TGD | Gene Details

Identifiers and Description

Gene Model Identifier
TTHERM_00059050

Standard Name
MYO11 (MYOsin)

Aliases
PreTt13089 | 4.m00488 | 3707.m00133

Description
Myosin like protein; fusion of a myosin and an RCC1 protein; member of proposed myosin Class XX, distinct from previously defined myosin class

Genome Browser

Gene Ontology Annotations

Cellular Component
myosin complex (IEA) | GO:0016459
Molecular Function
ATP binding (IEA) | GO:0005524
motor activity (IEA) | GO:0003774

Domains

( TIGR01612 ) rhoptry protein
( PF00063 ) Myosin head (motor domain)
( PF00612 ) IQ calmodulin-binding motif
( TIGR00864 ) polycystin cation channel protein
( PF04508 ) Viral A-type inclusion protein repeat
( PF00415 ) Regulator of chromosome condensation (RCC1)

Gene Expression Profile

Tetrahymena Functional Genomics Database: TTHERM_00059050

Homologs (v.2006 protein sequences)

Source Identifier Score Description

ParameciumDB GSPATP00013457001 1.00028573512974e-115 Paramecium tetraurelia GSPATP0
0013457001 protein

TAIR AT1G50360 2.00053300678404e-93 myosin family protein

IPI(HUMAN) IPI:IPI00215758.3 8.00369324265737e-87 Tax_Id=9606 Splice Isoform 6
of Myosin-7A

DictyBase DDB0188056 2.99860689205368e-84 myoE myosin IE

DictyBase DDB0216200 2.99860689205368e-84 myoE myosin IE

WormBase T10H10.1 5.00062406930149e-83 WBGene00002039 hum-6 myosin

ToxoDB 49.m00001 9.9980745806224e-81 Toxoplasma gondii myosin E, pu
tative

FlyBase FBgn0040299 1.9993206333383e-80

FlyBase FBgn0040299 1.9993206333383e-80

SGD YAL029C 1.99980996899167e-77 MYO4 SGDID:S000000027, Chr I f
rom 92271-87856, reverse compl
ement, Verified ORF, "One of t
wo type V myosins; required fo
r mother-specific HO expressio
n, for the bud tip localizatio
n of ASH1 and IST2 mRNA; facil
itates growth and orientation
of ER tubules along with She3p
"

CryptoDB EAK90372 1.99946965831496e-75 Cryptosporidium parvum (Iowa)
protein EAK90372

PlasmoDB PF13_0233 6.00118235861315e-70 Plasmodium falciparum 0233

Source	Identifier	Score	Description
ParameciumDB	GSPATP00013457001	1.00028573512974e-115	Paramecium tetraurelia GSPATP0 0013457001 protein
TAIR	AT1G50360	2.00053300678404e-93	myosin family protein
IPI(HUMAN)	IPI:IPI00215758.3	8.00369324265737e-87	Tax_Id=9606 Splice Isoform 6 of Myosin-7A
DictyBase	DDB0188056	2.99860689205368e-84	myoE myosin IE
DictyBase	DDB0216200	2.99860689205368e-84	myoE myosin IE
WormBase	T10H10.1	5.00062406930149e-83	WBGene00002039 hum-6 myosin
ToxoDB	49.m00001	9.9980745806224e-81	Toxoplasma gondii myosin E, pu tative
FlyBase	FBgn0040299	1.9993206333383e-80
FlyBase	FBgn0040299	1.9993206333383e-80
SGD	YAL029C	1.99980996899167e-77	MYO4 SGDID:S000000027, Chr I f rom 92271-87856, reverse compl ement, Verified ORF, "One of t wo type V myosins; required fo r mother-specific HO expressio n, for the bud tip localizatio n of ASH1 and IST2 mRNA; facil itates growth and orientation of ER tubules along with She3p "
CryptoDB	EAK90372	1.99946965831496e-75	Cryptosporidium parvum (Iowa) protein EAK90372
PlasmoDB	PF13_0233	6.00118235861315e-70	Plasmodium falciparum 0233

General Information

Paragraph No Gene Name Paragraph Text
10 MYO1,
MYO12,
MYO11,
MYO10,
MYO9,
MYO8,
MYO5,
MYO4,
MYO3,
MYO2,
MYO13 Proteins of the myosin superfamily are ATP-dependent molecular motors that travel unidirectionally along actin filaments. The myosin heavy chain proteins are comprised of three domains: a head (motor) domain responsible for ATP hydrolysis at the N-terminus, a neck (lever arm) region, and a C-terminal tail region. Thirteen predicted myosin heavy chain genes have been identified in the Tetrahymena genome and named MYO1-MYO13. A phylogenetic analysis comparing these predicted proteins with the 19 previously identified myosin classes suggests that Myo1p-Myo12p belong to a previously undescribed class of myosins. This new family, designated Class XX, does not include Myo13p, which did not branch with this class or any of the other classes in the analysis. The neck and tail regions of the Tetrahymena myosins include a variety of domains characterized in other myosin classes, with each protein containing one or more of the following domains: coiled-coil (which may support dimerization); IQ motif (binding sites for calmodulin or calmodulin-like proteins); FERM domain (Four-point-one protein, Ezrin, Radixin, Moesin homology); and MyTH4 domain (Myosin Tail Homology 4).

Associated Literature

Ref:16505385: Foth BJ, Goedecke MC, Soldati D (2006) New insights into myosin evolution and classification. Proceedings of the National Academy of Sciences of the United States of America 103(10):3681-6
Ref:15988740: Williams SA, Gavin RH (2005) Myosin genes in Tetrahymena. Cell motility and the cytoskeleton 61(4):237-43

Sequences

>TTHERM_00059050(coding)
ATGATGCAATTTGAGGAAGGAGCACCAGTTTGGTATTCTCTTAAAGAAGGTCTGAAGAAT
ACTTCAAAATAAGCTGATGCACCTGCTTTCGTAGAATCAGTAGTCATTTCTGTAATTGAT
AAAAATAAATCTTTAATATAATTGCTAGATTAGCCCAGCCCTTCAATACTAAGCTTGCTT
AATGAGAAACAAGCTAACTAGGCAAAGCCTTCTAATTTATAAATTCAATAAGGTGGAAAT
TAAAACTTAATTGTTGTTGATAATATTTTTTTGGAACCTAGATATGATAAAGAGGATGGA
GATTATTCTTCAATAAATGATTTAGTTAACCTTCCTTTTTTAAATGAACCTGAATTGCTT
AAAGCAATAGCTCAAAGATATGTTTAGGATAAAATATTTAGCTATGTTGGTCCTACTCTT
GTTGTAGTAAATCCTTATAAAAGAATGGATCATCTATTTAATGAAAAAACACAAGAATTG
TACTAAGAGAAAGTTATTTAAAATTAAGATATTTACTCTGAATAGCCTCACATATTTGGA
ATAGCTGCTTATTGTATGCAAAGTATTTTGTAAGAAAAAACACTTAAATAAGCGATTGTA
ATATCAGGAGAGTCTGGTGCAGGTAAGACTGAAAATACAAAATATGCTATGAAATTTTTA
ACCCAAATGAATGCTTAATTTTAATAGTAAAATACACCTTAAACTTTGACTAATTTGAGA
GAAAGCTACTTAAACTTAAAATCTAGATAAACTCTAAAATCAACTGTCTCTATAGAATAA
AGAATATTAAACTGCAATCCAATTTTAGAAGCTTTTGGTAATGCTAAAACAACAAGAAAT
GATAATTCATCTAGATTTGGAAAATTAGTTATCTTGCATTTAAAGGAAGATATTGGTTCT
TCATTTTCAATCAAGTAAAAGTAAAAAAAACTAGTAATTTCGTCTGCTTCTCTTACAAAC
TACTTGCTAGAAAAAAGCAGGATAGTTTAAATTTCGCAATAAGAAAGGAATTATCATATT
TTTTATCATCTTCTAAAAGGAGCTGAGCCTCAATTTCTTTCTCAATTAGGATTGAGTCCA
GATATTTCTTCTTATAGGTATTTAAAAAGTGAGTGCAGTAATGTTGATACTTTATCTGAT
GAATAGCTGTTTTTAGAAGTTATGTCAAGTTTAGATGATTTGAATTTTACTGAAATAGAA
TAAAAGGGAATTTGGAATATAGTTAGCTGTGTCCTTTTGTTAGGAAATCTAGATTTTGAA
GAAGTTAAAACAACAGGCGATTCTTGCACTATTTCGCCTAAATAGAAATAAACAGTAGAA
ACTATATGTAAAAAGCTTTAGTGTACTGAAAAAGAATTAAATGACGCTTTAACAACTAAA
AAAAGATAAGTTAACAACAATGTTACAACTTCTCCTCTTTCTATCAAAGAGTCAATAGAT
AATAGAGACTCTTACAGTAAATTTTTATATGAAAAGCTATTCAATTGGATAGTATTTAGA
TTAAATTAGTCTATTATGGACTAAGACGAAGTAGACTAGTATACATTGCATGCCTTCGCT
CCTCAATAAAAGAGGCAAAGCATAACACAAGGGAAGAAGAGATAAATAGAGATTTTAGAT
ATATTTGGGTTTGAGGTGTTTGAGAATAACAGCTTTGAGTAATTGTGCATAAATTTTGCA
AATGAAAAGCTTTAATAACTTTATATTAGCTATATTTATGAGGGAGAAAGAAACATATTT
AAATAATAAGGATTAGAAAAATATTTAATGGAAATAAAGTATACTGATAATAAATCTATT
ATAGAGGCTCTTGACAAGCCTAAAGATCCTATTGGAGTTTTTAATTTAATTGATGATTCA
AGCAATTTAAGTACTGGAAGTGACTTAAATTTGATATCTCAAATGGAAAGGGAGCATAAA
TCAAATAGTTAGCATGTTTCCTTTTCTTAGATTTAAAAAACTAATTTTACTATTCACCAC
TCAACAGGGAGTATTGAATACAATATTACTAACTTTAGGGCAAAGAATAAGGATGAAGTC
TCATTAGCATTATAAAACTTAGCTTAATAAAAAACAATTAAGTCAATCATTTAGCTAGGA
ATTACAGATTTTAATACTTAATAAGTTGGGAGTAGAGTAACAGATAAATTTTTAGGTTCA
AAATTCAGACTTTAAATGAAAAAGTTAATGGAAGAATTAAGCTCTTGTGAGTGCCAATTT
GTAAGATGTATTAAACCTAATGCATCAAAAAAGGCAGGATTTATATAACCTAGATATTCT
CTGAATTAAATAAACTGTCTTGGTGTTTTAGAGACAATCCGTGTCAGGAAATAAGGATTT
TATAAAGACCACTGGGAGCTATATCCACCAAATTTCAATGAAATTAAAGCAGATGTAACT
ACTATGTTTTAAAAAATAACAGATTATTAAAGACTAAGTTAAAAATTAGTGGAGATGAAT
GTTGACCAAAAATAATTAGAATAAAATAATATTTTATTTGGAAATAGCATGATTTTTATA
AAAGAAAGTGCTTTAATGATCCTAACATCAAAGCTGATACAAACAAAATTGTTTAGAAAT
TACAAGCTTAAAAAATGGTTAAAAAACAGAAAGAAAGTTAAACAATTTTTGAAAGGATTA
ATTTATAGATTCAGATATTTAAAATCTGATGTTGTTGCAAAAATAAGAGGAATGAGGAAA
GCTAAGGAATTAGAAGCAAAGCAAAATATTTCTGCTAAGAAAATTTAAAAAATGATCAGA
AATTTTATCTTAAAGAAAAGAATGAAAGAAATCAGGGCAGCTTTGATGATATAACGTGCA
TATATTATGTACAAAAAGAAAGAATATTACAAATAGAAACTTAAAGGTATCAAGGAGTTT
ATAAAATCGAAATTTTTGATGTTAAAGGAAAGATCAATTTATAAAAAAAAGCTTAAAAGT
ATCCTACAAATATAAAAGTGGTATAAAAAAAATTTACAATAGAGATAAATTGAAATGTGC
AAAAAAGTCATTATGGTAATTAGTTAATCGCTTGACAAGTCTTGGCTAAAAATCAGAAAT
ATTTCAGCTATTAAGATTCAATCCCTAGTTAGAATGTTCTTGGCTAAAATTAACAACTAC
GGTATTGTAAAACAATCAAGAGAAGCTAAAAATGTAATTCTAGAAAGAAAAGCTATCTAA
AAAATTTAAAGGTATTGGAGATATAGAAATTTTTATTTATCAATGAAAAGATATAGAAAC
GCTGCTTACAGAATACAAGCCTATTTCAGAAAAAAGTGGTGCTCTGCTCTATTTCAGCTT
ATCAAAAAGAATACTAAATTCATTTAGATGCATGTAAGGTCTTGGTTGAATTAAAAATAT
TTTCTAACTGAGAAATGGGTTAAATATGATTGGAATTCAGTTAAAAGAGATGAAATGCTT
AATTAGCAAAACTTGGTCATTCTTGGAATTCCTTATAAAAAAAATTTGGTGAAAAACTTA
AAATTTTAAGAATTAAAAAATTAGTTTTATGAGTAGCACACTGTATTAAGCTTACAAAGA
GCCTAAAAAAAAATTGAGTATTTATAAAAAAAACAAAAGAACCTGGATAGATAAGATAGT
TTAGCAAAATTAGCAGCTTTAAAATAAAAGATAAAATCTTAGAAAAGTATTGTTTTATCT
TCAGCGAAGGTAAGTCAATAGCAATCTATTTAAGAATTCGAAGATTTAGGCTTAGATTAA
TAGTTAAAAATCCTAAAATCATCTATTAAGTTAGGAGGAGCAGAAAAGCAGGAGATATAA
AAATAATCTCCAATTAATGAAATTAATATTAAGCTTGATGATTGTTTAAATGGTATTGAT
TAAAATATCTTAATGTAAAATTAATTTGGCAAAATATAAATGTAAATAACCTTGAAAGAT
AATGATCAATATTAGACTTAAGTAAATGAATTCACTTCAAATAATTAGCCTAAAATTTAA
GAGTATTACTATCATGATTTGGGTCTTGAAAAGGATCATATATTATATGATTTTAATTCA
GAAAGCAGAAAAAAGCAAGTTTAAAGTTAGCTACAGGCAAAAAGAATGTCAGTTGATGTG
ATAAAGCTAAATACTATTTTACTTGATTTCGATTAATAACCATAATCACATGAAATTTAT
ACTTCTTAAATATGGGCACAGCATTACTAGGATATTCAGAGTGAACTTGAGTAATCAAAC
TCTTCAATTTTAAAAATTTTTATTGGAGATTCTTATACTACAATAGTCGGAGATAACTCA
GTCTGTTATACGTTTGGAGATGAGTTTTTAAATCATCAAGTTCACACAACAGATTAATAA
ATTTATTATAGTCCTGATAAGTTTTTAAATGATTAACCCTTATAATCTAAAATAAGTTAA
TCATCTAATAGATATTAGTAATAAACCAAAAACACATCTAACATCTATGAAAGTCCAAAT
CTACAAAGATAAATTCCTAATTACTAAGCACAATTATATTCTACTCCTCAAAAAAAATTA
TAAAATGATCTCATACCCTCTGTACTTTAAAATAATCCTCTATTTGTTTAATTAGAAACT
TAAAACTATTAATAGAATAGTTAAAAAAAATTTTAAAGTAGCTATAGTCCATAAGACTAA
TACAATAACTCTTAGCAAAAATTAAAAATGAACTAAAATAATTCAAATAATAGCTTATAT
AATAGCTTGAGAAAGTAAGCTGGTCTTTTCTAAAACTAAGAACCACCTGAACAAATCTCT
ACTTAAACTTTAAACACCTAAAATAATATTTCATATTAAACCGAAGAATAATTTAATCCA
CCTAAAAAGGTGATAAAATGCAAAATAGATAAAATAAATAGCATTTTCAAGGCTAATAAT
CAGCTGTTCATTCAAAATTAACTAAAGGATATGTATTGCTGGGGAGACAATAGTCAATTT
GAAATACCCTTTTTTGAAGATATTTATTTGTATGAAATTTCTAAAATTGATCCTTAAAAA
TCATAGTAAATTTCTTAAATAGATTAGCAAGCCATTTCTAATTAGTTTTTTTATTTGTTA
ACTGATGGAGATGTTTTACACTATAATTATAAAAAATCTATTGACTTTGAAAGAATCAGA
TTCCCTGTCTAAATATCTTAAATAAGCTGTGGAGGTCATTTTACTATGTTTTTGTCAATT
TAGGGTACACTATTCTCTTCTGGCTAAAATACTTCAGGGGAATTAGGTCATGGTGATAGA
CTATTTAGAAAAAGTCCTTAACTTATAAGCTCATTTAAGAAATTTGGAGAAAAGATCAAA
TAAGTATCTTGCGGGCTAAAGCATACAATATGTCTCACAGCATTAGGAAAGATTTTTTCC
TGGGGAAACAATAGATTTGGGTAACTAGGTGTAGGAGATACTAAATATAGATCAAATCCA
TAATTAATTTTTGTGAAAAGTAAATCTATAGACTCAATCAATTCATTTTTGCAAGTTAGA
GCTGGTTTAAGATCAAGCATAGTTTTAACAATTGACAAGCGTCTAGCGTGGTGGGGAACG
AACTCATGTTTAGATCACTAAGTATTTCCAATTGAATTAAATTTACAAGATTATAAAAAT
GATTTGAATTCTAAAGAATTGATACCTATTAAACTAATGAGTAGCTGGAGTAAAAATCTT
AGCCTTTTTTATATTATTGTAGCTGATATTACATATTGTTATAGCTAAAACAAAAGTGTA
ATCATTAAATCTCTACAGTCTCTTTCTTAGAAATGGGAAGACTAGCAAATTTTCCCTAGT
GCAGATAAAAACATAATGAAATACATACAAATAAAAGGGATGAGATAAACTAATATAGAA
TAGTGA

>TTHERM_00059050(protein)
MMQFEEGAPVWYSLKEGLKNTSKQADAPAFVESVVISVIDKNKSLIQLLDQPSPSILSLL
NEKQANQAKPSNLQIQQGGNQNLIVVDNIFLEPRYDKEDGDYSSINDLVNLPFLNEPELL
KAIAQRYVQDKIFSYVGPTLVVVNPYKRMDHLFNEKTQELYQEKVIQNQDIYSEQPHIFG
IAAYCMQSILQEKTLKQAIVISGESGAGKTENTKYAMKFLTQMNAQFQQQNTPQTLTNLR
ESYLNLKSRQTLKSTVSIEQRILNCNPILEAFGNAKTTRNDNSSRFGKLVILHLKEDIGS
SFSIKQKQKKLVISSASLTNYLLEKSRIVQISQQERNYHIFYHLLKGAEPQFLSQLGLSP
DISSYRYLKSECSNVDTLSDEQLFLEVMSSLDDLNFTEIEQKGIWNIVSCVLLLGNLDFE
EVKTTGDSCTISPKQKQTVETICKKLQCTEKELNDALTTKKRQVNNNVTTSPLSIKESID
NRDSYSKFLYEKLFNWIVFRLNQSIMDQDEVDQYTLHAFAPQQKRQSITQGKKRQIEILD
IFGFEVFENNSFEQLCINFANEKLQQLYISYIYEGERNIFKQQGLEKYLMEIKYTDNKSI
IEALDKPKDPIGVFNLIDDSSNLSTGSDLNLISQMEREHKSNSQHVSFSQIQKTNFTIHH
STGSIEYNITNFRAKNKDEVSLALQNLAQQKTIKSIIQLGITDFNTQQVGSRVTDKFLGS
KFRLQMKKLMEELSSCECQFVRCIKPNASKKAGFIQPRYSLNQINCLGVLETIRVRKQGF
YKDHWELYPPNFNEIKADVTTMFQKITDYQRLSQKLVEMNVDQKQLEQNNILFGNSMIFI
KESALMILTSKLIQTKLFRNYKLKKWLKNRKKVKQFLKGLIYRFRYLKSDVVAKIRGMRK
AKELEAKQNISAKKIQKMIRNFILKKRMKEIRAALMIQRAYIMYKKKEYYKQKLKGIKEF
IKSKFLMLKERSIYKKKLKSILQIQKWYKKNLQQRQIEMCKKVIMVISQSLDKSWLKIRN
ISAIKIQSLVRMFLAKINNYGIVKQSREAKNVILERKAIQKIQRYWRYRNFYLSMKRYRN
AAYRIQAYFRKKWCSALFQLIKKNTKFIQMHVRSWLNQKYFLTEKWVKYDWNSVKRDEML
NQQNLVILGIPYKKNLVKNLKFQELKNQFYEQHTVLSLQRAQKKIEYLQKKQKNLDRQDS
LAKLAALKQKIKSQKSIVLSSAKVSQQQSIQEFEDLGLDQQLKILKSSIKLGGAEKQEIQ
KQSPINEINIKLDDCLNGIDQNILMQNQFGKIQMQITLKDNDQYQTQVNEFTSNNQPKIQ
EYYYHDLGLEKDHILYDFNSESRKKQVQSQLQAKRMSVDVIKLNTILLDFDQQPQSHEIY
TSQIWAQHYQDIQSELEQSNSSILKIFIGDSYTTIVGDNSVCYTFGDEFLNHQVHTTDQQ
IYYSPDKFLNDQPLQSKISQSSNRYQQQTKNTSNIYESPNLQRQIPNYQAQLYSTPQKKL
QNDLIPSVLQNNPLFVQLETQNYQQNSQKKFQSSYSPQDQYNNSQQKLKMNQNNSNNSLY
NSLRKQAGLFQNQEPPEQISTQTLNTQNNISYQTEEQFNPPKKVIKCKIDKINSIFKANN
QLFIQNQLKDMYCWGDNSQFEIPFFEDIYLYEISKIDPQKSQQISQIDQQAISNQFFYLL
TDGDVLHYNYKKSIDFERIRFPVQISQISCGGHFTMFLSIQGTLFSSGQNTSGELGHGDR
LFRKSPQLISSFKKFGEKIKQVSCGLKHTICLTALGKIFSWGNNRFGQLGVGDTKYRSNP
QLIFVKSKSIDSINSFLQVRAGLRSSIVLTIDKRLAWWGTNSCLDHQVFPIELNLQDYKN
DLNSKELIPIKLMSSWSKNLSLFYIIVADITYCYSQNKSVIIKSLQSLSQKWEDQQIFPS
ADKNIMKYIQIKGMRQTNIEQ

>TTHERM_00059050(gene)
ATGATGCAATTTGAGGAAGGAGCACCAGTTTGGTATTCTCTTAAAGAAGGTCTGAAGAAT
ACTTCAAAATAAGCTGATGCACCTGCTTTCGTAGAATCAGTAGTCATTTCTGTAATTGAT
AAAAATAAATCTTTAATATAATTGCTAGATTAGCCCAGCCCTTCAATACTAAGCTTGCTT
AATGAGAAACAAGCTAACTAGGCAAAGCCTTCTAATTTATAAATTCAATAAGGTGGAAAT
TAAAACTTAATTGTTGTTGATAATATTTTTTTGGAACCTAGATATGATAAAGAGGATGGA
GATTATTCTTCAATAAATGATTTAGTTAACCTTCCTTTTTTAAATGAACCTGAATTGCTT
AAAGCAATAGCTCAAAGATATGTTTAGGATAAAATATTTAGCTATGTTGGTCCTACTCTT
GTTGTAGTAAATCCTTATAAAAGAATGGATCATCTATTTAATGAAAAAACACAAGAATTG
TACTAAGAGAAAGTTATTTAAAATTAAGATATTTACTCTGAATAGCCTCACATATTTGGA
ATAGCTGCTTATTGTATGCAAAGTATTTTGTAAGAAAAAACACTTAAATAAGCGATTGTA
ATATCAGGAGAGTCTGGTGCAGGTAAGACTGAAAATACAAAATATGCTATGAAATTTTTA
ACCCAAATGAATGCTTAATTTTAATAGTAAAATACACCTTAAACTTTGACTAATTTGAGA
GAAAGCTACTTAAACTTAAAATCTAGATAAACTCTAAAATCAACTGTCTCTATAGAATAA
AGAATATTAAACTGCAATCCAATTTTAGAAGCTTTTGGTAATGCTAAAACAACAAGAAAT
GATAATTCATCTAGATTTGGAAAATTAGTTATCTTGCATTTAAAGGAAGATATTGGTTCT
TCATTTTCAATCAAGTAAAAGTAAAAAAAACTAGTAATTTCGTCTGCTTCTCTTACAAAC
TACTTGCTAGAAAAAAGCAGGATAGTTTAAATTTCGCAATAAGAAAGGAATTATCATATT
TTTTATCATCTTCTAAAAGGAGCTGAGCCTCAATTTCTTTCTCAATTAGGATTGAGTCCA
GATATTTCTTCTTATAGGTAACAAAAAAGTATTATTTTAAATTAGCTCATACTTATTATT
TTTGAACTTCAAAAAGGTATTTAAAAAGTGAGTGCAGTAATGTTGATACTTTATCTGATG
AATAGCTGTTTTTAGAAGTTATGTCAAGTTTAGATGATTTGAATTTTACTGAAATAGAAT
AAAAGGGAATTTGGAATATAGTTAGCTGTGTCCTTTTGTTAGGAAATCTAGATTTTGAAG
AAGTTAAAACAACAGGCGATTCTTGCACTATTTCGCCTAAATAGAAATAAACAGTAGAAA
CTATATGTAAAAAGCTTTAGTGTACTGAAAAAGAATTAAATGACGCTTTAACAACTAAAA
AAAGATAAGTTAACAACAATGTTACAACTTCTCCTCTTTCTATCAAAGAGTCAATAGATA
ATAGAGACTCTTACAGTAAATTTTTATATGAAAAGCTATTCAATTGGATAGTATTTAGAT
TAAATTAGTCTATTATGGACTAAGACGAAGTAGACTAGTATACATTGCATGCCTTCGCTC
CTCAATAAAAGAGGCAAAGCATAACAGTAAACAATTTTATTATTAATTAATTAAATCGTT
AAAAATAAATAAAAAATTGAAGGAGATATCTTAAGTCTTTAAAAAATGTTTGTTTGTTTT
AAAAGCAGATTAATATTAAATAAGTATTTTCTTGTTTTTGGATAAGAGACTTTGCTCTAT
TTATGAATTTTATTAATAATTATTTTAATTTTAATAAAGCAAGGGAAGAAGAGATAAATA
GAGATTTTAGATATATTTGGGTTTGAGGTGTTTGAGAATAACAGCTTTGAGTAATTGTGC
ATAAATTTTGCAAATGAAAAGCTTTAATAACTTTATATTAGCTATATTTATGAGGGAGAA
AGAAACATATTTAAATAATAAGGATTAGAAAAATATTTAATGGAAATAAAGTATACTGAT
AATAAATCTATTATAGAGGCTCTTGACAAGCCTAAAGATCCTATTGGAGTTTTTAATTTA
ATTGATGATTCAAGCAATTTAAGTACTGGAAGTGACTTAAATTTGATATCTCAAATGGAA
AGGGAGCATAAATCAAATAGTTAGCATGTTTCCTTTTCTTAGATTTAAAAAACTAATTTT
ACTATTCACCACTCAACAGGGAGTATTGAATACAATATTACTAACTTTAGGGCAAAGAAT
AAGGATGAAGTCTCATTAGCATTATAAAACTTAGCTTAATAAAAAACAATTAAGTCAATC
ATTTAGCTAGGAATTACAGATTTTAATACTTAATAAGTTGGGAGTAGAGTAACAGATAAA
TTTTTAGGTTCAAAATTCAGACTTTAAATGAAAAAGTTAATGGAAGAATTAAGCTCTTGT
GAGTGCCAATTTGTAAGATGTATTAAACCTAATGCATCAAAAAAGGCAGGATTTATATAA
CCTAGATATTCTCTGAATTAAATAAACTGTCTTGGTGTTTTAGAGACAATCCGTGTCAGG
AAATAAGGGTATGTTTACAGAGCTGATTATTTTAGATTTTATAAAGACCACTGGGAGCTA
TATCCACCAAATTTCAATGAAATTAAAGCAGATGTAACTACTATGTTTTAAAAAATAACA
GATTATTAAAGACTAAGTTAAAAGTAATATTTACTTTAGAATTTCAAGAATCACTTTTTA
ATAGAGTTTTACATCAAATATTAGATTAGTGGAGATGAATGTTGACCAAAAATAATTAGA
ATAAAATAATATTTTATTTGGAAATAGCATGATTTTTATAAAAGAAAGTGCTTTAATGAT
CCTAACATCAAAGCTGATACAAACAGTAAAAATAAATAATTTTAATAAAATCATAAATTT
ATTTATTTAATTAATATTAGAAAGAAGAAATCAATCGCAATGTTAAATTAATACAGAAAT
TGTTTAGAAATTACAAGCTTAAAAAATGGTTAAAAAACAGAAAGAAAGTTAAACAATTTT
TGAAAGGATTAATTTATAGATTCAGATATTTAAAATCTGATGTTGTTGCAAAAATAAGAG
GAATGAGGAAAGCTAAGGAATTAGAAGCAAAGCAAAATATTTCTGCTAAGAAAATTTAAA
AAATGATCAGAAATTTTATCTTAAAGAAAAGAATGAAAGAAATCAGGGCAGCTTTGATGA
TATAACGTGCATATATTATGTACAAAAAGAAAGAATATTACAAATAGAAACTTAAAGGTA
TCAAGGAGTTTATAAAATCGAAATTTTTGATGTTAAAGGAAAGATCAATTTATAAAAAAA
AGCTTAAAAGTATCCTACAAATATAAAAGTGGTATAAAAAAAATTTACAATAGAGATAAA
TTGAAATGTGCAAAAAAGTCATTATGGTAATTAGTTAATCGCTTGACAAGTCTTGGCTAA
AAATCAGAAATATTTCAGCTATTAAGATTCAATCCCTAGTTAGAATGTTCTTGGCTAAAA
TTAACAACTACGGTATTGTAAAACAATCAAGAGAAGCTAAAAATGTAATTCTAGAAAGAA
AAGCTATCTAAAAAATTTAAAGGTATTGGAGATATAGAAATTTTTATTTATCAATGAAAA
GATATAGAAACGCTGCTTACAGAATACAAGCCTATTTCAGAAAAAAGTGGTGCTCTGCTC
TATTTCAGCTTATCAAAAAGAATACTAAATTCATTTAGATGCATGTAAAATAAATTTACT
TTAACAGAATATTTAGTTATTATTTAAATTAAAAACCTTTTTTCTCTCATATTGTTTTAT
TCAAATATTATTTCAATCTATTTTTTTAGTTTAAAATTTTATGAGATTTTATTTTTCATA
AATAATTTCTAAAGGTAAGGTCTTGGTTGAATTAAAAATATTTTCTAACTGAGAAATGGG
TTAAATATGATTGGAATTCAGTTAAAAGAGATGAAATGCTTAATTAGCAAAACTTGGTCA
TTCTTGGAATTCCTTATAAAAAAAATTTGGTGAAAAACTTAAAATTTTAAGAATTAAAAA
ATTAGTTTTATGAGTAGCACACTGTATTAAGCTTACAAAGAGCCTAAAAAAAAATTGAGT
ATTTATAAAAAAAACAAAAGAACCTGGATAGATAAGATAGTTTAGCAAAATTAGCAGCTT
TAAAATAAAAGATAAAATCTTAGAAAAGTATTGTTTTATCTTCAGCGAAGGTAAGTCAAT
AGCAATCTATTTAAGAATTCGAAGATTTAGGCTTAGATTAATAGTTAAAAATCCTAAAAT
CATCTATTAAGTTAGGAGGAGCAGAAAAGCAGGAGATATAAAAATAATCTCCAATTAATG
AAATTAATATTAAGCTTGATGATTGTTTAAATGGTATTGATTAAAATATCTTAATGTAAA
ATTAATTTGGCAAAATATAAATGTAAATAACCTTGAAAGATAATGATCAATATTAGACTT
AAGTAAATGAATTCACTTCAAATAATTAGCCTAAAATTTAAGAGTATTACTATCATGATT
TGGGTCTTGAAAAGGATCATATATTATATGATTTTAATTCAGAAAGCAGAAAAAAGCAAG
TTTAAAGTTAGCTACAGGCAAAAAGAATGTCAGTTGATGTGATAAAGCTAAATACTATTT
TACTTGATTTCGATTAATAACCATAATCACATGAAATTTATACTTCTTAAATATGGGCAC
AGCATTACTAGGATATTCAGAGTGAACTTGAGTAATCAAACTCTTCAATTTTAAAAATTT
TTATTGGAGATTCTTATACTACAATAGTCGGAGATAACTCAGTCTGTTATACGTTTGGAG
ATGAGTTTTTAAATCATCAAGTTCACACAACAGATTAATAAATTTATTATAGTCCTGATA
AGTTTTTAAATGATTAACCCTTATAATCTAAAATAAGTTAATCATCTAATAGATATTAGT
AATAAACCAAAAACACATCTAACATCTATGAAAGTCCAAATCTACAAAGATAAATTCCTA
ATTACTAAGCACAATTATATTCTACTCCTCAAAAAAAATTATAAAATGATCTCATACCCT
CTGTACTTTAAAATAATCCTCTATTTGTTTAATTAGAAACTTAAAACTATTAATAGAATA
GTTAAAAAAAATTTTAAAGTAGCTATAGTCCATAAGACTAATACAATAACTCTTAGCAAA
AATTAAAAATGAACTAAAATAATTCAAATAATAGCTTATATAATAGCTTGAGAAAGTAAG
CTGGTCTTTTCTAAAACTAAGAACCACCTGAACAAATCTCTACTTAAACTTTAAACACCT
AAAATAATATTTCATATTAAACCGAAGAATAATTTAATCCACCTAAAAAGGTGATAAAAT
GCAAAATAGATAAAATAAATAGCATTTTCAAGGCTAATAATCAGCTGTTCATTCAAAATT
AACTAAAGGATATGTATTGCTGGGGAGACAATAGTCAATTTGAAATACCCTTTTTTGAAG
ATATTTATTTGTATGAAATTTCTAAAATTGATCCTTAAAAATCATAGTAAATTTCTTAAA
TAGATTAGCAAGCCATTTCTAATTAGTTTTTTTATTTGTTAACTGATGGAGATGTTTTAC
ACTATAATTATAAAAAATCTATTGACTTTGAAAGAATCAGATTCCCTGTCTAAATATCTT
AAATAAGCTGTGGAGGTCATTTTACTATGTTTTTGTCAATTTAGGGTACACTATTCTCTT
CTGGCTAAAATACTTCAGGGGAATTAGGTCATGGTGATAGACTATTTAGAAAAAGTCCTT
AACTTATAAGCTCATTTAAGAAATTTGGAGAAAAGATCAAATAAGTATCTTGCGGGCTAA
AGCATACAATATGTCTCACAGCATTAGGTATTTATTAAATTATATCGTTTAAAAAAAACA
TCATATATCTTACATTTATTTTTTAATATCAGGAAAGATTTTTTCCTGGGGAAACAATAG
ATTTGGGTAACTAGGTGTAGGAGATACTAAATATAGATCAAATCCATAATTAATTTTTGT
GAAAAGTAAATCTATAGACTCAATCAATTCATTTTTGCAAGTTAGAGCTGGTTTAAGATC
AAGCATAGTTTTAACAATTGACAAGCGTCTAGCGTGGTGGGGAACGAACTCATGTTTAGA
TCACTAAGTATTTCCAATTGAATTAAATTTACAAGATTATAAAAATGTAATTTGTTAATT
TTTGATTATTAATTACAAAATTAATTTATAAAATTTGAAAATTAAATTAAGGATTTGAAT
TCTAAAGAATTGATACCTATTAAACTAATGAGTAGCTGGAGTAAAAATCTTAGCCTTTTT
TATATTATTGTAGCTGATATTACATATTGTTATAGCTAAAACAAAAGTGTAATCATTAAA
TCTCTACAGTCTCTTTCTTAGAAATGGGAAGACTAGCAAAGTAATTAAAAAATTGTTTTT
CAATTTAACTAAATTTTTTTAATAATATAATTTATTGTAGTTTTCCCTAGTGCAGATAAA
AACATAATGAAATACATACAAATAAAAGGGATGAGATAAACTAATATAGAATAGTGA

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Paragraph No	Gene Name	Paragraph Text
10	MYO1, MYO12, MYO11, MYO10, MYO9, MYO8, MYO5, MYO4, MYO3, MYO2, MYO13	Proteins of the myosin superfamily are ATP-dependent molecular motors that travel unidirectionally along actin filaments. The myosin heavy chain proteins are comprised of three domains: a head (motor) domain responsible for ATP hydrolysis at the N-terminus, a neck (lever arm) region, and a C-terminal tail region. Thirteen predicted myosin heavy chain genes have been identified in the Tetrahymena genome and named MYO1-MYO13. A phylogenetic analysis comparing these predicted proteins with the 19 previously identified myosin classes suggests that Myo1p-Myo12p belong to a previously undescribed class of myosins. This new family, designated Class XX, does not include Myo13p, which did not branch with this class or any of the other classes in the analysis. The neck and tail regions of the Tetrahymena myosins include a variety of domains characterized in other myosin classes, with each protein containing one or more of the following domains: coiled-coil (which may support dimerization); IQ motif (binding sites for calmodulin or calmodulin-like proteins); FERM domain (Four-point-one protein, Ezrin, Radixin, Moesin homology); and MyTH4 domain (Myosin Tail Homology 4).