Identifiers and Description

Gene Model Identifier

TTHERM_00313730

Standard Name

THD11 (Tetrahymena Histone Deacetylase 11)

Aliases

PreTt03560 | 30.m00369 | 3810.m01981

Description

Sir2-like histone deacetylase; suppresses DNA transcription by deacetylation of histones

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• NAD+ binding (IEA) | GO:0070403
• hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (IEA) | GO:0016811
• zinc ion binding (IEA) | GO:0008270

Biological Process

• chromatin silencing (IEA) | GO:0006342
• regulation of transcription (IEA) | GO:0045449
• protein deacetylation (IEA) | GO:0006476

Domains

No Data fetched for Domains

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.2%

TetraMine Data

TTHERM_00313730

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_03386.1	9.997093137033517e-262	transcriptional regulator, Sir 2 family protein (387 aa)
Oxytricha	Contig19063.0.g74	2.9990837046884738e-127	Sir2 family
Stentor Coeruleus	SteCoe_10597	1.1677812485237086e-60
WormBase	WBGene00004803	1.0000422327488734e-24	locus:sir-2.4 NAD-dependent protein deacetylase sir-2.4 status:Confirmed UniProt:Q95 Q89 protein_id:CCD61225.1
DictyBase	DDB_G0283917	4.0009493637353324e-18	sir2A on chromosome: 4 positio n 1272110 to 1273864
SGD	YPL015C	0.000000000000006000101554955223	HST2 Cytoplasmic member of the silencing information regulat or 2 (Sir2) family of NAD(+)-d ependent protein deacetylases; modulates nucleolar (rDNA) an d telomeric silencing; possess es NAD(+)-dependent histone de acetylase activity in vitro

General Information

No Data fetched for General Information

Associated Literature

1. Ref:18178773: Smith JJ, Torigoe SE, Maxson J, Fish LC, Wiley EA (2008) A class II histone deacetylase acts on newly synthesized histones in Tetrahymena. Eukaryotic cell 7(3):471-82
2. Ref:SUPR000191
3. Ref:SUPR000128

Sequences

>TTHERM_00313730(coding)
ATGGATACTGCTCATAAAACAGTAAACGAAAAGAAAGAATACTTTGATTCTCCGGAATTA
TTAGAAGCAAAAGTCACTTAGTTGGCAGATATGATTAAATAGTCAAATCACTTTGTTTGC
TTTACAGGTGCTGGAATATCTACTTCAGCAGGTATAGCTGATTTTAGAAGTGGAGTTAAC
ACAGTCTTGAAAACTGGACCTGGTTTGTGGGAAAAGATGGCTTAAAAAGTAGGAAATCAA
CCTAAAAAACACAAAGTTATAATGTCTAGAGCTGTTCCAACTAAAAGCCATATGGCACTA
GTTAAGTTGAATCAAGAAGGAATTCTTAAGTATTTAATCAGTTAAAATATAGACGGCTTA
CATAGAAGAAGTGGATTCAACCCTAATAGCCTATCTGAACTACATGGAAACACTAATTTA
GAGAAATGTTTAAAATGTGGAAAGTCTTATATGAGAGATTATAGAGTGAGAAAAGCTTTA
GATGTTCATGACCACTTAACAGGAAGGATTTGCGACAATTAGAAATGTGGTGGCGAATTA
GTAGATACAATTGTTAATTTTGGAGAGAATTTACCCAAAAAAGATATGGAATAAGGTTTT
TTTAACTCAAAATAAGCAGATTTACACTTAGTTTTAGGAAGTAGTTTAAGAGTTACTCCA
GCAGCTGATATGCCTCTAGCAACTGCTTAAAATGGAAATAAATTAGTTGTGGTTAATTTA
CAAAAAACCCCTCTAGATAGCTTGTGTGCCTTAAGAATATATGCTTTGATTGATGATGTC
ATGGTTCTACTTATGAAAAAGCTAGGTTTAGAGATACCAGAATTTATTCTGCAGAGAACT
ATTGTGATTAAAAAGACAAACTAAAATACAATAAACGTTTTTAGTGAAGACAAAGATGGT
TGTCCATATGACATTTTTAAGTAAATTGTTTTGGATTAAGGCAAAAAGTAACCATTTGAG
ATTTAGGTTAAAGCACCTTACATATTCAATATCACAAATCCATAATTTGCCATAAAGCTA
GGATTTTTTGAACATTATAAAGAAGGACCATTCAGATTAGATTTAAATTTATAAAATCTA
CCTCTTGGATAAAAGACTAAGTATTTAATATAATTCTCACCAAAATTACAAAAGTGGATT
AGTTGTGAAAAAATATAATGA

>TTHERM_00313730(protein)
MDTAHKTVNEKKEYFDSPELLEAKVTQLADMIKQSNHFVCFTGAGISTSAGIADFRSGVN
TVLKTGPGLWEKMAQKVGNQPKKHKVIMSRAVPTKSHMALVKLNQEGILKYLISQNIDGL
HRRSGFNPNSLSELHGNTNLEKCLKCGKSYMRDYRVRKALDVHDHLTGRICDNQKCGGEL
VDTIVNFGENLPKKDMEQGFFNSKQADLHLVLGSSLRVTPAADMPLATAQNGNKLVVVNL
QKTPLDSLCALRIYALIDDVMVLLMKKLGLEIPEFILQRTIVIKKTNQNTINVFSEDKDG
CPYDIFKQIVLDQGKKQPFEIQVKAPYIFNITNPQFAIKLGFFEHYKEGPFRLDLNLQNL
PLGQKTKYLIQFSPKLQKWISCEKIQ

>TTHERM_00313730(gene)
ATGGATACTGCTCATAAAACAGTAAACGAAAAGAAAGAATACTTTGATTCTCCGGAATTA
TTAGAAGCAAAAGTCACTTAGTTGGCAGATATGATTAAATAGTCAAATCACTTTGTTTGC
TTTACAGGTGCTGGAATATCTACTTCAGCAGGTATAGCTGATTTTAGAAGTGGAGTTAAC
ACAGTCTTGAAAACTGGACCTGGTTTGTGGGAAAAGATGGCTTAAAAAGTAGGAAATCAA
CCTAAAAAACACAAAGTTATAATGTCTAGAGCTGTTCCAACTAAAAGCCATATGGCACTA
GTTAAGTTGAATCAAGAAGGAATTCTTAAGTATTTAATCAGTTAAAATATAGACGGCTTA
CATAGAAGAAGTGGATTCAACCCTAATAGCCTATCTGAACTACATGGAAACACTAATTTA
GAGAAATGTTTAAAATGTGGAAAGTCTTATATGAGAGATTATAGAGTGAGAAAAGCTTTA
GATGTTCATGACCACTTAACAGGAAGGATTTGCGACAATTAGAAATGTGGTGGCGAATTA
GTAGATACAATTGTTAATTTTGGAGAGAATTTACCCAAAAAAGATATGGAATAAGGTTTT
TTTAACTCAAAATAAGCAGATTTACACTTAGTTTTAGGAAGTAGTTTAAGAGTTACTCCA
GCAGCTGATATGCCTCTAGCAACTGCTTAAAATGGAAATAAATTAGTTGTGGTTAATTTA
CAAAAAACCCCTCTAGATAGCTTGTGTGCCTTAAGAATATATGCTTTGATTGATGATGTC
ATGGTTCTACTTATGAAAAAGCTAGGTTTAGAGATACCAGAATTTATTCTGCAGAGAACT
ATTGTGATTAAAAAGACAAACTAAAATACAATAAACGTTTTTAGTGAAGACAAAGATGGT
TGTCCATATGACATTTTTAAGTAAATTGTTTTGGATTAAGGCAAAAAGTAACCATTTGAG
ATTTAGGTTAAAGCACCTTACATATTCAATATCACAAATCCATAATTTGCCATAAAGCTA
GGATTTTTTGAACATTATAAAGAAGGACCATTCAGATTAGATTTAAATTTATAAAATCTA
CCTCTTGGATAAAAGACTAAGTATTTAATATAATTCTCACCAAAATTACAAAAGTGGATT
AGTTGTGAAAAAATATAATGA