Identifiers and Description

Gene Model Identifier

TTHERM_00859330

Standard Name

THD10 (Tetrahymena Histone Deacetylase 10)

Aliases

PreTt09095 | 152.m00115

Description

Sir2-like histone deacetylase; homolog of Danio rerio SIRT5

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• NAD+ binding (IEA) | GO:0070403
• hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (IEA) | GO:0016811
• zinc ion binding (IEA) | GO:0008270

Biological Process

• chromatin silencing (IEA) | GO:0006342
• regulation of transcription (IEA) | GO:0045449
• protein deacetylation (IEA) | GO:0006476

Domains

• ( PF02146 ) transcriptional regulator, Sir2 family

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 23.4%

TetraMine Data

TTHERM_00859330

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_07219.1	8.997766383757294e-176	transcriptional regulator, Sir 2 family protein (285 aa)
Oxytricha	Contig5479.0.g78	1.0004460510701209e-64	Sir2 family
Stentor Coeruleus	SteCoe_21869	3.975449735908647e-31
DictyBase	DDB_G0283917	0.000000000006001570085597868	sir2A on chromosome: 4 positio n 1272110 to 1273864
WormBase	WBGene00004800	0.00000000009001903211590313	locus:sir-2.1 status:Partial ly_confirmed UniProt:D3YT50 protein_id:CBK19468.1
SGD	YPL015C	0.000000019990673443141236	HST2 Cytoplasmic member of the silencing information regulat or 2 (Sir2) family of NAD(+)-d ependent protein deacetylases; modulates nucleolar (rDNA) an d telomeric silencing; possess es NAD(+)-dependent histone de acetylase activity in vitro

General Information

No Data fetched for General Information

Associated Literature

1. Ref:18178773: Smith JJ, Torigoe SE, Maxson J, Fish LC, Wiley EA (2008) A class II histone deacetylase acts on newly synthesized histones in Tetrahymena. Eukaryotic cell 7(3):471-82
2. Ref:SUPR000182

Sequences

>TTHERM_00859330(coding)
ATGCAAACCAATTTACATCAACTAATTGCTAAAAGAATTCAAAGCGCAAGCTGTCTTATT
ATCACAGCAGGAGCAGGAATGGGTGTAGATTCAGGACTTCCAGATTTTAGGGGGAAAGAA
GGATTTTGGAACAATTACATTCCTTTTAGGAATAAATTCTCTTTCACTGAGTGTGCTAAT
CCATAATTTTTATTAGATCATCCAAATTTATTTTGGGGGTTTTATGGACACAGACTCCAT
TTATATAGAGAAACACAACCTCACAAAGGTTTTGGAATGTTAAAAACTTGGAGTTAAAAT
AAAAAAAGTTTTGTACTCACCTCAAATGTTGATGGACATTTCTAAAAAGCAGGATTTGAT
AATAAGAGTGTTTATGAAGTTCATGGCTCAATTAATTTTATGCAATGCACAAGCTGTTAA
AGAATTTATTCAGCAGATGGATACAATATTATTTATGATATGAATACATTTGAGGCTAAA
GATCCACTTCCTAATTGTAAGAATTGTGTAAATGTTATAGTACGTCCTAATATTTTGATG
TTTGGGGATTACTCTTTTATGTCAGATAGAGTTGAAGAATAAGAAGATAGGTATCTGTAG
TTTAAAAATCAATTAACTACATAAGATAGAATTATTGTTTTAGAATTTGGAGCAGGGGAA
GCTGTTGCAACTATAAGGATGATGGGCGAAGAATTATTCTTAAAATACAAGCATATAACA
TTCATAAGAGTTAATCCAAGAGATGATAATTCTCCTTTTGGTTGGAAGTAATAGTAAAAT
ACAGAAGATAAAGCTTTTTATGCATTAAAATAAGGGGCTCTTGAAGCAATAACATAAATC
TAATAATATATGTTGTGA

>TTHERM_00859330(protein)
MQTNLHQLIAKRIQSASCLIITAGAGMGVDSGLPDFRGKEGFWNNYIPFRNKFSFTECAN
PQFLLDHPNLFWGFYGHRLHLYRETQPHKGFGMLKTWSQNKKSFVLTSNVDGHFQKAGFD
NKSVYEVHGSINFMQCTSCQRIYSADGYNIIYDMNTFEAKDPLPNCKNCVNVIVRPNILM
FGDYSFMSDRVEEQEDRYLQFKNQLTTQDRIIVLEFGAGEAVATIRMMGEELFLKYKHIT
FIRVNPRDDNSPFGWKQQQNTEDKAFYALKQGALEAITQIQQYML

>TTHERM_00859330(gene)
ATGCAAACCAATTTACATCAACTAATTGCTAAAAGAATTCAAAGCGCAAGCTGTCTTATT
ATCACAGCAGGAGCAGGAATGGGTGTAGATTCAGGACTTCCAGATTTTAGGGGGAAAGAA
GGTATTAGAATATAATCTCCACAAAATGCATAATATTTTTAGTTACATTTTTTTTTAATT
TTAGGATTTTGGAACAATTACATTCCTTTTAGGAATAAATTCTCTTTCACTGAGTGTGCT
AATCCATAATTTTTATTAGAGTATTTTTATTAGTTAAATGATATATCTACATTTTTATTT
ATTTTGGTATAAACTAGTCATCCAAGTAATCAAATATTAACTAGCATACAATATTTGACT
TTTTCATCATTAAATTGAAGATTTATTTTGGGGGTTTTATGGACACAGACTCCATTTATA
TAGAGAAACACAACCTCACAAAGGTTTTGGAATGTTAAAAACTTGGAGTTAAAATAAAAA
AAGTTTTGTACTCACCTCAAATGTTGATGGACATTTCTAAAAAGCAGGTAAATTTATTAT
TTTATATTACATTATTGAGTTTTTAAGCTATTTTATATGTAAATTTGTTTAAAATAATGA
ATTTTAGGATTTGATAATAAGAGTGTTTATGAAGTTCATGGCTCAATTAATTTTATGCAA
TGCACAAGCTGTTAAAGAATTTATTCAGCAGATGGTAAATATCATTAAAATCTATCTATC
TATAAACCGTAACTGCTTCGATATATCTGAGCCAAGGACACCATTTTTTATTTGACCATT
TCTTTCATTAACAACCTCCCTCCCTCTCGGCTTTAATTTTAAGATGAATTGGAGGAGCAG
AGTTTTTAAGGTATGAATTTTATATCTCTATTTATATCTAAAGGATACAATATTATTTAT
GATATGAATACATTTGAGGCTAAAGATCCACTTCCTAATTGTAAGAATTGTGTAAATGTT
ATAGTACGTCCTAATATTTTGATGTTTGGGGATTACTCTTTTATGTCAGATAGAGTTGAA
GAATAAGAAGATAGGTATCTGTAGTTTAAAAATCAATTAACTACATAGTAATAATTGAAT
AAATTAATATTAAATATTAACTTATGTTTTATTTTTTATTTAAAGAGATAGAATTATTGT
TTTAGAATTTGGAGCAGGGGAAGCTGTTGCAACTATAAGGATGATGGGCGAAGAATTATT
CTTAAAATACAAGTAAAAATAAATAAAACTCAAATTGATATATTTATCTTTTTTAAAATT
TAGGCATATAACATTCATAAGAGTTAATCCAAGAGATGATAATTCTCCTTTTGGTTGGAA
GTAATAGTAAAATACAGAAGATAAAGCTTTTTATGCATTAAAATAAGGGGCTCTTGAAGC
AATAACATAAATCTAATAATATATGTTGTGA