Identifiers and Description
Gene Model Identifier
TTHERM_01018450Standard Name
THD12 (Tetrahymena Histone Deacetylase 12)Aliases
PreTt27762 | 199.m00055Description
THD12 SIR2 family transcriptional regulator; Sir2-like histone deacetylase; suppresses DNA transcription by deacetylation of histones; homolog of Mus muscalus SIRT6Genome Browser (Macronucleus)
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Genome Browser (Micronucleus)
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Gene Ontology Annotations
Molecular Function
- NAD+ binding (IEA) | GO:0070403
- hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (IEA) | GO:0016811
- zinc ion binding (IEA) | GO:0008270
Biological Process
- protein deacetylation (IEA) | GO:0006476
- chromatin silencing (IEA) | GO:0006342
- regulation of transcription (IEA) | GO:0045449
Domains
- ( PF02146 ) transcriptional regulator, Sir2 family
Gene Expression Profile
Change in Gene Expression
TMHMM
TMHMM
Signal Peptide
Signal Peptide Present?: No
Presense Probability: 10.6%
TetraMine Data
TTHERM_01018450
WebApollo
Fullscreen View
Tetrahymena Stock Center
No Data fetched for StockID
Homologs (v.2006 protein sequences)
Source Identifier Score Description Tetrahymena borealis EI9_01119.1 9.997093137033517e-262 transcriptional regulator, Sir
2 family protein (387 aa)
Oxytricha Contig19063.0.g74 1.0001788721085356e-149 Sir2 family
Stentor Coeruleus SteCoe_10597 1.9503933001302485e-65 WormBase WBGene00004803 3.0010664139725277e-29 locus:sir-2.4 NAD-dependent
protein deacetylase sir-2.4
status:Confirmed UniProt:Q95
Q89 protein_id:CCD61225.1
DictyBase DDB_G0283917 5.998633383648922e-18 sir2A on chromosome: 4 positio
n 1272110 to 1273864
SGD YPL015C 0.00000000000004998767099442072 HST2 Cytoplasmic member of the
silencing information regulat
or 2 (Sir2) family of NAD(+)-d
ependent protein deacetylases;
modulates nucleolar (rDNA) an
d telomeric silencing; possess
es NAD(+)-dependent histone de
acetylase activity in vitro
General Information
No Data fetched for General Information
Associated Literature
- Ref:18178773: Smith JJ, Torigoe SE, Maxson J, Fish LC, Wiley EA (2008) A class II histone deacetylase acts on newly synthesized histones in Tetrahymena. Eukaryotic cell 7(3):471-82
- Ref:SUPR000225
- Ref:SUPR000117
Sequences
>TTHERM_01018450(coding)
ATGGATACTGCACACAAAACAGAAGATGAAAAAAAGGAATACTTCGATGCTCCTGATGTT
TTAGAATAAAAGGTTACTCTTTTAGCTGAAATGATTAAAACTTCAAAGCACTTTGTAGCT
TTCACAGGAGCAGGAATTTCTACTTCTACAGGAATTCCTGATTTTAGAAGTGGAATTAAC
ACTGTTCTTCCTACTGGACCAGGAGCTTGGGAGAAATTAGCCTAAAAAGTTGATAATAAG
CATAAAAATATCAAGACTAGCATGTTGAAAGCTATTCCTTCACCCACACATATGGCTTTG
GTTTAGTTACAAAAAATAGGTTATTTGAAATTCCTTATTAGCTAAAATGTAGACGGATTG
CACAGAAGAAGTGGTTTCTCACCCTAACACTTAGCTGAATTGCATGGCAATACAAATCTT
GAAAAATGTAAAAAATGTGGCAAAGAATACTTGAGAGATTTTAGAGTTAGAAATGCATAG
AAAGTTCATGATCACAAAACAGGTAGAAAGTGCAGCGATTAAAAATGCAAAGGAGATCTT
TATGACTCTATTATAAATTTTGGTGAAAATTTACCTGAAAAAGATTTAAATGAAGGATTT
GCTTAATCAAAAAAATCTGATTTGCATTTGGTTTTAGGAAGTAGTTTAAGAGTAACACCT
GCTGCAGACATGCCTGCCACCACTGCAGAAAAAGGTCAAAAATTAGTTATAATAAACTTG
CAAAAAACTCCTTTAGACTCAGTAGCTACTCTCAGAATAAATGCTATGTGTGATGATGTT
ATGAAAATGGTTATGAAAAAACTTGGATTAGATATACCAGAATTCACTCTTGAAAGAAGA
GTTGTCTTAGAAAAAACAGGTATGAATGCCTTAACAGTTTCAAGCTAAGACTCGGACGAT
TCCCCCTATGATTTGTTTAAATAAATTAAAGTAGATTACGGCAAAATACATCCTGAATAA
ACTTTACTTAAGGCTCCATTCAATATCATACCAAAAAATAAAACATTCTCTCTAAATTTA
AGCTTTTATGGACACTATGGCGAGCAAGATTTTAACTTAAATATCGATATGGCTGCTCTC
TCCATTAATAAAAAAGTGAAATATTTAATACAATATTCACCAAAAGAATAAAAATGGATT
AGTTGCAAAGAAATATGA>TTHERM_01018450(protein)
MDTAHKTEDEKKEYFDAPDVLEQKVTLLAEMIKTSKHFVAFTGAGISTSTGIPDFRSGIN
TVLPTGPGAWEKLAQKVDNKHKNIKTSMLKAIPSPTHMALVQLQKIGYLKFLISQNVDGL
HRRSGFSPQHLAELHGNTNLEKCKKCGKEYLRDFRVRNAQKVHDHKTGRKCSDQKCKGDL
YDSIINFGENLPEKDLNEGFAQSKKSDLHLVLGSSLRVTPAADMPATTAEKGQKLVIINL
QKTPLDSVATLRINAMCDDVMKMVMKKLGLDIPEFTLERRVVLEKTGMNALTVSSQDSDD
SPYDLFKQIKVDYGKIHPEQTLLKAPFNIIPKNKTFSLNLSFYGHYGEQDFNLNIDMAAL
SINKKVKYLIQYSPKEQKWISCKEI>TTHERM_01018450(gene)
ATGGATACTGCACACAAAACAGAAGATGAAAAAAAGGAATACTTCGATGCTCCTGATGTT
TTAGAATAAAAGGTTACTCTTTTAGCTGAAATGATTAAAACTTCAAAGCACTTTGTAGCT
TTCACAGGAGCAGGAATTTCTACTTCTACAGGAATTCCTGATTTTAGAAGTGGAATTAAC
ACTGTTCTTCCTACTGGACCAGGAGCTTGGGAGAAATTAGCCTAAAAAGTTGATAATAAG
CATAAAAATATCAAGACTAGCATGTTGAAAGCTATTCCTTCACCCACACATATGGCTTTG
GTTTAGTTACAAAAAATAGGTTATTTGAAATTCCTTATTAGCTAAAATGTAGACGGATTG
CACAGAAGAAGTGGTTTCTCACCCTAACACTTAGCTGAATTGCATGGCAATACAAATCTT
GAAAAATGTAAAAAATGTGGCAAAGAATACTTGAGAGATTTTAGAGTTAGAAATGCATAG
AAAGTTCATGATCACAAAACAGGTAGAAAGTGCAGCGATTAAAAATGCAAAGGAGATCTT
TATGACTCTATTATAAATTTTGGTGAAAATTTACCTGAAAAAGATTTAAATGAAGGATTT
GCTTAATCAAAAAAATCTGATTTGCATTTGGTTTTAGGAAGTAGTTTAAGAGTAACACCT
GCTGCAGACATGCCTGCCACCACTGCAGAAAAAGGTCAAAAATTAGTTATAATAAACTTG
CAAAAAACTCCTTTAGACTCAGTAGCTACTCTCAGAATAAATGCTATGTGTGATGATGTT
ATGAAAATGGTTATGAAAAAACTTGGATTAGATATACCAGAATTCACTCTTGAAAGAAGA
GTTGTCTTAGAAAAAACAGGTATGAATGCCTTAACAGTTTCAAGCTAAGACTCGGACGAT
TCCCCCTATGATTTGTTTAAATAAATTAAAGTAGATTACGGCAAAATACATCCTGAATAA
ACTTTACTTAAGGCTCCATTCAATATCATACCAAAAAATAAAACATTCTCTCTAAATTTA
AGCTTTTATGGACACTATGGCGAGCAAGATTTTAACTTAAATATCGATATGGCTGCTCTC
TCCATTAATAAAAAAGTGAAATATTTAATACAATATTCACCAAAAGAATAAAAATGGATT
AGTTGCAAAGAAATATGA