Identifiers and Description

Gene Model Identifier

TTHERM_00854280

Standard Name

TPT1 (tRNA 2'-phosphotransferase 1)

Aliases

PreTt12253 | 151.m00066

Description

TPT1 RNA 2-prime-phosphotransferase Tpt1/KptA family protein; RNA 2'-phosphotransferase- Tpt1 / KptA family protein

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• transferase activity, transferring phosphorus-containing groups (IEA) | GO:0016772

Biological Process

• tRNA splicing, via endonucleolytic cleavage and ligation (IEA) | GO:0006388

Domains

• ( PF01885 ) RNA 2'-phosphotransferase, Tpt1 / KptA

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 11.1%

TetraMine Data

TTHERM_00854280

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_13254.1	8.001476333098533e-119	RNA 2-phosphotransferase, Tpt1 /KptA family protein (237 aa)
DictyBase	DDB_G0286929	5.0020095550341075e-51	DDB_G0286929 on chromosome: 4 position 5090123 to 5090773
Oxytricha	Contig3963.0.g42	8.001824328206442e-49	RNA 2-phosphotransferase, Tpt1 / KptA family
SGD	YOL102C	9.99967697349061e-30	TPT1 tRNA 2-phosphotransferase , catalyzes the final step in yeast tRNA splicing: the trans fer of the 2-PO(4) from the sp lice junction to NAD(+) to for m ADP-ribose 1-2cyclic phospha te and nicotinamide
Stentor Coeruleus	SteCoe_23725	1.2995814250075031e-24

General Information

No Data fetched for General Information

Associated Literature

1. Ref:25303953: Cranert S, Heyse S, Linger BR, Lescasse R, Price C (2014) Tetrahymena Pot2 is a developmentally regulated paralog of Pot1 that localizes to chromosome breakage sites but not to telomeres. Eukaryotic cell 13(12):1519-29
2. Ref:24297442: Premkumar VL, Cranert S, Linger BR, Morin GB, Minium S, Price C (2014) The 3' overhangs at Tetrahymena thermophila telomeres are packaged by four proteins, Pot1a, Tpt1, Pat1, and Pat2. Eukaryotic cell 13(2):240-5

Sequences

>TTHERM_00854280(coding)
ATGAAAAAGAGTTACGGAGGAAAGCGTAGAGATGACAATCCAGATGTTGGATTATCAAAG
AAGCTTGCATGGCTTTTGAGACATGGCGCAGAAAAGGAAGGTCTCAATATGGGTTCTGAT
GGCTATGTTTTACTTTAAGAGATCATGTCCAGAAATGATTTCAGTACCATAACATTCGAT
AAAGTTAAAAGCGTGGTAGATAACAACGATAAGAAAAGATTTGAAATGATTTAAAAAGAA
CATAACGGAAAGATTGAGTGGTTTATTAGAGCTAGTTAGGGACATACCATATCTTCTATT
AACGATGAAGAGTTATTGGACAAAATATCTTTAGATGTTGCATCTTCTCTTGGAATCGTT
GTCCATGGAACATATAAATAATTCTGGGAACCTATATCTAAGGAAGGTTTAAAGACAATG
CAAAGAAACCATATTCATTTTGCTATTGGATATCCTGGCGATAAGGAAGTTATTTCTGGA
ATGAGAAAAACTTGTGATGTATACATTGAAATAGATTTAGTTAAGGCTATTAACGATGGA
ATTGATTTCTTTATGTCAAAAAATAATGTAGTTCTAACTTCTGGTATCAATAAAGTTTTA
CCTCCCAAGTACTTCAAGGTAGTTAAAGATAGAAATGGAAAGATCTTATTTGCATAGCCT
GAAAAATTAGTAGAATAAAAAGATGATAATAAAGAAGAAATAGAGGAACAAAAATAAAGC
AACTGA

>TTHERM_00854280(protein)
MKKSYGGKRRDDNPDVGLSKKLAWLLRHGAEKEGLNMGSDGYVLLQEIMSRNDFSTITFD
KVKSVVDNNDKKRFEMIQKEHNGKIEWFIRASQGHTISSINDEELLDKISLDVASSLGIV
VHGTYKQFWEPISKEGLKTMQRNHIHFAIGYPGDKEVISGMRKTCDVYIEIDLVKAINDG
IDFFMSKNNVVLTSGINKVLPPKYFKVVKDRNGKILFAQPEKLVEQKDDNKEEIEEQKQS
N

>TTHERM_00854280(gene)
ATGAAAAAGAGTTACGGAGGAAAGCGTAGAGATGACAATCCAGATGTTGGATTATCAAAG
AAGCTTGCATGGCTTTTGAGACATGGCGCAGAAAAGGAAGGTCTCAATATGGGTTCTGAT
GGCTATGTTTTACTTTAAGAGATCATGTCCAGAAATGATTTCAGTACCATAACATTCGAT
AAAGTTAAAAGCGTGGTAGATAACAACGATAAGAAAAGATTTGAAATGATTTAAAAAGAA
CATAACGGAAAGATTGAGTGGTTTATTAGAGCTAGTTAGGGACATACCATATCTTCTATT
AACGATGAAGAGTTATTGGACAAAATATCTTTAGATGTTGCATCTTCTCTTGGAATCGTT
GTCCATGGAACATATAAATAATTCTGGGAACCTATATCTAAGGAAGGTTTAAAGACAATG
CAAAGAAACCATATTCATTTTGCTATTGGATATCCTGGCGATAAGGAAGTTATTTCTGGA
ATGAGAAAAACTTGTGATGTATACATTGAAATAGATTTAGTTAAGGCTATTAACGATGGA
ATTGATTTCTTTATGTCAAAAAATAATGTAGTTCTAACTTCTGGTATCAATAAAGTTTTA
CCTCCCAAGTACTTCAAGGTAGTTAAAGATAGAAATGGAAAGATCTTATTTGCATAGCCT
GAAAAATTAGTAGAATAAAAAGATGATAATAAAGAAGAAATAGAGGAACAAAAATAAAGC
AACTGA