Identifiers and Description

Gene Model Identifier

TTHERM_00700900

Standard Name

TPA2 (Tetrahymena P-type ATPase )

Aliases

PreTt14887 | 109.m00105

Description

P-type ATPase; putative Na(+)/K(+) or H(+)/K(+) ATPase; constitutively expressed; expression upregulated at 37C and downregulated by starvation

Genome Browser (Macronucleus)

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Genome Browser (Micronucleus)

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Gene Ontology Annotations

Cellular Component

Molecular Function

  • catalytic activity (IEA) | GO:0003824
  • ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism (IEA) | GO:0015662
  • ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism (ISS) | GO:0015662 | Ref:9124316
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances (IEA) | GO:0016820
  • ATP binding (IEA) | GO:0005524

Biological Process

Domains

  • ( PF07813 ) LTXXQ motif
  • ( PF00122 ) E1-E2 ATPase
  • ( TIGR01487 ) SPP-like hydrolase, Archaeal
  • ( PF07670 ) transporter gate domain protein
  • ( TIGR01497 ) K+-transporting ATPase, B subunit
  • ( PF00702 ) haloacid dehalogenase-like hydrolase
  • ( PF08282 ) haloacid dehalogenase-like hydrolase
  • ( TIGR01511 ) copper-translocating P-type ATPase
  • ( PF00690 ) Cation transporter/ATPase, N-terminus
  • ( TIGR01512 ) cadmium-translocating P-type ATPase
  • ( PF00689 ) Cation transporting ATPase, C-terminus
  • ( TIGR01524 ) magnesium-translocating P-type ATPase
  • ( PF06790 ) Uncharacterised protein family (UPF0259)
  • ( TIGR01482 ) Sucrose-phosphate phosphatase subfamily
  • ( TIGR01525 ) heavy metal translocating P-type ATPase
  • ( TIGR01647 ) plasma-membrane proton-efflux P-type ATPase
  • ( TIGR01522 ) calcium-transporting P-type ATPase, PMR1-type
  • ( TIGR01106 ) Na,H/K antiporter P-type ATPase, alpha
  • ( TIGR01517 ) calcium-translocating P-type ATPase, PMCA-type
  • ( TIGR01116 ) calcium-translocating P-type ATPase, SERCA-type
  • ( TIGR01523 ) potassium/sodium efflux P-type ATPase, fungal-type
  • ( TIGR01652 ) phospholipid-translocating P-type ATPase, flippase
  • ( TIGR01657 ) P-type ATPase of unknown pump
  • ( TIGR01494 ) ATPase, P-type (transporting), HAD superfamily,

Gene Expression Profile

  • Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.3%

TetraMine Data

TTHERM_00700900

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

SourceIdentifierScoreDescription
Stentor CoeruleusSteCoe_244780
WormBaseWBGene000011379.997093137033517e-262locus:eat-6 status:Confirmed
UniProt:P90735 protein_id
:CAB02694.1
Tetrahymena borealisEI9_01247.19.997093137033517e-262Na,H/K antiporter P-type ATPas
e, alpha subunit protein (1197
aa)
DictyBaseDDB_G02679249.997093137033517e-262DDB_G0267924 on chromosome: 1
position 1128799 to 1132710
OxytrichaContig21999.0.g1289.997093137033517e-262E1-E2 ATPase
SGDYGL167C9.999453238338778e-112PMR1 High affinity Ca2+/Mn2+ P
-type ATPase required for Ca2+
and Mn2+ transport into Golgi
; involved in Ca2+ dependent p
rotein sorting and processing;
mutations in human homolog AT
P2C1 cause acantholytic skin c
ondition Hailey-Hailey disease

General Information

No Data fetched for General Information

Associated Literature

  1. Ref:11952090: Linder JU, Schultz JE (2002) Guanylyl cyclases in unicellular organisms. Molecular and cellular biochemistry 230(1-2):149-58
  2. Ref:10428960: Linder JU, Engel P, Reimer A, Krüger T, Plattner H, Schultz A, Schultz JE (1999) Guanylyl cyclases with the topology of mammalian adenylyl cyclases and an N-terminal P-type ATPase-like domain in Paramecium, Tetrahymena and Plasmodium. The EMBO journal 18(15):4222-32
  3. Ref:9405804: Wang S, Gao D, Penny J, Krishna S, Takeyasu K (1997) P-type ATPases in Tetrahymena. Annals of the New York Academy of Sciences 834( ):158-60
  4. Ref:9124316: Wang S, Takeyasu K (1997) Primary structure and evolution of the ATP-binding domains of the P-type ATPases in Tetrahymena thermophila. The American journal of physiology 272(2 Pt 1):C715-28

Sequences

>TTHERM_00700900(coding)
ATGAGTTAAGTTAATGTCAGGTAGTCTGCCTCTCTCGTAAGAAAATTCGAAGAAATGAGG
CAGTCTATCTAAATCAACAACTCTATTCAGCAAATGAGATAGAGTTAATAGTACTAGACT
GGTATTCAAGAAAACTAAGATGGCAACAAAGTAGCCCATAGAAACGCAGACGTCCTCGAA
GAAATAGGTTTGAAGACTGAAGATGTCTTCATCAATAACAATGGAACATAGGTATAATAG
CAACAAGATCACCATGCTAAAGGCAAATAAATTTCTAAAGAAGACAAGTCTAAGAAAGAA
TTAGTCGAAAAAGTTGACCACAAGATTTCTCTTGAGGAACTTAGATAAAAGTATGAAACT
GACTACTAAAAGGGTCTTACCGAAGAATAAGCTGCTCATTTACTCAAAATTCATGGTGAG
AATAAACTTACTGAGAAGGTAAAAACTCCTTTCTGGGTTAAGATTCTTATTGAATTGACT
AATGGTTTCGCGCTCTTACTTTGGATCAGTGCTGGTTTATGTTTCCTTGCTTATGGCCTA
AGTCCTGATGATCCCTCTAACATCTATTTGGCTATTGTCATTCTCGTTGTCATCTTCATC
ACTACCGCTATTACTTTCCAACAGAATTCCAAGAGTGAAGCTCTGATGAACTCATTTAAA
AACTTCATTCCTGCAAAATGTATTGTAATCAGAGGAGGATAACCAAAGTCAATTGATGCA
GCTCACTTGGTTGTTGGTGATATAGTATCTATCAGATTGGGAGAGAAGATACCAGCTGAT
ATTCGTATCCTTGAATCAAATGAAATGAAAGTTGATAACTCACCTCTCACTGGTGAGTGC
GAACCTCTTTTGCGTACTGTTGAGTGCTCTCATCCCGAAAGTTATCTAGAAACCTCAAAT
ATTGCTTTCTTTGGTACTTTATGCAAAGAAGGTAATGGCAAAGGTATTGTCATTTGCACC
GGTGATAGAACTACTCTTGGATAAATCGCTGATTTGTCATCAGGTGAGAAAAAGGTTAAG
ACTCCTCTTCGTTAAGAACTTGACCGTTTTGTCATTTTAATTACTATCATCGCTATTTTC
CTTGGTGTTCTTTTCTTCTTGTTAGCCTACTTCTACATGAAATACGATTACATGGTTTGC
ATCGTTTTTGGTATTGGTATTCTTGTCGCTAACGTACCCGAAGGTTTATTGGGTTGCATT
ACCATTTCCTTGGCTATTACTGCTAAGAATCTCGCTGTAAAAAATGTTCTTGTTAAGAAT
CTAGAAGCTGTTGAAACCCTTGGTTCTACTTCTTGTATTTGCTCAGACAAAACTGGTACT
CTTACTCAGAATGTTATGTCTGTCAAGAATATGTGGTTTAAGGATAAGATTTACATGTGC
AAGAACAAAGTCCATCTTAAGCAAGGTGAAATTCCTGAGTACGATATCAACGATAACGAT
TTCTAAACCCTTCAAAAGGCTGCTATGTTGAGTAGTGAAGCTCGTTTTGATACCTCCTCA
GTTAAAGACCAATCTAACATCGACTACATAACATGTCCAGTTATGGGAGATGCCACCGAA
ACTGGTATCATTAGATTCTTTTAATACATTGATGATGTCAACAAATTCCGTGAAAGATAT
TAAATTGCTAAAAACCCTGATGGAACATACGGTAAAATGCCTTTTAACTCATAAGTTAAA
TTTGCATTGACCATCATTCAAGAATAGCTTCCTGGTAGCAACTACACTGTTTATATCAAA
GGTGCTCCTGAAAAGATTTGGAGTTACTGCAATTCAGTTATGATTAATGGCTAACCAAGT
CAAATTGATTAAACATGGTAGAAGAAATTCAAAGCAGTCAATCTCACTTTTGGTAAGGGA
GGTGAAAGAGTTCTTGGATTTGCTAAGCTCCATTTACCTGCTGAAGATTTCCCTGAAGGC
TTTATTTTCAATGTTTCTTCACTTTAAAAATTCCCCTTCAAATTGGCTAATTTCTAGTTC
TGCGGTCTTATTTCATTGATGGATCCTCCTAAAACTAGAGTTCCCTATGCAATTTTGGAA
TGCAGATCTGCTGGTGTCAAAGTTATCATGGTTACAGGCGATCAACCTCCTACTGCTGCT
GCCATCGCCAAAGAAGTCAACATTATTCCTAAGGAAGTTATTACTAATGAAGATATCTTG
GAACAAAATCCCAGTAAAACTTGGTGGGAAGCAAGTGAAGAGTGCGAGGCTATCATTGTC
CATGGTGATAGAATCGTAGAATCGTTTGAGAAATCATTATCTGAGTAAAAATAAGAAAAC
TTCTACTTGCGTTAATGGGTAAAAAAACAATATTGCGTATTTGCAAGAACAACACCTGCT
CAAAAATTACAAATTGTAGATGCTTGCCAAATGGAAGGATTTATTGTCGCTGCAACAGGT
GATGGTGTCAACGACTCTCCTGCTATCAAGAAAGCTGATATTGGTATTTCAATGAACTTG
TCAGGATCTGATGTTACTAAAGATGCTGCTGATATGGTTTTAATTGATGATGATTTTGCT
TCTATTGTTTTGGGTGTTGAAGAAGGTAGAAAAATCTTCGATAACTTAAAGAAGACTGTT
GTCTATCTTCTTACTTCTAATATGACTGAAGTCGTTCCCTTCTTGGCTTTCATTATTTTG
GAATTACCTTTACCTCTCTCTAGTATTTACATGTTAGTTATTTGTGTCGGAACTGATGTT
TGGCCTGCCATTTCTTTAGCATATGAAGAAGCTGAACTTGATGTTATGACTAGAAGACCT
CGTCTAAAATCTGAACATCTTGTTTCTAATAAATTGATTACAATCGCTTACCTTCAAACT
GGTTAAATTGCAAGTGCAGCAGGATTCCTAGGTTACTATGTTGCATTTAACTATTTCGGT
TTCCCAGTCCTTTCATTATTTGGTATGGCTTCTGGATCAGGTTACAAACCACCCAAAAAT
GATTTCAACGAAAGCTACATCAATCCTATCACAAATTAGATAGACAAGAATTACAATACA
GAAATATATAAGATAACAGGAACTACTCGTTGTGACTAATTAAATAAAGATTAACAAGAT
AAATTAGACAAATTAAAATACACTGTAGACTGGTTTACTGTTACTGAAGGTAACTACGAT
TTAAGAAAGACATTTGTAAAATGTGATACAGATTCAGGTATTTTTGTTCCCATTTACAAA
TGGAGTGACTGCGATATTACCTTGAGTAAAAATAAATCACCTATCACTGACTAAACTGCC
TGTTATTCAACTGATGCTTAAAGATATGCATAAAGTGTCTACTTCATCAGTGTTGTCTTA
CTACAATGGTCAAATATCTTTGCTTGCAAGAGTAGATCAACAAGTTACTCAACCACAGCA
TTTAATTCTATTATGATTCATGGTGTCATCTTCGAAACTTGTTTAACCGTTTTCCTTTAA
TACGTCCCAGGAGTATAAGAAGTCTTCGGTGGTAGACCTCTATTCTTCTGGCTCTGGACA
CCAGCCTTAATTTTCAGTATAACTTTACTTGTTTATGATGAATTAAGAAAATTCCTTTGT
AGACATGTTAAGTGGTATTACAAATACTGTTACTGGTGA


>TTHERM_00700900(protein)
MSQVNVRQSASLVRKFEEMRQSIQINNSIQQMRQSQQYQTGIQENQDGNKVAHRNADVLE
EIGLKTEDVFINNNGTQVQQQQDHHAKGKQISKEDKSKKELVEKVDHKISLEELRQKYET
DYQKGLTEEQAAHLLKIHGENKLTEKVKTPFWVKILIELTNGFALLLWISAGLCFLAYGL
SPDDPSNIYLAIVILVVIFITTAITFQQNSKSEALMNSFKNFIPAKCIVIRGGQPKSIDA
AHLVVGDIVSIRLGEKIPADIRILESNEMKVDNSPLTGECEPLLRTVECSHPESYLETSN
IAFFGTLCKEGNGKGIVICTGDRTTLGQIADLSSGEKKVKTPLRQELDRFVILITIIAIF
LGVLFFLLAYFYMKYDYMVCIVFGIGILVANVPEGLLGCITISLAITAKNLAVKNVLVKN
LEAVETLGSTSCICSDKTGTLTQNVMSVKNMWFKDKIYMCKNKVHLKQGEIPEYDINDND
FQTLQKAAMLSSEARFDTSSVKDQSNIDYITCPVMGDATETGIIRFFQYIDDVNKFRERY
QIAKNPDGTYGKMPFNSQVKFALTIIQEQLPGSNYTVYIKGAPEKIWSYCNSVMINGQPS
QIDQTWQKKFKAVNLTFGKGGERVLGFAKLHLPAEDFPEGFIFNVSSLQKFPFKLANFQF
CGLISLMDPPKTRVPYAILECRSAGVKVIMVTGDQPPTAAAIAKEVNIIPKEVITNEDIL
EQNPSKTWWEASEECEAIIVHGDRIVESFEKSLSEQKQENFYLRQWVKKQYCVFARTTPA
QKLQIVDACQMEGFIVAATGDGVNDSPAIKKADIGISMNLSGSDVTKDAADMVLIDDDFA
SIVLGVEEGRKIFDNLKKTVVYLLTSNMTEVVPFLAFIILELPLPLSSIYMLVICVGTDV
WPAISLAYEEAELDVMTRRPRLKSEHLVSNKLITIAYLQTGQIASAAGFLGYYVAFNYFG
FPVLSLFGMASGSGYKPPKNDFNESYINPITNQIDKNYNTEIYKITGTTRCDQLNKDQQD
KLDKLKYTVDWFTVTEGNYDLRKTFVKCDTDSGIFVPIYKWSDCDITLSKNKSPITDQTA
CYSTDAQRYAQSVYFISVVLLQWSNIFACKSRSTSYSTTAFNSIMIHGVIFETCLTVFLQ
YVPGVQEVFGGRPLFFWLWTPALIFSITLLVYDELRKFLCRHVKWYYKYCYW


>TTHERM_00700900(gene)
ATGAGTTAAGTTAATGTCAGGTAGTCTGCCTCTCTCGTAAGAAAATTCGAAGAAATGAGG
CAGTCTATCTAAATCAACAACTCTATTCAGCAAATGAGATAGAGTTAATAGTACTAGACT
GGTATTCAAGAAAACTAAGATGGCAACAAAGTAGCCCATAGAAACGCAGACGTCCTCGAA
GAAATAGGTTTGAAGACTGAAGATGTCTTCATCAATAACAATGGAACATAGGTATAATAG
CAACAAGATCACCATGCTAAAGGCAAATAAATTTCTAAAGAAGACAAGTCTAAGAAAGAA
TTAGTCGAAAAAGTTGACCACAAGATTTCTCTTGAGGAACTTAGATAAAAGTATGAAACT
GACTACTAAAAGGGTCTTACCGAAGAATAAGCTGCTCATTTACTCAAAATTCATGGTGAG
AATAAACTTACTGAGAAGGTAAAAACTCCTTTCTGGGTTAAGATTCTTATTGAATTGACT
AATGGTTTCGCGCTCTTACTTTGGATCAGTGCTGGTTTATGTTTCCTTGCTTATGGCCTA
AGTCCTGATGATCCCTCTAACATCTATTTGGCTATTGTCATTCTCGTTGTCATCTTCATC
ACTACCGCTATTACTTTCCAACAGAATTCCAAGAGTGAAGCTCTGATGAACTCATTTAAA
AACTTCATTCCTGCAAAATGTATTGTAATCAGAGGAGGATAACCAAAGTCAATTGATGCA
GCTCACTTGGTTGTTGGTGATATAGTATCTATCAGATTGGGAGAGAAGATACCAGCTGAT
ATTCGTATCCTTGAATCAAATGAAATGAAAGTTGATAACTCACCTCTCACTGGTGAGTGC
GAACCTCTTTTGCGTACTGTTGAGTGCTCTCATCCCGAAAGTTATCTAGAAACCTCAAAT
ATTGCTTTCTTTGGTACTTTATGCAAAGAAGGTAATGGCAAAGGTATTGTCATTTGCACC
GGTGATAGAACTACTCTTGGATAAATCGCTGATTTGTCATCAGGTGAGAAAAAGGTTAAG
ACTCCTCTTCGTTAAGAACTTGACCGTTTTGTCATTTTAATTACTATCATCGCTATTTTC
CTTGGTGTTCTTTTCTTCTTGTTAGCCTACTTCTACATGAAATACGATTACATGGTTTGC
ATCGTTTTTGGTATTGGTATTCTTGTCGCTAACGTACCCGAAGGTTTATTGGGTTGCATT
ACCATTTCCTTGGCTATTACTGCTAAGAATCTCGCTGTAAAAAATGTTCTTGTTAAGAAT
CTAGAAGCTGTTGAAACCCTTGGTTCTACTTCTTGTATTTGCTCAGACAAAACTGGTACT
CTTACTCAGAATGTTATGTCTGTCAAGAATATGTGGTTTAAGGATAAGATTTACATGTGC
AAGAACAAAGTCCATCTTAAGCAAGGTGAAATTCCTGAGTACGATATCAACGATAACGAT
TTCTAAACCCTTCAAAAGGCTGCTATGTTGAGTAGTGAAGCTCGTTTTGATACCTCCTCA
GTTAAAGACCAATCTAACATCGACTACATAACATGTCCAGTTATGGGAGATGCCACCGAA
ACTGGTATCATTAGATTCTTTTAATACATTGATGATGTCAACAAATTCCGTGAAAGATAT
TAAATTGCTAAAAACCCTGATGGAACATACGGTAAAATGCCTTTTAACTCATAAGTTAAA
TTTGCATTGACCATCATTCAAGAATAGCTTCCTGGTAGCAACTACACTGTTTATATCAAA
GGTGCTCCTGAAAAGATTTGGAGTTACTGCAATTCAGTTATGATTAATGGCTAACCAAGT
CAAATTGATTAAACATGGTAGAAGAAATTCAAAGCAGTCAATCTCACTTTTGGTAAGGGA
GGTGAAAGAGTTCTTGGATTTGCTAAGCTCCATTTACCTGCTGAAGATTTCCCTGAAGGC
TTTATTTTCAATGTTTCTTCACTTTAAAAATTCCCCTTCAAATTGGCTAATTTCTAGTTC
TGCGGTCTTATTTCATTGATGGATCCTCCTAAAACTAGAGTTCCCTATGCAATTTTGGAA
TGCAGATCTGCTGGTGTCAAAGTTATCATGGTTACAGGCGATCAACCTCCTACTGCTGCT
GCCATCGCCAAAGAAGTCAACATTATTCCTAAGGAAGTTATTACTAATGAAGATATCTTG
GAACAAAATCCCAGTAAAACTTGGTGGGAAGCAAGTGAAGAGTGCGAGGCTATCATTGTC
CATGGTGATAGAATCGTAGAATCGTTTGAGAAATCATTATCTGAGTAAAAATAAGAAAAC
TTCTACTTGCGTTAATGGGTAAAAAAACAATATTGCGTATTTGCAAGAACAACACCTGCT
CAAAAATTACAAATTGTAGATGCTTGCCAAATGGAAGGATTTATTGTCGCTGCAACAGGT
GATGGTGTCAACGACTCTCCTGCTATCAAGAAAGCTGATATTGGTATTTCAATGAACTTG
TCAGGATCTGATGTTACTAAAGATGCTGCTGATATGGTTTTAATTGATGATGATTTTGCT
TCTATTGTTTTGGGTGTTGAAGAAGGTAGAAAAATCTTCGATAACTTAAAGAAGACTGTT
GTCTATCTTCTTACTTCTAATATGACTGAAGTCGTTCCCTTCTTGGCTTTCATTATTTTG
GAATTACCTTTACCTCTCTCTAGTATTTACATGTTAGTTATTTGTGTCGGAACTGATGTT
TGGCCTGCCATTTCTTTAGCATATGAAGAAGCTGAACTTGATGTTATGACTAGAAGACCT
CGTCTAAAATCTGAACATCTTGTTTCTAATAAATTGATTACAATCGCTTACCTTCAAACT
GGTTAAATTGCAAGTGCAGCAGGATTCCTAGGTTACTATGTTGCATTTAACTATTTCGGT
TTCCCAGTCCTTTCATTATTTGGTATGGCTTCTGGATCAGGTTACAAACCACCCAAAAAT
GATTTCAACGAAAGCTACATCAATCCTATCACAAATTAGATAGACAAGAATTACAATACA
GAAATATATAAGATAACAGGAACTACTCGTTGTGACTAATTAAATAAAGATTAACAAGAT
AAATTAGACAAATTAAAATACACTGTAGACTGGTTTACTGTTACTGAAGGTAACTACGAT
TTAAGAAAGACATTTGTAAAATGTGATACAGATTCAGGTATTTTTGTTCCCATTTACAAA
TGGAGTGACTGCGATATTACCTTGAGTAAAAATAAATCACCTATCACTGACTAAACTGCC
TGTTATTCAACTGATGCTTAAAGATATGCATAAAGTGTCTACTTCATCAGTGTTGTCTTA
CTACAATGGTCAAATATCTTTGCTTGCAAGAGTAGATCAACAAGTTACTCAACCACAGCA
TTTAATTCTATTATGATTCATGGTGTCATCTTCGAAACTTGTTTAACCGTTTTCCTTTAA
TACGTCCCAGGAGTATAAGAAGTCTTCGGTGGTAGACCTCTATTCTTCTGGCTCTGGACA
CCAGCCTTAATTTTCAGTATAACTTTACTTGTTTATGATGAATTAAGAAAATTCCTTTGT
AGACATGTTAAGTGGTATTACAAATACTGTTACTGGTGA