Identifiers and Description

Gene Model Identifier

TTHERM_01299650

Standard Name

TOP1 (Topoisomerase I)

Aliases

PreTt17571 | 315.m00022

Description

Eukaryotic DNA topoisomerase I, catalytic core family protein

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• chromosome (IEA) | GO:0005694

Molecular Function

• DNA binding (IEA) | GO:0003677
• DNA topoisomerase type II (ATP-hydrolyzing) activity (IEA) | GO:0003918
• DNA topoisomerase type I activity (IEA) | GO:0003917

Biological Process

• DNA topological change (IEA) | GO:0006265

Domains

• ( PF01028 ) Eukaryotic DNA topoisomerase I, catalytic
• ( PF02919 ) Eukaryotic DNA topoisomerase I, DNA

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 11.1%

TetraMine Data

TTHERM_01299650

WebApollo

Fullscreen View

Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Stentor Coeruleus	SteCoe_24070	0
Tetrahymena borealis	EI9_19658.1	9.997093137033517e-262	eukaryotic DNA topoisomerase I , catalytic core family protei n (691 aa)
Oxytricha	Contig11896.0.g103	9.997093137033517e-262	Eukaryotic DNA topoisomerase I , catalytic core
DictyBase	DDB_G0283205	1.9990846765523993e-155	top1 on chromosome: 4 position 416900 to 419809
SGD	YOL006C	1.999872053281847e-142	TOP1 Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positi vely and negatively supercoile d DNA; functions in replicatio n, transcription, and recombin ation
WormBase	WBGene00006595	1.0003279799459891e-139	locus:top-1 DNA topoisomeras e 1 status:Confirmed UniPr ot:O17966 protein_id:CAB0763 9.1

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_01299650(coding)
ATGAGTAGCAAGAAGAACACTAAGAAAGTCTCTGATAGCGAGGACGATGATTTTGAAGAG
GAAGAAGATGAATCAGAAGGTTCAGGAGAGGAGGATTCCGCTGAAAATAGTGTCAAAGAA
GAAGAAGATGAAGAAGAAGAAGAAAACGGTGATAATGAAATTAAAGAGGAAGATAACGCA
GATACAAAAATAGAAGTTAAGGATGAAAATGAAGATGATGAAGAAGAAGAAGAATTTAAA
CCTTCGATTAATGGCAATAAAAGAAAGAACGATACACCTGTTGAAAAGGCAGCAGGATTG
TCAAATGCTAAATAAGTGAAAACATCTGGCGGTGATGCAGTTAAGAAACCAGTGTAAAAG
TAACAAGACAGTGATGATGAAGACGATGAAAACAGTGATATTAAATGGAAATATTTAGAG
CATCACGGAGTGCTATTCCCCGATTATTGGTAAAAGCATAATGTAAGACCTAGGTATGAT
GGAAAACCTATTGATTTAAATCTCTTGTAAGAAGAAATGGCTACTTATTGGTCATAAACT
TTAGGAACAGATTGGGAACATAAACCTAAGTACAGAGAGAATTTTTCAAAACAATTCCTC
GATACCTTTGGTAAGGATAAAGGTAAATATGACTTTGATAAGTTCGACTTCACTCCTATA
AAAATACATCTTGAAGAGCAAAAAGAAATCCGTAAAAATCGCTCCAAAGAAGAAAAAAAT
CAAGAAAAGTAGAAAAAAGAAAGGCTTTCTGATTATTATGCTGGCGCAATTCTAGACGGA
TTTAGAGAAAAAGTAGGATAATTCATGATTGAACCTCCAACTCTCTTTAAAGGTAGAGGT
GAACATCCAAAAATGGGTATGATGAAAGGTCGTATTTAACCAGAAGCTGTTGTTATTAAT
ATCTCAAAAGATGCACCTGTCCCAAAATGTTCAGTTCCTGGTCATGGTTGGAGTGAAATA
GTCCACAAACAAGATGTTACTTGGTTAGCAAGCTACAAGGATGATTCTGTAAAGAAGCAA
CATAAATATATCTTCTTATCTGCTGAAAGTAAGCTTAAGGCAGAAAATGATAAAAAGAAA
TACGAAAAAGCAAGACGTCTTAAAAATTTAATTGGATAGATTCGTGAAAATTACGAGAGA
AAATTAAGAAGTAGTGATCCTGTTGATAGATAATTAGGTACTGCTACTTACTTGATTGAT
AAGTTAGCACTCAGAGTTGGTAATGAAAAATCAGAAGAAGAAGCAGATACTGTCGGTTGC
TGCTCTTTGAGAGTTGAGCATATTTAAGTTATAGAAGATACCTAGATTGGATTCGATTTC
TTAGGTAAGGATTCTATGAGATATCAAAATACTGTAAAAGTTACTGAGATTGTTTGGAAA
AATATGTAGTCTTTTATCAAGAATAAAAAACCTGGTGATGATTTATTCGATAGAATTGAT
GCAAGTAGCCTAAATGAATATTTAAAGAGTTAGATGGAAGGTTTGACAGCAAAAGTTTTT
AGAACTTATAATGCTTCTCACACTCTTTAAAAAGAATTAGACAAGGCTGATGAAGAAGGC
CTTGATAAGATGGATTTAAAAGATAAACTTAATTTTTATGATGAAGCTAACAGAAATGTT
GCCATTCTTTGTAACCATCAAAAAACAGTAGGCAAAAACTTTGATGTAATGGTTGGAAAA
ATGGAACAAAGAATTAATGTTTATAAAGATTATGAAAAGGAATTACATACTCATTTAAAC
AAATGCAAAAAGAATGGAGTCAATGCTTATGAAAAAGAAGTTATCTTAGAAGAAAAGGAT
GATGGAAAACATAAAATGTTTGTTAAAAAGTTCCCTGGAACAAAGGAAAAAATTTAAGAA
GCTATTGAAAAAATTAAAAAGAAGATAGACGAAGAATAAAATAAAAAATAATCTAAAGAG
AAGAACAAAGAAATTGCCTTAGGTACTTCTAAAACAAATTACAACGATCCTAGAATATCT
GTTGTTTGGTGTAAAAAGTGGGAAGTTCCTGTAGAAAAAGTTTTCCCTAAAACTCTCATT
GCTAAGTTCGTTTGGGCTATGGATACAGATTTAGAGTGGTCATTCTGA

>TTHERM_01299650(protein)
MSSKKNTKKVSDSEDDDFEEEEDESEGSGEEDSAENSVKEEEDEEEEENGDNEIKEEDNA
DTKIEVKDENEDDEEEEEFKPSINGNKRKNDTPVEKAAGLSNAKQVKTSGGDAVKKPVQK
QQDSDDEDDENSDIKWKYLEHHGVLFPDYWQKHNVRPRYDGKPIDLNLLQEEMATYWSQT
LGTDWEHKPKYRENFSKQFLDTFGKDKGKYDFDKFDFTPIKIHLEEQKEIRKNRSKEEKN
QEKQKKERLSDYYAGAILDGFREKVGQFMIEPPTLFKGRGEHPKMGMMKGRIQPEAVVIN
ISKDAPVPKCSVPGHGWSEIVHKQDVTWLASYKDDSVKKQHKYIFLSAESKLKAENDKKK
YEKARRLKNLIGQIRENYERKLRSSDPVDRQLGTATYLIDKLALRVGNEKSEEEADTVGC
CSLRVEHIQVIEDTQIGFDFLGKDSMRYQNTVKVTEIVWKNMQSFIKNKKPGDDLFDRID
ASSLNEYLKSQMEGLTAKVFRTYNASHTLQKELDKADEEGLDKMDLKDKLNFYDEANRNV
AILCNHQKTVGKNFDVMVGKMEQRINVYKDYEKELHTHLNKCKKNGVNAYEKEVILEEKD
DGKHKMFVKKFPGTKEKIQEAIEKIKKKIDEEQNKKQSKEKNKEIALGTSKTNYNDPRIS
VVWCKKWEVPVEKVFPKTLIAKFVWAMDTDLEWSF

>TTHERM_01299650(gene)
ATGAGTAGCAAGAAGAACACTAAGAAAGTCTCTGATAGCGAGGACGATGATTTTGAAGAG
GAAGAAGATGAATCAGAAGGTTCAGGAGAGGAGGATTCCGCTGAAAATAGTGTCAAAGAA
GAAGAAGATGAAGAAGAAGAAGAAAACGGTGATAATGAAATTAAAGAGGAAGATAACGCA
GATACAAAAATAGAAGTTAAGGATGAAAATGAAGATGATGAAGAAGAAGAAGAATTTAAA
CCTTCGATTAATGGCAATAAAAGAAAGAACGATACACCTGTTGAAAAGGCAGCAGGATTG
TCAAATGCTAAATAAGTGAAAACATCTGGCGGTGATGCAGTTAAGAAACCAGTGTAAAAG
TAACAAGACAGTGATGATGAAGACGATGAAAACAGTGATATTAAATGGAAATATTTAGAG
CATCACGGAGTGCTATTCCCCGATTATTGGTAAAAGCATAATGTAAGACCTAGGTATGAT
GGAAAACCTATTGATTTAAATCTCTTGTAAGAAGAAATGGCTACTTATTGGTCATAAACT
TTAGGAACAGATTGGGAACATAAACCTAAGTACAGAGAGAATTTTTCAAAACAATTCCTC
GATACCTTTGGTAAGGATAAAGGTAAATATGACTTTGATAAGTTCGACTTCACTCCTATA
AAAATACATCTTGAAGAGCAAAAAGAAATCCGTAAAAATCGCTCCAAAGAAGAAAAAAAT
CAAGAAAAGTAGAAAAAAGAAAGGCTTTCTGATTATTATGCTGGCGCAATTCTAGACGGA
TTTAGAGAAAAAGTAGGATAATTCATGATTGAACCTCCAACTCTCTTTAAAGGTAGAGGT
GAACATCCAAAAATGGGTATGATGAAAGGTCGTATTTAACCAGAAGCTGTTGTTATTAAT
ATCTCAAAAGATGCACCTGTCCCAAAATGTTCAGTTCCTGGTAAAATAAATTAATTTATT
TATTATAATTATCTATGATAAATAAAAAATTTTAAGTATCCTACTAAAAGTTATAAACAA
ACAACAAGCATTCATTCATTCATTCATTCATTTTCTGGCCAATTAAATTTTAATATCTTT
AAACTTAATATTCTCTCTTTTCATAATATAATTATGTTTATAATGCCAATATTAAATCAA
TTTGTTTCATATTTAATGTATTTTCAAAAGCTATACATCCTTAATTAATCATATTTAGCT
TTTTACACAAGACTGTATTCATATATGTAGATAGATATTTAACGAATTTCCTAAAAAATA
ATTAGGTCATGGTTGGAGTGAAATAGTCCACAAACAAGATGTTACTTGGTTAGCAAGCTA
CAAGGATGATTCTGTAAAGAAGCAACATAAATATATCTTCTTATCTGCTGAAAGTAAGCT
TAAGGCAGAAAATGATAAAAAGAAATACGAAAAAGCAAGACGTCTTAAAAATTTAATTGG
ATAGATTCGTGAAAATTACGAGAGAAAATTAAGAAGTAGTGATCCTGTTGATAGATAATT
AGGTACTGCTACTTACTTGATTGATAAGTTAGCACTCAGAGTTGGTAATGAAAAATCAGA
AGAAGAAGCAGATACTGTCGGTTGCTGCTCTTTGAGAGTTGAGCATATTTAAGTTATAGA
AGATACCTAGATTGGATTCGATTTCTTAGGTATTTAAATTTTTTTCTATTATTAAAATAA
TCAATTTATTTTTATTTATTTATGTAGACAAAATTTTATATAAAATTAATTTTTAAAAAA
AGGTAAGGATTCTATGAGATATCAAAATACTGTAAAAGTTACTGAGATTGTTTGGAAAAA
TATGTAGTCTTTTATCAAGAATAAAAAACCTGGTGATGATTTATTCGATAGAATTGATGC
AAGTAGCCTAAATGAATATTTAAAGAGTTAGATGGAAGGTTTGACAGCAAAAGTTTTTAG
AACTTATAATGCTTCTCACACTCTTTAAAAAGAATTAGACAAGGCTGATGAAGAAGGCCT
TGATAAGATGGATTTAAAAGATAAACTTAATTTTTATGATGAAGCTAACAGAAATGTTGC
CATTCTTTGTAACCATCAAAAAACAGTAGGCAAAAACTTTGATGTAATGGTTGGAAAAAT
GGAACAAAGAATTAATGTTTATAAAGATTATGAAAAGGAATTACATACTCATTTAAACAA
ATGCAAAAAGAATGGAGTCAATGCTTATGAAAAAGAAGTTATCTTAGAAGAAAAGGATGA
TGGAAAACATAAAATGTTTGTTAAAAAGTTCCCTGGAACAAAGGAAAAAATTTAAGAAGC
TATTGAAAAAATTAAAAAGAAGATAGACGAAGAATAAAATAAAAAATAATCTAAAGAGAA
GAACAAAGAAATTGCCTTAGGTACTTCTAAAACAAATTACAACGATCCTAGAATATCTGT
TGTTTGGTGTAAAAAGTGGGAAGTTCCTGTAGAAAAAGTTTTCCCTAAAACTCTCATTGC
TAAGTTCGTTTGGGCTATGGATACAGATTTAGAGTGGTCATTCTGA