Identifiers and Description

Gene Model Identifier

TTHERM_00420880

Standard Name

TPA7 (Tetrahymena P-type ATPase)

Aliases

PreTt07213 | 46.m00268 | 3679.m00118

Description

P-type ATPase; putative Na(+)/K(+) or H(+)/K(+) ATPase

Genome Browser

Gene Ontology Annotations

Cellular Component

• membrane (IEA) | GO:0016020
• macronucleus (IDA) | GO:0031039 | Ref:9124316

Molecular Function

• hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances (IEA) | GO:0016820
• ATP binding (IEA) | GO:0005524
• catalytic activity (IEA) | GO:0003824
• ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism (IEA) | GO:0015662
• ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism (ISS) | GO:0015662 | Ref:9124316

Biological Process

• cation transport (IEA) | GO:0006812
• ATP biosynthetic process (IEA) | GO:0006754
• metabolic process (IEA) | GO:0008152

Domains

• ( PF00122 ) E1-E2 ATPase
• ( TIGR01487 ) SPP-like hydrolase, Archaeal
• ( PF07670 ) transporter gate domain protein
• ( TIGR01497 ) K+-transporting ATPase, B subunit
• ( PF00702 ) haloacid dehalogenase-like hydrolase
• ( PF01773 ) Na+ dependent nucleoside transporter
• ( PF08282 ) haloacid dehalogenase-like hydrolase
• ( TIGR01511 ) copper-translocating P-type ATPase
• ( PF00690 ) Cation transporter/ATPase, N-terminus
• ( TIGR01512 ) cadmium-translocating P-type ATPase
• ( PF00689 ) Cation transporting ATPase, C-terminus
• ( PF01957 ) Nodulation efficiency protein D (NfeD)
• ( PF08113 ) Cytochrome c oxidase subunit IIa
• ( TIGR01524 ) magnesium-translocating P-type ATPase
• ( TIGR01482 ) Sucrose-phosphate phosphatase subfamily
• ( TIGR01525 ) heavy metal translocating P-type ATPase
• ( TIGR01484 ) HAD-superfamily hydrolase, subfamily IIB
• ( TIGR01647 ) plasma-membrane proton-efflux P-type ATPase
• ( TIGR01522 ) calcium-transporting P-type ATPase, PMR1-type
• ( TIGR01106 ) Na,H/K antiporter P-type ATPase, alpha
• ( TIGR01517 ) calcium-translocating P-type ATPase, PMCA-type
• ( TIGR01116 ) calcium-translocating P-type ATPase, SERCA-type
• ( TIGR01523 ) potassium/sodium efflux P-type ATPase, fungal-type
• ( TIGR01652 ) phospholipid-translocating P-type ATPase, flippase
• ( TIGR01657 ) P-type ATPase of unknown pump
• ( TIGR01494 ) ATPase, P-type (transporting), HAD superfamily,
• ( PF03720 ) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding

Gene Expression Profile

• Tetrahymena Functional Genomics Database: TTHERM_00420880

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
IPI(HUMAN)	IPI:IPI00640401.1	9.99709313703352e-262	INV:HIT000016484;HIT000026903 ;HIT000026909|VEGA:OTTHUMP0 00 00029880 Tax_Id=9606 Cation-tr ansporting ATPase
ParameciumDB	GSPATP00000481001	9.99709313703352e-262	Paramecium tetraurelia GSPATP0 0000481001 protein
WormBase	B0365.3	9.99709313703352e-262	WBGene00001137 eat-6 Na(+)/K(+ ) ATPase alpha subunit
FlyBase	FBgn0002921	9.99709313703352e-262
DictyBase	DDB0185106	9.99731681937898e-180	ionA Sodium/potassium-transpor ting ATPase alpha-4 chain
DictyBase	DDB0169159	9.99731681937898e-180	ionA Sodium/potassium-transpor ting ATPase alpha-4 chain
SGD	YGL167C	6.99942886807893e-92	PMR1 SGDID:S000003135, Chr VII from 190474-187622, reverse c omplement, Verified ORF, "High affinity Ca2+/Mn2+ P-type ATP ase required for Ca2+ and Mn2+ transport into Golgi; involve d in Ca2+ dependent protein so rting and processing; mutation s in human homolog ATP2C1 caus e acantholytic skin condition Hailey-Hailey disease"
ToxoDB	65.m01184	3.00036186930044e-85	Toxoplasma gondii P-type ATPas e, putative
TAIR	AT1G10130	1.00022237125043e-79	calcium-transporting ATPase 3, endoplasmic reticulum-type (A CA6) (ECA3)
CryptoDB	EAK87832	6.99861161427514e-73	Cryptosporidium parvum (Iowa) protein EAK87832
PlasmoDB	PFL0590c	5.00174235931608e-68	Plasmodium falciparum PFL0590c

General Information

No Data fetched for General Information

Associated Literature

1. Ref:11952090: Linder JU, Schultz JE (2002) Guanylyl cyclases in unicellular organisms. Molecular and cellular biochemistry 230(1-2):149-58
2. Ref:10428960: Linder JU, Engel P, Reimer A, Krüger T, Plattner H, Schultz A, Schultz JE (1999) Guanylyl cyclases with the topology of mammalian adenylyl cyclases and an N-terminal P-type ATPase-like domain in Paramecium, Tetrahymena and Plasmodium. The EMBO journal 18(15):4222-32
3. Ref:9405804: Wang S, Gao D, Penny J, Krishna S, Takeyasu K (1997) P-type ATPases in Tetrahymena. Annals of the New York Academy of Sciences 834( ):158-60
4. Ref:9124316: Wang S, Takeyasu K (1997) Primary structure and evolution of the ATP-binding domains of the P-type ATPases in Tetrahymena thermophila. The American journal of physiology 272(2 Pt 1):C715-28

Sequences

>TTHERM_00420880(coding)
ATGTAATAACATATAAACGATATCGATAATCGTAGACGTGTTTCATCTATAGCTTTGCAC
TTTGAAGAGCTGAGATAAACAGTGACATTAAATAATGCTGTCAGAGAAAGAAAATAAACT
TAGCACCTTCACAACTACAGCTAAAAATAGTAACATTATGAAAACAAGATACCCCACTCA
AATAAATATACTATGGAATATGAGGATCTAGAGACTTAAGATACAAGTTTAATAGAGCAA
GTTTAACAAAACCATTAAAACCATGACGAAATGGTTGAATAAGCTGCAAACTAAATCTAA
GCTAAAGTAGATCATAAAATTGCTTTAGATAAGCTTTACAAAAAGTATTAAACTAGTTCT
TAAAAGGGTTTAACAACAGACCAAGCAAGTAAGTTACTCGAGGAACACGGTGAAAATAAA
TTAACTGAAAAAGATAAAACACCATGGTGGGTTTTACTTCTCAAGGAATTAACTAATGGG
TTTGCTATTATGCTTTGGCTGGGTGGTATTTTGTGTTTTATTACTTATGGCTTAAATTCT
TCAGATCCCTCTAATCTTTATTTAGGTATTGTTATCATAATTGTTATCAGTATTACAGCT
GTTATAACTTTTTAATAAAATGCTAAATCTGAAGCTATTATGGAATCTTTTAAAAATTTT
ATTCCTCAAAACTCTACTGTAATTAGAGATGGTAGTATCAAAAATATTTCTGCAGTGACT
TTAGTTGTTGGTGACATAGTATTAGTAAAAGCTGGTGAAAAAATTCCTGCAGATATTCGT
ATTATTGAATCTAACGAAATGAAAGTAGATAATTCTCCTCTAACAGGTGAGTGTGAACCA
CTTCTTCGTACAGTAGAATGCTCTCATCCAGATAGCTATCTTGAAACTTCTAACCTTGCA
TTCTTTGGAACTCTTTGCAAAGAAGGAACAGGAAAGGGAATCGTTATTTGTACTGGTGAT
AGAACAACACTTGGATAAATTGCGGATCTAACCTCTAGTGATAAAAAGGCTAAAACTCCT
TTGAGAATCGAGCTAGATCGTTTCGTTTTAATGATTACTATTATTGCAATTTTTCTTGGT
GTTCTATTCTTTTTCTTAGCTTTTTTTGTTATGAATTATGATTCTCTTACATGTATTATT
TTTGGTATTGGTATTCTAGTTGCTAACGTCCCAGAAGGCTTACTTGGCTGTATTACAGTC
TCTCTAGCTATTACAGCTAAGAATCTCTCTAAAAAGTAGGTATTAGTAAAAAATCTAGAA
GCAGTAGAAACCTTAGGGTCAACTACATGTATTTGCTCAGACAAAACAGGTACTCTTACT
CAAAATGTTATGTCTGTGAAGCATATGTGGTACAATAATAGAATTCATATAGCTCAGAAC
TAAAAATTGCTAAATGGAAATAAGGCTGATTATGATATGAATGATCCTAACTTTATGATG
CTTCATTAATCTGCTATGATTTGCAGCGAAGCTCGTTTCGACACATCTAGCTTACCCGAT
TAAACAGATATAGATTATTTAACATGCCCAGTAATTGGGGATGCAACTGAAACAGGCTTA
ATTCGCTTCTATTAATATATTTCCGATGTCAACAAATTCCGTGATAGATTCAAAGTAGTT
CGTAATCCTGATGGTACTTAAGCTAAAATGCCTTTCAATTCTTCAGTGAAATTTGCATTA
ACAATAGTTGAAGAAAAAACATAAAATAGTAATTATTGTGTATATATTAAAGGAGCTCCT
GAGAAAATATGGGCTTATTGCTCTTCTGTACTTATAGGCTAAAAACCTGATATTATTAAT
TAAAAATGGAAAGATGAATTTAAAAAGGTTAATCTTATTTTTGGTAAGGGAGGCGAAAGA
GTACTCGGATTTGCAAGATTACCTCTTCCTTCTGACTTATATCCTATGGGATCTCATTTT
ACTGTTTCATCAATATCGAAATTCAACTTTAAACTGGAAAACTTTTAATTTTGTGGTTTA
GTTTCCTTAATGGATCCTCCGAAAACTAGAGTTCCAGCTGCTATACTTGAATGCAGATCT
GCTGGTATAAAAGTTATAATGGTTACTGGAGATTAACCTCCAACAGCAGCAGCAATAGCT
AAAGAAGTAAATATTGTACCAAAAGACATTTAAACAAATGAAGATATACTAGAGTAAAAT
CCTGATATTGATTGGTTTGATGCAAGTGAAAAATGTGAAGCAATAGTTGTACATGGAGAC
AGAATAGTAGAGTCTATTGATAGATGCTCGTAAGAAGGGAGAGATGATGAATTATACTAT
CTAAGGAGATGGGTAAATAAACCTTATTGCGTTTTTGCTCGTACTACACCAGCATAAAAA
CTTTAAATAGTGAATGCTTGCTAAAAAGAAGGCTTTATTTGCGCAGTTACTGGTGATGGA
GTTAATGATTCTCCTGCTATTAAATAAGGCGATATCGGAATTTCAATGAATATTTCAGGT
AGTGATGTGACTAAAGATGCTGCTGATATGATTCTTCTTGACGATGATTTTGCTTCTATC
GTTAGTGGAATTGAAGAAGGCAGAAAAATTTTTGATAACCTTAAAAAAACAGTAGTTTAT
CTTTTAACATCAAATATGACTGAAATTGTTCCCTTCTTAGCCTTCATAGTTTGCCAAATT
CCTCTCCCTCTTTCCAGTATATTTATGCTCGTTATATGTGTTGGTACTGATATTTGGCCA
GCTATTTCTCTAGCATATGAAGAAGCCGAATTAGATGTGATGACAAGAAAACCACGTACA
AAGGAAGAACATCTTGTTTCAGCAAAGTTAATAACTATATCTTATCTTATGTTAGGTTAA
ATTGGATCAGCAGGTGGATTTATTGGATATTTTGTGTGCTTTAATTATTTAGGCTTTCCT
GTTAAATCTTTATTTGGTATTGCAAATGCTGAAGGATATAAACCTCCTGTAAATGACTTC
AATACTTATCATAATAATGATCCATATTTTAACTCAGCTTTACATGCTCTCACTTTGGGT
GACTGTAATAAAAATGCTAAAGCTGCTGAAAAGATTAAATACACTATTGACTGGTCAAAT
TTAAATGATGTTAATTATGATCTGAGAAAATCATTACTTAAATGTAATTCTTAAGGTTAG
TGGGTCCCTGCAATTGAATGGAGTCATTGTAATGTCAACTCTTCAAGTTATAAATCAGAT
AGTGTCAAAGTAACTTCTTGTTATTCAATAGATGCTATATACTGGGCATAATCAGTTTAC
TTTGTATCAATTGTAACTATTTAATGGTCAAATATTTTTGCCTGTAAGTCTAGAAAAATG
AGTTTTACAACATCTGCTTTTAACAAAACCATGGTTTAAGGAGTTATTTTTGAGACACTA
ATAGCATTATTCCTTCTCTATGTCCCAGGTGTCTAAGATGTATTTGGAGGAAGATCCCTC
CCATTTTTCTTGTTTGGTATACCAGGAATATGTTTGAGTATAACTCTTCTTGCTTGGGAG
GAGACAAGAAAATATTTAGCTAGAACCTAAAGATGGTTTTTGAAATATGCTTTATGGTGA

>TTHERM_00420880(protein)
MQQHINDIDNRRRVSSIALHFEELRQTVTLNNAVRERKQTQHLHNYSQKQQHYENKIPHS
NKYTMEYEDLETQDTSLIEQVQQNHQNHDEMVEQAANQIQAKVDHKIALDKLYKKYQTSS
QKGLTTDQASKLLEEHGENKLTEKDKTPWWVLLLKELTNGFAIMLWLGGILCFITYGLNS
SDPSNLYLGIVIIIVISITAVITFQQNAKSEAIMESFKNFIPQNSTVIRDGSIKNISAVT
LVVGDIVLVKAGEKIPADIRIIESNEMKVDNSPLTGECEPLLRTVECSHPDSYLETSNLA
FFGTLCKEGTGKGIVICTGDRTTLGQIADLTSSDKKAKTPLRIELDRFVLMITIIAIFLG
VLFFFLAFFVMNYDSLTCIIFGIGILVANVPEGLLGCITVSLAITAKNLSKKQVLVKNLE
AVETLGSTTCICSDKTGTLTQNVMSVKHMWYNNRIHIAQNQKLLNGNKADYDMNDPNFMM
LHQSAMICSEARFDTSSLPDQTDIDYLTCPVIGDATETGLIRFYQYISDVNKFRDRFKVV
RNPDGTQAKMPFNSSVKFALTIVEEKTQNSNYCVYIKGAPEKIWAYCSSVLIGQKPDIIN
QKWKDEFKKVNLIFGKGGERVLGFARLPLPSDLYPMGSHFTVSSISKFNFKLENFQFCGL
VSLMDPPKTRVPAAILECRSAGIKVIMVTGDQPPTAAAIAKEVNIVPKDIQTNEDILEQN
PDIDWFDASEKCEAIVVHGDRIVESIDRCSQEGRDDELYYLRRWVNKPYCVFARTTPAQK
LQIVNACQKEGFICAVTGDGVNDSPAIKQGDIGISMNISGSDVTKDAADMILLDDDFASI
VSGIEEGRKIFDNLKKTVVYLLTSNMTEIVPFLAFIVCQIPLPLSSIFMLVICVGTDIWP
AISLAYEEAELDVMTRKPRTKEEHLVSAKLITISYLMLGQIGSAGGFIGYFVCFNYLGFP
VKSLFGIANAEGYKPPVNDFNTYHNNDPYFNSALHALTLGDCNKNAKAAEKIKYTIDWSN
LNDVNYDLRKSLLKCNSQGQWVPAIEWSHCNVNSSSYKSDSVKVTSCYSIDAIYWAQSVY
FVSIVTIQWSNIFACKSRKMSFTTSAFNKTMVQGVIFETLIALFLLYVPGVQDVFGGRSL
PFFLFGIPGICLSITLLAWEETRKYLARTQRWFLKYALW

>TTHERM_00420880(gene)
ATGTAATAACATATAAACGATATCGATAATCGTAGACGTGTTTCATCTATAGCTTTGCAC
TTTGAAGAGCTGAGATAAACAGTGACATTAAATAATGCTGTCAGAGAAAGAAAATAAACT
TAGCACCTTCACAACTACAGCTAAAAATAGTAACATTATGAAAACAAGATACCCCACTCA
AATAAATATACTATGGAATATGAGGATCTAGAGACTTAAGATACAAGTTTAATAGAGCAA
GTTTAACAAAACCATTAAAACCATGACGAAATGGTTGAATAAGCTGCAAACTAAATCTAA
GCTAAAGTAGATCATAAAATTGCTTTAGATAAGCTTTACAAAAAGTATTAAACTAGTTCT
TAAAAGGGTTTAACAACAGACCAAGCAAGTAAGTTACTCGAGGAACACGGTGAAAATAAA
TTAACTGAAAAAGATAAAACACCATGGTGGGTTTTACTTCTCAAGGAATTAACTAATGGG
TTTGCTATTATGCTTTGGCTGGGTGGTATTTTGTGTTTTATTACTTATGGCTTAAATTCT
TCAGATCCCTCTAATCTTTATTTAGGTATTGTTATCATAATTGTTATCAGTATTACAGCT
GTTATAACTTTTTAATAAAATGCTAAATCTGAAGCTATTATGGAATCTTTTAAAAATTTT
ATTCCTCAAAACTCTACTGTAATTAGAGATGGTAGTATCAAAAATATTTCTGCAGTGACT
TTAGTTGTTGGTGACATAGTATTAGTAAAAGCTGGTGAAAAAATTCCTGCAGATATTCGT
ATTATTGAATCTAACGAAATGAAAGTAGATAATTCTCCTCTAACAGGTGAGTGTGAACCA
CTTCTTCGTACAGTAGAATGCTCTCATCCAGATAGCTATCTTGAAACTTCTAACCTTGCA
TTCTTTGGAACTCTTTGCAAAGAAGGAACAGGAAAGGGAATCGTTATTTGTACTGGTGAT
AGAACAACACTTGGATAAATTGCGGATCTAACCTCTAGTGATAAAAAGGCTAAAACTCCT
TTGAGAATCGAGCTAGATCGTTTCGTTTTAATGATTACTATTATTGCAATTTTTCTTGGT
GTTCTATTCTTTTTCTTAGCTTTTTTTGTTATGAATTATGATTCTCTTACATGTATTATT
TTTGGTATTGGTATTCTAGTTGCTAACGTCCCAGAAGGCTTACTTGGCTGTATTACAGTC
TCTCTAGCTATTACAGCTAAGAATCTCTCTAAAAAGTAGGTATTAGTAAAAAATCTAGAA
GCAGTAGAAACCTTAGGGTCAACTACATGTATTTGCTCAGACAAAACAGGTACTCTTACT
CAAAATGTTATGTCTGTGAAGCATATGTGGTACAATAATAGAATTCATATAGCTCAGAAC
TAAAAATTGCTAAATGGAAATAAGGCTGATTATGATATGAATGATCCTAACTTTATGATG
CTTCATTAATCTGCTATGATTTGCAGCGAAGCTCGTTTCGACACATCTAGCTTACCCGAT
TAAACAGATATAGATTATTTAACATGCCCAGTAATTGGGGATGCAACTGAAACAGGCTTA
ATTCGCTTCTATTAATATATTTCCGATGTCAACAAATTCCGTGATAGATTCAAAGTAGTT
CGTAATCCTGATGGTACTTAAGCTAAAATGCCTTTCAATTCTTCAGTGAAATTTGCATTA
ACAATAGTTGAAGAAAAAACATAAAATAGTAATTATTGTGTATATATTAAAGGAGCTCCT
GAGAAAATATGGGCTTATTGCTCTTCTGTACTTATAGGCTAAAAACCTGATATTATTAAT
TAAAAATGGAAAGATGAATTTAAAAAGGTTAATCTTATTTTTGGTAAGGGAGGCGAAAGA
GTACTCGGATTTGCAAGATTACCTCTTCCTTCTGACTTATATCCTATGGGATCTCATTTT
ACTGTTTCATCAATATCGAAATTCAACTTTAAACTGGAAAACTTTTAATTTTGTGGTTTA
GTTTCCTTAATGGATCCTCCGAAAACTAGAGTTCCAGCTGCTATACTTGAATGCAGATCT
GCTGGTATAAAAGTTATAATGGTTACTGGAGATTAACCTCCAACAGCAGCAGCAATAGCT
AAAGAAGTAAATATTGTACCAAAAGACATTTAAACAAATGAAGATATACTAGAGTAAAAT
CCTGATATTGATTGGTTTGATGCAAGTGAAAAATGTGAAGCAATAGTTGTACATGGAGAC
AGAATAGTAGAGTCTATTGATAGATGCTCGTAAGAAGGGAGAGATGATGAATTATACTAT
CTAAGGAGATGGGTAAATAAACCTTATTGCGTTTTTGCTCGTACTACACCAGCATAAAAA
CTTTAAATAGTGAATGCTTGCTAAAAAGAAGGCTTTATTTGCGCAGTTACTGGTGATGGA
GTTAATGATTCTCCTGCTATTAAATAAGGCGATATCGGAATTTCAATGAATATTTCAGGT
AGTGATGTGACTAAAGATGCTGCTGATATGATTCTTCTTGACGATGATTTTGCTTCTATC
GTTAGTGGAATTGAAGAAGGCAGAAAAATTTTTGATAACCTTAAAAAAACAGTAGTTTAT
CTTTTAACATCAAATATGACTGAAATTGTTCCCTTCTTAGCCTTCATAGTTTGCCAAATT
CCTCTCCCTCTTTCCAGTATATTTATGCTCGTTATATGTGTTGGTACTGATATTTGGCCA
GCTATTTCTCTAGCATATGAAGAAGCCGAATTAGATGTGATGACAAGAAAACCACGTACA
AAGGAAGAACATCTTGTTTCAGCAAAGTTAATAACTATATCTTATCTTATGTTAGGTTAA
ATTGGATCAGCAGGTGGATTTATTGGATATTTTGTGTGCTTTAATTATTTAGGCTTTCCT
GTTAAATCTTTATTTGGTATTGCAAATGCTGAAGGATATAAACCTCCTGTAAATGACTTC
AATACTTATCATAATAATGATCCATATTTTAACTCAGCTTTACATGCTCTCACTTTGGGT
GACTGTAATAAAAATGCTAAAGCTGCTGAAAAGATTAAATACACTATTGACTGGTCAAAT
TTAAATGATGTTAATTATGATCTGAGAAAATCATTACTTAAATGTAATTCTTAAGGTTAG
TGGGTCCCTGCAATTGAATGGAGTCATTGTAATGTCAACTCTTCAAGTTATAAATCAGAT
AGTGTCAAAGTAACTTCTTGTTATTCAATAGATGCTATATACTGGGCATAATCAGTTTAC
TTTGTATCAATTGTAACTATTTAATGGTCAAATATTTTTGCCTGTAAGTCTAGAAAAATG
AGTTTTACAACATCTGCTTTTAACAAAACCATGGTTTAAGGAGTTATTTTTGAGACACTA
ATAGCATTATTCCTTCTCTATGTCCCAGGTGTCTAAGATGTATTTGGAGGAAGATCCCTC
CCATTTTTCTTGTTTGGTATACCAGGAATATGTTTGAGTATAACTCTTCTTGCTTGGGAG
GAGACAAGAAAATATTTAGCTAGAACCTAAAGATGGTTTTTGAAATATGCTTTATGGTGA