Identifiers and Description
Gene Model Identifier
TTHERM_00112430
Standard Name
MYO1 (MYOsin)
Aliases
PreTt27057 | 8.m00317 | 3812.m02353
Description
Myosin heavy chain; molecular motor involved in phagocytosis and macronuclear elongation; has putative ATP-binding and phosphorylation sites; member of proposed Class XX, distinct from previously defined myosin classes, putative
Genome Browser (Macronucleus)
Genome Browser (Micronucleus)
Gene Ontology Annotations
Cellular Component Molecular Function Biological Process
Domains
No Data fetched for Domains
Gene Expression Profile
Tetrahymena Functional Genomics Database:
Change in Gene Expression
TMHMM
Signal Peptide
Signal Peptide Present?: No
Presense Probability: 12.5%
TetraMine Data
TTHERM_00112430
WebApollo
Fullscreen View
Tetrahymena Stock Center
No Data fetched for StockID
Homologs (v.2006 protein sequences)
Source Identifier Score Description
Tetrahymena borealis EI9_03972.1 9.997093137033517e-262 myosin (1836 aa)
Oxytricha Contig18292.0.g108 2.9998177333176706e-124 Myosin head (motor domain)
DictyBase DDB_G0288679 1.9992982665753866e-121 myoE on chromosome: 5 position
1829072 to 1832587
WormBase WBGene00002038 1.0002857351297358e-115 locus:hum-5 status:Confirmed
UniProt:G5ECZ0 protein_id
:CAA84673.1
SGD YAL029C 1.0001900614163146e-108 MYO4 One of two type V myosin
motors (along with MYO2) invol
ved in actin-based transport o
f cargos; required for mRNA tr
ansport, including ASH1 mRNA,
and facilitating the growth an
d movement of ER tubules into
the growing bud along with She
3p
General Information
Paragraph No Gene Name Paragraph Text 10 MYO1 ,
MYO12 ,
MYO11 ,
MYO10 ,
MYO9 ,
MYO4 ,
MYO5 ,
MYO4 ,
MYO3 ,
MYO2 ,
MYO13 Proteins of the myosin superfamily are ATP-dependent molecular motors that travel unidirectionally along actin filaments. The myosin heavy chain proteins are comprised of three domains: a head (motor) domain responsible for ATP hydrolysis at the N-terminus, a neck (lever arm) region, and a C-terminal tail region. Thirteen predicted myosin heavy chain genes have been identified in the Tetrahymena genome and named MYO1-MYO13. A phylogenetic analysis comparing these predicted proteins with the 19 previously identified myosin classes suggests that Myo1p-Myo12p belong to a previously undescribed class of myosins. This new family, designated Class XX, does not include Myo13p, which did not branch with this class or any of the other classes in the analysis. The neck and tail regions of the Tetrahymena myosins include a variety of domains characterized in other myosin classes, with each protein containing one or more of the following domains: coiled-coil (which may support dimerization); IQ motif (binding sites for calmodulin or calmodulin-like proteins); FERM domain (Four-point-one protein, Ezrin, Radixin, Moesin homology); and MyTH4 domain (Myosin Tail Homology 4).
Associated Literature
Ref:17688250 : Hosein RE, Gavin RH (2007) Myo1 localizes to phagosomes, some of which traffic to the nucleus in a Myo1-dependent manner in Tetrahymena thermophila. Cell motility and the cytoskeleton 64(12):926-35Ref:16505385 : Foth BJ, Goedecke MC, Soldati D (2006) New insights into myosin evolution and classification. Proceedings of the National Academy of Sciences of the United States of America 103(10):3681-6Ref:15810016 : Hosein RE, Williams SA, Gavin RH (2005) Directed motility of phagosomes in Tetrahymena thermophila requires actin and Myo1p, a novel unconventional myosin. Cell motility and the cytoskeleton 61(1):49-60Ref:15988740 : Williams SA, Gavin RH (2005) Myosin genes in Tetrahymena. Cell motility and the cytoskeleton 61(4):237-43Ref:11128708 : Williams SA, Hosein RE, Garcés JA, Gavin RH (2000) MYO1, a novel, unconventional myosin gene affects endocytosis and macronuclear elongation in Tetrahymena thermophila. The Journal of eukaryotic microbiology 47(6):561-8Ref:9627986 : Garcés J, Gavin RH (1998) A PCR screen identifies a novel, unconventional myosin heavy chain gene (MYO1) in Tetrahymena thermophila. The Journal of eukaryotic microbiology 45(3):252-9
Sequences
>TTHERM_00112430(coding)ATG AAT AAA AGT TAT TAA GAA TGG ATT AAT CCT AAT GTA GAG TGT TGG GTT TGG CTC AAA TAT GAA AAT TCT TAG CAA AAT TAA AAC AAT TCT GAA AAT GGA TAA TAT TTC TAG TGC GTT ATT CAA TCA GTA TAA AAA GAA AAG AAT TTA GCA AAG ATA AAA GTT ACT TGT AAA GAA GAA TAA TTA GGA AAT CGA ATA TCA GAT TAA GCA ATT AAT GGA TAA TTA GAT GTT TAA TTT GAA AGA TTA TTA GAA AAG GAA ATT ATG GTT GAT TCT CTT CAA ACT TTA GGT TAT TCA GAT ATG GTT CAT ATG AAG TAT TTA AAT GAG GCT GAA ATA ATC AAT AAT TTG AGA AAG CGA TAT TAA AAT AAT ATG ATT TTC ACA TAT ATT GGA CCA ACT TTG GTA GTT ATG AAT CCA TAT AAA GAA ATA GAA GGA GTA TAA GAT AAT CAA GTA ATA GAT AAA ATA AAA TCT GAT CTA GGC ATA AAA TTT GAA GAG GAT TTC AAA ATG AAT AAT CTG AGC ACC AAC TAA AAT ATT ATA AAC ACA CCT CAT ACA TAT ACT GTA AGC GGA TTA GCC TAC AAA TAA ATG TTT AGC AAT AAG AAA AAT TAA GCA ATA GTT ATA TCA GGC GAA AGT GGA GCA GGT AAA ACA GAA AAT GCT AAA TTA TCG ATG CAA TTT TTA ACA AGT TTG AGT TCA GGG TCT GAT AAA TAA AAT GAT TTA CTC AAT TAA TTA AAG ACT CAA ACA GCT AAG AAT ATT CTA TTA GAA GAG TTT AAC TAA TTT GCA ATA GAA GTA AAA ATA CTT GCT TGT AAT CCT ATT CTA GAA GCT TTT GGT AAT GCT AAA ACA GTA AGA AAT AAT AAT TCC TCT AGA TTT GGT AAA TAC GTA AAA ATC TAC ATA GAT AAA ACA TCT TAA AAG ATA AAT GGA GCC TCC ATT GAT AGC TAC TTA CTC GAA AAG AGC AGA ATA CCT TGT CCA GGA AAG GGA GAG AGA AAT TAT CAC ATT TTT TAC CAC ATG CTA AAA GGA AAT CAA GAA CTA TCT AAT TTG AGA TTG AGT TAG TTC AAA AAT TTA TCT GAT TTT GAT TAT CTA AAG AAA AGT GAC TGC TTT GAG GTT GAG AAC ATT TAA GAT GCT AAA CTC TAT TTG GAA GTA AAG AAG TCC TTC AGA TAA ATG AAT TTC TCT AAC TAA GAG TAA GAA GCT ATA TTT TCT CTA ATA TCT GCG ATA CTA CTG TTA GGC AAT GCA AAT TTA GAC TCA TCA AAA GCT AGC GAC ACT CAG GCT CCA ACT TTT TTG AAC ATG AGT TTA CCG ACA CAT CAT AAA GAA TTC AAA AAT GCC TCT GAG TTA CTC TAA GTT AAT CCT AAA GAC CTT GAA GAG TCT TTA GTA TTT AAG GTA AGG AAA GTT GGA ACT ACA GTA ATT AAA TCT CCA TAA ACT GCT GAA GAA TGC TTG TCT ATG AGA GAC AGT CTA AGT AAA AAT CTA TAT GAT AGT CTT TTT AAC TTT TTG GTT TGG AAG TTA AAT TAA AAT TTG TTG CCA CCT TAA GAT TTG CTA AAT AAA TCA TTA AGC ATA GGC CTT TTA GAT ATA TTT GGT TTT GAG AGC TTT GAT ATA AAC TCA TTT GAG CAG CTT TGC ATT AAT TTT ACC AAT GAA AAA TTT TAG TAA TTG TAT GTT TAA TAT GTT TTC AAA AGC GAA GAA GAA GAT TAT AAA TAA GAA GGA ATT TTG GAT GTA TTT TCT GAT TTA TAA TAT TAA GAG AAT TAG CTC ATT ATT GAT ACA ATT GAA AAA AAA CCC AAT GGA ATC ATG GTG CTT TTA GAT GAA AAT TGC TCA TTG GGA TCA GGG ACG GAT GAT TCT TTT TTA AAT TAA ATT ACA AAA AAC CAC TCT AAA AAT CAA CTT GTC AGC TTC CCT AAA AAA GAT AAA TAT TCT TTC AGC CTT AGT CAT ACA GCA AAA CAA GTT GTA TAT GAT GTG CGC GGA TTT AGA GAT AAA AAT AAA GAT GAA GTG AGT ACC GAA GTA GAA AAA TGT CTT TAA AGT AGT AAA TGT CCA GTT ATT GCG AAT TTA TTA TCT TAT TAA GGG TCT TAA ACT TAG TAG AAT AAA GAA ACT TAA AAT CTT CAA AAT TTT GGA AAT AAT TTA AAT TTT AAA AAA GCT GAA ATT AGT AAT CAA ATG AAC TCA AGT AAA AAG AAT GTA AAG TTT CTA GGC TAA AAA TTT AGA TAA TCT TTA TAG GAA TTA ATG ATA GAA TTG AAT AAT AGC GAT GTT CAC TTC ATA AGA TGT ATA AAA CCA AAC GAA GAA AAG AAA AAG AAT TTT TTT AAG TAT GAT TAT GTT TAT TAG CAA GTA CAG TAT TTA GGC ATA CTT GAT TCC ATT AAA ATC CGC AAA GTT GGA TAT TCT TAC AGA ATG ACT TAT GAA AAC TTT TTC TTA GAA TAC CAA GAA CTG GGA TAG AAA ACA AAA GGA TTA ACA TTG TAG AAG GTT TAG CAA TAA AAG TTA GAT TTA AAA TAA TTA ATT ACA ACA GAA ATA TTT GAA AAG ACC AAT TTA TTG CAA AAT AAA TAA CTT CCT TAG AAA TGT GTA GCA TTT GGA AAA ACA AAA ATA TTT CTC AAA AAT GAA GTT ATG AAG ATT TTG CAT GAA AAA ATT TAA GAA ATT ATT TAA TAA AGA AAA AAA TAT GCA AAG CGA ATT ATT GTC TCA ATT TAA AAA TAT CTG TTT AGG AAA TAC TTC CAT AAG AAT TTA ATG AAA ATA AAA AAT TAA TTA ATT AAA TTG CAA TCA TTT GCT AGA ATG GCT ATT TAA AGA TAA AAA TTC CTA AGG AAA AAG AAA TCA ATA TTA AAA ATG AAG AAG CTT ATT AGG CTA AGA ATG TTG GGA TAA GGA ATC TCT GCA TTT AGG TTA AAC TAT ATC TCA TTT GTG TGG GAT TTG GTT TGT TTT ATG ATA TTT GAT AAA ACA AAT ATT CAT ATT GCA TTT TAG TAA ATT AAA TAT TAT CGT AAC CCA AAT AAA ACT AAG CCT GTT GTT CAA AAT TAA ACA TCT ACA ATT TAG TAA AAT AAA TAG TAA AAT CAA CAA CCT TAA AAA AGC CAA AAT TAA GTT ACT TCA TCA TTT TAA GTA AAT AAT TAA ATG ATG CAA TAA AAA TAA AGT CTT GTA GGC CAA TAA ATT TAA TCT ATT GTA AAC GAG CTT AAT TTA GGT GAG ATA TAA ATT AAT AAA ACC TAA CAA GAT TTA AAA GAC TTT AGA AAA TCA AAG ATT ATA CCT TAA GTT AAC TTG AAT CCA TCA CAT AGT AGT AAG AGG GCC AGC AAT GCT TGG AGA TAA ACC CTA ATT GCA AGT AGT AGT TAA AAT AAA ATT AAT AAA GAT TTG TAG CTA TCT GAA TTA GGA GAG TAG AAG CTG ATA AAT ATG AAA GAA ACA ACT GAC TAA AAA GAA AAA ATT AAA TAT ACT AAA CCT CTG ATA TTA TAA TTT ACA GAG TAT AAC CCT GCT TAT TAG TAT GCA GAG TTT AAT ATG GAG AGT GCA ATA GAT TTA GAA GAT GTT CCT AAT AGT TTA GAT TTT GAG GGT GAA TTA AAT GAT TTG ATA AGT GAA GAA ATC ATT CAA TAA ATA AAA AAA AAT AAC TTT TAT TCA CAC CTT TCT TTT ATT CTT GCA AAA AGA ACA AAA TGG GGA ATC ACA CAA ACT TAA GAG AAA ATA ATG AGG CAC TAG CTT AAA CCA ATT TCA AAT CCA CTA ACA AAT ATT GCT GAT TTG AAG AAT ATA ATC ACC TAT GAA GAC ACA AAA GAT GCT GTT TAA TCA ATT AGG AGT ATT ATT CAA TAA AAT AAT TTA TAT AAT GAC ACA TCA ACA TAG ACT TAA AGA CCA ATT AAT TAT GAA GAT GCT AGA ACT GGA AAA TTA GAT AAG TAA GTA TCT AAA TAA ATT ACT AAC GAT TAA TCA CAA AAA TTA GCA ACT GTC TTT TCG AAA TAT TCT CTG ATG AAC CCA AGA AAA GCT AGT GTT AGA GAC ACA AAC TCA CTT GAA CAA ATT GTC CTA TAA TAA AGA AAA CTT ACA AAA TTA ATT TAG TAT AAA AAA TTT TCT CCT TCA GAA AAA GCT ATT AAC ATA TTT AAA ACT CTC TTA AAG TGC ACA GGA GAA AGA AAA TCC CGA TAT AAC AGA CAC AAC AAT ATC ATA AAG CTT CTT ACC CTT TGT AAC GAA GAG TCA ATC GAC CTA AAA GAA GAA GTT TAC GTT TAA TTA TGC AAA TAA TTA AGT GCA AAT GAT AAA AAG GAG TCA AGA ATA AAA TAT TTA AAG CTG TTT GCT ATT ATA AGC AGC ATA CTG CCA ACA ACC AGT AGA TTT TAT TAT CCT TTA CTT CAC TTT TTA TAT ATG AGA AAT ACA GAT ACT CAA ATA GAA TAG GAT GAG AGA AAA TGG TAC TAA TAC TGT TTT CAA AGA ATT TAT AAA AGT GAG TAA ATA CAA AGA GGA TGC ATC CCA ACT GAT ACT GAA ATT GTA ATG ATT GAG AAT AAG AAA CAA ATT TTG ATT AGA GTT TAT CTT CTA AAT GAA ATC CCA ATT ACT GTA GGA GTA GAA AGC TAT ACT AGT GTG AAG ATG CTT AAG CAG GAG CTA CTT TAG AAA ATA GGT ATA ACC TAA AGA CAT GAA TAT TAT GGC CTT ATG GAA GTA AGA AAC AAT ATT AAG AAA AAG AGA AAA GAA ACG AGA TTT ATA GAT GAA AGT GAG AGA GTA ATG GAT GTG ATA GCT TTT TGG GAA AAT GAG TAG TAT TTA TTT GGA TCT CAA TTA AAT TCT TCT TTC ATA CAT AGC AAC TCA AAA TAA AAT GAT GAA GGT ATT GAG CAA TTC AAC CTT TAA AAT TAT TAG GAT CTT GAA GGA CTT AAA ATT TAC CTT GGA ATC AGA ATA CTT TTT TCA TTT TAA GAA AAC GAT AAA GAA GCA ATA AGC GTT TTC TAC ACT TAG CTA TCT TCA GAA GTA CTT GAA GGA AAG TAT GCA CCT TTG GAG GAA AAA GAT TAC TTG AAT TTG GCT GCT TTA TAA CTG TGC ATA GAT TTT CCA AGA GAC GTC ATT TTA AAA GAA ATA TCT AAA AGA TAG AGT ATC AAT GCA GAT AGT GGG TCT CCA TAA AGA ACA TAG AGT AAT TTT TTG AGT GCT ACT AGC TAA AGT GAA AGC GGT GCA TCA CAG CTT AAA AAG CTT TCT TAT TAA GAT ATT GAA CAG ATT GAT GAA TAA GAT GAA TAC GAA CAA TTC ATA TAA AAT AGA AAT GAA ATT TTA ATT GAT CCG GTT TTT TAC ATA CCA GCT AAA ATG TAT TTC TAA AAA GAT ATT CAG TAA TGG TAA CAC TTA ATA CTA TAG AAT TTG GTT GAT AAT AGA CTT TTA AAG AAA GAG TAC ACT CCA TCT TAA GCA AAG TTA GCC TAC ATA CTT TAT CTT AGT AAG TAA GAT TTG TTT ATG AGT ACA ATA TTT AGA GAT GTA AAA TAC CAA AGA ATC AAA ATT AAA ACA CTA AAT GAC ACA CTT TCT TCT AAA GAA AAA TAT GAG CAA ATG ATT TAA TAA AAT TAA CAA ATT CCC ATT AAA GAC GAG ATA CTT TTA GCA ATA AAC CCA TCT AAT ATT CTG ATG TGC GAT TCT ATA GGT TTA AAT AGA CCA AAA AGA AGA GTG CAA ATT AAA AAT ATC TAA AAA TTT TGC TGC ACT GAG AAG GAA GTT ATA GTA ATA TCT CAT GAT AAT ACA AAA CAT ATT TTT GAA ACT CCC CAA TAC TGT AGA GAA ATA GCT TTC TTA ATT CGC TCT TAC TTG AGA ATA TTT TAT TAA AAA TAA TAG TAA CAA CAA TAA TAA GAA AAA AGT CAA TGA >TTHERM_00112430(protein)M N K S Y Q E W I N P N V E C W V W L K Y E N S Q Q N Q N N S E N G Q Y F Q C V I Q S V Q K E K N L A K I K V T C K E E Q L G N R I S D Q A I N G Q L D V Q F E R L L E K E I M V D S L Q T L G Y S D M V H M K Y L N E A E I I N N L R K R Y Q N N M I F T Y I G P T L V V M N P Y K E I E G V Q D N Q V I D K I K S D L G I K F E E D F K M N N L S T N Q N I I N T P H T Y T V S G L A Y K Q M F S N K K N Q A I V I S G E S G A G K T E N A K L S M Q F L T S L S S G S D K Q N D L L N Q L K T Q T A K N I L L E E F N Q F A I E V K I L A C N P I L E A F G N A K T V R N N N S S R F G K Y V K I Y I D K T S Q K I N G A S I D S Y L L E K S R I P C P G K G E R N Y H I F Y H M L K G N Q E L S N L R L S Q F K N L S D F D Y L K K S D C F E V E N I Q D A K L Y L E V K K S F R Q M N F S N Q E Q E A I F S L I S A I L L L G N A N L D S S K A S D T Q A P T F L N M S L P T H H K E F K N A S E L L Q V N P K D L E E S L V F K V R K V G T T V I K S P Q T A E E C L S M R D S L S K N L Y D S L F N F L V W K L N Q N L L P P Q D L L N K S L S I G L L D I F G F E S F D I N S F E Q L C I N F T N E K F Q Q L Y V Q Y V F K S E E E D Y K Q E G I L D V F S D L Q Y Q E N Q L I I D T I E K K P N G I M V L L D E N C S L G S G T D D S F L N Q I T K N H S K N Q L V S F P K K D K Y S F S L S H T A K Q V V Y D V R G F R D K N K D E V S T E V E K C L Q S S K C P V I A N L L S Y Q G S Q T Q Q N K E T Q N L Q N F G N N L N F K K A E I S N Q M N S S K K N V K F L G Q K F R Q S L Q E L M I E L N N S D V H F I R C I K P N E E K K K N F F K Y D Y V Y Q Q V Q Y L G I L D S I K I R K V G Y S Y R M T Y E N F F L E Y Q E L G Q K T K G L T L Q K V Q Q Q K L D L K Q L I T T E I F E K T N L L Q N K Q L P Q K C V A F G K T K I F L K N E V M K I L H E K I Q E I I Q Q R K K Y A K R I I V S I Q K Y L F R K Y F H K N L M K I K N Q L I K L Q S F A R M A I Q R Q K F L R K K K S I L K M K K L I R L R M L G Q G I S A F R L N Y I S F V W D L V C F M I F D K T N I H I A F Q Q I K Y Y R N P N K T K P V V Q N Q T S T I Q Q N K Q Q N Q Q P Q K S Q N Q V T S S F Q V N N Q M M Q Q K Q S L V G Q Q I Q S I V N E L N L G E I Q I N K T Q Q D L K D F R K S K I I P Q V N L N P S H S S K R A S N A W R Q T L I A S S S Q N K I N K D L Q L S E L G E Q K L I N M K E T T D Q K E K I K Y T K P L I L Q F T E Y N P A Y Q Y A E F N M E S A I D L E D V P N S L D F E G E L N D L I S E E I I Q Q I K K N N F Y S H L S F I L A K R T K W G I T Q T Q E K I M R H Q L K P I S N P L T N I A D L K N I I T Y E D T K D A V Q S I R S I I Q Q N N L Y N D T S T Q T Q R P I N Y E D A R T G K L D K Q V S K Q I T N D Q S Q K L A T V F S K Y S L M N P R K A S V R D T N S L E Q I V L Q Q R K L T K L I Q Y K K F S P S E K A I N I F K T L L K C T G E R K S R Y N R H N N I I K L L T L C N E E S I D L K E E V Y V Q L C K Q L S A N D K K E S R I K Y L K L F A I I S S I L P T T S R F Y Y P L L H F L Y M R N T D T Q I E Q D E R K W Y Q Y C F Q R I Y K S E Q I Q R G C I P T D T E I V M I E N K K Q I L I R V Y L L N E I P I T V G V E S Y T S V K M L K Q E L L Q K I G I T Q R H E Y Y G L M E V R N N I K K K R K E T R F I D E S E R V M D V I A F W E N E Q Y L F G S Q L N S S F I H S N S K Q N D E G I E Q F N L Q N Y Q D L E G L K I Y L G I R I L F S F Q E N D K E A I S V F Y T Q L S S E V L E G K Y A P L E E K D Y L N L A A L Q L C I D F P R D V I L K E I S K R Q S I N A D S G S P Q R T Q S N F L S A T S Q S E S G A S Q L K K L S Y Q D I E Q I D E Q D E Y E Q F I Q N R N E I L I D P V F Y I P A K M Y F Q K D I Q Q W Q H L I L Q N L V D N R L L K K E Y T P S Q A K L A Y I L Y L S K Q D L F M S T I F R D V K Y Q R I K I K T L N D T L S S K E K Y E Q M I Q Q N Q Q I P I K D E I L L A I N P S N I L M C D S I G L N R P K R R V Q I K N I Q K F C C T E K E V I V I S H D N T K H I F E T P Q Y C R E I A F L I R S Y L R I F Y Q K Q Q Q Q Q Q Q E K S Q >TTHERM_00112430(gene)ATG AAT AAA AGT TAT TAA GAA TGG ATT AAT CCT AAT GTA GAG TGT TGG GTT TGG CTC AAA TAT GAA AAT TCT TAG CAA AAT TAA AAC AAT TCT GAA AAT GGA TAA TAT TTC TAG TGC GTT ATT CAA TCA GTA TAA AAA GAA AAG AAT TTA GCA AAG ATA AAA GTT ACT TGT AAA GAA GAA TAA TTA GGA AAT CGA ATA TCA GAT TAA GCA ATT AAT GGA TAA TTA GAT GTT TAA TTT GAA AGA TTA TTA GAA AAG GAA ATT ATG GTT GAT TCT CTT CAA ACT TTA GGT TAT TCA GAT ATG GTT CAT ATG AAG TAT TTA AAT GAG GCT GAA ATA ATC AAT AAT TTG AGA AAG CGA TAT TAA AAT AAT ATG ATT TTC ACA TAT ATT GGA CCA ACT TTG GTA GTT ATG AAT CCA TAT AAA GAA ATA GAA GGA GTA TAA GAT AAT CAA GTA ATA GAT AAA ATA AAA TCT GAT CTA GGC ATA AAA TTT GAA GAG GAT TTC AAA ATG AAT AAT CTG AGC ACC AAC TAA AAT ATT ATA AAC ACA CCT CAT ACA TAT ACT GTA AGC GGA TTA GCC TAC AAA TAA ATG TTT AGC AAT AAG AAA AAT TAA GCA ATA GTT ATA TCA GGC GAA AGT GGA GCA GGT AAA ACA GAA AAT GCT AAA TTA TCG ATG CAA TTT TTA ACA AGT TTG AGT TCA GGG TCT GAT AAA TAA AAT GAT TTA CTC AAT TAA TTA AAG ACT CAA ACA GCT AAG AAT ATT CTA TTA GAA GAG TTT AAC TAA TTT GCA ATA GAA GTA AAA ATA CTT GCT TGT AAT CCT ATT CTA GAA GCT TTT GGT AAT GCT AAA ACA GTA AGA AAT AAT AAT TCC TCT AGA TTT GGT AAA TAC GTA AAA ATC TAC ATA GAT AAA ACA TCT TAA AAG ATA AAT GGA GCC TCC ATT GAT AGC TAC TTA CTC GAA AAG AGC AGA ATA CCT TGT CCA GGA AAG GGA GAG AGA AAT TAT CAC ATT TTT TAC CAC ATG CTA AAA GGA AAT CAA GAA CTA TCT AAT TTG AGA TTG AGT TAG TTC AAA AAT TTA TCT GAT TTT GAT TAT CTA AAG AAA AGT GAC TGC TTT GAG GTT GAG AAC ATT TAA GAT GCT AAA CTC TAT TTG GAA GTA AAG AAG TCC TTC AGA TAA ATG AAT TTC TCT AAC TAA GAG TAA GAA GCT ATA TTT TCT CTA ATA TCT GCG ATA CTA CTG TTA GGC AAT GCA AAT TTA GAC TCA TCA AAA GCT AGC GAC ACT CAG GCT CCA ACT TTT TTG AAC ATG AGT TTA CCG ACA CAT CAT AAA GAA TTC AAA AAT GCC TCT GAG TTA CTC TAA GTT AAT CCT AAA GAC CTT GAA GAG TCT TTA GTA TTT AAG GTA AGG AAA GTT GGA ACT ACA GTA ATT AAA TCT CCA TAA ACT GCT GAA GAA TGC TTG TCT ATG AGA GAC AGT CTA AGT AAA AAT CTA TAT GAT AGT CTT TTT AAC TTT TTG GTT TGG AAG TTA AAT TAA AAT TTG TTG CCA CCT TAA GAT TTG CTA AAT AAA TCA TTA AGC ATA GGC CTT TTA GAT ATA TTT GGT TTT GAG AGC TTT GAT ATA AAC TCA TTT GAG CAG CTT TGC ATT AAT TTT ACC AAT GAA AAA TTT TAG TAA TTG TAT GTT TAA TAT GTT TTC AAA AGC GAA GAA GAA GAT TAT AAA TAA GAA GGA ATT TTG GAT GTA TTT TCT GAT TTA TAA TAT TAA GAG AAT TAG CTC ATT ATT GAT ACA ATT GAA AAA AAA CCC AAT GGT AAA TTC TTA TTT TCA TAT TTT ACA TTT TGA TTT ATA TTT TAT TTA AAG GAA TCA TGG TGC TTT TAG ATG AAA ATT GCT CAT TGG GAT CAG GGA CGG ATG ATT CTT TTT TAA ATT AAA TTA CAA AAA ACC ACT CTA AAA ATC AAC TTG TCA GCT TCC CTA AAA AAG ATA AAT ATT CTT TCA GCC TTA GTC ATA CAG CAA AAC AAG TTG TAT ATG ATG TGC GCG GAT TTA GAG ATA AAA ATA AAG ATG AAG TGA GTA CCG AAG TAG AAA AAT GTC TTT AAA GTA GTA AAT GTC CAG TTA TTG CGA ATT TAT TAT CTT ATT AAG GGT CTT AAA CTT AGT AGA ATA AAG AAA CTT AAA ATC TTC AAA ATT TTG GAA ATA ATT TAA ATT TTA AAA AAG CTG AAA TTA GTA ATC AAA TGA ACT CAA GTA AAA AGA ATG TAA AGT TTC TAG GCT AAA AAT TTA GAT AAT CTT TAT AGG AAT TAA TGA TAG AAT TGA ATA ATA GCG ATG TTC ACT TCA TAA GAT GTA TAA AAC CAA ACG AAG AAA AGA AAA AGA ATT TTT TTA AGT ATG ATT ATG TTT ATT AGC AAG TAC AGT ATT TAG GCA TAC TTG ATT CCA TTA AAA TCC GCA AAG TTG GAT ATT CTT ACA GAA TGA CTT ATG AAA ACT TTT TCT TAG AAT ACC AAG AAC TGG GAT AGA AAA CAA AAG GAT TAA CAT TGT AGA AGG TTT AGC AAT AAA AGT TAG ATT TAA AAT AAT TAA TTA CAA CAG AAA TAT TTG AAA AGA CCA ATT TAT TGC AAA ATA AAT AAC TTC CTT AGA AAT GTG TAG CAT TTG GAA AAA CAA AAA TAT TTC TCA AAA ATG AAG TTA TGA AGA TTT TGC ATG AAA AAA TTT AAG AAA TTA TTT AAT AAA GAA AAA AAT ATG CAA AGC GAA TTA TTG TCT CAA TTT AAA AAT ATC TGT TTA GGA AAT ACT TCC ATA AGA ATT TAA TGA AAA TAA AAA ATT AAT TAA TTA AAT TGC AAT CAT TTG CTA GAA TGG CTA TTT AAA GAT AAA AAT TCC TAA GGA AAA AGA AAT CAA TAT TAA AAA TGA AGA AGC TTA TTA GGC TAA GAA TGT TGG GAT AAG GAA TCT CTG CAT TTA GGT TAA ACT ATA TCT CAT TTG TGT GGG ATT TGG TTT GTT TTA TGA TAT TTG ATA AAA CAA ATA TTC ATA TTG CAT TTT AGT AAA TTA AAT ATT ATC GTA ACC CAA ATA AAA CTA AGC CTG TTG TTC AAA ATT AAA CAT CTA CAA TTT AGT AAA ATA AAT AGT AAA ATC AAC AAG TAA AAT TAA AAT AAA TAT TTA AAT GTT TAT TTA AAT TTT TTT ATT TTA AAA TAG CCT TAA AAA AGC CAA AAT TAA GTT ACT TCA TCA TTT TAA GTA AAT AAT TAA ATG ATG CAA TAA AAA TAA AGT CTT GTA GGC CAA TAA ATT TAA TCT ATT GTA AAC GAG CTT AAT TTA GGT GAG ATA TAA ATT AAT AAA ACC TAA CAA GAT TTA AAA GAC TTT AGA AAA TCA AAG ATT ATA CCT TAA GTT AAC TTG AAT CCA TCA CAG TAT TTA ATT TTA TTT AAA TTA TTT ATT TAA TTC GTA CAA ATT TTA AGA GAA ATC AAA ATC TAT AAA AAA TTT TTT TAG GAT TTA AAA ATT TGA GCT ATG ATT AGA TGT TAA ACA TTT TCT TAT TTT GCA TTA AAT TGA ATT TAA ATA AAA TCA TGC AAT TAT TAA TTT GAA AAT CAA TTT AAA TTA AAT TAA TAA TAA AAA TTT TAG TGA AAT TAT TAA GAC CTA CAC CCA TAA AAT GGA TTG AAA AAA TAT TTT CAC TAC TTA AAA TAT TTG TTT TAA TTA AAT TTT AAA TAA AAA TTA ATT AGT AGT AGT AAG AGG GCC AGC AAT GCT TGG AGA TAA ACC CTA ATT GCA AGT AGT AGT TAA AAT AAA ATT AAT AAA GAT TTG TAG CTA TCT GAA TTA GGA GAG TAG AAG CTG ATA AAT ATG AAA GAA ACA ACT GAC TAA AAA GAA AAA ATT AAA TAT ACT AAA CCT CTG ATA TTA TAA TTT ACA GAG TAT AAC CCT GCT TAT TAG TAT GCA GAG TTT AAT ATG GAG AGT GCA ATA GAT TTA GAA GAT GTT CCT AAT AGT TTA GAT TTT GAG GGT GAA TTA AAT GAT TTG ATA AGT GAA GAA ATC ATT CAA TAA ATA AAA AAA AAT AAC TTT TAT TCA CAC CTT TCT TTT ATT CTT GCA AAA AGA ACA AAA TGG GGA ATC ACA CAA ACT TAA GAG AAA ATA ATG AGG CAC TAG CTT AAA CCA ATT TCA AAT CCA CTA ACA AAT ATT GCT GAT TTG AAG AAT ATA ATC ACC TAT GAA GAC ACA AAA GAT GCT GTT TAA TCA ATT AGG AGT ATT ATT CAA TAA AAT AAT TTA TAT AAT GAC ACA TCA ACA TAG ACT TAA AGA CCA ATT AAT TAT GAA GAT GCT AGA ACT GGA AAA TTA GAT AAG TAA GTA TCT AAA TAA ATT ACT AAC GAT TAA TCA CAA AAA TTA GCA ACT GTC TTT TCG AAA TAT TCT CTG ATG AAC CCA AGA AAA GCT AGT GTT AGA GAC ACA AAC TCA CTT GAA CAA ATT GTC CTA TAA TAA AGA AAA CTT ACA AAA TTA ATT TAG TAT AAA AAA TTT TCT CCT TCA GAA AAA GCT ATT AAC ATA TTT AAA ACT CTC TTA AAG TGC ACA GGA GAA AGA AAA TCC CGA TAT AAC AGA CAC AAC AAT ATC ATA AAG CTT CTT ACC CTT TGT AAC GAA GAG TCA ATC GAC CTA AAA GAA GAA GTA AAT TAA AAT TTT TTT GTC AAA ATA CAT ATT TGA TTT TAA TCT CTT TTT CTT TTT TTT TTA GTG AAA AAT AAG AAT AAA TTA AAA AAA ATA AAT GCT TTA TCA ATA AAT AAA AAT TTT ATC AGC ATT AAT TAA GTT TTT AAA CTA ATA TTT TAA TCT TTT ATG ATT CAA ATA ACA TTT TTG AAA ACC ATT TTT TAA ATA TGC ATT TTG GGA AAT TTT AAA TTG ATG AAT TAA AAT ATT TTA GGT TTA CGT TTA ATT ATG CAA ATA ATT AAG TGC AAA TGA TAA AAA GGA GTC AAG AAT AAA ATA TTT AAA GCT GTT TGC TAT TAT AAG CAG CAT ACT GCC AAC AAC CAG TAG ATT TTA TTA TCC TTT ACT TCA CTT TTT ATA TAT GAG AAA TAC AGA TAC TCA AAT AGA ATA GGA TGA GAG AAA ATG GTA CTA ATA CTG TTT TCA AAG AAT TTA TAA AAG TGA GTA AAT ACA AAG AGG ATG CAT CCC AAC TGA TAC TGA AAT TGT AAT GAT TGA GAA TAA GAA ACA AAT TTT GAT TAG AGT TTA TCT TCT AAA TGA AAT CCC AAT TAC TGT AGG AGT AGA AAG CTA TAC TAG TGT GAA GAT GCT TAA GCA GGA GCT ACT TTA GAA AAT AGG TAT AAC CTA AAG ACA TGA ATA TTA TGG CCT TAT GGA AGT AAG AAA CAA TAT TAA GAA AAA GAG AAA AGA AAC GAG ATT TAT AGA TGA AAG TGA GAG AGT AAT GGA TGT GAT AGC TTT TTG GGA AAA TGA GTA GTA TTT ATT TGG ATC TCA ATT AAA TTC TTC TTT CAT ACA TAG CAA CTC AAA ATA AAA TGA TGA AGG TAT TGA GCA ATT CAA CCT TTA AAA TTA TTA GGA TCT TGA AGG ACT TAA AAT TTA CCT TGG AAT CAG AAT ACT TTT TTC ATT TTA AGA AAA CGA TAA AGA AGC AAT AAG CGT TTT CTA CAC TTA GCT ATC TTC AGA AGT ACT TGA AGG AAA GTA TGC ACC TTT GGA GGA AAA AGA TTA CTT GAA TTT GGC TGC TTT ATA ACT GTG CAT AGA TTT TCC AAG AGA CGT CAT TTT AAA AGA AAT ATC TAA AAG ATA GAG TAT CAA TGC AGA TAG TGG GTC TCC ATA AAG AAC ATA GAG TAA TTT TTT GAG TGC TAC TAG CTA AAG TGA AAG CGG TGC ATC ACA GCT TAA AAA GCT TTC TTA TTA AGA TAT TGA ACA GAT TGA TGA ATA AGA TGA ATA CGA ACA ATT CAT ATA AAA TAG AAA TGA AAT TTT AAT TGA TCC GGT TTT TTA CAT ACC AGC TAA AAT GTA TTT CTA AAA AGA TAT TCA GTA ATG GTA ACA CTT AAT ACT ATA GAA TTT GGT TGA TAA TAG ACT TTT AAA GAA AGA GTA CAC TCC ATC TTA AGC AAA GTT AGC CTA CAT ACT TTA TCT TAG TAA GTA AGA TTT GTT TAT GAG TAC AAT ATT TAG AGA TGT AAA ATA CCA AAG AAT CAA AAT TAA AAC ACT AAA TGA CAC ACT TTC TTC TAA AGA AAA ATA TGA GCA AAT GAT TTA ATA AAA TTA ACA AAT TCC CAT TAA AGA CGA GAT ACT TTT AGC AAT AAA CCC ATC TAA TAT TCT GAT GTG CGA TTC TAT AGG TTT AAA TAG ACC AAA AAG AAG AGT GCA AAT TAA AAA TAT CTA AAA ATT TTG CTG CAC TGA GAA GGA AGT TAT AGT AAT ATC TCA TGA TAA TAC AAA ACA TAT TTT TGA AAC TCC CCA ATA CTG TAG AGA AAT AGC TTT CTT AAT TCG CTC TTA CTT GAG AAT ATT TTA TTA AAA ATA ATA GTA ACA ACA ATA ATA AGA AAA AAG TCA ATG A