Identifiers and Description

Gene Model Identifier

TTHERM_00242120

Standard Name

AAT1 (Aspartyl protease AcetylTransferase 1)

Aliases

PreTt18950 | 20.m00414 | 3706.m00178 | APAT1

Description

eukaryotic aspartyl protease

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• aspartic-type endopeptidase activity (IEA) | GO:0004190
• N-acetyltransferase activity (IEA) | GO:0008080

Biological Process

• metabolic process (IEA) | GO:0008152
• proteolysis (IEA) | GO:0006508

Domains

• ( PF08445 ) FR47-like protein
• ( PF01657 ) Domain of unknown function
• ( PF00026 ) Eukaryotic aspartyl protease
• ( PF00583 ) acetyltransferase, GNAT family
• ( TIGR03065 ) sortase B signal domain, QVPTGV
• ( TIGR01575 ) ribosomal-protein-alanine acetyltransferase

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: Yes
Presense Probability: 88.7%

TetraMine Data

TTHERM_00242120

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_07781.1	8.998537725811687e-130	hypothetical protein (433 aa)
DictyBase	DDB_G0279411	1.9991095569230066e-20	ctsD on chromosome: 3 position 2104523 to 2105867
WormBase	WBGene00000217	0.000000000000001999258566166494	locus:asp-4 status:Confirmed UniProt:Q21966 protein_id :CAA90633.1
Oxytricha	Contig20708.0.g67	0.000000000000008002679274403579	Eukaryotic aspartyl protease
SGD	YPL154C	0.000000000000020000882446601127	PEP4 Vacuolar aspartyl proteas e (proteinase A), required for the posttranslational precurs or maturation of vacuolar prot einases; important for protein turnover after oxidative dama ge; synthesized as a zymogen, self-activates
Stentor Coeruleus	SteCoe_31827	0.0000000007582560427911907

General Information

Paragraph No	Gene Name	Paragraph Text
92	AAT1	APAT1 contains an Asp domain (E-value 3.9e-32). Proteins that contain this domains typically catalyze the transfer of acetyl groups and include pepsin-like aspartate proteases. APAT1 is likely to cut peptide bonds, take out the aspartyl group, and substitute it with an acetyl group. Paragraph by: Anna Cechony and Marzia Zendali (undergraduates), Keck Science Department, Scripps College.

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00242120(coding)
ATGATTTTTTAAAATAGAAATTTTCTGCTACTTTTCTTAGGTTTTCTATCTTTATTTTCT
ATCATAAGCTCTAAAGAAGTTTAACTGATTAAGATTGATTTGGATAAAAATGAAAGAGAT
AATGAAAAAACTCTCTTATCATAAAGCTCAACTATCAATTTGTTAAATTAGGAAAATCTT
GCTTATGTTGGATTAGTATAAATTGGTACTCCTGCTTAAAATTTTTATGTTATATATGAT
ACAGGTTCTAATGATCTTTTTGTTTAATAATATGGTTGTTAAGGGTGTACAGTTACACCT
AGTTTAGGCTATACACCAAATGTCTATAAATCTTGGCTATCATCTACAAGCAGTGTTTCA
ACTAATAAAATATAGCTGAGTTATGGATCATTAACTGCATACGGATATAAAGGAAATGAA
AGTGTTTGGTTAAATGGGCACGCTGCAACTGCATTTAAAATGATATTTGTTTATCAAGAA
GGTAGTTCATAGTTTGGTAGTAAAAGTTCAGCTTTTGATGGTATAATGGGTTTGTCTAAT
GCCTAATCAAATATTAATATATTTGAATAAGGAAAATCGGAAGGAGTTTTAAATACTTCT
CTCTTTGCATTTGATTTAGCAAATAATAAATTTTACTATGATGATATCGATTAAAAATAT
CTCGATGCTCCATCAGTACCTTGTTCCATGGATGATAGATGGACATTCACAATTTTAGGC
CTTCATATTAATGGATAAGATTATACTGATAGTTTAAGCTCTTAAGATGGCTTAGTTGAC
TCAGGAACATCTTTGATTTATTTAAGCAATGGAGTTATATCTGCAATTGTAAATTCAAGT
AGTAAATTTTCAAGTAGACTTTAAGGAGCATATAGCTTAGATAATTGTGCTGGTTGCTTA
TGCTAAGAAATCAATTTTCTTCCTGTAATAGAATTTTATTCAAGAGGAGCTTTAATACTG
TTACCTCCTTCTTAGTACATGATGGTATATTCTTAATACTGTATATTGTCAATTTAAGAC
AGCTCATAATTCGGATTCAATCTTTTAGGTGATGCTTTTATGAGATAGCTAGTTGTTACA
TACAACAAATAAGATAATGAAATGACTTTCTATGGACCAAACAGCTCTTTTATGACTAAC
AAGAAAACTATACCAACTTTTATAGTTTTAACAGTATTTGCTGCATTAGGAATTTTAGCA
CTCCTTTTTGTTTCATATAGAGCTCATAAAGTTAAACAAAGTTTATATTACAATAACTCA
CCTTTAACTAGGAGATTAATTTGA

>TTHERM_00242120(protein)
MIFQNRNFLLLFLGFLSLFSIISSKEVQLIKIDLDKNERDNEKTLLSQSSTINLLNQENL
AYVGLVQIGTPAQNFYVIYDTGSNDLFVQQYGCQGCTVTPSLGYTPNVYKSWLSSTSSVS
TNKIQLSYGSLTAYGYKGNESVWLNGHAATAFKMIFVYQEGSSQFGSKSSAFDGIMGLSN
AQSNINIFEQGKSEGVLNTSLFAFDLANNKFYYDDIDQKYLDAPSVPCSMDDRWTFTILG
LHINGQDYTDSLSSQDGLVDSGTSLIYLSNGVISAIVNSSSKFSSRLQGAYSLDNCAGCL
CQEINFLPVIEFYSRGALILLPPSQYMMVYSQYCILSIQDSSQFGFNLLGDAFMRQLVVT
YNKQDNEMTFYGPNSSFMTNKKTIPTFIVLTVFAALGILALLFVSYRAHKVKQSLYYNNS
PLTRRLI

>TTHERM_00242120(gene)
ATGATTTTTTAAAATAGAAATTTTCTGCTACTTTTCTTAGGTTTTCTATCTTTATTTTCT
ATCATAAGTAAACTCTTTGCTATTATATTTTACTGCGCAAAATTCATTATAAATTATCAG
CAATTCCAATTATCATATTAAAATAGGCTCTAAAGAAGTTTAACTGATTAAGATTGATTT
GGATAAAAATGAAAGAGATAATGAAAAAACTCTCTTATCATAAAGCTCAACTATCAATTT
GTTAAATTAGGAAAATGTAATATAACTATTATAAATTTATAATGTATTAAATTTAAATTT
GAAATTTATTTACAGCTTGCTTATGTTGGATTAGTATAAATTGGTACTCCTGCTTAAAAT
TTTTATGTTATATATGATACAGGTTCTAATGTAATTATTTATTTACTTCAAATCTTTAAA
AATATACTCATTATTATAATAAATATAAGGATCTTTTTGTTTAATAATATGGTTGTTAAG
GGTGTACAGTTACACCTAGTTTAGGCTATACACCAAATGTCTATAAATCTTGGCTATCAT
CTACAAGCAGTGTTTCAACTAATAAAATATAGCTGAGTGTAATAAATCTTTTATTTTTAA
AGAATTTAACTAACTACAACTAAAAAATAAATAGTATGGATCATTAACTGCATACGGATA
TAAAGGAAATGAAAGTGTTTGGTTAAATGGGCACGCTGCAACTGCATTTAAAATGATATT
TGTTTATCAAGAAGGTAGTTCATAGTTTGGTAGTAAAAGTGTAATGAATTTACAATTTAA
TTTTGTTAGAAATTAAATTAGAATAACTAAAATGAAATTTAATTTTTTTTTTTTCCAAAC
AGTCAGCTTTTGATGGTATAATGGGTTTGTCTAATGCCTAATCAAATATTAATATATTTG
AATAAGGAAAATCGGAAGGAGTTTTAAATGTAATTTTTTACTTTACAATAGACTAAATAA
ATTGAAATATATTTCATAATTCAAAGACTTCTCTCTTTGCATTTGATTTAGCAAATAATA
AATTTTACTATGATGATATCGATTAAAAATATCTCGATGCTCCATCAGTACCTTGTTCCA
TGGATGATAGATGGGTAAATTTTTAATTTCTTGAGAAATTATAACAATTTTGATTTTATA
ATTTCTAATAGACATTCACAATTTTAGGCCTTCATATTAATGGATAAGATTATACTGATA
GTTTAAGCTCTTAAGATGGCTTAGTTGACTCAGGAACATCTTTGATTTATTTAAGCAATG
GTATTGAAATATAAACTAATAATATAATTAAATACTTTTACTATGACATTTTTTTTTAAA
AAACTATATCATTTTAAAAATATTATATTTTAATAAAACTAAAAGGAGTTATATCTGCAA
TTGTAAATTCAAGTAGTAAATTTTCAAGTAGACTTTAAGGAGCATATAGCTTAGATAATT
GTGCTGGTTGCTTATGCTAAGAAATCAATTTTCTTCCTGTAATAGAATTTTATTCAAGAG
GAGCTTTAATACTGTTACCTCCTTCTTAGTACATGATGGTATATTCTTAATACTGTATAT
TGTCAATTTAAGACAGCTCATAATTCGGATTCAATCTTTTAGGTGATGCTTTTATGAGAT
AGCTAGTTGTTACATACAACAAATAAGATAATGAAATGACTTTCTATGGGTATATTTTAA
ATAAATATAATTAATAGTATGTTTTATCAATTTAAATTTTAACTTAATAGACCAAACAGC
TCTTTTATGACTAACAAGAAAACTATACCAACTTTTATAGTTTTAACAGTATTTGCTGCA
TTAGGAATTTTAGCACTCCTTTTTGTTTCATATAGAGCTCATAAAGTTAAACAAAGTTTA
TATTACAATAACTCACCTTTAACTAGGAGATTAATTTGA