Identifiers and Description

Gene Model Identifier

TTHERM_00151600

Standard Name

TGS1 (Trimethyl Guanosine Synthase 1)

Aliases

PreTt20818 | 12.m00492 | 3700.m00212

Description

Trimethyl Guanosine Synthase. Responsible enzyme for hypermethylation of guanosine 5' caps.

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Molecular Function

• methyltransferase activity (IEA) | GO:0008168

Biological Process

• 7-methylguanosine RNA capping (IEA) | GO:0009452
• RNA methylation (IEA) | GO:0001510

Domains

• ( PF08241 ) methyltransferase domain
• ( PF08242 ) methyltransferase domain
• ( TIGR02072 ) biotin biosynthesis protein BioC
• ( TIGR00675 ) DNA (cytosine-5-)-methyltransferase

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.8%

TetraMine Data

TTHERM_00151600

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_05114.1	9.997093137033517e-262	hypothetical protein (720 aa)
DictyBase	DDB_G0288547	0.00000000000007997998332353294	DDB_G0288547 on chromosome: 5 position 1676407 to 1677541
Oxytricha	Contig19029.0.g57	0.000000000800327577657144	RNA cap guanine-N2 methyltrans ferase
SGD	YPL157W	0.000000100009565553302	TGS1 Trimethyl guanosine synth ase, conserved nucleolar methy l transferase that converts th e m(7)G cap structure of snRNA s, snoRNAs, and telomerase TLC 1 RNA to m(2,2,7)G; also requi red for nucleolar assembly and splicing of meiotic pre-mRNAs
WormBase	WBGene00011631	0.0000009995106777214876	status:Confirmed UniProt:A8W HU4 protein_id:CAP19342.1

General Information

No Data fetched for General Information

Associated Literature

1. Ref:SUPR000061

Sequences

>TTHERM_00151600(coding)
ATGTTTAATTGCTGTTTAAAGAATAATTAAAAGCATGACGATGATGATAACGGCAATAAA
AAAAAGGATAAAAGGCTAAAAAGTTAAATAAATATGAAGACAATCAACACTAATGATGAA
TCTATCTCTTAATTATAAGATACAAAACATTATACAAATAATTTAACAGTAACAAAGACA
GATATTTAGAATAATATGAATGCTAATACAGGAATACATAATTAATAAGGGTATATATCT
GAAAAAAGTATACTCTCTCATTTGAATAGTGAGAAGAAAAACCATAGAGACACAGTAGAA
ACACATAATAACAATAACAACAATTATAATAGCTTTTTTACTTCTGGTATGAATACTCCT
AATTATGACTATAATTTCAAAGGTTAAGATATCAATTAATCTGATAAAAAAGGCAATTAG
TAAGTAGCAACTGAGAAGGATAAAACAATTGCTTGTTCTTTAGATGCGAGTAATTTAGAG
CATTTTTAAAAAATTTTTGAAAAGAAGTAGGTAAAAGATTAGTAATTCGTGTAGCAAATA
GACCAGTAAGTAAAGCAAAGGTTTCTTTTGAATAAATTCTTTTTTTTGAGAGACTAAGGA
AATAAGTATGTTACTCTTGCTTATTGCAGTTATTAAGCTTTTTATGTTAATGGCGGGACA
TTTAATTATTCATTAGCGTCAAATAAGAGTACATAAAGTATCTTAAATAACACTAGTTTA
TTATTCAAAGCAGCTCCTAATTAGAATTTAAATGTTTCAAAGCAAATAAATACAAGCTAA
GATAGTATAAATTCTTAAAACAATTCTACTATCTTTACTACTAGTAAAGTACAAAATAAC
AATGTTGATTTTTTAAACTACTAAAGTCTATATGCAAAATTTAAAGTAGATATGGATTAG
ACTGAAAATTTCACACCTTAAAAAATAGCATTTCATATTGCCTAAAAATTTAAAAAATAC
CCTATCTTAATAGACGCCTGCTGTGGTATTGGAGGAAATACTGTGCAATTTTCCAAAATC
AATAAATTTGTTTTTGCTGTTGACTAGAGCTATAGAGCTATTAAAACATGCAATGAAAAC
ATAAAAAACCACAAATAAGATGTCTCAAATGTAGAATTCATTTAAGCAGATTTTTTATCA
TTAGAGTGTGGCGAGCTAGGCTAATTAAGAGCTGATATTGTATTCATAAATCCACAGATA
GATATGATTTCTGAAACAACAAAACCTGATATCTTTAAGCATTCTTCTCCTAATCTCTTA
AAAGCAATGAAAAATGCATACAGAATGTCAAAAAACATAGCTATTCTACTACCCTATTAC
ATAGATATAAACCAAATTCCTATATTATTGGATAAGTTTTATAGAATCTACAGAAATTTT
CCTTTAGACATGATTTAACATCACTGCCCTCACATAGAGATTATTTATATGAATGGAAAA
ATTAAGTATTTCTTGATTTTATTAGGTGACGCATCTAAGATATCTTAAGAAGATGAAATT
AAATTTCTCCAAGAGTACATATTAGATAATAGTCCATATAAAGGACCTTATGAAGAAAAA
GTGTTAGAGTTGTTAAATACTATATTAAGGAAAGTAGGTATGTTTAAATTAATTAGATGT
TTAGCTAAATCAATTGATATCAATGATCTTTAGAAGTAAAAAAATTTACTAAATTCTTTT
AGTGATGAATTAGAAAAAGAGGGCATTATCCATCAAAAAGAAATCAAAAATATGTTAAAT
TTAACAAACAATATTTCAAATGTTTGTGAAAGTGCTTCTGACTTAGTAGGGTCTCCAAAC
TAATTTCCAAACAGTTTCACATCTTAATAAAGCTTTTAGTTAAATGTTTAATAAGGTTCT
CTTGTATAATCTTAGGAATTAAATTAATAGTTACCAAAAGCTACTAGCTCAAAGTAAATA
TCATTTGATAAGGATTCATAAAGCAACTCATTTTATGGAGGAGGAGTAGAAAGCAGTCTC
GGAGATTTGTTAGAAAAAAAAGATAGCTTAAGTGAAAATGATATTTCTGATAATTACTCC
AATAATGAAAGTGATTTCTATTTCGATGAATATAATAACATTCCAATAGATGGAAATAAA
ATTAATTTAAATGTAAATAATCAAATAAAGTCAATTTGA

>TTHERM_00151600(protein)
MFNCCLKNNQKHDDDDNGNKKKDKRLKSQINMKTINTNDESISQLQDTKHYTNNLTVTKT
DIQNNMNANTGIHNQQGYISEKSILSHLNSEKKNHRDTVETHNNNNNNYNSFFTSGMNTP
NYDYNFKGQDINQSDKKGNQQVATEKDKTIACSLDASNLEHFQKIFEKKQVKDQQFVQQI
DQQVKQRFLLNKFFFLRDQGNKYVTLAYCSYQAFYVNGGTFNYSLASNKSTQSILNNTSL
LFKAAPNQNLNVSKQINTSQDSINSQNNSTIFTTSKVQNNNVDFLNYQSLYAKFKVDMDQ
TENFTPQKIAFHIAQKFKKYPILIDACCGIGGNTVQFSKINKFVFAVDQSYRAIKTCNEN
IKNHKQDVSNVEFIQADFLSLECGELGQLRADIVFINPQIDMISETTKPDIFKHSSPNLL
KAMKNAYRMSKNIAILLPYYIDINQIPILLDKFYRIYRNFPLDMIQHHCPHIEIIYMNGK
IKYFLILLGDASKISQEDEIKFLQEYILDNSPYKGPYEEKVLELLNTILRKVGMFKLIRC
LAKSIDINDLQKQKNLLNSFSDELEKEGIIHQKEIKNMLNLTNNISNVCESASDLVGSPN
QFPNSFTSQQSFQLNVQQGSLVQSQELNQQLPKATSSKQISFDKDSQSNSFYGGGVESSL
GDLLEKKDSLSENDISDNYSNNESDFYFDEYNNIPIDGNKINLNVNNQIKSI

>TTHERM_00151600(gene)
ATGTTTAATTGCTGTTTAAAGAATAATTAAAAGCATGACGATGATGATAACGGCAATAAA
AAAAAGGATAAAAGGCTAAAAAGTTAAATAAATATGAAGACAATCAACACTAATGATGAA
TCTATCTCTTAATTATAAGATACAAAACATTATACAAATAATTTAACAGTAACAAAGACA
GATATTTAGAATAATATGAATGCTAATACAGGAATACATAATTAATAAGGGTATATATCT
GAAAAAAGTATACTCTCTCATTTGAATAGTGAGAAGAAAAACCATAGAGACACAGTAGAA
ACACATAATAACAATAACAACAATTATAATAGCTTTTTTACTTCTGGTATGAATACTCCT
AATTATGACTATAATTTCAAAGGTTAAGATATCAATTAATCTGATAAAAAAGGCAATTAG
TAAGTAGCAACTGAGAAGGATAAAACAATTGCTTGTTCTTTAGATGCGAGTAATTTAGAG
CATTTTTAAAAAATTTTTGAAAAGAAGTAGGTAAAAGATTAGTAATTCGTGTAGCAAATA
GACCAGTAAGTAAAGCAAAGGTTTCTTTTGAATAAATTCTTTTTTTTGAGAGACTAAGGA
AATAAGTATGTTACTCTTGCTTATTGCAGTTATTAAGCTTTTTATGTTAATGGCGGGACA
TTTAATTATTCATTAGCGTCAAATAAGAGTACATAAAGTATCTTAAATAACACTAGTTTA
TTATTCAAAGCAGCTCCTAATTAGAATTTAAATGTTTCAAAGCAAATAAATACAAGCTAA
GATAGTATAAATTCTTAAAACAATTCTACTATCTTTACTACTAGTAAAGTACAAAATAAC
AATGTTGATTTTTTAAACTACTAAAGTCTATATGCAAAATTTAAAGTAGATATGGATTAG
ACTGAAAATTTCACACCTTAAAAAATAGCATTTCATATTGCCTAAAAATTTAAAAAATAC
CCTATCTTAATAGACGCCTGCTGTGGTATTGGAGGAAATACTGTGCAAGTAATACTTAAA
TATAACAATCAAAAATTTACAATTTATTTTTCAATAACATTTTAATAATTTTACAATTTT
TTATTTAATAAAAATAGTTTTCCAAAATCAATAAATTTGTTTTTGCTGTTGACTAGAGCT
ATAGAGCTATTAAAACATGCAATGAAAACATAAAAAACCACAAATAAGATGTCTCAAATG
TAGAATTCATTTAAGCAGATTTTTTATCATTAGAGTGTGGCGAGCTAGGCTAATTAAGAG
CTGATATTGTATTCATAAATCCACAGATAGATATGATTTCTGAAACAACAAAACCTGATA
TCTTTAAGCATTCTTCTCCTAATCTCTTAAAAGCAATGAAAAATGCATACAGAATGTCAA
AAAACATAGCTATTCTACTACCCTATTACATAGATATAAACCAAATTCCTATATTATTGG
ATAAGTTTTATAGAATCTACAGAAATTTTCCTTTGTAAATTTAAGAATTTTAATTTTCCA
AAATACTTATTTATTTGAATTAAAAAAATAATATTTTTGTAGAGACATGATTTAACATCA
CTGCCCTCACATAGAGATTATTTATATGAATGGAAAAATTAAGTATTTCTTGATTTTATT
AGGTGACGCATCTAAGGTTATTTAATTTATATTTTTAATTTATATGAATTTGTTAAATTA
ATTTTTAAAAAATAGATATCTTAAGAAGATGAAATTAAATTTCTCCAAGAGTACATATTA
GATAATAGTCCATATAAAGGACCTTATGAAGAAAAAGTGTTAGAGTTGTTAAATACTATA
TTAAGGAAAGTAGGTATGTTTAAATTAATTAGATGTTTAGCTAAATCAATTGATATCAAT
GATCTTTAGAAGTAAAAAAATTTACTAAATTCTTTTAGTGATGAATTAGAAAAAGAGGGC
ATTATCCATCAAAAAGAAATCAAAAATATGTTAAATTTAACAAACAATATTTCAAATGTT
TGTGAAAGTGCTTCTGACTTAGTAGGGTCTCCAAACTAATTTCCAAACAGTTTCACATCT
TAATAAAGCTTTTAGTTAAATGTTTAATAAGGTTCTCTTGTATAATCTTAGGAATTAAAT
TAATAGTTACCAAAAGCTACTAGCTCAAAGTAAATATCATTTGATAAGGATTCATAAAGC
AACTCATTTTATGGAGGAGGAGTAGAAAGCAGTCTCGGAGATTTGTTAGAAAAAAAAGAT
AGCTTAAGTGAAAATGATATTTCTGATAATTACTCCAATAATGAAAGTGATTTCTATTTC
GATGAATATAATAACATTCCAATAGATGGAAATAAAATTAATTTAAATGTAAATAATCAA
ATAAAGTCAATTTGA