Identifiers and Description
Gene Model Identifier
TTHERM_00456750
Standard Name
TOP2B (TOPoisomerase 2B
)
Aliases
PreTt20305 | 53.m00207 | 3712.m00067
Description
TOP2B DNA topoisomerase IV; DNA topoisomerase type 2
Genome Browser (Macronucleus)
Genome Browser (Micronucleus)
Gene Ontology Annotations
Cellular Component Molecular Function Biological Process
Domains
( TIGR01059 ) DNA gyrase, B subunit
( TIGR01063 ) DNA gyrase, A subunit
( PF04702 ) Vicilin N terminal region
( TIGR01055 ) DNA topoisomerase IV, B subunit
( TIGR01058 ) DNA topoisomerase IV, B subunit
( TIGR01061 ) DNA topoisomerase IV, A subunit
( TIGR01062 ) DNA topoisomerase IV, A subunit
( PF00521 ) DNA gyrase/topoisomerase IV, A subunit
( PF00204 ) DNA topoisomerase II (N-terminal region)
( TIGR00162 ) conserved hypothetical protein TIGR00162
( PF02518 ) ATPase, histidine kinase-, DNA gyrase
Gene Expression Profile
Tetrahymena Functional Genomics Database:
Change in Gene Expression
TMHMM
Signal Peptide
Signal Peptide Present?: No
Presense Probability: 10.1%
TetraMine Data
TTHERM_00456750
WebApollo
Fullscreen View
Tetrahymena Stock Center
No Data fetched for StockID
Homologs (v.2006 protein sequences)
Source Identifier Score Description
Stentor Coeruleus SteCoe_19754 0
WormBase WBGene00010785 9.997093137033517e-262 locus:top-2 Probable DNA top
oisomerase 2 status:Partiall
y_confirmed UniProt:Q23670
protein_id:CAA88867.1
Tetrahymena borealis EI9_13766.1 9.997093137033517e-262 DNA gyrase/topoisomerase IV, A
subunit protein (1604 aa)
DictyBase DDB_G0270418 9.997093137033517e-262 top2 on chromosome: 1 position
4831688 to 4836353
Oxytricha Contig14442.0.g108 9.997093137033517e-262 DNA gyrase/topoisomerase IV, s
ubunit A
SGD YNL088W 9.997093137033517e-262 TOP2 Topoisomerase II, relieve
s torsional strain in DNA by c
leaving and re-sealing the pho
sphodiester backbone of both p
ositively and negatively super
coiled DNA; cleaves complement
ary strands; localizes to axia
l cores in meiosis
General Information
No Data fetched for General Information
Associated Literature
Ref:28621664 : Akematsu T, Fukuda Y, Garg J, Fillingham JS, Pearlman RE, Loidl J (2017) Post-meiotic DNA double-strand breaks occur in Tetrahymena, and require Topoisomerase II and Spo11. eLife 6( ): Ref:17821280 : Harrison JA, Fowler EH (1945) AN ANTIGEN-ANTIBODY REACTION WITH TETRAHYMENA WHICH RESULTS IN DYSTOMY. Science (New York, N.Y.) 102(2638):65-6
Sequences
>TTHERM_00456750(coding)ATG TCA GTC GAA ACA ACT TAT CAA AAA AAG ACA CAA CTT GAA CAT ATT TTA TTG AGA CCA GAT ACT TAC GTA GGT TCC AAT GAA TAC CAA GAT GAA TAA ATG TGG GTT CTA GCA GAT GAC GGA TCA TCT TTT GAA AAC AGA CAA ATA AAG TAT GTC CCA GCT CTT TAT AAA ATC TTT GAT GAA ATT CTT GTC AAC GCA GCT GAT AAC TAT TAG AGA GAT AAG AGA ATG AAA AGA TTA GAT GTA ATT ATT GAT CAA AAG AAC AAT TGT ATT TCA ATC CTA AAC GAC GGA AAA GGA ATT CCT GTT TAG ATT CAT AAA GAA TAT AAT ATT TAT GTT CCA GAA CTT ATT TTT GGA CAT CTT TTG ACT TCT TCA AAT TAT AAT GAC GAA GAA AAA AAA GTT GTA GGA GGT AGA AAT GGT TTT GGT GCA AAG CTT ACC AAT ATA TTT TCA ACT AAG TTT ATT GTA GAA TCA GCA GAC TCT AAA AAC AAA AAG AAA TTT TAA ATG ACT TGG ACA AAA AAC ATG TCT GAA TAA TCT GAA CCA CAA ATA TCA AGT TAT ACC GAA AGC GAC TAC ACA AAA ATC ACT TTT TAC CCT GAC TTA AAG AAA TTC CAC ATG AAA GAA CTA GAA AAG GAT ATT GTT GAC TTG ATG AAA AAA AGA GTA TAT GAT ATG GCT GGT GTC ATT GGC GGC TCT GTT AAA GTA TCA TTA AAT GGA GAA AGA ATT TCA ATA AGT TCA TTC TCT GAT TAT TGC GAT TTT TAT TTA AAG AAC CAA GGT GCA GAA GTA ATT AAG GTA TCA GAT AAT AAA GGT ACC AAT AAT TAA AGA TGG GAA GTT ATA GCA AGT TTA TCA GAG GGC TAA TTC TAA TAA GTT TCA TTT GTT AAT TCA ATT TGC ACC TCA AAG GGA GGT ACT CAT GTT AAC TAC ATA ACT GAC TAA ATC ACT GAA AAA TTG ATG GAA ACT TTG AAA AAA AAG GAG AAA AGT CTT AAC ATT AAG TAA TTT TAG GTT AAG AGT CAT TTA TGG ATT TTC GTT AAT TGC TTG ATT GAG AAT CCC TCT TTC GAT ACT TAA ACT AAA GAA ACA CTA ACT TTA AGA TAA TAA AGC TTC GGT TCA ACC TGT GAA GTT TCT GAA AAG TTT ATC AAA GAA CTC TTA AAA TCA AAT ATT ATT AAT CAT ATC CTC CTT TAA GCT AGA GCT AAA GAG TAA GCA AAG ATG GCT AAA ACT TTG TCT GCT AAA AAG CAA AGT AGA TTA TTA GGA GTT CCT AAG CTG GAA GAT GCA AAC GAT GCA GGT ACA AGA AAC GCT GAA AGC TGT ACA CTA ATT ATA ACA GAA GGT GAT TCT GCC AAA GCT TTA GCT ATG AGT GGT ATT GAA GTT GTT GGA AGA GAT AAA TTT GGT GTC TTC CCA TTA AAG GGT AAA ATG TTA AAT GTA AGA GAT TCT ACA AGC AAG CAA ATT ACA GAA AAT TTA GAA ATC TAA AAT ATC ATC AAG GTA ATG GGT ATG AAG CTA AAT ACA AAC TAT GAT AAT GTT AAA AGT TTG AGA TAT GGA TCA ATT ATG ATT ATG GCT GAT TAA GAT CAC GAT GGT TCC CAT ATC AAA GGT TTA TTC ATT AAC TTT ATA TAG AAT TTT TGG CCC AGC TTG TTC TAA ATG GAT GGT TTT CTT AAA GAA TTT ATT ACA CCA ATC GTG AAA GTT AGA AAA GGT AAT TAA TCA ATA AGC TTC TTT AGT ATT CAA GAC TTT AAA AGA TGG AAA AGC ACA TGC CCA AAC TAG CAT TTA TGG AAA ATT AAG TAT TAC AAA GGT CTT GGT ACT TCA ACC GAT TAA GAA GCC TAA GAA TAT TTT GGA AAT ATA AAC AAG CAT GTC ATT AGT TTT AAA TAC AAT GGT AAG GAT GAT GAA GAT GCT ATT GAT TTG GCT TTT AAT AAG AAG AGA GCT GAA GAC CGT AAA AAA TGG TTA GTT AAA TAT GAC CCA GAA GAA AAT GTT GAC CAC TCA TAA AAA CAT TTG ACA TAC AAA GAT TTT GTT AAT AAG GAG CTA ATT AAT TTT TCT AAT TCT GAT AAT GCA AGA TCT ATT CCC AGC CTT TGT GAT GGT TTA AAG CCT GGT TAA AGA AAA ATT CTT TTT GCA TGC TTT AAG AGA AAC TTG AAG AAT GAA ATT AAA GTA GCT TAG TTA TCT GGT TAT GTA GCT GAA CAC TCC GCT TAT CAC CAT GGT GAA TAA TCT TTA GAA TCT ACC ATT GTA GGT ATG GCT TAG AGT TTC GTT GGT ACA AAT AAC ATC AAT TAC CTC ATG CCT ATA GGT CAA TTC GGT TCT CGT AAC ATG GGA GGA AAG GAA GCT GCA TCT GCA AGA TAT ATC CAT ACT TGC TTA AAT AAA ATT ACT CGT TGT GTT TTC CCT GAG CCA GAC GAT CAT ATT CTC TAC TAC CTT GAA GAT GAA GGA TAA TAG GTA GAA CCT ATT TAT TAC CTT CCT ATC ATC CCT ACA GCT CTT TTA AAT GGT GCT GAT GGT ATC GGT ACA GGT TGG TCT ACT AGT ATT CCT TGC TAT AAC CCA AGA GAA TTA GTT GAT TCA ATT GAA AAA AGA ATG ATG GGA GTT CCC TTT ACT GAT TTA TTG CCA TGG TAC AAA GGT TTC ACT GGT GAA ATT TCT AAT AAC GAA AAA TCT TAA ATT ACT GTT AGT GGA AAG TAC CAT TTA GTA AAT GAA ACA ACA ATA GAA ATT ACT GAA TTA CCT ATT AAG AAA TGG ATT AGA GAT TAT AAG AAC TTT TTA GAA GAG AAA TTA GAA TCT ACT AAA GAT AAG GAT CCC GAA ATT GAA GAT ATT AAG GAA TAT CAT GCT GGT AAT AGA GTG CAT TTT GTA GTT AAA ATG AGC GAA AAG CAA ATG GAA AAA GTA TAA AGG GAA GGT ATT GAC AAA TAC TTC AAA TTA TAA TCA ACT ATT CCT ACT ACA AAC ATG GTT TTA TTC AAT CAT GAA GGA AAA CTT ACT AGA TAT GCT AAT ATT TGC GAA ATT ATG GAA GAG TTT TAT GAA GTT AGA TTA AAT GCA TAT AAA AGG AGA AAG GAA TAT TTG GTC TCT AAA ATC GAA CGT GAT TTA GAA ATT CTT TCT AAT AAA AAA AGA TTC ATT TTA GCT GTC ATA AAT GAA TCT ATT AGA GTA AGA AAC GCT AAG AGA AAA GAC TTG ATC AAA GAA CTA AGC GTC TAA GGT TAC GTC TAA ATG AAA GAT ATG CCA AAA ATT AAA TCA AGT AAG CTT ACA AGC TAA CTT GAA TAA GAA TAA AAT TAA GAT AGT AAT GAA GAA AAT TTT GAA ACT AAT CCT AAT GAG ATT AAT GCT AAA GAG TAT AAC TAT CTC CTT AGT TTG CCT ATG TGG AGC TTG ACT TAT GAA AAA GTT GAA GAG ATA AAG TAA GAA TAA AAA AAT AAG TAG GAC GAG TTA GAC AAG CTT GTT GCT ACT GAA GTT ATT GAT ATT TGG AAA GAA GAT CTT AAA AAC TTC ATT GAA TGC CTT GAT TAA ATT GAG GAA GAA GAA GAT GAA GAA ATG CGT AAA AGA ATG AAG AAA CAA AGC AAC TCT AAA GTT AAA TAA GGC AGT ACA GCT AGT TCT AAG TTA AAG AAA AAA CCA ACC AAG AAG AAA TAA GAT AGT GAC GAT GAT GAC GAT GAT GCC ATG GAT ATA GAG GAA GAT GGA GAT GGA TCA GAT TTT GAT ACA GGC AAG AAA AAA TAG AAG AAA AAA CCT TCA TCA GCT CCT TCT TCA TAA GCA GGA CCT AAG GGA AAG ATC GGT GAT TAT AAA CCT AAT TTG TCT TAA GAT ACA GGA ATA AGC AGT AAA ACA AAT AAA AAT AAT TAA AAT ACT CTC GGG TTT ATC AAA TAG TAA GCT CCA ATT ACT ACT TAA GTT AAG ACT CAA CCA GAA GTC AAA AAA CCA GTA GAT CCT TTG CTT GAA ACT TTA GAA AAA TAT ACT TTC AAG AAA GAA AAT ACT TAA ACA TAA AAA GAA GAA AAT AAT ACA TAA AAT TCA GTT ATA TCT TAA ATA CTT TCA TAA AAC TAT TCT CTA TCA CTT GAA GAG AGA CTT AAA TTG AGG GCA GGG GAA AAC TCA TAA AAT TTG ACT CAA TAA ACA AAT GGA TTT TCC TAA TAA GTA AAT ACA TAA TAA GAC TAT AAT AAC TTG GGC AAT AAA GAT GAA GAA GAA GAA GAT GAC CTT CTC TTT AAC TTC AAA AAA GAA AAG AAA GAG AAA TAA TCA ACT GAT ATT TTT GAT GAA TTA GAT GAT CTT GAT GCA CTT TTT AAT GAA AAA CGC TAA GGA GCA GAC CTC GAA AAT GAA GAA GAG TAG CTG ACC AAA AAA AGA GTT CTG AAT GAA GGA GAA CCA AAA AGT ATA GCT TAA AAT AAA AAA TAA ACA AAA GAA ATA AAT GAT GAA GAT CTT GAA TAT AAT TTG TTT AAG GAT GAA AAG CCA AAG TAA AAA AAG CCT CCT GCT ACT GCT GCT TCA AAA TCA AAG AAA GTG ATA AAT AAA AAT GAA GAT GAT GAT GAA GAC TTT AAT GAT GAT TTA TCA GAA GAT GAA AAA CCA AAG AAG AAA AGG TCC AAT TAA ACT TAA TCA AAA ACC AAA AAA TAG AAA AAT GAA AGT GAA GAT GAA GAT TTT AAT AGC AAA GAA TCT GAT GAA AAA CCT AAA TAA AGA AAA TCT AAT TCT AAC TCA TAA AAA GCA AGG AAA CCT AAG AAA ATG AGT GAT GAT GAG GGA GAA GAA GAT GAT GAT TTT ATC ATA CCT GAT GAG GAT TCT GAT GAA GAA AAA CCT AAG AAG AGA AAG AGT AAT GCA ACA AAA CCT AAA AAT AAT AAA GAA GAT AAA GAT AAT CAA AAG TCT AAA AAA AAT AGA ACC GAT TCA CCA AAA CTT AAA ATA ACA AAT TCA GAA GAT GAA GAT GTT GCT GAA TTA AAG CAA AAT GAA GTT TTA TAA ACC AGA ACA AGA GGT AAA AGA AAC CCA ATT CCT CGT AAA ATG ATC ATT GAT AAT TCT GAT GAA GAT TTC AGT GAA GAG GAA GAA TTT GGA AAT AGC AAA AAG AAA TCA GTA AAT AGT AAA AGC CAA AAA AAA TAA AAA GAC GAT GAA TCA TCG GAT GAA TGC TAT TTC TGA >TTHERM_00456750(protein)M S V E T T Y Q K K T Q L E H I L L R P D T Y V G S N E Y Q D E Q M W V L A D D G S S F E N R Q I K Y V P A L Y K I F D E I L V N A A D N Y Q R D K R M K R L D V I I D Q K N N C I S I L N D G K G I P V Q I H K E Y N I Y V P E L I F G H L L T S S N Y N D E E K K V V G G R N G F G A K L T N I F S T K F I V E S A D S K N K K K F Q M T W T K N M S E Q S E P Q I S S Y T E S D Y T K I T F Y P D L K K F H M K E L E K D I V D L M K K R V Y D M A G V I G G S V K V S L N G E R I S I S S F S D Y C D F Y L K N Q G A E V I K V S D N K G T N N Q R W E V I A S L S E G Q F Q Q V S F V N S I C T S K G G T H V N Y I T D Q I T E K L M E T L K K K E K S L N I K Q F Q V K S H L W I F V N C L I E N P S F D T Q T K E T L T L R Q Q S F G S T C E V S E K F I K E L L K S N I I N H I L L Q A R A K E Q A K M A K T L S A K K Q S R L L G V P K L E D A N D A G T R N A E S C T L I I T E G D S A K A L A M S G I E V V G R D K F G V F P L K G K M L N V R D S T S K Q I T E N L E I Q N I I K V M G M K L N T N Y D N V K S L R Y G S I M I M A D Q D H D G S H I K G L F I N F I Q N F W P S L F Q M D G F L K E F I T P I V K V R K G N Q S I S F F S I Q D F K R W K S T C P N Q H L W K I K Y Y K G L G T S T D Q E A Q E Y F G N I N K H V I S F K Y N G K D D E D A I D L A F N K K R A E D R K K W L V K Y D P E E N V D H S Q K H L T Y K D F V N K E L I N F S N S D N A R S I P S L C D G L K P G Q R K I L F A C F K R N L K N E I K V A Q L S G Y V A E H S A Y H H G E Q S L E S T I V G M A Q S F V G T N N I N Y L M P I G Q F G S R N M G G K E A A S A R Y I H T C L N K I T R C V F P E P D D H I L Y Y L E D E G Q Q V E P I Y Y L P I I P T A L L N G A D G I G T G W S T S I P C Y N P R E L V D S I E K R M M G V P F T D L L P W Y K G F T G E I S N N E K S Q I T V S G K Y H L V N E T T I E I T E L P I K K W I R D Y K N F L E E K L E S T K D K D P E I E D I K E Y H A G N R V H F V V K M S E K Q M E K V Q R E G I D K Y F K L Q S T I P T T N M V L F N H E G K L T R Y A N I C E I M E E F Y E V R L N A Y K R R K E Y L V S K I E R D L E I L S N K K R F I L A V I N E S I R V R N A K R K D L I K E L S V Q G Y V Q M K D M P K I K S S K L T S Q L E Q E Q N Q D S N E E N F E T N P N E I N A K E Y N Y L L S L P M W S L T Y E K V E E I K Q E Q K N K Q D E L D K L V A T E V I D I W K E D L K N F I E C L D Q I E E E E D E E M R K R M K K Q S N S K V K Q G S T A S S K L K K K P T K K K Q D S D D D D D D A M D I E E D G D G S D F D T G K K K Q K K K P S S A P S S Q A G P K G K I G D Y K P N L S Q D T G I S S K T N K N N Q N T L G F I K Q Q A P I T T Q V K T Q P E V K K P V D P L L E T L E K Y T F K K E N T Q T Q K E E N N T Q N S V I S Q I L S Q N Y S L S L E E R L K L R A G E N S Q N L T Q Q T N G F S Q Q V N T Q Q D Y N N L G N K D E E E E D D L L F N F K K E K K E K Q S T D I F D E L D D L D A L F N E K R Q G A D L E N E E E Q L T K K R V L N E G E P K S I A Q N K K Q T K E I N D E D L E Y N L F K D E K P K Q K K P P A T A A S K S K K V I N K N E D D D E D F N D D L S E D E K P K K K R S N Q T Q S K T K K Q K N E S E D E D F N S K E S D E K P K Q R K S N S N S Q K A R K P K K M S D D E G E E D D D F I I P D E D S D E E K P K K R K S N A T K P K N N K E D K D N Q K S K K N R T D S P K L K I T N S E D E D V A E L K Q N E V L Q T R T R G K R N P I P R K M I I D N S D E D F S E E E E F G N S K K K S V N S K S Q K K Q K D D E S S D E C Y F >TTHERM_00456750(gene)ATG TCA GTC GAA ACA ACT TAT CAA AAA AAG ACA CAA CTT GAA CAT ATT TTA TTG AGA CCA GAT ACT TAC GTA GGT TCC AAT GAA TAC CAA GAT GAA TAA ATG TGG GTT CTA GCA GAT GAC GGA TCA TCT TTT GAA AAC AGA CAA ATA AAG TAT GTC CCA GCT CTT TAT AAA ATC TTT GAT GAA ATT CTT GTC AAC GCA GCT GAT AAC TAT TAG GTA AAT ACC AGC TTA AAA AAA CAT TTT TTT ATT TTT TTA AGT CTG ATC TGA TGA TAG ATA GAA AAC AAA CTA ACA CAT TTT AAT TTT ATA AAT AGA GAG ATA AGA GAA TGA AAA GAT TAG ATG TAA TTA TTG ATC AAA AGA ACA ATT GTA TTT CAA TCC TAA ACG ACG GAA AAG GAA TTC CTG TTT AGA TTC ATA AAG AAT ATA ATA TTT ATG TTC CAG AAC TTA TTT TTG GAC ATC TTT TGA CTT CTT CAA ATT ATA ATG ACG AAG AAA AAA AAG TTG TAG GAG GTA GAA ATG GTT TTG GTG CAA AGC TTA CCA ATA TAT TTT CAA CTA AGT TTA TTG TAG AAT CAG CAG ACT CTA AAA ACA AAA AGT AAA GTT ATT TGT TAT AAA AAT AAA TAG GAG GAG TTT AAA TTC AAA TTA CTT TTA ATT AGG AAA TTT TAA ATG ACT TGG ACA AAA AAC ATG TCT GAA TAA TCT GAA CCA CAA ATA TCA AGT TAT ACC GAA AGC GAC TAC ACA AAA ATC ACT TTT TAC CCT GAC TTA AAG AAA TTC CAC ATG AAA GAA CTA GAA AAG GTA AAA TGT GTT TTT TAA TAA GAA ATT ATC CAC TTT TAG CAA AAT AAA TTA ACC TTT TGT TTT AAA TAA TCT TTC AAA TAA TTA ATA GGA TAT TGT TGA CTT GAT GAA AAA AAG AGT ATA TGA TAT GGC TGG TGT CAT TGG CGG CTC TGT TAA AGT ATC ATT AAA TGG AGA AAG AAT TTC AAT AAG TTC ATT CTC TGA TTA TTG CGA TTT TTA TTT AAA GAA CCA AGG TGC AGA AGT AAT TAA GGT AAA TAT TAT TTA TTA TAT AAG GTG AAG GCA TTT AGA TAA AAT CTA TTT CTA ACA AAC AAA AGG TAT CAG ATA ATA AAG GTA CCA ATA ATT AAA GAT GGG AAG TTA TAG CAA GTT TAT CAG AGG GCT AAT TCT AAT AAG TAA TTA AAA AAT AAA TGA AAA AAA TAT CTA ATT TTA TTT TAT TTT TTT TAA AAG GTT TCA TTT GTT AAT TCA ATT TGC ACC TCA AAG GGA GGT ACT CAT GTT AAC TAC ATA ACT GAC TAA ATC ACT GAA AAA TTG ATG GAA ACT TTG AAA AAA AAG GAG AAA AGT CTT AAC ATT AAG TAA TTT TAG GTT AAG AGT CAT TTA TGG ATT TTC GTT AAT TGC TTG ATT GAG AAT CCC TCT TTC GAT ACT TAA ACT AAA GAA ACA CTA ACT TTA AGA TAA TAA AGC TTC GGT TCA ACC TGT GAA GTT TCT GAA AAG TTT ATC AAA GAA CTC TTA AAA TCA AAT ATT ATT AAT CAT ATC CTC CTT TAA GCT AGA GTA AAC ATT TAT TTT CAA ATT TTT CTT GAA TTA ATT TAC CAA TTT ATT TCT AGG CTA AAG AGT AAG CAA AGA TGG CTA AAA CTT TGT CTG CTA AAA AGC AAA GTA GAT TAT TAG GAG TTC CTA AGC TGG AAG ATG CAA ACG ATG CAG GTA AAT TAT TAA TTA ATT CAA ATT TAT AAC TTT TCT AAA AAT AAA TAT AGG TAC AAG AAA CGC TGA AAG CTG TAC ACT AAT TAT AAC AGA AGG TGA TTC TGC CAA AGC TTT AGC TAT GAG TGG TAT TGA AGT TGT TGG AAG AGA TAA ATT TGG TGT CTT CCC ATT AAA GGG TAA AAT GTT AAA TGT AAG AGA TTC TAC AAG CAA GCA AAT TAC AGA AAA TTT AGA AAT CTA AAA TAT CAT CAA GGT AAT GGG TAT GAA GCT AAA TAC AAA CTA TGA TAA TGT TAA AAG TTT GAG ATA TGG ATC AAT TAT GAT TAT GGC TGA TTA AGA TCA CGA TGG TTC CCA TAT CAA AGG TTT ATT CAT TAA CTT TAT ATA GAA TTT TTG GCC CAG CTT GTT CTA AAT GGA TGG TTT TCT TAA AGA ATT TAT TAC ACC AAT CGT GAA AGT TAG AAA AGG TAA TTA ATC AAT AAG CTT CTT TAG TAT TCA AGA CTT TAA AAG ATG GAA AAG CAC ATG CCC AAA CTA GCA TTT ATG GAA AAT TAA GTA TTA CAA AGG TCT TGG TAC TTC AAC CGA TTA AGA AGC CTA AGA ATA TTT TGG AAA TAT AAA CAA GCA TGT CAT TAG TTT TAA ATA CAA TGG TAA GGA TGA TGA AGA TGC TAT TGA TTT GGC TTT TAA TAA GAA GAG AGC TGA AGA CCG TAA AAA ATG GTT AGT TAA ATA TGA CCC AGA AGA AAA TGT TGA CCA CTC ATA AAA ACA TTT GAC ATA CAA AGA TTT TGT TAA TAA GGA GCT AAT TAA TTT TTC TAA TTC TGA TAA TGC AAG GTA AAT AAA TTA TTA AAC AAA TTA TCA TAT TGA CTT ATA ATT TTT TAA TTT TAA AAA TAG ATC TAT TCC CAG CCT TTG TGA TGG TTT AAA GCC TGG TTA AAG AAA AAT TCT TTT TGC ATG CTT TAA GAG AAA CTT GAA GAA TGA AAT TAA AGT AGC TTA GTT ATC TGG TTA TGT AGC TGA ACA CTC CGC TTA TCA CCA TGG TGA ATA ATC TTT AGA ATC TAC CAT TGT AGG TAT GGC TTA GAG TTT CGT TGG TAC AAA TAA CAT CAA TTA CCT CAT GCC TAT AGG TCA ATT CGG TTC TCG TAA CAT GGG AGG AAA GGT ATT AAT TTT ATT TTC AAA AAC TTT TTC TTA AAG TTA TTA TAA AAT ATA GGA AGC TGC ATC TGC AAG ATA TAT CCA TAC TTG CTT AAA TAA AAT TAC TCG TTG TGT TTT CCC TGA GCC AGA CGA TCA TAT TCT CTA CTA CCT TGA AGA TGA AGG ATA ATA GGT AGA ACC TAT TTA TTA CCT TCC TAT CAT CCC TAC AGC TCT TTT AAA TGG TAT TAA AAA AAA TAA AAT TCA AAT TAA ATA CTA ACT CAA TTT TAT AAA AGG TGC TGA TGG TAT CGG TAC AGG TTG GTC TAC TAG TAT TCC TTG CTA TAA CCC AAG AGA ATT AGT TGA TTC AAT TGA AAA AAG AAT GAT GGG AGT TCC CTT TAC TGA TTT ATT GCC ATG GTA CAA AGT AAG ATA AAA ATT TAC TAA TAA AAT TTT CTA AAA AAT TGA AAA TTA TTT ATT TAC ACA AAC AAG GGT TTC ACT GGT GAA ATT TCT AAT AAC GAA AAA TCT TAA ATT ACT GTT AGT GGA AAG TAC CAT TTA GTA AAT GAA ACA ACA ATA GAA ATT ACT GAA TTA CCT ATT AAG AAA TGG ATT AGA GAT TAT AAG AAC TTT TTA GAA GAG AAA TTA GAA TCT ACT AAA GAT AAG GAT CCC GAA ATT GAA GAT ATT AAG GAA TAT CAT GCT GGT AAT AGA GTG CAT TTT GTA GTT AAA ATG AGC GAA AAG CAA ATG GAA AAA GTA ATT AAT ATA TGA TGA AAA ACA AAC AAA CTA AAA ATT AAT TTT ATT AAA TTC AAG GTA TAA AGG GAA GGT ATT GAC AAA TAC TTC AAA TTA TAA TCA ACT ATT CCT ACT ACA AAC ATG GTT TTA TTC AAT CAT GAA GGA AAA CTT ACT AGA TAT GCT AAT ATT TGC GAA ATT ATG GAA GAG TTT TAT GAA GTT AGA TTA AAT GCA TAT AAA AGG AGA AAG GAA TAT TTG GTC TCT AAA ATC GAA CGT GAT TTA GAA ATT CTT TCT AAT AAA AAA AGA TTC ATT TTA GCT GTC ATA AAT GAA TCT ATT AGA GTA AGA AAC GCT AAG AGA AAA GAC TTG ATC AAA GAA CTA AGC GTC TAA GGT TAC GTC TAA ATG AAA GAT ATG CCA AAA ATT AAA TCA AGT AAG CTT ACA AGC TAA CTT GAA TAA GAA TAA AAT TAA GAT AGT AAT GAA GAA AAT TTT GAA ACT AAT CCT AAT GAG ATT AAT GCT AAA GAG TAT AAC TAT CTC CTT AGT TTG CCT ATG TGG AGC TTG ACT TAT GAA AAA GTT GAA GAG ATA AAG TAA GAA TAA AAA AAT AAG TAG GAC GAG TTA GAC AAG CTT GTT GCT ACT GAA GTT ATT GAT ATT TGG AAA GAA GAT CTT AAA AAC TTC ATT GAA TGC CTT GAT TAA ATT GAG GAA GAA GAA GAT GAA GAA ATG CGT AAA AGA ATG AAG AAA CAA AGC AAC TCT AAA GGT AAT TTA AAT TTT TAA TTC AAT ATA AAT AGT TTT AAA ATG CTT TTT AAT ATG AAA GTT AAA TAA GGC AGT ACA GCT AGT TCT AAG TTA AAG AAA AAA CCA ACC AAG AAG AAA TAA GAT AGT GAC GAT GAT GAC GAT GAT GCC ATG GAT ATA GAG GAA GAT GGA GAT GGA TCA GAT TTT GAT ACA GGC AAG AAA AAA TAG AAG AAA AAA CCT TCA TCA GCT CCT TCT TCA TAA GCA GGA CCT AAG GGA AAG ATC GGT GAT TAT AAA CCT AAT TTG TCT TAA GAT ACA GGA ATA AGC AGT AAA ACA AAT AAA AAT AAT TAA AAT ACT CTC GGG TTT ATC AAA TAG TAA GCT CCA ATT ACT ACT TAA GTT AAG ACT CAA CCA GAA GTC AAA AAA CCA GTA GAT CCT TTG CTT GAA ACT TTA GAA AAA TAT ACT TTC AAG AAA GAA AAT ACT TAA ACA TAA AAA GAA GAA AAT AAT ACA TAA AAT TCA GTT ATA TCT TAA ATA CTT TCA TAA AAC TAT TCT CTA TCA CTT GAA GAG AGA CTT AAA TTG AGG GCA GGT AAA AAA TTA CAA AAA ATA TTT TAT TTT TAC ATT ATT CAT AAT AAA AAA TAG GGG AAA ACT CAT AAA ATT TGA CTC AAT AAA CAA ATG GAT TTT CCT AAT AAG TAA ATA CAT AAT AAG ACT ATA ATA ACT TGG GCA ATA AAG ATG AAG AAG AAG AAG ATG ACC TTC TCT TTA ACT TCA AAA AAG AAA AGA AAG AGA AAT AAT CAA CTG ATA TTT TTG ATG AAT TAG ATG ATC TTG ATG CAC TTT TTA ATG AAA AAC GCT AAG GAG CAG ACC TCG AAA ATG AAG AAG AGT AGC TGA CCA AAA AAA GAG TTC TGA ATG AAG GAG AAC CAA AAA GTA TAG CTT AAA ATA AAA AAT AAA CAA AAG AAA TAA ATG ATG AAG ATC TTG AAT ATA ATT TGT TTA AGG ATG AAA AGC CAA AGT AAA AAA AGC CTC CTG CTA CTG CTG CTT CAA AAT CAA AGA AAG TGA TAA ATA AAA ATG AAG ATG ATG ATG AAG ACT TTA ATG ATG ATT TAT CAG AAG ATG AAA AAC CAA AGA AGA AAA GGT CCA ATT AAA CTT AAT CAA AAA CCA AAA AAT AGA AAA ATG AAA GTG AAG ATG AAG ATT TTA ATA GCA AAG AAT CTG ATG AAA AAC CTA AAT AAA GAA AAT CTA ATT CTA ACT CAT AAA AAG CAA GGA AAC CTA AGA AAA TGA GTG ATG ATG AGG GAG AAG AAG ATG ATG ATT TTA TCA TAC CTG ATG AGG ATT CTG ATG AAG AAA AAC CTA AGA AGA GAA AGA GTA ATG CAA CAA AAC CTA AAA ATA ATA AAG AAG ATA AAG ATA ATC AAA AGT CTA AAA AAA ATA GAA CCG ATT CAC CAA AAC TTA AAA TAA CAA ATT CAG AAG ATG AAG ATG TTG CTG AAT TAA AGC AAA ATG AAG TTT TAT AAA CCA GAA CAA GAG GTA AAA GAA ACC CAA TTC CTC GTA AAA TGA TCA TTG ATA ATT CTG ATG AAG ATT TCA GTG AAG AGG AAG AAT TTG GAA ATA GCA AAA AGA AAT CAG TAA ATA GTA AAA GCC AAA AAA AAT AAA AAG ACG ATG AAT CAT CGG ATG AAT GCT ATT TCT GA