Identifiers and Description

Gene Model Identifier

TTHERM_00526990

Standard Name

THD14 (Tetrahymena Histone Deacetylase 14)

Aliases

PreTt06437 | 66.m00236 | 3722.m00094 | SHD9 | HST2

Description

NAD(+)-dependent protein deacetylase; member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• NAD+ binding (IEA) | GO:0070403
• hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (IEA) | GO:0016811
• zinc ion binding (IEA) | GO:0008270

Biological Process

• chromatin silencing (IEA) | GO:0006342
• regulation of transcription (IEA) | GO:0045449
• protein deacetylation (IEA) | GO:0006476

Domains

• ( PF01853 ) MOZ/SAS family
• ( PF02146 ) transcriptional regulator, Sir2 family
• ( PF02148 ) Zn-finger in ubiquitin-hydrolases and other

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.1%

TetraMine Data

TTHERM_00526990

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_13434.1	9.997093137033517e-262	hypothetical protein (3586 aa)
Oxytricha	Contig9367.0.g58	1.000296925633081e-74	Sir2 family
DictyBase	DDB_G0283917	9.996907204735647e-62	sir2A on chromosome: 4 positio n 1272110 to 1273864
SGD	YPL015C	3.00017180903994e-49	HST2 Cytoplasmic member of the silencing information regulat or 2 (Sir2) family of NAD(+)-d ependent protein deacetylases; modulates nucleolar (rDNA) an d telomeric silencing; possess es NAD(+)-dependent histone de acetylase activity in vitro
WormBase	WBGene00004800	8.003782782428492e-46	locus:sir-2.1 NAD-dependent protein deacetylase sir-2.1 status:Partially_confirmed U niProt:Q21921 protein_id:CAA 94364.1
Stentor Coeruleus	SteCoe_29687	9.602680054508676e-24

General Information

No Data fetched for General Information

Associated Literature

1. Ref:21933443: Slade KM, Freggiaro S, Cottrell KA, Smith JJ, Wiley EA (2011) Sirtuin-mediated nuclear differentiation and programmed degradation in Tetrahymena. BMC cell biology 12( ):40
2. Ref:18178773: Smith JJ, Torigoe SE, Maxson J, Fish LC, Wiley EA (2008) A class II histone deacetylase acts on newly synthesized histones in Tetrahymena. Eukaryotic cell 7(3):471-82
3. Ref:SUPR000087

Sequences

>TTHERM_00526990(coding)
ATGAGTTCTGAAATTAGTAAAACAGATTTAAGCAATTTAGAATCAAATACAGATTCTATG
AGCGAGGCTTAGAAGGAAGCTTAATTAATTGGGTTTGCTGTAGAACCTAAGCTTGACTGC
CCTCATTTTGAATAGCTTAATGTTATCACTTTGACAGAAGTCTTTAATGATATGACATTA
GAAACTTTAAATAAGCCTTGTAAGACTTGTAACCATATTGGAGAAAACTGGATTTGCTTA
CATTGTACTGACATATTTTGCTCTAGATATATAAATAAAGATATGGCTAAACACGTTGAA
AGCAATTAAGAGCACTGTCTAGTATTTTCTTTTTCTGATGGTAGTTTTTGGTGCTACAAA
TGTGATAATTACATTTCAAATAAAACTATTAAGGATCTTTAGAAAACATTTTCAAAGGTT
AAGCATGGAGGATAAGAATCAAATGAAGAAGAAGAAGAAAAAGAAGATGATATTCATGCA
ATAGCTGCTTAACTTCTTTAGATGCATCTAAACAAAAAAGGTTAAGATGGTATTTAAGAA
GAATTTACCTACTAAAATTTAATTGATGGTTTGAGAGATATTTCTCCTGATTAAGAGAAA
AATTAAGATGACAAATACAATAACAGACAGTTCAATCGAATTGTGTTTTTGACTGGAGCA
GGTATTAGTGTGTCTGCTGGTATTCCAGATTTTAGAACTCCTGGATCTGGTTTATACTCC
CAACTCTAGAAATACAAGTTGCCATATCCTGAAGCAATTTTTGAAATAAATTATTTCAAA
CATCATCCATAGCCATTCTATACTCTTTGTAAAGAATTCTCAAGTTGCGGATCTCACTTT
ACTTCTAGTCACTTCTTTATAGCTGAAACTAATAGAAGAAATCGTCTTTTAATTAATTTT
TCTTAAAATATTGACGGATTAGAACTAGAAGCAGGACTTCCTGAATCAAAACTAGTTTAA
GCTCATGGTCATTTTAGAACAGCAAAGTGTGTTAACTGTAAAAAAGTTGCAGATATTGAA
TTATTCAATGAAGCAGTTAAAAATGATAAAATATGTTATTGCAAAGAATGTGAGGAAGGT
ATTGTAAAACCTGATATTGTTTTCTTTGGTGAGAGTCTTCCATAGAGTTTCTTTTAATAA
ATAGACAGCTTAAATAAGGCTGATTTGGTATTCGTCATGGGAACTTCTCTCAAAGTTTTT
CCATTTGCAGCTTTAGTTGATTTATTCAAAGAAGATGTCCCAATAGTATTGATTAATAGA
GAAAACCCTGGAATAAAAAGAAGAAGATTCCTATTTTTAGAAGGTGAAATAGATGACAAT
GTAGAAAAAATTATGAAGGATATTTCTTGGGATTTTCCTGAAATTAAAAGAACATACCCT
GAAGGAACTGTATTAGAGAAGAAATAAAACCTTTGA

>TTHERM_00526990(protein)
MSSEISKTDLSNLESNTDSMSEAQKEAQLIGFAVEPKLDCPHFEQLNVITLTEVFNDMTL
ETLNKPCKTCNHIGENWICLHCTDIFCSRYINKDMAKHVESNQEHCLVFSFSDGSFWCYK
CDNYISNKTIKDLQKTFSKVKHGGQESNEEEEEKEDDIHAIAAQLLQMHLNKKGQDGIQE
EFTYQNLIDGLRDISPDQEKNQDDKYNNRQFNRIVFLTGAGISVSAGIPDFRTPGSGLYS
QLQKYKLPYPEAIFEINYFKHHPQPFYTLCKEFSSCGSHFTSSHFFIAETNRRNRLLINF
SQNIDGLELEAGLPESKLVQAHGHFRTAKCVNCKKVADIELFNEAVKNDKICYCKECEEG
IVKPDIVFFGESLPQSFFQQIDSLNKADLVFVMGTSLKVFPFAALVDLFKEDVPIVLINR
ENPGIKRRRFLFLEGEIDDNVEKIMKDISWDFPEIKRTYPEGTVLEKKQNL

>TTHERM_00526990(gene)
ATGAGTTCTGAAATTAGTAAAACAGATTTAAGCAATTTAGAATCAAATACAGATTCTATG
AGCGAGGCTTAGAAGGAAGCTTAATTAATTGGGTTTGCTGTAGAACCTAAGCTTGACTGC
CCTCATTTTGAATAGCTTAATGTTATCACTTTGACAGAAGTCTTTAATGATATGACATTA
GAAACTTTAAATAAGCCTTGTAAGACTTGTAACCATATTGGAGAAAACTGGATTTGCTTA
CATTGTACTGACATATTTTGCTCTAGATATATAAATAAAGATATGGCTAAACACGTTGAA
AGCAATTAAGAGCACTGTCTAGTATTTTCTTTTTCTGATGGTAGTTTTTGGTGCTACAAA
TGTGATAATTACATTTCAAATAAAACTATTAAGGATCTTTAGAAAACATTTTCAAAGGTT
AAGCATGGAGGATAAGAATCAAATGAAGAAGAAGAAGAAAAAGAAGATGATATTCATGCA
ATAGCTGCTTAACTTCTTTAGATGCATCTAAACAAAAAAGGTTAAGATGGTATTTAAGAA
GAATTTACCTACTAAAATTTAATTGATGGTTTGAGAGATATTTCTCCTGATTAAGAGAAA
AATTAAGATGACAAATACAATAACAGACAGTTCAATCGAATTGTGTTTTTGACTGGAGCA
GGTATTAGTGTGTCTGCTGGTATTCCAGATTTTAGAACTCCTGGATCTGGTTTATACTCC
CAACTCTAGAAATACAAGTTGCCATATCCTGAAGCAATTTTTGAAATAAATTATTTCAAA
CATCATCCATAGCCATTCTATACTCTTTGTAAAGAATTCTCAAGTTGCGGATCTCACTTT
ACTTCTAGTCACTTCTTTATAGCTGAAACTAATAGAAGAAATCGTCTTTTAATTAATTTT
TCTTAAAATATTGACGGATTAGAACTAGAAGCAGGACTTCCTGAATCAAAACTAGTTTAA
GCTCATGGTCATTTTAGAACAGCAAAGTGTGTTAACTGTAAAAAAGTTGCAGATATTGAA
TTATTCAATGAAGCAGTTAAAAATGATAAAATATGTTATTGCAAAGAATGTGAGGAAGGT
ATTGTAAAACCTGATATTGTTTTCTTTGGTGAGAGTCTTCCATAGAGTTTCTTTTAATAA
ATAGACAGCTTAAATAAGGCTGATTTGGTATTCGTCATGGGTAATAAATACAATATTTTT
TTTTAAAGTTATAAATCTTTTAAAATTTAATATAAATAGGAACTTCTCTCAAAGTTTTTC
CATTTGCAGCTTTAGTTGATTTATTCAAAGAAGATGTCCCAATAGTATTGATTAATAGAG
AAAACCCTGGAATAAAAAGAAGAAGATTCCTATTTTTAGAAGGTGAAATAGATGACAATG
TAGAAAAAATTATGAAGGATATTTCTTGGGATTTTCCTGAAATTAAAAGAACATACCCTG
AAGGAACTGTATTAGAGAAGAAATAAAACCTTTGA