Identifiers and Description

Gene Model Identifier

TTHERM_00502610

Standard Name

THD6 (Tetrahymena Histone Deacetylase 6)

Aliases

PreTt08100 | 63.m00278 | 3716.m00130 | THD6 | RPD3

Description

Histone deacetylase family protein; suppresses DNA transcription by deacetylation of histones

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• integral component of membrane (IEA) | GO:0016021

Molecular Function

• ATPase activity, coupled to transmembrane movement of substances (IEA) | GO:0042626
• ATPase activity (IEA) | GO:0016887
• ATP binding (IEA) | GO:0005524

Biological Process

• transport (IEA) | GO:0006810

Domains

• ( PF00850 ) Histone deacetylase family

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10%

TetraMine Data

TTHERM_00502610

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_09551.1	9.997093137033517e-262	histone deacetylase (457 aa)
WormBase	WBGene00001836	2.0005528695435914e-146	locus:hda-3 Histone deacetyl ase status:Confirmed UniPr ot:G5ECH0 protein_id:CAB0322 4.1
DictyBase	DDB_G0268024	5.002003259710477e-145	hdaA on chromosome: 1 position 1320084 to 1322172
SGD	YNL330C	1.0004982362389172e-141	RPD3 Histone deacetylase; regu lates transcription, silencing , and other processes by influ encing chromatin remodeling; f orms at least two different co mplexes which have distinct fu nctions and members
Oxytricha	Contig1866.0.g68	3.001349705199738e-130	Histone deacetylase domain
Stentor Coeruleus	SteCoe_31554	2.8946403116483003e-63

General Information

No Data fetched for General Information

Associated Literature

1. Ref:18178773: Smith JJ, Torigoe SE, Maxson J, Fish LC, Wiley EA (2008) A class II histone deacetylase acts on newly synthesized histones in Tetrahymena. Eukaryotic cell 7(3):471-82
2. Ref:SUPR000098

Sequences

>TTHERM_00502610(coding)
ATGGAAGATGATATTAGAACAATTTATGAAGGGAAAAGAATTAGTTATTTCTATAATCCT
GAAATAGGAAAGTTTTACTACAGCAAAGATCACCCTATGAAACCAAAAAGAGTTGCTATG
GCACATTCTTTAATTTAAAATTTTGGTCTGTATAAAGACTTAGATGTTTACACTGCTCGT
TAAGCTACTTTTGAAGAAATGATCAAATTTCACGATATAGAATATATTAATTATCTACAA
AATTATGTTAGTAATGGTTGGACATAAGAGCTAAAAAAGCTGAAACAAGATCCCTTAATA
AATTTAGAATCTTCATACCATATAAATAACCCTAAAAAAAGATAAACAAGCAAAGTAGGA
GATACTTCTGATTGCCCAGGTTTTGAAGGTCTTTATAATTTTTGTTAGATTAGTGCTGGT
GGTTCTTTAGATTGCGCATCAATGATTATAAATCAATAATCTGATATTGCTATCAACTGG
GGAGGTGGTTTACATCATGCAAAGAAAAAAGAAGCTAGTGGATTTTGTTATGTTAATGAT
ATTGTTTTGTGTGCATTAGAGTTATTAAAGTATTATCCAAGAGTAATTTATATTGATATT
GATGTTCATCATGGCGATGGTGTAGAAGAAGCTTTTTTCCTTACAAATCGTGTGATGACA
GTTAGTTTTCATGAATATGGTGATGACTTCTTCCCAGGAAGTGGCTCTCTAAATTCTATT
GGCGATGGACCAGGCAAATATCATGCTATTAATGTACCTTTAAGACCAGGAATCAATGAT
GAAACATTTGAACAAGTATTTAAGGATGTTATGAAAAAAGTAATGGAAGTATATAGACCT
AATGTAATATTGCTATAATGCGGAGCTGATTCATTAGCATATGATAAGCTAGGACACTTC
AATTTATCAACAAAAGGGCATGGAAAAGCTGTAGAATATATGAAAAGCTTTGGTATTCCT
CTAATATTAATGGGAGGTGGTGGTTATAATGTACCAAATGTTGCAAGATGCTGGGCTTAT
GAGACATCTATTTGTGTTGGAAATAAAATTGATGGAAATATTCCTATTACTGAGCCGTTT
TATGACTATTTTGGTCCAGATCATAAACTCCATGTTACTCCTAAAAATAATGTGGATAAT
AAAAATACCAAGGATGAGCTCCATTAGAAGGTTTCAACCGTTCATGAATATTTAAGATAA
ATAGAAAGTGCACCTTCTATGGCATTCCATCACACCCCTGATAATAGTAAATTTGCAGAA
GAAGAATAAAATATAGATGAAGAATTTGATTATGATATGGATGATGAAGAGTTAGAAAGA
TATTTTAAATAGAAAGAAAAACCTATTATAATGAATAATAGATATATTTGA

>TTHERM_00502610(protein)
MEDDIRTIYEGKRISYFYNPEIGKFYYSKDHPMKPKRVAMAHSLIQNFGLYKDLDVYTAR
QATFEEMIKFHDIEYINYLQNYVSNGWTQELKKLKQDPLINLESSYHINNPKKRQTSKVG
DTSDCPGFEGLYNFCQISAGGSLDCASMIINQQSDIAINWGGGLHHAKKKEASGFCYVND
IVLCALELLKYYPRVIYIDIDVHHGDGVEEAFFLTNRVMTVSFHEYGDDFFPGSGSLNSI
GDGPGKYHAINVPLRPGINDETFEQVFKDVMKKVMEVYRPNVILLQCGADSLAYDKLGHF
NLSTKGHGKAVEYMKSFGIPLILMGGGGYNVPNVARCWAYETSICVGNKIDGNIPITEPF
YDYFGPDHKLHVTPKNNVDNKNTKDELHQKVSTVHEYLRQIESAPSMAFHHTPDNSKFAE
EEQNIDEEFDYDMDDEELERYFKQKEKPIIMNNRYI

>TTHERM_00502610(gene)
ATGGAAGATGATATTAGAACAATTTATGAAGGGAAAAGAATTAGTTATTTCTATAATCCT
GAAATAGGAAAGTATTGCATTTATACTTAGCACATATTAGAGCTTATATTAAACTTTTAT
AATATCATTAAATTTAACAAATCTATAATTAATAATATTTTTAGGTTTTACTACAGCAAA
GATCACCCTATGAAACCAAAAAGAGTTGCTATGGCACATTCTTTAATTTAAAATTTTGGT
CTGTATAAAGACTTAGATGTTTACACTGCTCGTTAAGCTACTTTTGAAGAAATGATCAAA
TTTCACGATATAGAATATATTAATTATCTACAAAATTATGTTAGTAATGGTTGGACATAA
GAGCTAAAAAAGCTGAAACAAGATCCCTTAATAAATTTAGAATCTTCATACCATATAAAT
AACCCTAAAAAAAGATAAACAAGCAAGTATTGCATATTTTTTAATTTATCTAATTACTTT
GCATCTTTACTTTTTATATTGAACTCATCTATATAAAAATATAGAGTAGGAGATACTTCT
GATTGCCCAGGTTTTGAAGGTCTTTATAATTTTTGTTAGATTAGTGCTGGTGGTTCTTTA
GATTGCGCATCAATGATTATAAATCAATAATCTGATATTGCTATCAACTGGGGAGGTGGT
TTACATCATGCAAAGAAAAAAGAAGCTAGTGGATTTTGTTATGTTAATGATATTGTTTTG
TGTGCATTAGAGTTATTAAAGTATTATCCAAGAGTAATTTATATTGATATTGATGTTCAT
CATGGCGATGGTGTAGAAGAAGCTTTTTTCCTTACAAATCGTGTGATGACAGTTAGTTTT
CATGAATATGGTGATGACTTCTTCCCAGGTAACATATTTGTTTATGAATCATATAGCTTT
TTGAAATAGATTTAGAAGTTAATAATAAATCATAAATTAAAAAAAAAAATAAATCCAAGC
TTTGAAAATAGAATTATTATAAATCATAATGAGAATTCAATTTTTTAAAAATAAAAATTG
TTTATTTAAATAGGAAGTGGCTCTCTAAATTCTATTGGCGATGGACCAGGCAAATATCAT
GCTATTAATGTACCTTTAAGACCAGGAATCAATGATGAAACATTTGAACAAGTATTTAAG
GATGTTATGAAAAAAGTAATGGAAGTATATAGACCTAATGTAATATTGCTATAATGCGGA
GCTGATTCATTAGCATATGATAAGGTAAAATTAATTATTGTTAGAGTATTTATTTTTAAA
TAATGATTGATTATTGTTAAAAAAGCTAGGACACTTCAATTTATCAACAAAAGGGCATGG
AAAAGCTGTAGAATATATGAAAAGCTTTGGTATTCCTCTAATATTAATGGGAGGTGGTGG
TTATAATGTACCAAATGTTGCAAGATGCTGGGCTTATGAGACATCTATTTGTGTTGGAAA
TAAAATTGATGGAAATATTCCTATTACTGAGCCGTTTTATGACTATTTTGGTCCAGATCA
TAAACTCCATGTTACTCCTAAAAATAATGTGGATAATAAAAATACCAAGGATGAGCTCCA
TTAGAAGGTTTCAACCGTTCATGAATATTTAAGATAAATAGAAAGTGCACCTTCTATGGC
ATTCCATCACACCCCTGATAATAGTAAATTTGCAGAAGAAGAATAAAATATAGATGAAGA
ATTTGATTATGATATGGATGATGAAGAGTTAGAAAGATATTTTAAATAGAAAGAAAAACC
TATTATAATGAATAATAGATATATTTGA