Identifiers and Description

Gene Model Identifier

TTHERM_00508990

Standard Name

TPA6 (Tetrahymena P-type ATPase)

Aliases

PreTt10684 | 64.m00164 | 3723.m00027

Description

Na,H/K antiporter P-type ATPase, alpha subunit family protein; P-type ATPase; putative Na(+)/K(+) or H(+)/K(+) ATPase

Genome Browser (Macronucleus)

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Genome Browser (Micronucleus)

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Gene Ontology Annotations

Cellular Component

Molecular Function

  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances (IEA) | GO:0016820
  • ATP binding (IEA) | GO:0005524
  • catalytic activity (IEA) | GO:0003824
  • ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism (IEA) | GO:0015662

Biological Process

Domains

  • ( PF00122 ) E1-E2 ATPase
  • ( TIGR00099 ) Cof-like hydrolase
  • ( TIGR02988 ) S4 domain protein YaaA
  • ( TIGR01487 ) SPP-like hydrolase, Archaeal
  • ( TIGR01497 ) K+-transporting ATPase, B subunit
  • ( PF00702 ) haloacid dehalogenase-like hydrolase
  • ( PF08282 ) haloacid dehalogenase-like hydrolase
  • ( TIGR01511 ) copper-translocating P-type ATPase
  • ( PF00690 ) Cation transporter/ATPase, N-terminus
  • ( TIGR01512 ) cadmium-translocating P-type ATPase
  • ( PF00689 ) Cation transporting ATPase, C-terminus
  • ( TIGR01524 ) magnesium-translocating P-type ATPase
  • ( TIGR01525 ) heavy metal translocating P-type ATPase
  • ( TIGR01647 ) plasma-membrane proton-efflux P-type ATPase
  • ( TIGR01522 ) calcium-transporting P-type ATPase, PMR1-type
  • ( TIGR01106 ) Na,H/K antiporter P-type ATPase, alpha
  • ( TIGR01517 ) calcium-translocating P-type ATPase, PMCA-type
  • ( TIGR01116 ) calcium-translocating P-type ATPase, SERCA-type
  • ( TIGR01523 ) potassium/sodium efflux P-type ATPase, fungal-type
  • ( TIGR01652 ) phospholipid-translocating P-type ATPase, flippase
  • ( TIGR01657 ) P-type ATPase of unknown pump
  • ( TIGR01494 ) ATPase, P-type (transporting), HAD superfamily,
  • ( PF03720 ) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding

Gene Expression Profile

  • Tetrahymena Functional Genomics Database:

TetraMine Data

TTHERM_00508990

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

SourceIdentifierScoreDescription
Stentor CoeruleusSteCoe_244780
WormBaseWBGene000011379.997093137033517e-262locus:eat-6 status:Confirmed
UniProt:P90735 protein_id
:CAB02694.1
Tetrahymena borealisEI9_15482.19.997093137033517e-262Na,H/K antiporter P-type ATPas
e, alpha subunit protein (1215
aa)
DictyBaseDDB_G02679249.997093137033517e-262DDB_G0267924 on chromosome: 1
position 1128799 to 1132710
OxytrichaContig21999.0.g1289.997093137033517e-262E1-E2 ATPase
SGDYGL167C1.0001900614163146e-108PMR1 High affinity Ca2+/Mn2+ P
-type ATPase required for Ca2+
and Mn2+ transport into Golgi
; involved in Ca2+ dependent p
rotein sorting and processing;
mutations in human homolog AT
P2C1 cause acantholytic skin c
ondition Hailey-Hailey disease

General Information

No Data fetched for General Information

Associated Literature

  1. Ref:11952090: Linder JU, Schultz JE (2002) Guanylyl cyclases in unicellular organisms. Molecular and cellular biochemistry 230(1-2):149-58
  2. Ref:10428960: Linder JU, Engel P, Reimer A, Krüger T, Plattner H, Schultz A, Schultz JE (1999) Guanylyl cyclases with the topology of mammalian adenylyl cyclases and an N-terminal P-type ATPase-like domain in Paramecium, Tetrahymena and Plasmodium. The EMBO journal 18(15):4222-32
  3. Ref:9124316: Wang S, Takeyasu K (1997) Primary structure and evolution of the ATP-binding domains of the P-type ATPases in Tetrahymena thermophila. The American journal of physiology 272(2 Pt 1):C715-28
  4. Ref:9405804: Wang S, Gao D, Penny J, Krishna S, Takeyasu K (1997) P-type ATPases in Tetrahymena. Annals of the New York Academy of Sciences 834( ):158-60

Sequences

>TTHERM_00508990(coding)
ATGAAGGAAGTAGAACTTAATGAAAAAAGTATAAAAAATGATTTGCAAGACAATAACTAA
GTTCTAGACTAGTCTGTTAACAGGTCGATGAACTCTGCTATTGTACGTAAGTATGAAGAA
CTGAGATAGTCTATCAATATTCGTAATTCATAGAACTTTTATAAATCAAATAAAAATAAT
ACACAAGCACTTAAAGGCTTTGAAGAGCCTATTGATATTCCTAACCATGTAAATTCATTG
GTCAATTTTGATGGATATTCTTAAAATACAGAATACGATATGCATTAATAAATTACTGTA
CAAGAGAAAAAGCCAGCTGTTAGCACTACCGATAAAAATGAAAGATCTAAAGAAGAATTA
GCAGCTAAAGTAGATCATAAAATCTCTCTTAGTGAATTAAAAAATAAATATAAGACAGAT
TTTCAAAATGGCTTACAAGAAGATTAAGTAGGTGAACATTTAGCTTTGTATGGAGAAAAT
AAGCTCACAGAAAAATAAAAAACACCTGCATGGGTAGTCATTCTGAAAGAATTAACTAAC
GGTTTTGCTATCATGCTTTGGGTAAGTGCGGGGCTTTGCTTCTTAGCATATGGTCTAACC
CCAGATGACCCTTCAAATATGTATCTTGCAATTGTATTGCTAATTGTTATTTTCATTACA
GCTTTTATTACTTACTAATAAAATGCAAAAAGTGAAGCTCTACTAAATTCTTTTAAAAGC
TTCATACCTTAAAAATCTACTGTATTAAGAGATGGCAAGGTTAAAAATATTGAATCAATT
AAATTAGTTGTTGGAGATATTGTTCTGATTAAAGCCGGAGAAAAAATACCTGCTGATATC
CGTATATTAGAATCTTCTGAAATGAAAGTAGATAACTCTGCTCTCACTGGTGAAAGTGAA
CCTTAGCTCAGAACAGTTGATTGCTCTCACCCTGAAAACTATCTTGAAACTTCTAATATA
GCTTTCTTTGGTACACTTTGTAAAGAAGGTACAGCAAAAGGTATTGTTATTTGCACTGGT
GACAGAACTACTCTTGGGTAAATTGCAGATTTGTCTTCAGGTGAGAAGAAGTCTAAAACT
CCTTTACGTACAGAATTAGATAGATTTGTTTACATGGTTACTATACTAGGTATATTTTTA
TGCATTTTATTCTTCCTTTTAGCTTACTTAGTTATTGGGTTCCCAATAATGTCATGCATT
GTCTTTGGTATTGGTATCCTAGTCGCAAATGTTCCAGAAGGTTTATTAGGTTGTATTACT
ATTTGTCTAGCAATTACTGCTAAGAATCTTGCAAAAAAGCAGGTCCTTGTCAAAAACTTA
GAAGCTGTCGAAACTCTTGGTTCTACTTCTTGTATTTGTACTGACAAAACAGGTACTTTG
ACCTAAAATGTTATGACTGTTAAGCATATTTGGATTAATGATACTGTATTTGAAACTCCT
TATCTTTTACATCTTTAAAAAGGTTAATAACCTCCTTATGATACAAACGACATAGGCTTC
AAAACTCTTTAGTAGGCTGCTATGATTTCTAGTGAAGCAGTATTTGATTTATCTAGCTTA
TAAGATTAGACTAATGTTGATTATCTTAAATGCCCAGTTATTGGTGATGCCACCGAAACT
GGTTTGATACGTTTCTATTAATAGATTGACGATGTCAATAAATTTAGAAGTCAATTTAAA
ATTGTCAAAAACTCTGATGATACATAGAGTAGAATGCCTTTTAGCTCATAACACAAATTT
GCTCTTACTGTTGTTGAAGAAGAATCAGAAAACAGCTATTATGCAGTTTATATGAAAGGT
GCTCCTGAAAAAATTTGGAGTTACTGCTCAACTGTGTATAGTAATAACTAACTAAACGAA
ATTGACAACTAATGGTAGTAAAAATTTAAGTAAGTTAATTTATAATTTGGTAAAGGAGGA
GAAAGGGTTTTAGGTTTTGCTAAGCTTGTTCTTCCAGCAACTTAATTCCCAAAGGGTACT
CAATTCCATGTCCAAAATCCTTCTAAATTTACATTCTAACTTGCTAGATTCTAATTTTGC
GGATTAGTTTCTCTTATGGATCCTCCTAAACCAAGAGTTCCTTATGCTATCCTTGAGTGC
AGATCTGCAGGTATTAAGGTTATTATGGTTACTGGTGATTAACCTCCTACTGCTGCTGCC
ATTGCAAAAGAAGTTAATATAGTTCCACACGAAATTATTACTAATGAAGATTTGATGGAA
AACGACCAAACTCTTGACTGGTTCACTGCCAGTGAATAGTGTGAAGCTATTATTGTTCAT
GGTGATAGAATTCTAGAATCCTTTGAAAAATCGATTGAAGAAAAGAGAGAATCTCCTGAT
TTTTATCTTCGTCAATGGGTAAATAAACCATATTGTGTTTTCGCTAGAACCACCCCCGCC
TAAAAACTCTAAATTGTAGAGGCCTGTTAGAAGGAAGGCTTTATTGTCGCAGCAACTGGT
GATGGTGTTAATGATTCTCCTGCTATAAAAAAAGCTGATATTGGTGTTTCGATGAATCTA
TCTGGTAGTGATGTCACAAAAGATGCAGCAGATATGATTCTCCTTGATGATGATTTTGCT
TCAATTGTACTTGGTGTTGAAGAAGGTAGAAAAATTTTTGATAATCTAAAAAAATCATGT
GTTTACTTGCTTACTTCGAATATGACTGAAATTGTTCCATTCTTAGCATTTATCATTTTG
CTACTTCCTGTACCTCTTTCTAGTATATATATGCTCGTTTTACAAGTTGGTACAGATATA
TGGCCTGCTATTTCCCTAGCATATGAAGAAGCTGAATTAGATGTAATGACTAGAAAACCT
CGTAAAAAAACAGACCATTTATGCTCACTTAAATTAGTTACTATTGGTTATTTCTAAATG
GGTTAATTAGAAAGTGCAGCTGGTTTTGTTGGCTATTATATGATGTTTAACTATTTTGGT
TTCCCAGTTAGAGAATTATTTGGACTAGCTAATGTTTCTGGATACACTCCATTGAAAGAT
GATTTTGATGTCCATAAAAATCCTTTTACAGGCAATTAATAAGATCCTTATTTCAATAGC
GAAATATTAAGAGTTGCAGGAACATATGATTGCAGATTAGGTAAAAAGGCAGCAAGTTCT
ATTAAAAGTGATATTAATTGGTAGAAGTTAACAGATGGTAACTTCGACTTAAGAAAATCT
CTATTGAAGTGCAATGAATAGACTGGTGAATGGTTACCAACTGTAAATTGGAGTGATTGT
GATGTAAAATCTAGTAAAACTTGGTCAGATGTCACAAGTCAAACAGCTTGTTACAGTACT
GAAGCATTAAAGTGGGCATAAACAGGTTTCTTCTCTTCTGTTGTAACAAGTTAATGGTCT
AATGTATTTGCTTGTAAGAGTAGAAAAATGAGTTTTGTCACTTCTAGTGTTAATTCAGTA
ATGTTTTAAGGTATTATTTTTGAAACTGCTCTGCTTTGTTTCTTATTATATGTCCCAGGA
GTCCAAGTAGTTTTTGGAAGTAGACCTTATGAATTTTGGATGTTCTGTCATGGATTATTT
TTCAGTATATCTTTATTATTATGGGATGAAGTAAGAAAATTTACAACTAGACGTTTTAAA
TGGTTCTTCAAATTCGCTTATTGGTGA


>TTHERM_00508990(protein)
MKEVELNEKSIKNDLQDNNQVLDQSVNRSMNSAIVRKYEELRQSINIRNSQNFYKSNKNN
TQALKGFEEPIDIPNHVNSLVNFDGYSQNTEYDMHQQITVQEKKPAVSTTDKNERSKEEL
AAKVDHKISLSELKNKYKTDFQNGLQEDQVGEHLALYGENKLTEKQKTPAWVVILKELTN
GFAIMLWVSAGLCFLAYGLTPDDPSNMYLAIVLLIVIFITAFITYQQNAKSEALLNSFKS
FIPQKSTVLRDGKVKNIESIKLVVGDIVLIKAGEKIPADIRILESSEMKVDNSALTGESE
PQLRTVDCSHPENYLETSNIAFFGTLCKEGTAKGIVICTGDRTTLGQIADLSSGEKKSKT
PLRTELDRFVYMVTILGIFLCILFFLLAYLVIGFPIMSCIVFGIGILVANVPEGLLGCIT
ICLAITAKNLAKKQVLVKNLEAVETLGSTSCICTDKTGTLTQNVMTVKHIWINDTVFETP
YLLHLQKGQQPPYDTNDIGFKTLQQAAMISSEAVFDLSSLQDQTNVDYLKCPVIGDATET
GLIRFYQQIDDVNKFRSQFKIVKNSDDTQSRMPFSSQHKFALTVVEEESENSYYAVYMKG
APEKIWSYCSTVYSNNQLNEIDNQWQQKFKQVNLQFGKGGERVLGFAKLVLPATQFPKGT
QFHVQNPSKFTFQLARFQFCGLVSLMDPPKPRVPYAILECRSAGIKVIMVTGDQPPTAAA
IAKEVNIVPHEIITNEDLMENDQTLDWFTASEQCEAIIVHGDRILESFEKSIEEKRESPD
FYLRQWVNKPYCVFARTTPAQKLQIVEACQKEGFIVAATGDGVNDSPAIKKADIGVSMNL
SGSDVTKDAADMILLDDDFASIVLGVEEGRKIFDNLKKSCVYLLTSNMTEIVPFLAFIIL
LLPVPLSSIYMLVLQVGTDIWPAISLAYEEAELDVMTRKPRKKTDHLCSLKLVTIGYFQM
GQLESAAGFVGYYMMFNYFGFPVRELFGLANVSGYTPLKDDFDVHKNPFTGNQQDPYFNS
EILRVAGTYDCRLGKKAASSIKSDINWQKLTDGNFDLRKSLLKCNEQTGEWLPTVNWSDC
DVKSSKTWSDVTSQTACYSTEALKWAQTGFFSSVVTSQWSNVFACKSRKMSFVTSSVNSV
MFQGIIFETALLCFLLYVPGVQVVFGSRPYEFWMFCHGLFFSISLLLWDEVRKFTTRRFK
WFFKFAYW


>TTHERM_00508990(gene)
ATGAAGGAAGTAGAACTTAATGAAAAAAGTATAAAAAATGATTTGCAAGACAATAACTAA
GTTCTAGACTAGTCTGTTAACAGGTCGATGAACTCTGCTATTGTACGTAAGTATGAAGAA
CTGAGATAGTCTATCAATATTCGTAATTCATAGAACTTTTATAAATCAAATAAAAATAAT
ACACAAGCACTTAAAGGCTTTGAAGAGCCTATTGATATTCCTAACCATGTAAATTCATTG
GTCAATTTTGATGGATATTCTTAAAATACAGAATACGATATGCATTAATAAATTACTGTA
CAAGAGAAAAAGCCAGCTGTTAGCACTACCGATAAAAATGAAAGATCTAAAGAAGAATTA
GCAGCTAAAGTAGATCATAAAATCTCTCTTAGTGAATTAAAAAATAAATATAAGACAGAT
TTTCAAAATGGCTTACAAGAAGATTAAGTAGGTGAACATTTAGCTTTGTATGGAGAAAAT
AAGCTCACAGAAAAATAAAAAACACCTGCATGGGTAGTCATTCTGAAAGAATTAACTAAC
GGTTTTGCTATCATGCTTTGGGTAAGTGCGGGGCTTTGCTTCTTAGCATATGGTCTAACC
CCAGATGACCCTTCAAATATGTATCTTGCAATTGTATTGCTAATTGTTATTTTCATTACA
GCTTTTATTACTTACTAATAAAATGCAAAAAGTGAAGCTCTACTAAATTCTTTTAAAAGC
TTCATACCTTAAAAATCTACTGTATTAAGAGATGGCAAGGTTAAAAATATTGAATCAATT
AAATTAGTTGTTGGAGATATTGTTCTGATTAAAGCCGGAGAAAAAATACCTGCTGATATC
CGTATATTAGAATCTTCTGAAATGAAAGTAGATAACTCTGCTCTCACTGGTGAAAGTGAA
CCTTAGCTCAGAACAGTTGATTGCTCTCACCCTGAAAACTATCTTGAAACTTCTAATATA
GCTTTCTTTGGTACACTTTGTAAAGAAGGTACAGCAAAAGGTATTGTTATTTGCACTGGT
GACAGAACTACTCTTGGGTAAATTGCAGATTTGTCTTCAGGTGAGAAGAAGTCTAAAACT
CCTTTACGTACAGAATTAGATAGATTTGTTTACATGGTTACTATACTAGGTATATTTTTA
TGCATTTTATTCTTCCTTTTAGCTTACTTAGTTATTGGGTTCCCAATAATGTCATGCATT
GTCTTTGGTATTGGTATCCTAGTCGCAAATGTTCCAGAAGGTTTATTAGGTTGTATTACT
ATTTGTCTAGCAATTACTGCTAAGAATCTTGCAAAAAAGCAGGTCCTTGTCAAAAACTTA
GAAGCTGTCGAAACTCTTGGTTCTACTTCTTGTATTTGTACTGACAAAACAGGTACTTTG
ACCTAAAATGTTATGACTGTTAAGCATATTTGGATTAATGATACTGTATTTGAAACTCCT
TATCTTTTACATCTTTAAAAAGGTTAATAACCTCCTTATGATACAAACGACATAGGCTTC
AAAACTCTTTAGTAGGCTGCTATGATTTCTAGTGAAGCAGTATTTGATTTATCTAGCTTA
TAAGATTAGACTAATGTTGATTATCTTAAATGCCCAGTTATTGGTGATGCCACCGAAACT
GGTTTGATACGTTTCTATTAATAGATTGACGATGTCAATAAATTTAGAAGTCAATTTAAA
ATTGTCAAAAACTCTGATGATACATAGAGTAGAATGCCTTTTAGCTCATAACACAAATTT
GCTCTTACTGTTGTTGAAGAAGAATCAGAAAACAGCTATTATGCAGTTTATATGAAAGGT
GCTCCTGAAAAAATTTGGAGTTACTGCTCAACTGTGTATAGTAATAACTAACTAAACGAA
ATTGACAACTAATGGTAGTAAAAATTTAAGTAAGTTAATTTATAATTTGGTAAAGGAGGA
GAAAGGGTTTTAGGTTTTGCTAAGCTTGTTCTTCCAGCAACTTAATTCCCAAAGGGTACT
CAATTCCATGTCCAAAATCCTTCTAAATTTACATTCTAACTTGCTAGATTCTAATTTTGC
GGATTAGTTTCTCTTATGGATCCTCCTAAACCAAGAGTTCCTTATGCTATCCTTGAGTGC
AGATCTGCAGGTATTAAGGTTATTATGGTTACTGGTGATTAACCTCCTACTGCTGCTGCC
ATTGCAAAAGAAGTTAATATAGTTCCACACGAAATTATTACTAATGAAGATTTGATGGAA
AACGACCAAACTCTTGACTGGTTCACTGCCAGTGAATAGTGTGAAGCTATTATTGTTCAT
GGTGATAGAATTCTAGAATCCTTTGAAAAATCGATTGAAGAAAAGAGAGAATCTCCTGAT
TTTTATCTTCGTCAATGGGTAAATAAACCATATTGTGTTTTCGCTAGAACCACCCCCGCC
TAAAAACTCTAAATTGTAGAGGCCTGTTAGAAGGAAGGCTTTATTGTCGCAGCAACTGGT
GATGGTGTTAATGATTCTCCTGCTATAAAAAAAGCTGATATTGGTGTTTCGATGAATCTA
TCTGGTAGTGATGTCACAAAAGATGCAGCAGATATGATTCTCCTTGATGATGATTTTGCT
TCAATTGTACTTGGTGTTGAAGAAGGTAGAAAAATTTTTGATAATCTAAAAAAATCATGT
GTTTACTTGCTTACTTCGAATATGACTGAAATTGTTCCATTCTTAGCATTTATCATTTTG
CTACTTCCTGTACCTCTTTCTAGTATATATATGCTCGTTTTACAAGTTGGTACAGATATA
TGGCCTGCTATTTCCCTAGCATATGAAGAAGCTGAATTAGATGTAATGACTAGAAAACCT
CGTAAAAAAACAGACCATTTATGCTCACTTAAATTAGTTACTATTGGTTATTTCTAAATG
GGTTAATTAGAAAGTGCAGCTGGTTTTGTTGGCTATTATATGATGTTTAACTATTTTGGT
TTCCCAGTTAGAGAATTATTTGGACTAGCTAATGTTTCTGGATACACTCCATTGAAAGAT
GATTTTGATGTCCATAAAAATCCTTTTACAGGCAATTAATAAGATCCTTATTTCAATAGC
GAAATATTAAGAGTTGCAGGAACATATGATTGCAGATTAGGTAAAAAGGCAGCAAGTTCT
ATTAAAAGTGATATTAATTGGTAGAAGTTAACAGATGGTAACTTCGACTTAAGAAAATCT
CTATTGAAGTGCAATGAATAGACTGGTGAATGGTTACCAACTGTAAATTGGAGTGATTGT
GATGTAAAATCTAGTAAAACTTGGTCAGATGTCACAAGTCAAACAGCTTGTTACAGTACT
GAAGCATTAAAGTGGGCATAAACAGGTTTCTTCTCTTCTGTTGTAACAAGTTAATGGTCT
AATGTATTTGCTTGTAAGAGTAGAAAAATGAGTTTTGTCACTTCTAGTGTTAATTCAGTA
ATGTTTTAAGGTATTATTTTTGAAACTGCTCTGCTTTGTTTCTTATTATATGTCCCAGGA
GTCCAAGTAGTTTTTGGAAGTAGACCTTATGAATTTTGGATGTTCTGTCATGGATTATTT
TTCAGTATATCTTTATTATTATGGGATGAAGTAAGAAAATTTACAACTAGACGTTTTAAA
TGGTTCTTCAAATTCGCTTATTGGTGA