Identifiers and Description

Gene Model Identifier

TTHERM_00833750

Standard Name

THD17 (Tetrahymena Histone Deacetylase 17)

Aliases

PreTt14158 | 144.m00121

Description

Transcriptional regulator; Sir2 family protein

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• zinc ion binding (IEA) | GO:0008270
• NAD+ binding (IEA) | GO:0070403
• hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (IEA) | GO:0016811

Biological Process

• protein deacetylation (IEA) | GO:0006476
• chromatin silencing (IEA) | GO:0006342
• regulation of transcription (IEA) | GO:0045449

Domains

• ( PF02146 ) transcriptional regulator, Sir2 family

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.2%

TetraMine Data

TTHERM_00833750

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_10210.1	9.997093137033517e-262	transcriptional regulator, Sir 2 family protein (1549 aa)
Oxytricha	Contig21344.0.g34	9.000751454575209e-33	Sir2 family
Stentor Coeruleus	SteCoe_30793	0.0000000000002543665647376923
DictyBase	DDB_G0270928	0.00000000006996681903814525	sir2E on chromosome: 1 positio n 3398987 to 3400602
WormBase	WBGene00004800	0.000000004999139696582238	locus:sir-2.1 status:Partial ly_confirmed UniProt:D3YT50 protein_id:CBK19468.1
SGD	YDR191W	0.00000030014504373857585	HST4 Member of the Sir2 family of NAD(+)-dependent protein d eacetylases; involved along wi th Hst3p in silencing at telom eres, cell cycle progression, radiation resistance, genomic stability and short-chain fatt y acid metabolism

General Information

No Data fetched for General Information

Associated Literature

1. Ref:18178773: Smith JJ, Torigoe SE, Maxson J, Fish LC, Wiley EA (2008) A class II histone deacetylase acts on newly synthesized histones in Tetrahymena. Eukaryotic cell 7(3):471-82
2. Ref:SUPR000239
3. Ref:SUPR000181

Sequences

>TTHERM_00833750(coding)
ATGGAATAAACTGATAATAGCAACAAACAAACTTAGCAATAAGAAGAAACGAAAGATTAT
AGAAACTGCTCTTATGAAGAAGTCATGAAAATGATTGAAGAGACAAGATTGAATTGTTAA
AGGACAATGCAAATTTGCAACTAATCAATTTAAAGTATTGGAGAATCTATCAAAACGGTC
AATGAAGCAAAATAAAATATCGATGGCTTTTTCGATTAGTACAATTAAGCTATGAACAGC
TTGTGCGAGAAAATTGCTGGATCATTCTCAGGAATGAGTCGTTGTTTTTTAAAAAATGAG
AACACTGATAAGGAATTTGAAGATTCAAGATAAATAACAATCTAAGAAGGTGCATAGCTT
TTCAAAGACAAGAAAAAAGTTGTTTTTTTAACAGGAGCTGGCATTTCAGTTGCAAGTGGA
ATTCCAACATTTAGAGGAGTTGGTGCTGCACCTCTATTTGAAAAAGACGGTGTTACCTAT
TAAAATGAAGAAATTTCTACTTACAATTTTATGAAAAACAAACCAGATATTTTTTGGGAA
AGAAATTTGATATTCTTAGGAGGTTAATTGGGAAAGAAGTACAATGTATCTCACTTAAAG
ATTCAATAATTAGTCAATTAGTATAAATAAATCAAGACATCTTAACTTGGGAAGCAAAAT
GCTTATCAACCCTAAGCAGTAATTGTGACATAAAATACAGACGGTCTTCATTGCTAGGCA
TTTAATGAGTTAAATCCCAGAGAAACAAATTACATGAACAAAGATGATCCTCAATATGGA
TTTTGCCCTGATGTATTTGAAGTTCATGGTAGTAAAACTTTCCTTAGATGTGATAATTAA
GAATGCAAAGATTATGATAAAAAGTTTTTGTACCCATAAAAATATAATTCTTACAAAGAC
TTCATATGCGAAACTTGTAAAACTTAAGCTAGACCAAATGTGTTGTACTTTGATGAATCA
TATAATGAAAAAAATTATAGGATAAACACTTTGAAAGAATTAACTTCTGATATGGATCTA
TTGATATCTATAGGAACATAATTAGACACAGGATATGCTGCTTAAACTGTCAGTAGTGCA
GTTCAATAAAAGATTCCAGTCATAGAAATATCTTTAACACCAGTCATATAAAAAGGAGGT
CTAACTCTGAAAGGAAAAGCAGAAGAAGTTGTACCTCAATTATGTGATTTAGTAATGGAG
TTAAATAAATAATATTTGTAAAATAAATAATTACCCACACCACAACAAAAAGTAGCAACT
AAATCAATTGCTTAGAAAAGTTAAAACCCACTAAAAGATTAAAATTATAAAAGTAATAGC
AGTTTACAATCAACGAATACCAGCAACTCTTCCATTTCTACTAAAGTCTCAACTAATTCT
GCTAAACCTGCAGTAAAACCTCTTAATTAAAACCAAGCGAATACTAAAACTAATTAAAAA
CCATAAGTAAAATAAGTCAGTTCTACAAAGCCAAATGTTAAAATTGGTCTAACCACAAAG
GAAAAAAAGTGA

>TTHERM_00833750(protein)
MEQTDNSNKQTQQQEETKDYRNCSYEEVMKMIEETRLNCQRTMQICNQSIQSIGESIKTV
NEAKQNIDGFFDQYNQAMNSLCEKIAGSFSGMSRCFLKNENTDKEFEDSRQITIQEGAQL
FKDKKKVVFLTGAGISVASGIPTFRGVGAAPLFEKDGVTYQNEEISTYNFMKNKPDIFWE
RNLIFLGGQLGKKYNVSHLKIQQLVNQYKQIKTSQLGKQNAYQPQAVIVTQNTDGLHCQA
FNELNPRETNYMNKDDPQYGFCPDVFEVHGSKTFLRCDNQECKDYDKKFLYPQKYNSYKD
FICETCKTQARPNVLYFDESYNEKNYRINTLKELTSDMDLLISIGTQLDTGYAAQTVSSA
VQQKIPVIEISLTPVIQKGGLTLKGKAEEVVPQLCDLVMELNKQYLQNKQLPTPQQKVAT
KSIAQKSQNPLKDQNYKSNSSLQSTNTSNSSISTKVSTNSAKPAVKPLNQNQANTKTNQK
PQVKQVSSTKPNVKIGLTTKEKK

>TTHERM_00833750(gene)
AGTTAATTAAAATCAATACAACTAAATAAGTATTTTTATTTACAAATATAAATGGAATAA
ACTGATAATAGCAACAAACAAACTTAGCAATAAGAAGAAACGAAAGATTATAGAAACTGC
TCTTATGAAGAAGTCATGAAAATGATTGAAGAGACAAGATTGAATTGTTAAAGGACAATG
CAAATTTGCAACTAATCAATTTAAAGTATTGGAGAATCTATCAAAACGGTCAATGAAGCA
AAATAAAATATCGATGGCTTTTTCGATTAGTACAATTAAGCTATGAACAGCTTGTGCGAG
AAAATTGCTGGATCATTCTCAGGAATGAGTCGTTGTTTTTTGTAAGTATATCATTCACTT
ATTTAAACAACTAAATAAATTTTTTAAACATTAAAGAAAAAATGAGAACACTGATAAGGA
ATTTGAAGATTCAAGATAAATAACAATCTAAGAAGGTGCATAGCTTTTCAAAGACAAGAA
AAAAGTTGTTTTTTTAACAGGAGCTGGCATTTCAGTTGCAAGTGGAATTCCAACATTTAG
AGGAGTTGGTGCTGCACCTCTATTTGAAAAAGACGGTGTTACCTATTAAAATGAAGAAAT
TTCTACTTACAATTTTATGAAAAACAAACCAGATATTTTTTGGGAAAGAAATTTGATATT
CTTAGGAGGTTAATTGGGAAAGAAGTACAATGTATCTCACTTAAAGATTCAATAATTAGT
CAATTAGTATAAATAAATCAAGACATCTTAACTTGGGAAGCAAAATGCTTATCAACCCTA
AGCAGTAATTGTGACATAAAATACAGACGGTCTTCATTGCTAGGCATTTAATGAGTTAAA
TCCCAGAGAAACAAATTACATGAACAAAGATGATCCTCAATATGGATTTTGCCCTGATGT
ATTTGAAGTTCATGGTAGTAAAACTTTCCTTAGATGTGATAATTAAGAATGCAAAGATTA
TGATAAAAAGTTTTTGTACCCATAAAAATATAATTCTTACAAAGACTTCATATGCGAAAC
TTGTAAAACTTAAGCTAGACCAAATGTGTTGTACTTTGATGAATCATATAATGAAAAAAA
TTATAGGATAAACACTTTGAAAGAATTAACTTCTGATATGGATCTATTGATATCTATAGG
AACATAATTAGACACAGGATATGCTGCTTAAACTGTCAGTAGTGCAGTTCAATAAAAGAT
TCCAGTCATAGAAATATCTTTAACACCAGTCATATAAAAAGGAGGTCTAACTCTGAAAGG
AAAAGCAGAAGAAGTTGTACCTCAATTATGTGATTTAGTAATGGAGTTAAATAAATAATA
TTTGTAAAATAAATAATTACCCACACCACAACAAAAAGTAGCAACTAAATCAATTGCTTA
GAAAAGTTAAAACCCACTAAAAGATTAAAATTATAAAAGTAATAGCAGTTTACAATCAAC
GAATACCAGCAACTCTTCCATTTCTACTAAAGTCTCAACTAATTCTGCTAAACCTGCAGT
AAAACCTCTTAATTAAAACCAAGCGAATACTAAAACTAATTAAAAACCATAAGTAAAATA
AGTCAGTTCTACAAAGCCAAATGTTAAAATTGGTCTAACCACAAAGGAAAAAAAGTGAAA
TAAAATAATAAAACTAAATAAATTATCTACAAATTTTAATAATTATTTAATAAGAAATGT
AAATAAGTATTAGCTATAAATGAATTGATAAGAAATTTATTGTAAATATAAATATATTAA
TTAATATTTTAATAATAGTAATAATCT