Identifiers and Description

Gene Model Identifier

TTHERM_00833740

Standard Name

THD18 (Tetrahymena Histone Deacetylase 18)

Aliases

PreTt14157 | 144.m00120

Description

transcriptional regulator, Sir2 family protein

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• NAD+ binding (IEA) | GO:0070403
• hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (IEA) | GO:0016811
• zinc ion binding (IEA) | GO:0008270

Biological Process

• protein deacetylation (IEA) | GO:0006476
• chromatin silencing (IEA) | GO:0006342
• regulation of transcription (IEA) | GO:0045449

Domains

• ( PF02146 ) transcriptional regulator, Sir2 family

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.3%

TetraMine Data

TTHERM_00833740

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_10210.1	9.997093137033517e-262	transcriptional regulator, Sir 2 family protein (1549 aa)
Oxytricha	Contig21344.0.g34	1.9991517704232713e-32	Sir2 family
Stentor Coeruleus	SteCoe_30793	0.0000000000002543665647376923
DictyBase	DDB_G0270928	0.00000000019994075865167896	sir2E on chromosome: 1 positio n 3398987 to 3400602
SGD	YDR191W	0.0000000400154582995175	HST4 Member of the Sir2 family of NAD(+)-dependent protein d eacetylases; involved along wi th Hst3p in silencing at telom eres, cell cycle progression, radiation resistance, genomic stability and short-chain fatt y acid metabolism
WormBase	WBGene00004802	0.0000029996948234116693	locus:sir-2.3 NAD-dependent protein deacetylase sir-2.3 status:Partially_confirmed U niProt:Q20481 protein_id:CAA 90547.1

General Information

No Data fetched for General Information

Associated Literature

1. Ref:18178773: Smith JJ, Torigoe SE, Maxson J, Fish LC, Wiley EA (2008) A class II histone deacetylase acts on newly synthesized histones in Tetrahymena. Eukaryotic cell 7(3):471-82

Sequences

>TTHERM_00833740(coding)
ATGGAATAAACTGATAATAGCAGCAAACAAACTTAGCAATAAGAAGAAACGAAAGATTGT
AGAAACTGCTCTTATGAAGAAACCATGAAAACGATTGAAGAGACAAGACTAAATTGTTAA
AGGACAATGCAAATTTGCAACTAATCAATATAAACTATTGGAGAATCTATCAAAACAGCC
AATGAAGCAAAATAAAATATCGATGGCTTTTTCGATTAGTACAATTAAGCTATGAACAGC
TTGAGCGAGAAAATTTCTGGATCGTTCTCAGGAATGAGTCGTTGTTTTTTAAAAAATGAG
AACACTGATAAGTAATTTGAAGATTCAAGATAAATAACAGTTAAAGAAGGTGCATAATTT
TTCAAAGACAAGAAAAAAGTTGTTTTTTTGACAGGAGCTGGTATTTCAGTAGCAAGTGGA
ATTCCAACATTCAAAGGAGTTGGTGCTGCACCTCTTTTTGAAAAGGACGGAGTTACTTAT
CAAAATGAACAAATTTCTACTTATAATTTTATGAAAAACAAACCAGATATTTTTTGGGAA
AGAAATTTGATATTCTTAGGAGGTTAATTGGGAAAGAAATACAATGTATCTCACTTAAAG
ATTCAATAATTAGTCAATTAGTATAAATAAATCAAGACATCTTAACTTGGGAAGCAAAAT
GCTTATCAACCCTAAGCAGTAATTGTGACATAAAATACAGATGGTCTTCATTGCTAAGCT
TTTAATGAGTTAAATCCCAGAGAAACAAATTACATGAACAAAGATGATCCTCAATATGGA
TTTTGCCCTGATGTCTTTGAAGTTCATGGCAGTAAAACTTTCCTTAGATGTGATAATTAA
GAATGCAAAGATTATGACAAAAAGTTTTTGTACCCACAAAAATATGATTCTTACAAAGAC
TTCATTTGCGAAACTTGTAAAACCTAAGCTAGACCAAATGTATTGTACTTTGATGAATCT
TATGATGAAAAAAATTATAGGATAAACACTTTGAATGAATTAACTTCTGACATGGATCTA
TTGATATCTATAGGAACATAATTAGACACAGGATATGCTGCTTAAACTGTCAGTAATGCA
GTTCAATAAAAGATTCCAGTCATAGAAATATCTTTAACACCTGTCATATAAAAAGGAGGT
CTAACTCTGAAAGGAAAAGCAGAAGAAGTTGTACCTCAATTATGTGATTTAGTTATGGAA
TTAAATAAATAATTATTACCCACACAACAAAAAGTAGCAAATAAATCAATTGCTTAGAAA
AGTTAAAATCTACTAAAAGATTAAAATAATAAAAGCAATAGCTGTTTATAATCTACAAAT
ACCAGTAAATCTTCCATTTCTAATAAAGTATCAACTAATTCTGCTTAATCTGCAGTAAAA
ACTCTTAATTAAAACCAAGATAATACCTAAACTAATTAAAAACCATAAGTAAAATAAGTC
AGTTTTAGAAAGCCAAATATTAAAGTTGGTCTAAACACAAAGGTAAAAAAGTGA

>TTHERM_00833740(protein)
MEQTDNSSKQTQQQEETKDCRNCSYEETMKTIEETRLNCQRTMQICNQSIQTIGESIKTA
NEAKQNIDGFFDQYNQAMNSLSEKISGSFSGMSRCFLKNENTDKQFEDSRQITVKEGAQF
FKDKKKVVFLTGAGISVASGIPTFKGVGAAPLFEKDGVTYQNEQISTYNFMKNKPDIFWE
RNLIFLGGQLGKKYNVSHLKIQQLVNQYKQIKTSQLGKQNAYQPQAVIVTQNTDGLHCQA
FNELNPRETNYMNKDDPQYGFCPDVFEVHGSKTFLRCDNQECKDYDKKFLYPQKYDSYKD
FICETCKTQARPNVLYFDESYDEKNYRINTLNELTSDMDLLISIGTQLDTGYAAQTVSNA
VQQKIPVIEISLTPVIQKGGLTLKGKAEEVVPQLCDLVMELNKQLLPTQQKVANKSIAQK
SQNLLKDQNNKSNSCLQSTNTSKSSISNKVSTNSAQSAVKTLNQNQDNTQTNQKPQVKQV
SFRKPNIKVGLNTKVKK

>TTHERM_00833740(gene)
ATGGAATAAACTGATAATAGCAGCAAACAAACTTAGCAATAAGAAGAAACGAAAGATTGT
AGAAACTGCTCTTATGAAGAAACCATGAAAACGATTGAAGAGACAAGACTAAATTGTTAA
AGGACAATGCAAATTTGCAACTAATCAATATAAACTATTGGAGAATCTATCAAAACAGCC
AATGAAGCAAAATAAAATATCGATGGCTTTTTCGATTAGTACAATTAAGCTATGAACAGC
TTGAGCGAGAAAATTTCTGGATCGTTCTCAGGAATGAGTCGTTGTTTTTTGTAAGTAAAT
CATTCGCTTATTTAAACAACTAAATTTTTTTTTTTAACCAAAAAGAAAAAATGAGAACAC
TGATAAGTAATTTGAAGATTCAAGATAAATAACAGTTAAAGAAGGTGCATAATTTTTCAA
AGACAAGAAAAAAGTTGTTTTTTTGACAGGAGCTGGTATTTCAGTAGCAAGTGGAATTCC
AACATTCAAAGGAGTTGGTGCTGCACCTCTTTTTGAAAAGGACGGAGTTACTTATCAAAA
TGAACAAATTTCTACTTATAATTTTATGAAAAACAAACCAGATATTTTTTGGGAAAGAAA
TTTGATATTCTTAGGAGGTTAATTGGGAAAGAAATACAATGTATCTCACTTAAAGATTCA
ATAATTAGTCAATTAGTATAAATAAATCAAGACATCTTAACTTGGGAAGCAAAATGCTTA
TCAACCCTAAGCAGTAATTGTGACATAAAATACAGATGGTCTTCATTGCTAAGCTTTTAA
TGAGTTAAATCCCAGAGAAACAAATTACATGAACAAAGATGATCCTCAATATGGATTTTG
CCCTGATGTCTTTGAAGTTCATGGCAGTAAAACTTTCCTTAGATGTGATAATTAAGAATG
CAAAGATTATGACAAAAAGTTTTTGTACCCACAAAAATATGATTCTTACAAAGACTTCAT
TTGCGAAACTTGTAAAACCTAAGCTAGACCAAATGTATTGTACTTTGATGAATCTTATGA
TGAAAAAAATTATAGGATAAACACTTTGAATGAATTAACTTCTGACATGGATCTATTGAT
ATCTATAGGAACATAATTAGACACAGGATATGCTGCTTAAACTGTCAGTAATGCAGTTCA
ATAAAAGATTCCAGTCATAGAAATATCTTTAACACCTGTCATATAAAAAGGAGGTCTAAC
TCTGAAAGGAAAAGCAGAAGAAGTTGTACCTCAATTATGTGATTTAGTTATGGAATTAAA
TAAATAATTATTACCCACACAACAAAAAGTAGCAAATAAATCAATTGCTTAGAAAAGTTA
AAATCTACTAAAAGATTAAAATAATAAAAGCAATAGCTGTTTATAATCTACAAATACCAG
TAAATCTTCCATTTCTAATAAAGTATCAACTAATTCTGCTTAATCTGCAGTAAAAACTCT
TAATTAAAACCAAGATAATACCTAAACTAATTAAAAACCATAAGTAAAATAAGTCAGTTT
TAGAAAGCCAAATATTAAAGTTGGTCTAAACACAAAGGTAAAAAAGTGA