TGD | Gene Details

Identifiers and Description

Gene Model Identifier
TTHERM_00046470

Standard Name
MYO10 (MYOsin)

Aliases
PreTt11126 | 3.m01737 | 3824.m02887

Description
Myosin heavy chain; member of proposed myosin Class XX, distinct from previously defined myosin classes; contains predicted coiled-coil domain and IQ motifs predicted to bind a calmodulin family protein

Genome Browser

Gene Ontology Annotations

Cellular Component
myosin complex (IEA) | GO:0016459
Molecular Function
ATP binding (IEA) | GO:0005524
motor activity (IEA) | GO:0003774

Domains

No Data fetched for Domains

Gene Expression Profile

Tetrahymena Functional Genomics Database: TTHERM_00046470

Homologs (v.2006 protein sequences)

Source Identifier Score Description

ParameciumDB GSPATP00013457001 9.99709313703352e-262 Paramecium tetraurelia GSPATP0
0013457001 protein

IPI(HUMAN) IPI:IPI00376344.3 9.99679536751975e-103 INV:HIT000053916 Tax_Id=9606
Splice Isoform 1 of Myosin Ib

ToxoDB 49.m03333 7.99918061585779e-98 Toxoplasma gondii myosin, puta
tive

DictyBase DDB0185049 2.00004349420983e-96 myoI myosin VII class VII unco
nventional myosin

DictyBase DDB0217552 2.00004349420983e-96 myoI myosin VII class VII unco
nventional myosin

FlyBase FBgn0040299 1.00041373401058e-93

FlyBase FBgn0040299 1.00041373401058e-93

TAIR AT3G19960 3.99813721121173e-92 myosin (ATM)

SGD YAL029C 3.99979641053432e-91 MYO4 SGDID:S000000027, Chr I f
rom 92271-87856, reverse compl
ement, Verified ORF, "One of t
wo type V myosins; required fo
r mother-specific HO expressio
n, for the bud tip localizatio
n of ASH1 and IST2 mRNA; facil
itates growth and orientation
of ER tubules along with She3p
"

WormBase T10H10.1 5.00110240666229e-90 WBGene00002039 hum-6 myosin

CryptoDB EAK90414 9.99903095177562e-88 Cryptosporidium parvum (Iowa)
protein EAK90414

PlasmoDB PF13_0233 3.00052215021585e-68 Plasmodium falciparum 0233

Source	Identifier	Score	Description
ParameciumDB	GSPATP00013457001	9.99709313703352e-262	Paramecium tetraurelia GSPATP0 0013457001 protein
IPI(HUMAN)	IPI:IPI00376344.3	9.99679536751975e-103	INV:HIT000053916 Tax_Id=9606 Splice Isoform 1 of Myosin Ib
ToxoDB	49.m03333	7.99918061585779e-98	Toxoplasma gondii myosin, puta tive
DictyBase	DDB0185049	2.00004349420983e-96	myoI myosin VII class VII unco nventional myosin
DictyBase	DDB0217552	2.00004349420983e-96	myoI myosin VII class VII unco nventional myosin
FlyBase	FBgn0040299	1.00041373401058e-93
FlyBase	FBgn0040299	1.00041373401058e-93
TAIR	AT3G19960	3.99813721121173e-92	myosin (ATM)
SGD	YAL029C	3.99979641053432e-91	MYO4 SGDID:S000000027, Chr I f rom 92271-87856, reverse compl ement, Verified ORF, "One of t wo type V myosins; required fo r mother-specific HO expressio n, for the bud tip localizatio n of ASH1 and IST2 mRNA; facil itates growth and orientation of ER tubules along with She3p "
WormBase	T10H10.1	5.00110240666229e-90	WBGene00002039 hum-6 myosin
CryptoDB	EAK90414	9.99903095177562e-88	Cryptosporidium parvum (Iowa) protein EAK90414
PlasmoDB	PF13_0233	3.00052215021585e-68	Plasmodium falciparum 0233

General Information

Paragraph No Gene Name Paragraph Text
10 MYO1,
MYO12,
MYO11,
MYO10,
MYO9,
MYO8,
MYO5,
MYO4,
MYO3,
MYO2,
MYO13 Proteins of the myosin superfamily are ATP-dependent molecular motors that travel unidirectionally along actin filaments. The myosin heavy chain proteins are comprised of three domains: a head (motor) domain responsible for ATP hydrolysis at the N-terminus, a neck (lever arm) region, and a C-terminal tail region. Thirteen predicted myosin heavy chain genes have been identified in the Tetrahymena genome and named MYO1-MYO13. A phylogenetic analysis comparing these predicted proteins with the 19 previously identified myosin classes suggests that Myo1p-Myo12p belong to a previously undescribed class of myosins. This new family, designated Class XX, does not include Myo13p, which did not branch with this class or any of the other classes in the analysis. The neck and tail regions of the Tetrahymena myosins include a variety of domains characterized in other myosin classes, with each protein containing one or more of the following domains: coiled-coil (which may support dimerization); IQ motif (binding sites for calmodulin or calmodulin-like proteins); FERM domain (Four-point-one protein, Ezrin, Radixin, Moesin homology); and MyTH4 domain (Myosin Tail Homology 4).

Associated Literature

Ref:16505385: Foth BJ, Goedecke MC, Soldati D (2006) New insights into myosin evolution and classification. Proceedings of the National Academy of Sciences of the United States of America 103(10):3681-6
Ref:15988740: Williams SA, Gavin RH (2005) Myosin genes in Tetrahymena. Cell motility and the cytoskeleton 61(4):237-43

Sequences

>TTHERM_00046470(coding)
ATGGATGGACTTAAAGATTGGAAACAAAATGGAGCTCTTTGTTGGGTTGAAAGAGAGGTA
AGTGAGAATACTAAGTAGATTTTTGAGGAGGCTGTCATCAATACAAATTATTTTAGAAAA
AATGTGCTCATCAAAGTTTAAGATAAAGAAGAAGAAGTATCTTTGGATAAATTACACTAG
AGATCTCCTTATGAATAAAATGAAGATGATATGGTCAATATGAGAATATTAAATGATGCT
GAACTTGTTATTAACATATAAAAAAGATACTAAAATAACAAAATATTCACTTATGTTGGT
CCTACTCTTCTAGTCGTTAATCCATTTTAGTATGTTCCAGGGTTAAATACTGAAGAAAAA
ATGAGGTTTTACCACAATTAAATTATAGAAAATTCTAAGGGTAATGGTTCTTTAGCTATA
AAAAGCTTAGAACCACATGTATATGCTATAGCTGCAGAGTCATTTAGATCATTATTTGAT
TAAGAGAAAAACTAAGCTATTGTTATTAGTGGTGAATCAGGAGCAGGTAAAACTGAAAAT
GCAAAGTTATGCATGAAATTTTTAACAACTAGTATAAGCTAACATAAATCTCCCGAAAAA
GTACGTCTTAGAAAAAAAACCATTTCTTCTTTAGGACCTCCAATATTAGCTAGTCCAACA
TCCTCTATGCTTAGAGAAAGCAGCAAATCATAGTCTATAGAAGAAAAGATTTTAAGTTGC
AACCCTATCTTAGAATCTTTTGGTAATGCGAAGACTATTAGAAATGATAATTCTAGTCGT
TTTGATATGATTGATACTAAGATTATTGGAGCAGAAATTGCAAATTATTTACTTGAAAAA
GTCAGAATTATTTAATAGGGTGTAGAAGAAAGAAATTTTCATATATTCTATCATTTCTTG
AATGGTGCTAGTGTGCAGTAACTAAGCAAATACTATCTAGAAATAAATGGCAAACGCTTA
TAGCCTTAGTATTTTAGCTACTTAAAGAATCAAAATATAGAAGTAAAATCTATTGATGAC
TGTAAGCTTTACGAAGAAGTAGTTAATGCTTTAGATGTATTAGAATTAAATGAATTTGCA
GATTCTATATGGAGGATACTAGCTGCTATTTTGCATTTGGGAAATTTACAATTTAAATAA
TCTTAAATAAACAAAGATTAATTTGAAGTTTCTGATAAGCAGCAAATATAAATTATCTCT
AATCTACTTGGAATTTAAGCTGAGGAACTTGAAAGAGAGCTAACAATTAAATAATTTAAA
GTTTAAGGAGAAGGATTTGCCAAGGAATTGAGCTTACCAGAATGTTAAAATTAAAGAGAT
TCAATAGCAAAAGAGCTTTATGATAGACTTTTTAATTGGCTAGTGAACTAACTAAACAGG
ACGATAATGCCAAAAGACATTTCAAAATAGCAAATTTTATCATCAAATTTATACAAATCA
ATAGGTTTATTGGATATATATGGATTTGAGGTATTCTAAAAAAACGGTTTTGAATAATTC
TTTATCAATTACACAAATGAGAGACTTCACTAATTATATATTTCATACGTCTTTAAGGCA
GAAGAGTTAACATTTAAGGAAGAAAGACTTGAGTAGTATTTTAAAAAGCTTGATTTTAAA
GATAATTAAGATGTTATAGATGTGTTAGATAATAATGATAGGCAGAAGCCTCTTGGTATT
TTTAAGTTGTTAGAAGATAAATGTAAACAAAAAGGAACTATAATAGATGCTAAATTACTT
TCAGACATTTAAAAATAGCATGGAGATAAAGAAATTTACATTAAAAATCCAAATTATAAA
TTTAAAAATCCAAAGAAAATAAATGACTCAACATTTATAATTATACATACTGCAAAGGAG
GTTGAATATGATATTAAAGGATTTATAGAAAAAAATAAAGATGAGGTCAATGAAGGTTTA
ATAAATAAAATAAATAATTCATAAATAAGAGGAATCAGTTAAATCATAAGCGAAAAGGAT
AAAGAATTATTAGATGAAAGCACAGCATCATAATAAGTTAAAATGAGATAAATAAGTTAA
AAATTTATATCTGAAATGTCATTTCTTATGGATGTACTGATGTAATGTAATGTCTAATTT
ATTAGATGCATAAAGCCAAATGAAGAGAAAAAACCATAGTTATTTAATCAGGGTTTTACT
TTAAATTAAATTCGTTACTTAGGTGTATTGGAGTCAATTAACATCAGAAAGCAAAGTTAT
CCAATAAGATAAAGCTATGAATCATTTTTTAATAAATATTCACTCTTGATGCTAAACAAG
TTAAATATTTAAGATTAAATAAATAAAAAAAGTCTTGTTGAAGAATTGTTTAGAAAAAAT
TTCAGTTCAATACCAAAAGAGAACAGATTATTTGGGGTAACAAAAATTTTTTTCAAAAAC
TATGAAGTTCTGCAATAAATTGAAGATATATACAATAAAGAAATTTCGAATATACGCAAT
TTAGTTCTTAGAATTGAAAGTATATAATTGTTGTTTCTTCTTAAAAGAAAAAGAGCTTCT
GAAATAATTTAAAGTTACTGCTTTTAGAAAACAGCTATCTCTTATTATGAGCAAGCGATG
GAAAATATAAAAAAAATATAATTCCATTGGAGAGCAGCTTATTAGAGACTTAGAGAAGTT
AGAAGTAAAAGAATCAAAAATACTTATATTATAAAGGAAGTTTTGAATAAAGCTTGGTAA
AAAATATTTACCAGATCAGTTACGACAATAGTTGAAAAGACAAAAAAGCTAGTAAGATGC
TATTACTTAAAGTAGATGTTTTCAAAACAACTCTATGAAATAAGAACAAAAAAAGCAGCT
GTTATTTTTCTGAAACTTTTAAAAGGAAACTTTGTTAGAAAAAGAATAAAAAGGTTTAAT
TTAGCTGCATAGAAGATACAAGCCAAAGTTAAGTAGATTTGGCTTACTGAATTATATTAA
AAATTGAGAAAAGCAATAATTATTATTTAAAGAAATGCTAGAATATTTATCATAAGAAAA
AGAGAAAGGAATTAAAGAAATGCAGAATTTTTAGGACCATTAGAATAAAATCTAAAAAGA
ATACGTATTTCTGAAGAATTGCTTCTATTTAATGGTTAGTCTAAAGTTATTGATTAAAAC
ACTTCTTTATAAAATGAGATATTCCGTCTAGACAAGAGTTTAGAAAATGTTTTAGAAAAA
TCACATGAGCACTTCTTTTAGTAGAGAATGTATTTGTTTAGTTATGTCATTGATTTTGAA
ATATTATCTGATACAAGCGAAATTTATGATCCTTTGTGGTCATCTTTATACCAAGCTTCG
TTTAAGGATAACTACGATAAACAGTCATATATCTAGCACATTTCAATAGGAGATACTCAC
AGCTTAACCTGTAGCTTAAGCAGTAAGATTCATACTTGGGGATGGAACGATTTTGGGTAA
CTGGGAGTACCAATTGTAGATGAAGACGATCCTAACCAAGAATAAAACGTTTATACTGGT
ACATCAATTTACTCGATGAATGTCCCTCCTTAAATTAAAAGAATTGCACAAATTTCTTCT
GGTAGTAATCATTCTTTGCTACTTGATCACAGAGGGTAAATATGGTCTTGGGGTTGCAAC
AACAGAGGATAATTGGGACTGAATCATTATGAAAATATGGAAACACCGTAAAAGATTACA
TATCTAATGAATCCCAAAACCGAGTTTTGCAAAGTTGAGTGCAGAGATGATGAAAACTAT
GCTATCACAAAAAGTGGTTAACTATTTCACTGGCCCACTCTAGGAATGTAAGGTGAGTGT
GTGAATTACCCCCTTGAGGTAGTCATACCTAAAATAACCATTAAAGATGTGAGCTGTGGC
CATAAATTTGTAATGATTTTAAGTAACTCTGGGCTTTTATTTAGTTATGGAGAAAACAAA
GAAGGCTAATTAGGATTAGGAGATCTGAATCCAAGAAAAATACCTACTCTAGTTTACTGT
TTGAGAGATGCTGGAGAGAAAATAAGCTAAATAGATTGCGGATTTAAGCACACAATATGC
AAAACATCTTTAGGTAAGGTTTATACTTGGGGATGGGGAGGAAGAGGATAACTAGGACAT
GGAACAACAAATAATGAAATATACCCAAGAATTTTGTCATTTTCTAATTTGGCCAAAGAT
AAATAGACTCCAACGTTATTTAAAGATAAATGCCTGCAGGTAGTGGCAGGACATAGATGC
TCGATGCTTTTAATGGAAAGCAGGAAAATTTATCAATTTGGCTCCAATTCATCATTAGAT
CATTAATCTTTCCCAGTTGAATTTAATATCAGATCGAAAGTAACCAAAACAACTTACATT
ATTTTTTTAATCTTATATTAAATTATCAAGAGCGACAAATTAAGCTAGAATTTTTATGAG
CCGATCAGAATCCAATCTTCATGGAGTAAAACATTAAGCTTAATATATGTTACTTATGGA
AATACAAAAAATTGTTTTGAAAAAAATACTGTCCTAAAAACAAAAACAATAAATAATCTA
ACTTAAAAATGGGCTGATACAAACATAGATACAATTGACCCTCCATTTATAGAAAAGATA
GCAAACTATATTTCAGAGAAAAATATGAAAATGCCTTTGTTTAAAATGCCTACGATGCAG
TTCGAATCCAAAATTAAATATAATTAACTTAAACACGAACTTATCGAGGCTGATTAAATG
AATAAAATTGAAATAGAGTATATGAATGCCTTGCAATACGAATAATAAGAAATTTATAAT
CAAAACCATCTAAGCTAAGGCAATCATTTATTAATTGAAGATCCTTAACTCACTTACTAA
AACAGGTAAGTATTAGAAGAAATTAATTTCTAAAGAGAAAACTGGGAGGAATTTTAATCA
TTGGGTTTGGCACAAAGCACAAAAGACAGTTTAGTTGATCTTAACTATGAAGAATATTTT
AGAAATTAGCAAGAATTATAATAGAGAATTATCTAAGAACAACAATAATAATTATAATAA
GAAGAGGAAAACAGGGCTATAATAAACTCTTAGAAACTGAGTTAAAAGAAATAATACCCA
TCTTATAAAAAGTCAAACACTACATAATATCAAGTCGTAGAAATACCTGAAAGCAAGTCA
AATGCAAGTATATCTAATAATTCTATTAATAATAGTAAGAGACTTGATCAAAAAAGTATT
AACGACACACTATCTAAGGCCTCTTCATCATCTTTTAATAATAAATAAAAAAGCAGTAGT
AATTAGTCCTCATAAAATATAAAAAATTCATCAGTTGTGCAATAAGCTAATTAATAAAGT
TTATCATTTTTTGAATAGCAAGGAAACTTAGATAGGAGATAAATGTTATAAATAGTAAAG
GAAAAAGTGCTACAATTATCTAAAGTACCTGAAAATGAATGGACAGAAAATGATAGAAAA
TTTATGTAAGGAGCAATGCAATTAAGTTAATTTGACTTTGATAATGCTTCTGAAAATAAC
TTATCTAAATCATAAGATAATAGTTCAATTAATAATAGTCAGGCAAGCTAAAGAATGGAA
TAAATACCTACTGATAAAGCATAGTAAAATAACAGGGCTAGTATCAGCTCAAATTCTTCT
AAAAAAAGTGCAATCTCTCAAAAAAGTTAAAATCAACAAGAAAAAAATTAAAAGTAATAA
ATAAATCCTCAGCTTATTAATGTCAAAAAGAAATGGGATGAAATCAGAAACACTCCATAA
TAGCAGTGGACATAAAATGACTATCAATTTATGGAAATTGTAAAGGCAAATAACTTAGAA
AAAGTTTTATTAGAATTTGATTGA

>TTHERM_00046470(protein)
MDGLKDWKQNGALCWVEREVSENTKQIFEEAVINTNYFRKNVLIKVQDKEEEVSLDKLHQ
RSPYEQNEDDMVNMRILNDAELVINIQKRYQNNKIFTYVGPTLLVVNPFQYVPGLNTEEK
MRFYHNQIIENSKGNGSLAIKSLEPHVYAIAAESFRSLFDQEKNQAIVISGESGAGKTEN
AKLCMKFLTTSISQHKSPEKVRLRKKTISSLGPPILASPTSSMLRESSKSQSIEEKILSC
NPILESFGNAKTIRNDNSSRFDMIDTKIIGAEIANYLLEKVRIIQQGVEERNFHIFYHFL
NGASVQQLSKYYLEINGKRLQPQYFSYLKNQNIEVKSIDDCKLYEEVVNALDVLELNEFA
DSIWRILAAILHLGNLQFKQSQINKDQFEVSDKQQIQIISNLLGIQAEELERELTIKQFK
VQGEGFAKELSLPECQNQRDSIAKELYDRLFNWLVNQLNRTIMPKDISKQQILSSNLYKS
IGLLDIYGFEVFQKNGFEQFFINYTNERLHQLYISYVFKAEELTFKEERLEQYFKKLDFK
DNQDVIDVLDNNDRQKPLGIFKLLEDKCKQKGTIIDAKLLSDIQKQHGDKEIYIKNPNYK
FKNPKKINDSTFIIIHTAKEVEYDIKGFIEKNKDEVNEGLINKINNSQIRGISQIISEKD
KELLDESTASQQVKMRQISQKFISEMSFLMDVLMQCNVQFIRCIKPNEEKKPQLFNQGFT
LNQIRYLGVLESINIRKQSYPIRQSYESFFNKYSLLMLNKLNIQDQINKKSLVEELFRKN
FSSIPKENRLFGVTKIFFKNYEVLQQIEDIYNKEISNIRNLVLRIESIQLLFLLKRKRAS
EIIQSYCFQKTAISYYEQAMENIKKIQFHWRAAYQRLREVRSKRIKNTYIIKEVLNKAWQ
KIFTRSVTTIVEKTKKLVRCYYLKQMFSKQLYEIRTKKAAVIFLKLLKGNFVRKRIKRFN
LAAQKIQAKVKQIWLTELYQKLRKAIIIIQRNARIFIIRKRERNQRNAEFLGPLEQNLKR
IRISEELLLFNGQSKVIDQNTSLQNEIFRLDKSLENVLEKSHEHFFQQRMYLFSYVIDFE
ILSDTSEIYDPLWSSLYQASFKDNYDKQSYIQHISIGDTHSLTCSLSSKIHTWGWNDFGQ
LGVPIVDEDDPNQEQNVYTGTSIYSMNVPPQIKRIAQISSGSNHSLLLDHRGQIWSWGCN
NRGQLGLNHYENMETPQKITYLMNPKTEFCKVECRDDENYAITKSGQLFHWPTLGMQGEC
VNYPLEVVIPKITIKDVSCGHKFVMILSNSGLLFSYGENKEGQLGLGDLNPRKIPTLVYC
LRDAGEKISQIDCGFKHTICKTSLGKVYTWGWGGRGQLGHGTTNNEIYPRILSFSNLAKD
KQTPTLFKDKCLQVVAGHRCSMLLMESRKIYQFGSNSSLDHQSFPVEFNIRSKVTKTTYI
IFLILYQIIKSDKLSQNFYEPIRIQSSWSKTLSLIYVTYGNTKNCFEKNTVLKTKTINNL
TQKWADTNIDTIDPPFIEKIANYISEKNMKMPLFKMPTMQFESKIKYNQLKHELIEADQM
NKIEIEYMNALQYEQQEIYNQNHLSQGNHLLIEDPQLTYQNRQVLEEINFQRENWEEFQS
LGLAQSTKDSLVDLNYEEYFRNQQELQQRIIQEQQQQLQQEEENRAIINSQKLSQKKQYP
SYKKSNTTQYQVVEIPESKSNASISNNSINNSKRLDQKSINDTLSKASSSSFNNKQKSSS
NQSSQNIKNSSVVQQANQQSLSFFEQQGNLDRRQMLQIVKEKVLQLSKVPENEWTENDRK
FMQGAMQLSQFDFDNASENNLSKSQDNSSINNSQASQRMEQIPTDKAQQNNRASISSNSS
KKSAISQKSQNQQEKNQKQQINPQLINVKKKWDEIRNTPQQQWTQNDYQFMEIVKANNLE
KVLLEFD

>TTHERM_00046470(gene)
ATGGATGGACTTAAAGATTGGAAACAAAATGGTAATTTTATTTGAAACAAAATTTATATT
TTTATGAGGATAACTTTTAATGAGTAAATATAATTTAATAAAATGGAAGATAATTAGAAG
TTAATTAATTTAGAGCCTATCACTTAAATTTTATAATAAATATTATTTTTTATTTAGGAG
CTCTTTGTTGGGTTGAAAGAGAGGTAAGTGAGAATACTAAGTAGATTTTTGAGGAGGCTG
TCATCAATACAAATTATTTTAGAAAAAATGTGCTCATCAAAGTTTAAGATAAAGAAGAAG
AAGTATCTTTGGATAAATTACACTAGAGATCTCCTTATGAATAAAATGAAGATGATATGG
TCAATATGAGAATATTAAATGATGCTGAACTTGTTATTAACATATAAAAAAGATACTAAA
ATAACAAAATATTCACTTATGTTGGTCCTACTCTTCTAGTCGTTAATCCATTTTAGTATG
TTCCAGGGTTAAATACTGAAGAAAAAATGAGGTTTTACCACAATTAAATTATAGAAAATT
CTAAGGGTAATGGTTCTTTAGCTATAAAAAGCTTAGAACCACATGTATATGCTATAGCTG
CAGAGTCATTTAGATCATTATTTGATTAAGAGAAAAACTAAGCTATTGTTATTAGTGGTG
AATCAGGAGCAGGTAAAACTGAAAATGCAAAGTTATGCATGAAATTTTTAACAACTAGTA
TAAGCTAACATAAATCTCCCGAAAAAGTACGTCTTAGAAAAAAAACCATTTCTTCTTTAG
GACCTCCAATATTAGCTAGTCCAACATCCTCTATGCTTAGAGAAAGCAGCAAATCATAGT
CTATAGAAGAAAAGGTAATAATATTATTTTAATTTAAGTTATTAATTGATTATTATATTA
AAACCATTACTAATTTATTTGTATTTTATTAAAATTTTTTTTTGAATTTAGATTTTAAGT
TGCAACCCTATCTTAGAATCTTTTGGTAATGCGAAGACTATTAGAAATGATAATTCTAGT
CGTTTTGGTAAGTATGTAACATTATTCGTAGATATGATTGATACTAAGATTATTGGAGCA
GAAATTGCAAATTATTTACTTGAAAAAGTCAGAATTATTTAATAGGTGAGCTATTTATTT
ATCTATATATTTCTTTCACTATTAATTAACTAAATAATAATTTGAATTAGGGTGTAGAAG
AAAGAAATTTTCATATATTCTATCATTTCTTGAATGGTGCTAGTGTGCAGTAACTAAGCA
AATACTATCTAGAAATAAATGGCAAACGCTTATAGCCTTAGTATTTTAGCTACTTAAAGA
ATCAAAATATAGAAGTAAAATCTATTGATGACTGTAAGCTTTACGAAGAAGTAGTTAATG
CTTTAGATGTATTAGAATTAAATGAATTTGCAGATTCTATATGGAGGATACTAGCTGCTA
TTTTGCATTTGGGAAATTTACAATTTAAATAATCTTAAATAAACAGTATGACATTTTTTC
TTTGACTTATCAAGGTAGAAAATAATATATTATTAATAAATAAATAATTTTAGAAGATTA
ATTTGAAGTTTCTGATAAGCAGCAAATATAAATTATCTCTAATCTACTTGGAATTTAAGC
TGAGGAACTTGAAAGAGAGCTAACAATTAAATAATTTAAAGTTTAAGGAGAAGGATTTGC
CAAGGAATTGAGCTTACCAGAATGTTAAAATTAAAGAGATTCAATAGCAAAAGAGCTTTA
TGATAGACTTTTTAATTGGCTAGTGAACTAACTAAACAGGACGATAATGCCAAAAGACAT
TTCAAAATAGCAAATTTTATCATCAAATTTATACAAATCAATAGGTTTATTGGATATATA
TGGATTTGAGGTATTCTAAAAAAACGGTTTTGAATAATTCTTTATCAATTACACAAATGA
GAGACTTCACTAATTATATATTTCATACGTCTTTAAGGCAGAAGAGTTAGTAAGAATAAT
TAAAAAAAATAAAAATACTTTTTAATTTAAATTTCATTTGTAATAAATAGACATTTAAGG
AAGAAAGACTTGAGTAGTATTTTAAAAAGCTTGATTTTAAAGATAATTAAGATGTTATAG
ATGTGTTAGATAATAATGATAGGCAGAAGCCTCTTGGTATTTTTAAGTTGTTAGAAGATA
AATGTAAACAAAAAGGAACTATAATAGATGCTAAATTACTTTCAGACATTTAAAAATAGC
ATGGAGATAAAGAAATTTACATTAAAAATCCAAATTATAAATTTAAAAATCCAAAGAAAA
TAAATGACTCAACATTTATAATTATACATACTGCAAAGGAGGTTGAATATGATATTAAAG
GATTTATAGAAAAAAATAAAGATGAGGTCAATGAAGGTTTAATAAATAAAATAAATAATT
CATAAATAAGAGGAATCAGTTAAATCATAAGCGAAAAGGGTATTAAAAATATAATTAAAA
AACTTTAAGAGCTTTTATTTATTTATATTTAAAATTTTTTAAAGATAAAGAATTATTAGA
TGAAAGCACAGCATCATAATAAGTTAAAATGAGATAAATAAGTTAAAAATTTATATCTGA
AATGTCATTTCTTATGGATGTACTGATGTAATGTAATGTCTAATTTATTAGATGCATAAA
GCCAAATGAAGAGAAAAAACCATAGTTATTTAATCAGGGTTTTACTTTAAATTAAATTCG
TTACTTAGGTGTATTGGAGTCAATTAACATCAGAAAGCAAAGTTATCCAATAAGATAAAG
CTATGAATCATTTTTTAATAAATATTCACTCTTGATGCTAAACAAGTTAAATATTTAAGA
TTAAATAAATAAAAAAAGTCTTGTTGAAGAGTAAGAATAATTTTATTTTGCTTTTATAAA
AAAAATTATTTAAAATTTATTTTTTATGTTCAAATAGATTGTTTAGAAAAAATTTCAGTT
CAATACCAAAAGAGAACAGATTATTTGGGGTAACAAAAATTTTTTTCAAAAACTATGAAG
TTCTGCAATAAATTGAAGATATATACAATAAAGAAATTTCGAATATACGCAATTTAGTTC
TTAGAATTGAAAGTATATAATTGTTGTTTCTTCTTAAAAGAAAAAGAGCTTCTGAAATAA
TTTAAAGTTACTGCTTTTAGAAAACAGCTATCTCTTATTATGAGCAAGCGATGGAAAATA
TAAAAAAAATATAATTCCATTGGAGAGCAGCTTATTAGAGACTTAGAGAAGTTAGAAGTA
AAAGAATCAAAAATACTTATATTATAGTAATATTATTTTTATTTATTTATTTATTTGTTT
AAGAAAATTATATTTAAAGAAGGAAGTTTTGAATAAAGCTTGGTAAAAAATATTTACCAG
ATCAGTTACGACAATAGTTGAAAAGACAAAAAAGCTAGTAAGATGCTATTACTTAAAGTA
GATGTTTTCAAAACAACTCTATGAAATAAGAACAAAAAAAGCAGCTGTTATTTTTCTGAA
ACTTTTAAAAGGAAACTTTGTTAGAAAAAGAATAAAAAGGTTTAATTTAGCTGCATAGAA
GATACAAGCCAAAGTTAAGTAGATTTGGCTTACTGAATTATATTAAAAATTGAGAAAAGC
AATAATTATTATTTAAAGAAATGCTAGAATATTTATCATAAGAAAAAGAGAAAGGAATTA
AAGAAATGCAGAATTTTTAGGACCATTAGAATAAAATCTAAAAAGAATACGTATTTCTGA
AGAATTGCTTCTATTTAATGGTTAGTCTAAAGTTATTGATTAAAACACTTCTTTATAAAA
TGAGATAGTAAAATTTAATATATTAATTTGTTTTTAAAGTAGTAATCTTTTCAATTTAAA
ATTAGTTCCGTCTAGACAAGAGTTTAGAAAATGTTTTAGAAAAATCACATGAGCACTTCT
TTTAGTAGAGAATGTATTTGTTTAGTTATGTCATTGATTTTGAAATATTATCTGATACAA
GCGAAATTTATGATCCTTTGTGGTCATCTTTATACCAAGCTTCGTTTAAGGATAACTACG
ATAAACAGTCATATATCTAGCACATTTCAGTATAATTTAAAATAAATTAAATATATTTTT
ATTGAATTTTTATTGTAATTCAGATAGGAGATACTCACAGCTTAACCTGTAGCTTAAGCA
GTAAGATTCATACTTGGGGATGGAACGATTTTGGGTAACTGGGAGTACCAATTGTAGATG
AAGACGATCCTAACCAAGAATAAAACGTTTATACTGGTACATCAATTTACTCGATGAATG
TCCCTCCTTAAATTAAAAGAATTGCACAAATTTCTTCTGGTAGTAATCATTCTTTGCTAC
TTGATCACAGAGGGTAAATATGGTCTTGGGGTTGCAACAACAGAGGTAAATAAAATTATT
GTTAAAAATTAATATTAATTCTATAATATTAATTAGGATAATTGGGACTGAATCATTATG
AAAATATGGAAACACCGTAAAAGATTACATATCTAATGAATCCCAAAACCGAGTTTTGCA
AAGTTGAGTGCAGAGATGATGAAAACTATGCTATCACAAAAAGTGGTTAACTATTTCACT
GGCCCACTCTAGGTAATAAAAATAAAATAACAATATAATAGAAAAATAAACTATTAATTT
TAAAAAGGAATGTAAGGTGAGTGTGTGAATTACCCCCTTGAGGTAGTCATACCTAAAATA
ACCATTAAAGATGTGAGCTGTGGCCATAAATTTGTAATGATTTTAAGTAACTCTGGGCTT
TTATTTAGTTATGGAGAAAACAAAGAAGGCTAATTAGGATTAGGAGATCTGAATCCAAGA
AAAATACCTACTCTAGTTTACTGTTTGAGAGATGCTGGAGAGAAAATAAGCTAAATAGAT
TGCGGATTTAAGCACACAATATGCAAAACATCTTTAGGTATTTAAATATTACTTTTTTAT
GAAACTAAATTTATTTTTTAGGTAAGGTTTATACTTGGGGATGGGGAGGAAGAGGATAAC
TAGGACATGGAACAACAAATAATGAAATATACCCAAGAATTTTGTCATTTTCTAATTTGG
CCAAAGATAAATAGACTCCAACGTTATTTAAAGATAAATGCCTGCAGGTAGTGGCAGGAC
ATAGATGCTCGATGCTTTTAATGGAAAGCAGGAAAATTTATCAATTTGGCTCCAATTCAT
CATTAGATCATTAATCTTTCCCAGTTGAATTTAATATCAGATCGAAAGTAACCAAAACAA
CTTACATTATTTTTTTAATCTTATATTAAATTATCAAGAGCGACAAATTAAGCTAGAATT
TTTATGAGCCGATCAGAATCCAATCTTCATGGAGTAAAACATTAAGCTTAATATATGTTA
CTTATGGAAATACAAAAAATTGTTTTGAAAAAAATACTGTCCTAAAAACAAAAACAATAA
ATAATCTAACTTAAAAATGGGCTGATACAAACATAGATACAAGTAAATACTTTCAATGGA
TACTTATTTTTATCTTAATGGTATTTATGACTATTTTTTAAATAAAAATATAGTTGACCC
TCCATTTATAGAAAAGATAGCAAACTATATTTCAGAGAAAAATATGAAAATGCCTTTGTT
TAAAATGCCTACGATGCAGTTCGAATCCAAAATTAAATATAATTAACTTAAACACGAACT
TATCGAGGCTGATTAAATGAATAAAATTGAAATAGAGTATATGAATGCCTTGCAATACGA
ATAATAAGAAATTTATAATCAAAACCATCTAAGCTAAGGCAATCATTTATTAATTGAAGA
TCCTTAACTCACTTACTAAAACAGGTAAGTATTAGAAGAAATTAATTTCTAAAGAGAAAA
CTGGGAGGAATTTTAATCATTGGGTTTGGCACAAAGCACAAAAGACAGTTTAGTTGATCT
TAACTATGAAGAATATTTTAGAAATTAGCAAGAATTATAATAGAGAATTATCTAAGAACA
ACAATAATAATTATAATAAGAAGAGGAAAACAGGGCTATAATAAACTCTTAGAAACTGAG
TTAAAAGAAATAATACCCATCTTATAAAAAGTCAAACACTACATAATATCAAGTCGTAGA
AATACCTGAAAGCAAGTCAAATGCAAGTATATCTAATAATTCTATTAATAATAGTAAGAG
ACTTGATCAAAAAAGTATTAACGACACACTATCTAAGGCCTCTTCATCATCTTTTAATAA
TAAATAAAAAAGCAGTAGTAATTAGTCCTCATAAAATATAAAAAATTCATCAGTTGTGCA
ATAAGCTAATTAATAAAGTTTATCATTTTTTGAATAGCAAGGAAACTTAGATAGGTAAGA
TTAAAAAATAAATCCTTAATTATTGTTGAATTTAACAAATATTTTTTTATTTTATAGGAG
ATAAATGTTATAAATAGTAAAGGAAAAAGTGCTACAATTATCTAAAGTACCTGAAAATGA
ATGGACAGAAAATGATAGAAAATTTATGTAAGGAGCAATGCAATTAAGTTAATTTGACTT
TGATAATGCTTCTGAAAATAACTTATCTAAATCATAAGATAATAGTTCAATTAATAATAG
TCAGGCAAGCTAAAGAATGGAATAAATACCTACTGATAAAGCATAGTAAAATAACAGGGC
TAGTATCAGCTCAAATTCTTCTAAAAAAAGTGCAATCTCTCAAAAAAGTTAAAATCAACA
AGAAAAGTAATTAAAAATAAATTAAATATTAATCAAATCTAATTTTATTTAAAAAGAAAT
TAAAAGTAATAAATAAATCCTCAGCTTATTAATGTCAAAAAGAAATGGGATGAAATCAGA
AACACTCCATAATAGCAGTGGACATAAAATGACTATCAATTTATGGAAATTGTAAAGGCA
AATAACTTAGAAAAAGTTTTATTAGAATTTGATTGA

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Paragraph No	Gene Name	Paragraph Text
10	MYO1, MYO12, MYO11, MYO10, MYO9, MYO8, MYO5, MYO4, MYO3, MYO2, MYO13	Proteins of the myosin superfamily are ATP-dependent molecular motors that travel unidirectionally along actin filaments. The myosin heavy chain proteins are comprised of three domains: a head (motor) domain responsible for ATP hydrolysis at the N-terminus, a neck (lever arm) region, and a C-terminal tail region. Thirteen predicted myosin heavy chain genes have been identified in the Tetrahymena genome and named MYO1-MYO13. A phylogenetic analysis comparing these predicted proteins with the 19 previously identified myosin classes suggests that Myo1p-Myo12p belong to a previously undescribed class of myosins. This new family, designated Class XX, does not include Myo13p, which did not branch with this class or any of the other classes in the analysis. The neck and tail regions of the Tetrahymena myosins include a variety of domains characterized in other myosin classes, with each protein containing one or more of the following domains: coiled-coil (which may support dimerization); IQ motif (binding sites for calmodulin or calmodulin-like proteins); FERM domain (Four-point-one protein, Ezrin, Radixin, Moesin homology); and MyTH4 domain (Myosin Tail Homology 4).