Identifiers and Description

Gene Model Identifier

TTHERM_01018420

Standard Name

THD8 (Tetrahymena Histone Deacetylase 8)

Aliases

PreTt27759 | 199.m00052

Description

Sir2-like histone deacetylase; suppresses DNA transcription by deacetylation of histones

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• zinc ion binding (IEA) | GO:0008270
• NAD+ binding (IEA) | GO:0070403
• hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (IEA) | GO:0016811

Biological Process

• protein deacetylation (IEA) | GO:0006476
• chromatin silencing (IEA) | GO:0006342
• regulation of transcription (IEA) | GO:0045449

Domains

• ( PF00098 ) Zinc knuckle
• ( PF02146 ) transcriptional regulator, Sir2 family

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.8%

TetraMine Data

TTHERM_01018420

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_01121.1	9.997093137033517e-262	transcriptional regulator, Sir 2 family protein (386 aa)
Oxytricha	Contig19063.0.g74	4.999450098932641e-139	Sir2 family
Stentor Coeruleus	SteCoe_10597	2.8946403116483003e-63
WormBase	WBGene00004803	3.0000451088882257e-25	locus:sir-2.4 NAD-dependent protein deacetylase sir-2.4 status:Confirmed UniProt:Q95 Q89 protein_id:CCD61225.1
DictyBase	DDB_G0283917	8.997498379799854e-17	sir2A on chromosome: 4 positio n 1272110 to 1273864
SGD	YPL015C	0.0000000000000030004923591262316	HST2 Cytoplasmic member of the silencing information regulat or 2 (Sir2) family of NAD(+)-d ependent protein deacetylases; modulates nucleolar (rDNA) an d telomeric silencing; possess es NAD(+)-dependent histone de acetylase activity in vitro

General Information

No Data fetched for General Information

Associated Literature

1. Ref:18178773: Smith JJ, Torigoe SE, Maxson J, Fish LC, Wiley EA (2008) A class II histone deacetylase acts on newly synthesized histones in Tetrahymena. Eukaryotic cell 7(3):471-82
2. Ref:SUPR000231
3. Ref:SUPR000180
4. Ref:SUPR000158
5. Ref:SUPR000218

Sequences

>TTHERM_01018420(coding)
ATGAATACAGCTCATAAAACAGACGATGAAAAAAAGGAATTCTTTGATTCACCTAAAGAA
TTAGAAGAAAAAGTAAATATTTTAGTTGATATGATAAAACGTTCTGAGCACTTTGTTGCT
TTTACAGGTGCAGGTATTTCTACTTCTACTGGAATTCCAGATTTTAGAAGTGGTATCAAT
ACAGTACTTCCAACTGGTCCAGGTGCATGGGAAAAATTAGCTTAAAAGACAGGCAGCTCT
AAAAGTAATGTAAAAGTAAGCATGTCTAAGGCAATACCATCTCCTACTCATATGTCTCTT
GTTGAATTACAGAGATAAGGATATCTTAAATTTTTGATAAGTTAGAATGTAGATGGTTTA
CACAGAAGAAGTGGATTTTCTACTTACCACTTAGCCGAATTGCATGGCAACACAAATCTA
GAAAAATGCTAGAAGTGTGGCAAAGAATACATGAGAGATTTTAGAGTCAGAACAGCCCAA
TAAGTACATGATCATAAAACTGGTAGAAAGTGTGATAATTAATAATGTAACGGAGATCTA
TATGACTCTATTATAAATTTTGGTGAAAACCTCCCTGAAAAAGACTAAGATGATGGATTC
GTTCATTCTTAGTTGGCTGATTTGCATTTAGTTTTAGGAAGCAGTTTAAGAGTAACTCCT
GCAGCTGATATGCCTGAAACTACAGCAAAATTAGGAAAAAATTTAGTTATTGTTAATTTG
TAAAAGACTCCTCTTGATTCTTTAGCTACTCTCAGAATAAATGCCATGTGTGATGATGTT
ATGAAAATGGTTATGAAAAAGCTTAAAATAGAAATCCCAGAATTTATCTTAGAAAGAAGG
ATAGTCCTTTAAAAGGGAGATAAAAACAGTTTACTTGTTTCTGCAGAAGATTCAAATGAA
AGTCCTTATGAAATATATAAAAAAGTTACAATTGAATATGGAAAAGCAAACGAAGCTAAA
TAAAAAGCTCCTTTCAATTTCACCCCCAAGCAAAACCAATTCACAGTGAGTTTAGGTTTC
TATGAACATTATGGAGAGTAAGAATTCAAATTAGATGTTGATATGATAGCTTTACCACTC
AATAAAAAAGTGGTTTACTAAATATAATATTAAGTTAGTCTCTAAAAATGGATAAGCTGC
AAACAAATATGA

>TTHERM_01018420(protein)
MNTAHKTDDEKKEFFDSPKELEEKVNILVDMIKRSEHFVAFTGAGISTSTGIPDFRSGIN
TVLPTGPGAWEKLAQKTGSSKSNVKVSMSKAIPSPTHMSLVELQRQGYLKFLISQNVDGL
HRRSGFSTYHLAELHGNTNLEKCQKCGKEYMRDFRVRTAQQVHDHKTGRKCDNQQCNGDL
YDSIINFGENLPEKDQDDGFVHSQLADLHLVLGSSLRVTPAADMPETTAKLGKNLVIVNL
QKTPLDSLATLRINAMCDDVMKMVMKKLKIEIPEFILERRIVLQKGDKNSLLVSAEDSNE
SPYEIYKKVTIEYGKANEAKQKAPFNFTPKQNQFTVSLGFYEHYGEQEFKLDVDMIALPL
NKKVVYQIQYQVSLQKWISCKQI

>TTHERM_01018420(gene)
ATGAATACAGCTCATAAAACAGACGATGAAAAAAAGGAATTCTTTGATTCACCTAAAGAA
TTAGAAGAAAAAGTAAATATTTTAGTTGATATGATAAAACGTTCTGAGCACTTTGTTGCT
TTTACAGGTGCAGGTATTTCTACTTCTACTGGAATTCCAGATTTTAGAAGTGGTATCAAT
ACAGTACTTCCAACTGGTCCAGGTGCATGGGAAAAATTAGCTTAAAAGACAGGCAGCTCT
AAAAGTAATGTAAAAGTAAGCATGTCTAAGGCAATACCATCTCCTACTCATATGTCTCTT
GTTGAATTACAGAGATAAGGATATCTTAAATTTTTGATAAGTTAGAATGTAGATGGTTTA
CACAGAAGAAGTGGATTTTCTACTTACCACTTAGCCGAATTGCATGGCAACACAAATCTA
GAAAAATGCTAGAAGTGTGGCAAAGAATACATGAGAGATTTTAGAGTCAGAACAGCCCAA
TAAGTACATGATCATAAAACTGGTAGAAAGTGTGATAATTAATAATGTAACGGAGATCTA
TATGACTCTATTATAAATTTTGGTGAAAACCTCCCTGAAAAAGACTAAGATGATGGATTC
GTTCATTCTTAGTTGGCTGATTTGCATTTAGTTTTAGGAAGCAGTTTAAGAGTAACTCCT
GCAGCTGATATGCCTGAAACTACAGCAAAATTAGGAAAAAATTTAGTTATTGTTAATTTG
TAAAAGACTCCTCTTGATTCTTTAGCTACTCTCAGAATAAATGCCATGTGTGATGATGTT
ATGAAAATGGTTATGAAAAAGCTTAAAATAGAAATCCCAGAATTTATCTTAGAAAGAAGG
ATAGTCCTTTAAAAGGGAGATAAAAACAGTTTACTTGTTTCTGCAGAAGATTCAAATGAA
AGTCCTTATGAAATATATAAAAAAGTTACAATTGAATATGGAAAAGCAAACGAAGCTAAA
TAAAAAGCTCCTTTCAATTTCACCCCCAAGCAAAACCAATTCACAGTGAGTTTAGGTTTC
TATGAACATTATGGAGAGTAAGAATTCAAATTAGATGTTGATATGATAGCTTTACCACTC
AATAAAAAAGTGGTTTACTAAATATAATATTAAGTTAGTCTCTAAAAATGGATAAGCTGC
AAACAAATATGA