Saettone A, Ponce M, Nabeel-Shah S, Fillingham J (2019) RACS: rapid analysis of ChIP-Seq data for contig based genomes. BMC bioinformatics 20(1):533 PUBMED:31664892
Tian M, Mochizuki K, Loidl J (2019) Non-coding RNA Transcription in Tetrahymena Meiotic Nuclei Requires Dedicated Mediator Complex-Associated Proteins. Current biology : CB ( ): PUBMED:31280995
Garg J, Saettone A, Nabeel-Shah S, Cadorin M, Ponce M, Marquez S, Pu S, Greenblatt J, Lambert JP, Pearlman RE, Fillingham J (2019) The Med31 Conserved Component of the Divergent Mediator Complex in Tetrahymena thermophila Participates in Developmental Regulation. Current biology : CB 29(14):2371-2379.e6 PUBMED:31280994
Identifiers and Description
Gene Model Identifier
TTHERM_00382290
Standard Name
MNDP1 (Homolog of budding yeast MND1 (meiotic non disjunction)and fission yeast MCP7)
Aliases
PreTt10386 | 40.m00271
Description
In budding yeast, the Mnd1 protein forms a complex with Hop2 to promote homologous chromosome pairing and meiotic DSB repair. Mnd1 requires Hop2 to localize to chromosomes. There exists an ubiquitously expressed paralog, MNDP1.
MND1 Protein required for reco
mbination and meiotic nuclear
division; forms a complex with
Hop2p, which is involved in c
hromosome pairing and repair o
f meiotic double-strand breaks
Hop2 and Mnd1 are meiosis-specific proteins that function in a complex in budding yeast. Their general architecture is strikingly similar, and therefore they are potentially homologous protein families. The Hop2-Mnd1 system seems to have undergone duplication in the evolutionary history of Tetrahymena, because both protein families are represented by two homologs with distinct expression patterns in this species. Just as for HOP2 (meiotic) and HOPP2 (ubiquitous), there is a meiotic (MND1)and a ubiquitously expressed (MNDP1) version, which raises the possibility that a meiotic and a ubiquitous Mnd1p-Hop2p complex exists.
Associated Literature
Ref:18522989: Mochizuki K, Novatchkova M, Loidl J (2008) DNA double-strand breaks, but not crossovers, are required for the reorganization of meiotic nuclei in Tetrahymena. Journal of cell science 121(Pt 13):2148-58