Identifiers and Description

Gene Model Identifier

TTHERM_00127000

Standard Name

TMLH1 (Tetrahymena homolog of budding yeast MLH1)

Aliases

PreTt09363 | 9.m00384 | 3699.m00093

Description

TMLH1 DNA mismatch repair protein putative; DNA mismatch repair protein- C-terminal domain containing protein

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• ATP binding (IEA) | GO:0005524
• mismatched DNA binding (IEA) | GO:0030983

Biological Process

• mismatch repair (IEA) | GO:0006298

Domains

• ( TIGR00585 ) DNA mismatch repair protein MutL
• ( PF01119 ) DNA mismatch repair protein, C-terminal
• ( PF02518 ) ATPase, histidine kinase-, DNA gyrase

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.4%

TetraMine Data

TTHERM_00127000

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_09117.1	9.997093137033517e-262	DNA mismatch repair protein do main-containing protein (747 a a)
SGD	YMR167W	8.999119107228014e-72	MLH1 Protein required for mism atch repair in mitosis and mei osis as well as crossing over during meiosis; forms a comple x with Pms1p and Msh2p-Msh3p d uring mismatch repair; human h omolog is associated with here ditary non-polyposis colon can cer
DictyBase	DDB_G0287393	9.999565105288807e-71	mlh1 on chromosome: 5 position 247623 to 250277
Oxytricha	Contig14864.0.g42	6.9991332754409754e-68	DNA mismatch repair protein, C -terminal domain
WormBase	WBGene00003373	9.004195835458823e-61	locus:mlh-1 status:Confirmed UniProt:Q9XU10 protein_id :CAB07283.2
Stentor Coeruleus	SteCoe_23547	2.3802664086944007e-26

General Information

No Data fetched for General Information

Associated Literature

1. Ref:23935123: Lukaszewicz A, Howard-Till RA, Loidl J (2013) Mus81 nuclease and Sgs1 helicase are essential for meiotic recombination in a protist lacking a synaptonemal complex. Nucleic acids research 41(20):9296-309

Sequences

>TTHERM_00127000(coding)
ATGAATCATTCCTAACCCTTAGAAAATACTGGTCCTCAGATCAAGAAGCTCCCATAAGAG
CTTATCGATAAGATTGCAGCTGGTGAAGTAGTACAACGTCCATCTGCAGCTGTTAAGGAG
CTTATTGAGAACTGTCTTGATGCTGGATCAAGTGAAATTTCAGTAGGGTTAGTATAAGGA
GGGTTAAAGTAGCTTATTGTAGAAGATAATGGTTCTGGAATTCACAAAGACGATTTTCCA
CTTCTCTGCGAAAGGTTTGCTACCTCTAAGATAAATGAGTTTAATGACCTTTAGAGTTTA
GTTTCATTTGGCTTTAGAGGAGAAGCGTTAGCCTCTATTTCTTTTGTCTCCAACTTGAAA
ATCACATCTCGAAAACCTAATTCTGACCTAGGATATAAAGCTAGTTTCAAAAACGGTGTT
ATGCTTGGTGAAGAGCCTGAAGCAGTGAACTGTACTGAAGGGACTACAGTAGATGTCTAG
GATTTATTTTTTAACTATGATGCAAGGAGAAAAAGTTTAAATGTTAACGAAGAAAAAAAA
AGAGTACTCAAATTGATCGGACAATTTGCTATGCATCATGCTAAATTGAGATTTAAATTT
AAAAGTGATAACCAAATTCAATTCTCATCTCACAGTGTGCTTGGCTCTACAGAATTGCAA
AGAAGAGAATAAATTATGTAGCAAATTACTAAGATTGCAGATAAAAGCTTTACTTCATGT
GAAAGTGAGTCGACAGAATATTAAGTTAAATTTAAAGGAACTTTTTCCAACATTGGAGCT
ACTAAAAAATACAAAGAAATCACTCTCTTTATAAATAATCGTTTGGTTGAATGTGAATCT
ATCAAAAAAGCAGTAGAACGCTCTTACCAGTCTTGTTATTAAAGTATTCATGAAGAAGAA
GGTGGATATTTTTGCTACTTGAGCTTAGAAATGAATCCAAAGAACTTGGATCCTAATGTT
CACCCAACAAAAAAAGAAGTCAAATTCTTATTTGAGTACGAAATAGCAAAAGAAATTGAA
TCATGGATTTTCGAAAATTTGAAAAATTGTGGAGTTATCAAACAACTTTCAGCAAATATT
TCATAAAGAACATCTTCATTTGAAACTTCAAATGTGAAAAGAAGTAGCTCAAGTCAATTA
TATTTTGGTTCTTAGAGCAATTTATCTAAGCAAAATTCTGATTACTATCAACCCACCAAG
CAAATTCGTGTAGATCCCAGAGATTAGAAAATTACTAGATTCTTTTCAGTAGAAAGCTCT
GAAGATGGAAATAACAATTCAAATCAAAAAAATTATCAAAGTATTAATTATATTGAAGAG
CAGAAAGAAGAACATCTAAACAGTCAAGATGATATTGCTGAAGAACCTGTTGATATGATT
AAAAAGAAAAAGATGCTCAATGAAGAAAGAAATTAAACTTCAATCAGTAATATAGGAAGC
TCTGACTAATTAGATGCTAATAATGCTCGTTCAAGTGTCATCGATAGGGCAAATTCTTAA
GTTAATGACCCACGTATTTAAGTATAATAATAGTTATTGTCTTTAAGGAATCAAGATATC
CATGATACAACAAGTTCTTTCTTTAAAAATCTTACGTATGTTGGCTGTATTTCTTCTAAT
CACTTTCTAGCTCAATTTAGAGATGATCTCTACCTTATAAACTCTATTCCATTATGTTAA
GAAATATTTAAATTTGAAATTCTGAGAAACTTTGGATAGATTAAGCCTGTAGAGCTAAAT
TAAGCAATAGGTTTGAAGGATATTTTAGAGTATTTTTTATTAAATTTTGATGAGATACCG
AATGAGAAAAAGGAGTTCCATCTGTCAAATATGGATACTTACATCGAGTAATTTGGCTTA
TTGAGTGACTTTTTAAGAGACTCCGTAGGCATAGTCATCAAAGATTAAAAGCTCTTGGCT
TTCCCTAATTTATTTAATTTATTTGAAAATGATAATAACTTTAAAGATATCTCATACATT
CTGTTGAGAATAATCACCAAAGTTAATTTTAGCGAAATACTCTAATCAGGTATGGGCTTA
GCAAACGAATTATCATTCTACTTTGCTTGGCAATTAGAAAAATCGTTTAAAAATTAATTG
TAAAGACAGCATTTCTAGGAAACGCAAAAGCAGAAATGGGACGATTTCTTTGAATAAAAA
ATGCTCCCAATGATTAAAAAAAAACTTTCACTCCCTAAATTAGATATTAGCGAGTTTACA
GTTAAGCTATTTAAGCAAGAAGATGCATACAAGATCTTCGAAAGATGTTGA

>TTHERM_00127000(protein)
MNHSQPLENTGPQIKKLPQELIDKIAAGEVVQRPSAAVKELIENCLDAGSSEISVGLVQG
GLKQLIVEDNGSGIHKDDFPLLCERFATSKINEFNDLQSLVSFGFRGEALASISFVSNLK
ITSRKPNSDLGYKASFKNGVMLGEEPEAVNCTEGTTVDVQDLFFNYDARRKSLNVNEEKK
RVLKLIGQFAMHHAKLRFKFKSDNQIQFSSHSVLGSTELQRREQIMQQITKIADKSFTSC
ESESTEYQVKFKGTFSNIGATKKYKEITLFINNRLVECESIKKAVERSYQSCYQSIHEEE
GGYFCYLSLEMNPKNLDPNVHPTKKEVKFLFEYEIAKEIESWIFENLKNCGVIKQLSANI
SQRTSSFETSNVKRSSSSQLYFGSQSNLSKQNSDYYQPTKQIRVDPRDQKITRFFSVESS
EDGNNNSNQKNYQSINYIEEQKEEHLNSQDDIAEEPVDMIKKKKMLNEERNQTSISNIGS
SDQLDANNARSSVIDRANSQVNDPRIQVQQQLLSLRNQDIHDTTSSFFKNLTYVGCISSN
HFLAQFRDDLYLINSIPLCQEIFKFEILRNFGQIKPVELNQAIGLKDILEYFLLNFDEIP
NEKKEFHLSNMDTYIEQFGLLSDFLRDSVGIVIKDQKLLAFPNLFNLFENDNNFKDISYI
LLRIITKVNFSEILQSGMGLANELSFYFAWQLEKSFKNQLQRQHFQETQKQKWDDFFEQK
MLPMIKKKLSLPKLDISEFTVKLFKQEDAYKIFERC

>TTHERM_00127000(gene)
ATGAATCATTCCTAACCCTTAGAAAATACTGGTCCTCAGATCAAGAAGCTCCCATAAGAG
CTTATCGATAAGATTGCAGCTGGTGAAGTAGTACAACGTCCATCTGCAGGTATTTGAATC
CGTCCTTTTCTATTTTTCAATATCCTGATGATAGTTTCTTTCAAATCAAAGCATCACTTC
TTTGATTAAATAATTATCATATATCATTAAGCAGATTATTAATATCAAGAAATAAATATG
GGTTTTTAAAATTAAATTTTGCATTCCATTTTTCCTACGCTAGAAATCTAATTAAAGAAT
TTTTATTGCTGAATATTTTGTAGAAGTTATGATGCATTTTATTTACCCAATAAACTGTTT
GCTCTCATCAGCTTAAATTTAGAGTAAAATTAAGCTGCTTGCTATTCCTGATTATTTTCT
TTAGTATAAATTAGATTTTCAGTAAATTTAGGAATATTGTTTGTTTAGTATTTTAACATA
CAATAAATAATAAGGGCAAATAAATATGTTAGTTAACAAATGAAAGGACATAAAGGAGTT
GATTAAATGAAAGGATAAAATTTTAATTGATCATTTTATTAAATTTTTTTGTTTATTTAT
AATTAATTATAGCTGTTAAGGAGCTTATTGAGAACTGTCTTGATGCTGGATCAAGTGAAA
TTTCAGTAGGGTTAGTATAAGGAGGGTTAAAGTAGCTTATTGTAGAAGATAATGGTTCTG
GAATTCACAAAGACGATTTTCCACTTCTCTGCGAAAGGTTTGCTACCTCTAAGATAAATG
AGTTTAATGACCTTTAGAGTTTAGTTTCATTTGGCTTTAGAGGAGAAGCGTTAGCCTCTA
TTTCTTTTGTCTCCAACTTGAAAATCACATCTCGAAAACCTAATTCTGACCTAGGATATA
AAGCTAGTTTCAAAAACGGTGTTATGCTTGGTGAAGAGCCTGAAGCAGTGAACTGTACTG
AAGGGACTACAGTAGATGTCTAGGATTTATTTTTTAACTATGATGCAAGGTAAATTCAAT
TATAAATTAAAAATATGTTGTTGAAATAACAATTATCGCGTTAAAGCCATTCATTCATTT
ATCATAAAATCAAAATACTAATATATATTTTGATAATTTTCAAGAAAAATTTATAGTTTA
GAAACAAAGGTGTTAAAATTTTGTCATTCAATCAATCAATTTTCATTAATTTGATTACTA
TTTAATGTTTATTTCTCTCTCATTAACATTCATTTTAATGGCAATTAATCATTCATAATT
CTCAAATAAATTCTTCTTAAAGCTACGAAAATATTTAATTCTAGTAAAAGTGTATTGAAA
AAGGCTTGAACATATAAAAATATTTTTAATTCCTTCAAAGATTAACAGAAAGTTAGCAAA
AATAATTTATAGTTTTATACTTTTAAGGTGTTTAATTAATTGAATCAACCATAGCAAAGC
AAAAATAACAGCCCAATTTAGATAGCTTTTTTATTTAAAAATGCAAACAATATTATACAG
TTTATAAATGCTGCTCTGTAGCTATTGAAGAGAAAGAGAGAGATTTATTTTTGGCTGTTA
TGAATTGAATGAAATTGATAATGATAATTGAGATTAGAAAGTAAGTATTATTAAATAAAA
TAGGGGGTCTACGAATATTCGAAAGAATTATAATCAATTGGCTTTACTTTTTTTTTCTTT
TTGATTTAGAAGGTGAAAGTAAATTTACAAAATATGTTAATAGAGATAAAAATTTTTGGT
ATTTCCTTCAGCTTACGTTAATTTATTTAATTTAAATGCAAATAAATTACTAAAACTTAA
TACCTTGCCATTTTTGGAAGTAAAGAAATAAATAAAAAAATATAATTTTGAAGAAATCCT
TTTTATCTTTTTAATTTTCCTAAATTTTATCTTCTAATTCAATAATTTTGAATGAATGAT
TTCTTTGCCACTAATAAAAATTAAGTTTTGAGATAGAAATAAAATAATTAAATTGATTTA
GATTATTATTAAATTAATGAATGCGCACAATTTTTTTTTATAAATGAATTAATATTTGAC
TCAATCAATCAACCTAAACTAAAAACTCTACCCAGTTGATTATTTTTTATATCTACTAAT
TATTAATTTAAATTTCTTGTTCGTTCACCCATAAAACAAACAAAAAAGTTTTTACTTTAA
ACCAAATATTTTAAAATATTGTCCACGTAATTAAATAACAAAGGGTTATTTTAATATTAA
TAATTATAAATATATTCATTGATTAATACACTCATAATAAATACCTTCTACTTTATAAAA
AATATAATTAATTAATTAATTAATTAAATAAATAAATTTCTCACTTTAACTTATAATTCT
ATTTTAAATAATTAGGAGAAAAAGTTTAAATGTTAACGAAGAAAAAAAAAGAGTACTCAA
ATTGATCGGACAATTTGCTATGCATCATGCTAAATTGAGATTTAAATTTAAAAGTGATAA
CCAAATTCAATTCTCATCTCACAGTGTGCTTGGCTCTACAGAATTGCAAGTAAACTTTCG
TAAACATTAAATACATTTTAATTAATTCTAATTAAATTCTAGAGAAGAGAATAAATTATG
TAGCAAATTACTAAGATTGCAGATAAAAGCTTTACTTCATGTGAAAGTGAGTCGACAGAA
TATTAAGTTAAATTTAAAGGAACTTTTTCCAACATTGGAGCTACTAAAAAATACAAAGAA
ATCACTCTCTTTATAAATAATCGTTTGGTTGAATGTGAATCTATCAAAAAAGCAGTAGAA
CGCTCTTACCAGTCTTGTTATTAAGTAAAACCTTTTTACCTAATTAACTAATGAGATTTA
ATCAACAATTTTAATTATCATTAGAACTGCTTTAAATTTAATTTTATATAATAATTACAT
AACAATAATAATAATATATATATAGAGTATTCATGAAGAAGAAGGTGGATATTTTTGCTA
CTTGAGCTTAGAAATGAATCCAAAGAACTTGGATCCTAATGTTCACCCAACAAAAAAAGA
AGTCAAATTCTTATTTGAGTACGAAATAGCAAAAGAAATTGAATCATGGATTTTCGAAAA
TTTGAAAAATTGTGGAGTTATCAAACAACTTTCAGCAAATATTTCATAAAGAACATCTTC
ATTTGAAACTTCAAATGTGAAAAGAAGTAGCTCAAGTCAATTATATTTTGGTTCTTAGAG
CAATTTATCTAAGCAAAATTCTGATTACTATCAACCCACCAAGCAAATTCGTGTAGATCC
CAGAGATTAGAAAATTACTAGATTCTTTTCAGTAGAAAGCTCTGAAGATGGAAATAACAA
TTCAAATCAAAAAAATTATCAAAGTATTAATTATATTGAAGAGCAGAAAGAAGAACATCT
AAACAGTCAAGATGATATTGCTGAAGAACCTGTTGATATGATTAAAAAGAAAAAGATGCT
CAATGAAGAAAGAAATTAAACTTCAATCAGTAATATAGGAAGCTCTGACTAATTAGATGC
TAATAATGCTCGTTCAAGTGTCATCGATAGGGCAAATTCTTAAGTTAATGACCCACGTAT
TTAAGTATAATAATAGTTATTGTCTTTAAGGAATCAAGATATCCATGATACAACAAGTTC
TTTCTTTAAAAATCTTACGTATGTTGGCTGTATTTCTTCTAATCACTTTCTAGCTCAATT
TAGAGATGATCTCTACCTTATAAACTCTATTCCATTATGGTAAATTCATCTTTAAATCAT
TCGCTCTTTCTTTTAAATTTTAATGGAAACAAAAAAATAAACCAAAATATTTATTTATCA
TTTTAGAAACATTTTTTTGATTTTAATAACCAAAATATTTATTTTAAAAAAAGTTAAGAA
ATATTTAAATTTGAAATTCTGAGAAACTTTGGATAGATTAAGCCTGTAGAGCTAAATTAA
GCAATAGGTTTGAAGGATATTTTAGAGTATTTTTTATTAAATTTTGATGAGATACCGAAT
GAGAAAAAGGAGTTCCATCTGTCAAATATGGATGTATGTTAGTTATTTGTTAATTTTATC
AATAAATAAAATATTTTGATTAAAATTAGACTTACATCGAGTAATTTGGCTTATTGAGTG
ACTTTTTAAGAGACTCCGTAGGCATAGTCATCAAAGATTAAAAGCTCTTGGCTTTCCCTA
ATTTATTTAATTTATTTGAAAATGATAATAACTTTAAAGATATCTCATACATTCTGTTGA
GAATAATCACCAAAGTAAATAAATAAATAAAAAGCTATTTGCTTATTTACAAACAATATA
TAATAAACTTTTTAAATTCAAAGGTTAATTTTAGCGAAATACTCTAATCAGGTATGGGCT
TAGCAAACGAATTATCATTCTACTTTGCTTGGCAATTAGAAAAATCGTTTAAAAATTAAT
TGTAAAGACAGCATTTCTAGGAAACGCAAAAGCAGAAATGGGACGATTTCTTTGAATAAA
AAATGCTCCCAATGATTAAAAAAAAACTTTCACTCCCTAAATTAGATATTAGCGAGTTTA
CAGTTAAGCTATTTAAGCAAGAAGATGCATACAAGATCTTCGAAAGATGTTGA