Identifiers and Description

Gene Model Identifier

TTHERM_00316310

Standard Name

NHX1 (Sodium Hydrogen Exchanger 1)

Aliases

PreTt20942 | 31.m00244 | 3687.m00046

Description

Sodium/hydrogen exchanger family protein

Genome Browser

Gene Ontology Annotations

Cellular Component

• integral to membrane (IEA) | GO:0016021

Molecular Function

• solute:hydrogen antiporter activity (IEA) | GO:0015299

Biological Process

• cation transport (IEA) | GO:0006812

Domains

• ( TIGR00831 ) Na+/H+ antiporter
• ( PF03023 ) Virulence factor MVIN
• ( TIGR00840 ) sodium/hydrogen exchanger 3
• ( PF02378 ) Phosphotransferase system, EIIC
• ( PF00027 ) cyclic nucleotide-binding domain
• ( PF08946 ) Osmosensory transporter coiled coil
• ( PF07674 ) Protein of unknown function (DUF1603)
• ( PF07690 ) transporter, major facilitator family
• ( PF06790 ) Uncharacterised protein family (UPF0259)
• ( PF03547 ) transporter, auxin efflux carrier (AEC)
• ( PF00999 ) transporter, monovalent cation:proton antiporter-2 (CPA2)
• ( TIGR01726 ) amino ABC transporter, permease protein,

Gene Expression Profile

• Tetrahymena Functional Genomics Database: TTHERM_00316310

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
ParameciumDB	GSPATP00008531001	9.9978508813226e-163	Paramecium tetraurelia GSPATP0 0008531001 protein
TAIR	AT2G01980	1.00035036202303e-57	sodium proton exchanger, putat ive (NHX7) (SOS1)
CryptoDB	EAK87330	2.00032180237354e-33	Cryptosporidium parvum (Iowa) protein EAK87330
ToxoDB	129.m00252	5.99876005170019e-30	Toxoplasma gondii sodium/hydro gen exchanger, putative
IPI(HUMAN)	IPI:IPI00002841.1	3.00077937282216e-22	PROT:Q9UBY0|TREMBL:O00618|ENS EMBL:ENSP00000233969|REFSEQ :N P_003039 Tax_Id=9606 Sodium/hy drogen exchanger 2
FlyBase	FBgn0026787	7.00144647424944e-19
PlasmoDB	PF13_0019	9.99946582325553e-18	Plasmodium falciparum 0019
WormBase	ZK822.3c	4.00124758572913e-13	WBGene00003736 nhx-9
WormBase	ZK822.3a	4.00124758572913e-13	WBGene00003736 nhx-9 Na(+)/H(+ ) antiporter
DictyBase	DDB0202441	1.00026587228418e-09	nhe1 sodium/hydrogen exchanger Na-H exchanger
DictyBase	DDB0231789	1.00026587228418e-09	nhe1 sodium/hydrogen exchanger Na-H exchanger
SGD	YDR456W	2.00023732685282e-09	NHX1 SGDID:S000002864, Chr IV from 1367476-1369377, Verified ORF, "Endosomal Na+/H+ exchan ger, required for intracellula r sequestration of Na+; requir ed for osmotolerance to acute hypertonic shock"

General Information

Paragraph No	Gene Name	Paragraph Text
25	NHX1	NHX1 is an integral membrane protein that shares homology with other proteins containing a sodium hydrogen exchanger domain involved in transporting sodium and hydrogen ions across the concentration gradient between a cell and its surroundings. Functioning as an antiporter for sodium and hydrogen ions, the exchange function characteristic of this domain is highly dependent on pH. Although the exact molecular mechanisms responsible for this behavior are not well understood, a prominent current inference is that these exchanger proteins use ATP to transport ions across membranes. Paragraph by: Samuel Rubin and Owen Foster (undergraduates) Keck Science Deparment, Claremont Colleges

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00316310(coding)
ATGAACAATAGCACTGACACTTCAGCTGCTACATATTAGCCTAATTATTTTAGTACAATG
GCAGCATAAGCCATAGATGATTCAAAAATTAGTACAGAATCGCTTGTAGTGTTTTTCCTT
TTTGGAGGACTTATGATTGCAGGTTTTGTTAGGGAAATTAATAAAAAAACTAGCATTCCT
TACACTCCAATGCTTTTTGTTATTGGAATTTTTTTAGGAAAGTTTTCTGAAAGCATGGGA
ATACTAGGAATAACAATAAGCAAGATAAGTTTAATCAACCCTCATGGTATATTAATTATA
TTCCTCCCTGTGCTTATTTTCGAAAGTGGTTTTAATAGTGATTGGCATACTTTTAAAAAG
TAATCTGGCCAGATATTTTTACTTGCCTTCCCATGTGTACTATTTTCAGCCATATTTTTA
CTCATAAGTATCAAAGTTATTTTGAGATATGATGACTCTTATTACACTTGGAGTGGTGCA
TTTATGTTCGGTTCTATTCTCTCATGTACAGATACAGTAGCCGTCCTAGCTCTTTTAAAA
GAAGTAGGCGCTCCTAAAAAATTTAATTCGCTGATTGAAGGAGAATCATTACTTAACGAT
GGTACCTGTATGGTTCTTTTCCAAATATCAAGTGAATTCGCAAAAAAAGTTGATTAGAAT
ACATAAAATCAGTAATATTTTGATTTGTTTGAAGTGATCAAACTTTTGCTTTCTCTCACT
GTTGGTGGTACACTTCTCGGTATTGTTTTTGGCATGATAGCCTAGTTTTGGATGCGTAGA
ATACATAATGATCCGATATTGACAGTCAATATAACCTTCATTGTTTGCTATCTAACTTAC
TATGTAGCAGAAAATGTAGATATTGGAATAAAAGTCTCAGGAATTATGGCTCTAGTTTCT
CTTGGTATTTATCTCTCTATATTTGGTAAAACTAAAATTTCAAGTGAAGAAAAGAGAACT
GTTTATATTTTCTGGAAGTACGTAACTTATGCTGGTGAATCAATTATTTTTATATTAGCT
GGTGTATTAGTTGGTGTTAAAGTTTTAACATCTAATGGGGATTACGACACTATGTCAGGA
AGCGATAATGTTTCTTCTTCAATTTAAACTAGTGATTATTTTAAACTTTTTGGTCTTTAC
GTTTGTATGATCTTGAGTCGCTTTGGTAGTATTGCTTGCTTTATGTCTTGGTTGAGAAAA
TGGGGTTATGGTCTTACTTGGAAGGAAGTTTATGTCCTTGCTTACGGTGGTCTTAGAGGA
GCTATTGGTAATTTTATAAGTATTTCTTTTGCAATGATTGTTGCTAATGATGACTCTTAC
TCTCAAAAATTAAGAGATATTATTTTATTCGATATGGCTGGAAATGCAATTTTAACATTA
ATTATCAATGGAACAACTACTGGTCCTTTGATTAAGAGTTTAGGATTATGCGTTACAAGC
ACAGTTAGAGAAAGAGTCTTTTTAAATATTTTACAAGATTTGAAGGAAGATACTGAAAAA
AAGATTAATTATTTGAAATCTAATAACTATCTAAAGATGGTCAATTGGGATAGTGTTAAA
GAATATGTAGGATTAGCAGATTTGGAGCAAAGAATTACAAGATTAGAGTCAGATCTAACT
AAAAGAGAAGAAATTGAAGAGTATACAAGAAATATAAGAAATAAAAATGTAATTGATGCT
AAGATAGATGAACTTAAAAACTCTAATGAATTTTAAGAGTAGTAATCATTTGACTCAGAT
TCAACAAATCACAATCTTGATGAAAATATGATAGTTGAATTAAATTGGGATCTGGATACT
GAATAAGAAAGAATGAACTCATGGGAATTTCTTTCCAATTACTTTTACAATCCTATTTAC
ATCAAAGTGCTCTTTTAATTAAAAGGATGGCCTATTGTTGGATCTTATGCTGGTAACCTC
CTCTTTAACCATATCTCTAATATTTATGATGTCATTGCTGCTTATATTGAAGCTCATGAA
CAAGCTGAGCAACTTTGCATAGATCAATTCCCTTTCATTCCCTAAGTTTTAGAAATTATT
ATCAGAGAAAGCTAAGATAATAGAATGAGTGGCGAAGAGTATATCAAAAATGATTTAAAT
GTAAGTTTCCCAGAAATTACTAAACAAATCCAAACTAAGAAGGCAACCTACAGTTTATTA
GAGTGCTAAAAGAAAATAATAAAGAAGGGTATTTTGTTAGGTAAGATAGATGAAAAAGAA
AGAGATATATTAATGTAATAAATCGATGATAGAGTAGTTGCTTTAGACAACATCAAACCT
TCTTGGAAAGCTCCTCCAATCAAAAATTTCTTAGAAAATGTTCCATTCTTTAAACTCATC
CACAAAGATTTACTTCCATACATCATCAAAGAATCTGTTGAGATGATTTTTGAAAAAGAT
ATGTACATCATCAAAGAAGGTGAGAAAGCTAAATACTTTTTTGTTATCACTAGAGGTAGT
GCTACAGAAACAACATCTTAGAGCTTTTGCACATATCAAGAATAAAAGGAAGTTGGCAGT
TTAATTTCTCCTCACCACTTGATTGTACCAAGTTTGAGATACTTGACTTCCTGCATGGCT
AATGCAGTTGTATACGTTCTTGCTTTCCCTTTAAGCTCAATTTAGAAAGTTATCAAAGTT
AATTTAGAAATAAAGGAATATGTTTGGATGTAGAGTCTGAGAGCATTGAGTTAGCTTTTC
TATAATGAACTTAAACCTTTAGGAAGTTTAGATAGAAACAGTTTTATTAAACTTCAACCA
AAGTTGAAATTTGCTAAATATAACAAAGGGAAGACTATCTAGTGTGAAAGTGGTGGTATT
CTTTTGAAAGGACAAGTTTCGAGAAAGGATTTAACAGATGTGATGATGACATAATCTAAA
GTAAATAATGACGAGGTAAAAAAATCAGATTTGATTGATGGTAGAATTTATAAGGCATTT
TGTGTTTTAATGCCAGGATAAGCTTTTTCAGTTTTCACAGAAAAGAAGTGTACATTTTTG
CACTTTGCTGAAGACTGTGAAGAAATTAGGTTTATGATTAGTCATATGGACTACAATGTT
GGCATTAATTAGTAAACACCTCATACTCTTAACATATTTAGTCCTGTAGCTGTTTCTGGA
TCTCATAATAAGAGAAACAGTTTTTAAGCTCCCCACTTAAGTAGATTTGCAGGTAGACAT
ACTTTTAATAATTTAGAAGTAGTTGTGCAAGGTAGTGAAAATAAAATAAATTCAGGATAA
TAAATAGAATTGCAAAAGATGAAATCTAAATCATACTTAAACGACTAACAAATAAAGAGT
GTAAAGAGTGATGATGAAGAATCAGATGATAATAAAGAAAAGTGA

>TTHERM_00316310(protein)
MNNSTDTSAATYQPNYFSTMAAQAIDDSKISTESLVVFFLFGGLMIAGFVREINKKTSIP
YTPMLFVIGIFLGKFSESMGILGITISKISLINPHGILIIFLPVLIFESGFNSDWHTFKK
QSGQIFLLAFPCVLFSAIFLLISIKVILRYDDSYYTWSGAFMFGSILSCTDTVAVLALLK
EVGAPKKFNSLIEGESLLNDGTCMVLFQISSEFAKKVDQNTQNQQYFDLFEVIKLLLSLT
VGGTLLGIVFGMIAQFWMRRIHNDPILTVNITFIVCYLTYYVAENVDIGIKVSGIMALVS
LGIYLSIFGKTKISSEEKRTVYIFWKYVTYAGESIIFILAGVLVGVKVLTSNGDYDTMSG
SDNVSSSIQTSDYFKLFGLYVCMILSRFGSIACFMSWLRKWGYGLTWKEVYVLAYGGLRG
AIGNFISISFAMIVANDDSYSQKLRDIILFDMAGNAILTLIINGTTTGPLIKSLGLCVTS
TVRERVFLNILQDLKEDTEKKINYLKSNNYLKMVNWDSVKEYVGLADLEQRITRLESDLT
KREEIEEYTRNIRNKNVIDAKIDELKNSNEFQEQQSFDSDSTNHNLDENMIVELNWDLDT
EQERMNSWEFLSNYFYNPIYIKVLFQLKGWPIVGSYAGNLLFNHISNIYDVIAAYIEAHE
QAEQLCIDQFPFIPQVLEIIIRESQDNRMSGEEYIKNDLNVSFPEITKQIQTKKATYSLL
ECQKKIIKKGILLGKIDEKERDILMQQIDDRVVALDNIKPSWKAPPIKNFLENVPFFKLI
HKDLLPYIIKESVEMIFEKDMYIIKEGEKAKYFFVITRGSATETTSQSFCTYQEQKEVGS
LISPHHLIVPSLRYLTSCMANAVVYVLAFPLSSIQKVIKVNLEIKEYVWMQSLRALSQLF
YNELKPLGSLDRNSFIKLQPKLKFAKYNKGKTIQCESGGILLKGQVSRKDLTDVMMTQSK
VNNDEVKKSDLIDGRIYKAFCVLMPGQAFSVFTEKKCTFLHFAEDCEEIRFMISHMDYNV
GINQQTPHTLNIFSPVAVSGSHNKRNSFQAPHLSRFAGRHTFNNLEVVVQGSENKINSGQ
QIELQKMKSKSYLNDQQIKSVKSDDEESDDNKEK

>TTHERM_00316310(gene)
ATGAACAATAGCACTGACACTTCAGCTGCTACATATTAGCCTAATTATTTTAGTACAATG
GCAGCATAAGCCATAGATGATTCAAAAATTAGTACAGAATCGCTTGTAGTGTTTTTCCTT
TTTGGAGGACTTATGATTGCAGGTTTTGTTAGGGAAATTAATAAAAAAACTAGCATTCCT
TACACTCCAATGCTTTTTGTTATTGGAATTTTTTTAGGAAAGTTTTCTGAAAGCATGGGA
ATACTAGGAATAACAATAAGCAAGATAAGTTTAATCAACCCTCATGGTATATTAATTATA
TTCCTCCCTGTGCTTATTTTCGAAAGTGGTTTTAATAGTGATTGGCATACTTTTAAAAAG
TAATCTGGCCAGATATTTTTACTTGCCTTCCCATGTGTACTATTTTCAGCCATATTTTTA
CTCATAAGTATCAAAGTTATTTTGAGATATGATGACTCTTATTACACTTGGAGTGGTGCA
TTTATGTTCGGTTCTATTCTCTCATGTACAGATACAGTAGCCGTCCTAGCTCTTTTAAAA
GAAGTAGGCGCTCCTAAAAAATTTAATTCGCTGATTGAAGGAGAATCATTACTTAACGAT
GGTACCTGTATGGTTCTTTTCCAAATATCAAGTGAATTCGCAAAAAAAGTTGATTAGAAT
ACATAAAATCAGGTATTAAATTAAATCTTTTATATATAAACATTAGCTAAGATAGACAGA
TAATTATAGTTTATAGCTTAATTTTTATATTATTTTAAAATAAAACCTTAGCTTATATAT
TTTATTACTCAAAAAAAAAAGTAATTAGAGTACCCAAATAGTAATTTTAGTCTACATTTA
AAAAGCTATTAATTTTAAATAAATAAAATATGATGAGAATATTTAATATTTATATGAATT
AAATTAGTAATATTTTGATTTGTTTGAAGTGATCAAACTTTTGCTTTCTCTCACTGTTGG
TGGTACACTTCTCGGTATTGTTTTTGGCATGATAGCCTAGTTTTGGATGCGTAGAATACA
TAATGATCCGATATTGACAGTCAATATAACCTTCATTGTTTGCTATCTAACTTACTATGT
AGCAGAAAATGTAGATATTGGAATAAAAGTCTCAGGAATTATGGCTCTAGTTTCTCTTGG
TATTTATCTCTCTATATTTGGTAAAACTAAAATTTCAAGTGAAGAAAAGAGAACTGTTTA
TATTTTCTGGAAGTACGTAACTTATGCTGGTGAATCAATTATTTTTATATTAGCTGGTGT
ATTAGTTGGTGTTAAAGTTTTAACATCTAATGGGGATTACGACACTATGTCAGGAAGCGA
TAATGTTTCTTCTTCAATTTAAACTAGTGATTATTTTAAACTTTTTGGTCTTTACGTTTG
TATGATCTTGAGTCGCTTTGGTAGTATTGCTTGCTTTATGTCTTGGTTGAGAAAATGGGG
TTATGGTCTTACTTGGAAGGAAGTTTATGTCCTTGCTTACGGTGGTCTTAGAGGAGCTAT
TGGTAATTTTATAAGTAAGTTAAATAAAAATAATATTTTAAATTTTATTTAGGTATTTCT
TTTGCAATGATTGTTGCTAATGATGACTCTTACTCTCAAAAATTAAGAGATATTATTTTA
TTCGATATGGCTGGAAATGCAATTTTAACATTAATTATCAATGGAACAACTACTGGTAAT
TTGTTTAATTTTAAATAAAGTATTTATTACAAATTTTATGATATTTTTAGGTCCTTTGAT
TAAGAGTTTAGGATTATGCGTTACAAGCACAGTTAGAGAAAGAGTCTTTTTAAATATTTT
ACAAGATTTGAAGGAAGATACTGAAAAAAAGATTAATTATTTGAAATCTAATAACTATCT
AAAGATGGTCAATTGGGATAGTGTTAAAGAATATGTAGGATTAGCAGATTTGGAGCAAAG
AATTACAAGATTAGAGTCAGATCTAACTAAAAGAGAAGAAATTGAAGAGTATACAAGAAA
TATAAGAAATAAAAATGTAATTGATGCTAAGATAGATGAACTTAAAAACTCTAATGAATT
TTAAGAGTAGTAATCATTTGACTCAGATTCAACAAATCACAATCTTGATGAAAATATGAT
AGTTGAATGTAGAAATAGATTTTTGATGGCTCTCAAAGGAAATTATTGGTACAAAAATTT
CAAAAAAATTTATTTTTTTTATTTCTAACTTTAAATAATTTTGAATAAAGGGATATTTAT
GAAAGAAATCAGTGCAGCAGTAATGCTTTATTATTGTTGATTGATTCAGTAAATTGGGAT
CTGGATACTGAATAAGAAAGAATGAACTCATGGGAATTTCTTTCCAATTACTTTTACAAT
CCTATTTACATCAAAGTGCTCTTTTAATTAAAAGGATGGCCTATTGTTGGATCTTATGCT
GGTAACCTCCTCTTTAACCATATCTCTAATATTTATGATGTCATTGCTGCTTATATTGAA
GCTCATGAACAAGCTGAGCAACTTTGCATAGATCAATTCCCTTTCATTCCCTAAGTAAAT
AAATACATTTACAAGAGCATAAAAAAGAATTGTATTTTTTACAAATTAATATTAAAAATA
GGTTTTAGAAATTATTATCAGAGAAAGCTAAGATAATAGAATGAGTGGCGAAGAGTATAT
CAAAAATGATTTAAATGTAAGTTTCCCAGAAATTACTAAACAAATCCAAACTAAGAAGGC
AACCTACAGTTTATTAGAGTGCTAAAAGAAAATAATAAAGAAGGGTATTTTGTTAGGTAA
GATAGATGAAAAAGAAAGAGATATATTAATGTAATAAATCGATGATAGAGTAGTTGCTTT
AGACAACATCAAACCTTCTTGGAAAGCTCCTCCAATCAAAAATTTCTTAGAAAATGTAAT
ATTTTTATTTATAGTAAAATTTTTTAAAACAAAATAAAAAATAAAGGTTCCATTCTTTAA
ACTCATCCACAAAGATTTACTTCCATACATCATCAAAGAATCTGTTGAGATGATTTTTGA
AAAAGATATGTACATCATCAAAGAAGGTGAGAAAGCTAAATACTTTTTTGTTATCACTAG
AGGTAGTGCTACAGAAACAACATCTTAGAGCTTTTGCACGTAAATTTATAATTATTTATT
CAGTAAATGTTATGTCTTTTTAGATATCAAGAATAAAAGGAAGTTGGCAGTTTAATTTCT
CCTCACCACTTGATTGTACCAAGTTTGAGATACTTGACTTCCTGCATGGCTAATGCAGTT
GTATACGTTCTTGCTTTCCCTTTAAGCTCAATTTAGAAAGTTATCAAAGTTAATTTAGAA
ATAAAGGAATATGTTTGGATGTAGAGTCTGAGAGCATTGAGTTAGCTTTTCTATAATGAA
CTTAAACCTTTAGGAAGTTTAGATAGAAACAGTTTTATTAAACTTCAACCAAAGTTGAAA
TTTGCTAAATATAAGTAAACATTTTTAATAAATTAAATTTTTCTAGTTATGCTTAATTGA
TGGCTTAAAAAAATAGCAAAGGGAAGACTATCTAGTGTGAAAGTGGTGGTATTCTTTTGA
AAGGACAAGTTTCGAGAAAGGATTTAACAGATGTGATGATGACATAATCTAAAGTAAATA
ATGACGAGGTAAAAAAATCAGATTTGATTGATGGTAGAATTTATAAGGTAAATAAAATAT
TTATTAGTTATGAAAATATCATTTATTTTTAATCTTAAAAAAATAGGCATTTTGTGTTTT
AATGCCAGGATAAGCTTTTTCAGTTTTCACAGAAAAGAAGTGTACATTTTTGCACTTTGC
TGAAGACTGTGAAGAAATTAGGTTTATGATTAGTCATATGGACTACAATGTTGGCATTAA
TTAGTAAACACCTCATACTCTTAACATATTTAGTCCTGTAGCTGTTTCTGGATCTCATAA
TAAGAGAAACAGTTTTTAAGCTCCCCACTTAAGTAGATTTGCAGGTAGACATACTTTTAA
TAATTTAGAAGTAGTTGTGCAAGGTAGTGAAAATAAAATAAATTCAGGATAATAAATAGA
ATTGCAAAAGATGAAATCTAAATCATACTTAAACGACTAACAAATAAAGAGTGTAAAGAG
TGATGATGAAGAATCAGATGATAATAAAGAAAAGTGA