATTCAAAAATATAAT
AATTAATATCCGAATCAAAAATAAATAAATAAAAAAATAAATACCTACATATACAGAATC
TCATAAAAATAATTTACTCATCTATTCTTATATTTACTCCCATCATAACCAATATATTTT
TTAGCTTAAATTGTTAATGAATTCTTTTTGGGTCTATATATATATATTATAAAATATTGC
AAATATTGTAATATATTTTATATTTTAACTTGTAATTATAGATTTTAATTCAAAATCTTC
AATTCTAC

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Identifiers and Description

Gene Model Identifier

Standard Name

Aliases

Description

Genome Browser

Gene Ontology Annotations

Cellular Component

Molecular Function

Biological Process

Domains

Gene Expression Profile

Homologs (v.2006 protein sequences)

General Information

Associated Literature

Sequences

Wiki Links

External Links

Paragraph No	Gene Name	Paragraph Text
3	CDK1	Cyclin-dependent kinases (cdks) are a family of serine-threonine kinases that are involved in cell cycle control and cell division in eukaryotes. Cdks are catalytic subunits that are activated by association with proteins called cyclins, forming cyclin-cdk complexes. Cdk kinase activity is regulated by cyclin binding, phosphorylation and dephosphorylation, protein degradation, protein-protein interactions with cdk inhibitors, and subcellular localization.
4	CDK1	Tetrahymena thermophila Cdk1p shares homology with cdk homologs from other eukaryotes. It contains 11 catalytic domains characteristic of protein kinases, conserves all of the regulatory phosphorylation sites found in cdks, and has a slightly modified cyclin-binding PSTAIRE motif that is a hallmark of cdks. The Tetrahymena thermophila Cdk1p was also found to bind Saccharomyces cerevisiae p13suc1, a yeast cyclin.
5	CDK1	The level of Cdk1p fluctuates over the vegetative cell cycle, correlating with its histone H1 kinase activity. Cdk1p is associated with the basal bodies of the ciliary rows of the cell cortex and the oral apparatus. This localization, along with the phenotype of a partial CDK1 knockout phenotype of bent and buckled ciliary rows, suggests that Cdk1p is involved in cortical morphogenesis.