Identifiers and Description
Gene Model Identifier
TTHERM_01018420Standard Name
THD8 (Tetrahymena Histone Deacetylase 8)Aliases
PreTt27759 | 199.m00052Description
THD8 SIR2 family transcriptional regulator; Sir2-like histone deacetylase; suppresses DNA transcription by deacetylation of histonesGenome Browser (Macronucleus)
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Genome Browser (Micronucleus)
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Gene Ontology Annotations
Molecular Function
- hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (IEA) | GO:0016811
- zinc ion binding (IEA) | GO:0008270
- NAD+ binding (IEA) | GO:0070403
Biological Process
- protein deacetylation (IEA) | GO:0006476
- chromatin silencing (IEA) | GO:0006342
- regulation of transcription (IEA) | GO:0045449
Domains
Gene Expression Profile
Change in Gene Expression
TMHMM
TMHMM
Signal Peptide
Signal Peptide Present?: No
Presense Probability: 10.8%
TetraMine Data
TTHERM_01018420
WebApollo
Fullscreen View
Tetrahymena Stock Center
No Data fetched for StockID
Homologs (v.2006 protein sequences)
Source Identifier Score Description Tetrahymena borealis EI9_01121.1 9.997093137033517e-262 transcriptional regulator, Sir
2 family protein (386 aa)
Oxytricha Contig19063.0.g74 4.999450098932641e-139 Sir2 family
Stentor Coeruleus SteCoe_10597 2.8946403116483003e-63 WormBase WBGene00004803 3.0000451088882257e-25 locus:sir-2.4 NAD-dependent
protein deacetylase sir-2.4
status:Confirmed UniProt:Q95
Q89 protein_id:CCD61225.1
DictyBase DDB_G0283917 8.997498379799854e-17 sir2A on chromosome: 4 positio
n 1272110 to 1273864
SGD YPL015C 0.0000000000000030004923591262316 HST2 Cytoplasmic member of the
silencing information regulat
or 2 (Sir2) family of NAD(+)-d
ependent protein deacetylases;
modulates nucleolar (rDNA) an
d telomeric silencing; possess
es NAD(+)-dependent histone de
acetylase activity in vitro
General Information
No Data fetched for General Information
Associated Literature
- Ref:18178773: Smith JJ, Torigoe SE, Maxson J, Fish LC, Wiley EA (2008) A class II histone deacetylase acts on newly synthesized histones in Tetrahymena. Eukaryotic cell 7(3):471-82
- Ref:SUPR000218
- Ref:SUPR000231
- Ref:SUPR000180
- Ref:SUPR000158
Sequences
>TTHERM_01018420(coding)
ATGAATACAGCTCATAAAACAGACGATGAAAAAAAGGAATTCTTTGATTCACCTAAAGAA
TTAGAAGAAAAAGTAAATATTTTAGTTGATATGATAAAACGTTCTGAGCACTTTGTTGCT
TTTACAGGTGCAGGTATTTCTACTTCTACTGGAATTCCAGATTTTAGAAGTGGTATCAAT
ACAGTACTTCCAACTGGTCCAGGTGCATGGGAAAAATTAGCTTAAAAGACAGGCAGCTCT
AAAAGTAATGTAAAAGTAAGCATGTCTAAGGCAATACCATCTCCTACTCATATGTCTCTT
GTTGAATTACAGAGATAAGGATATCTTAAATTTTTGATAAGTTAGAATGTAGATGGTTTA
CACAGAAGAAGTGGATTTTCTACTTACCACTTAGCCGAATTGCATGGCAACACAAATCTA
GAAAAATGCTAGAAGTGTGGCAAAGAATACATGAGAGATTTTAGAGTCAGAACAGCCCAA
TAAGTACATGATCATAAAACTGGTAGAAAGTGTGATAATTAATAATGTAACGGAGATCTA
TATGACTCTATTATAAATTTTGGTGAAAACCTCCCTGAAAAAGACTAAGATGATGGATTC
GTTCATTCTTAGTTGGCTGATTTGCATTTAGTTTTAGGAAGCAGTTTAAGAGTAACTCCT
GCAGCTGATATGCCTGAAACTACAGCAAAATTAGGAAAAAATTTAGTTATTGTTAATTTG
TAAAAGACTCCTCTTGATTCTTTAGCTACTCTCAGAATAAATGCCATGTGTGATGATGTT
ATGAAAATGGTTATGAAAAAGCTTAAAATAGAAATCCCAGAATTTATCTTAGAAAGAAGG
ATAGTCCTTTAAAAGGGAGATAAAAACAGTTTACTTGTTTCTGCAGAAGATTCAAATGAA
AGTCCTTATGAAATATATAAAAAAGTTACAATTGAATATGGAAAAGCAAACGAAGCTAAA
TAAAAAGCTCCTTTCAATTTCACCCCCAAGCAAAACCAATTCACAGTGAGTTTAGGTTTC
TATGAACATTATGGAGAGTAAGAATTCAAATTAGATGTTGATATGATAGCTTTACCACTC
AATAAAAAAGTGGTTTACTAAATATAATATTAAGTTAGTCTCTAAAAATGGATAAGCTGC
AAACAAATATGA>TTHERM_01018420(protein)
MNTAHKTDDEKKEFFDSPKELEEKVNILVDMIKRSEHFVAFTGAGISTSTGIPDFRSGIN
TVLPTGPGAWEKLAQKTGSSKSNVKVSMSKAIPSPTHMSLVELQRQGYLKFLISQNVDGL
HRRSGFSTYHLAELHGNTNLEKCQKCGKEYMRDFRVRTAQQVHDHKTGRKCDNQQCNGDL
YDSIINFGENLPEKDQDDGFVHSQLADLHLVLGSSLRVTPAADMPETTAKLGKNLVIVNL
QKTPLDSLATLRINAMCDDVMKMVMKKLKIEIPEFILERRIVLQKGDKNSLLVSAEDSNE
SPYEIYKKVTIEYGKANEAKQKAPFNFTPKQNQFTVSLGFYEHYGEQEFKLDVDMIALPL
NKKVVYQIQYQVSLQKWISCKQI>TTHERM_01018420(gene)
ATGAATACAGCTCATAAAACAGACGATGAAAAAAAGGAATTCTTTGATTCACCTAAAGAA
TTAGAAGAAAAAGTAAATATTTTAGTTGATATGATAAAACGTTCTGAGCACTTTGTTGCT
TTTACAGGTGCAGGTATTTCTACTTCTACTGGAATTCCAGATTTTAGAAGTGGTATCAAT
ACAGTACTTCCAACTGGTCCAGGTGCATGGGAAAAATTAGCTTAAAAGACAGGCAGCTCT
AAAAGTAATGTAAAAGTAAGCATGTCTAAGGCAATACCATCTCCTACTCATATGTCTCTT
GTTGAATTACAGAGATAAGGATATCTTAAATTTTTGATAAGTTAGAATGTAGATGGTTTA
CACAGAAGAAGTGGATTTTCTACTTACCACTTAGCCGAATTGCATGGCAACACAAATCTA
GAAAAATGCTAGAAGTGTGGCAAAGAATACATGAGAGATTTTAGAGTCAGAACAGCCCAA
TAAGTACATGATCATAAAACTGGTAGAAAGTGTGATAATTAATAATGTAACGGAGATCTA
TATGACTCTATTATAAATTTTGGTGAAAACCTCCCTGAAAAAGACTAAGATGATGGATTC
GTTCATTCTTAGTTGGCTGATTTGCATTTAGTTTTAGGAAGCAGTTTAAGAGTAACTCCT
GCAGCTGATATGCCTGAAACTACAGCAAAATTAGGAAAAAATTTAGTTATTGTTAATTTG
TAAAAGACTCCTCTTGATTCTTTAGCTACTCTCAGAATAAATGCCATGTGTGATGATGTT
ATGAAAATGGTTATGAAAAAGCTTAAAATAGAAATCCCAGAATTTATCTTAGAAAGAAGG
ATAGTCCTTTAAAAGGGAGATAAAAACAGTTTACTTGTTTCTGCAGAAGATTCAAATGAA
AGTCCTTATGAAATATATAAAAAAGTTACAATTGAATATGGAAAAGCAAACGAAGCTAAA
TAAAAAGCTCCTTTCAATTTCACCCCCAAGCAAAACCAATTCACAGTGAGTTTAGGTTTC
TATGAACATTATGGAGAGTAAGAATTCAAATTAGATGTTGATATGATAGCTTTACCACTC
AATAAAAAAGTGGTTTACTAAATATAATATTAAGTTAGTCTCTAAAAATGGATAAGCTGC
AAACAAATATGA