Identifiers and Description

Gene Model Identifier

TTHERM_00043870

Standard Name

TGP2 (Tetrahymena G-DNA binding Protein )

Aliases

PreTt11064 | 3.m01838 | 3824.m02827

Description

G-quartet DNA binding protein; has dihydrolipoamide dehydrogenase (DLDH) activity; preferentially binds G4-DNA oligonucleotides with adjacent single-stranded domains

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• cytoplasm (IEA) | GO:0005737

Molecular Function

• oxidoreductase activity (IEA) | GO:0016491
• flavin adenine dinucleotide binding (IEA) | GO:0050660

Biological Process

• tRNA processing (IEA) | GO:0008033
• oxidation-reduction process (IEA) | GO:0055114
• cell redox homeostasis (IEA) | GO:0045454

Domains

No Data fetched for Domains

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 15.6%

TetraMine Data

TTHERM_00043870

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Stentor Coeruleus	SteCoe_5695	0
WormBase	WBGene00010794	9.997093137033517e-262	locus:dld-1 Dihydrolipoyl de hydrogenase, mitochondrial s tatus:Confirmed UniProt:O179 53 protein_id:CAB05249.2
Tetrahymena borealis	EI9_01865.1	9.997093137033517e-262	dihydrolipoamide dehydrogenase (489 aa)
Oxytricha	Contig16905.0.g78	9.997093137033517e-262	Pyridine nucleotide-disulphide oxidoreductase
DictyBase	DDB_G0291648	4.000089512234839e-180	lpd on chromosome: 6 position 70728 to 72507
SGD	YFL018C	1.0001465636795248e-178	LPD1 Dihydrolipoamide dehydrog enase, the lipoamide dehydroge nase component (E3) of the pyr uvate dehydrogenase and 2-oxog lutarate dehydrogenase multi-e nzyme complexes

General Information

No Data fetched for General Information

Associated Literature

1. Ref:9521745: Kee K, Niu L, Henderson E (1998) A Tetrahymena thermophila G4-DNA binding protein with dihydrolipoamide dehydrogenase activity. Biochemistry 37(12):4224-34

Sequences

>TTHERM_00043870(coding)
ATGTTCAAAACTTTTGTTCCTACTAGAAATCTTACCCATAGTCTTAGATAATTGTTCTCC
ACTAGCACTCAATATGATGTCGTCGTTATTGGTGGTGGTCCTGGTGGTTACGTAGCTGCC
ATTAAGGCTGGTTAATTAGGCTTAAAGACCGCTTGTGTTGAAAAGAGAGGTTCTTTGGGT
GGTACCTGCTTAAATGTTGGTTGCATTCCTTCAAAGGCTCTCTTAAACATCTCTTAAAAA
TATTATGATGCTTCCAAGCACTACAAAGAACTTGGTATCGAAGTTGAAGGTGTTAAAATG
AATTGGGCTCAAGCTTAAACAAAGAAGGCTGAAACAGTTACTGGTTTGACCAGAGGTATC
GAAAGTCTCTTCAAGAAGAATAAGGTTGACTACTTTGTTGGTACTGGTAGACTAAATGAC
AAGAACACTATTGGTATTAATCTTAACAATGGTACTTAGTAGGTTATTAACTCCAAGAAC
ATTATTATTGCTACTGGATCTGAACCTACTCCTTTCCCTGGTCTCAACTTCGACGAAAAG
GTTATCATCTCTTCAACTGGTGCTCTCTCTTTACCCTAGATCCCTAAGAAATTAATCGTT
ATTGGTGCTGGTGTTATTGGTTTAGAAATGGGTTCTGTTTACCAAAGATTAGGTACTCAA
GTTACTGTCATTGAATTTGCTGATTAAATTTGCCCTTTCCTTGATACTGATGTTGCTAAG
GCTTTCCAATAGAGCTTAAAGAAATAAGGTTTACAAATTTTGACTGGCCATAAGGTTGTT
TCTGGTTAAAACTTCGGTACTCACGGTAGCGTAGTTGTTGAACCTGTTAAGGGAGGTCCA
TCTTAGACCTTTGAAGCTGATCATATTTTAGTTTCTACAGGTCGTAGACCTTATGTTGAT
GGCTTAAATGCTAAGGAAATCGGTATTGAGTTTGACAACAAAAATAGAATCATCACTAAC
TCCCACTTACAAACCAACATTCCCAATATTTATGCCATAGGTGATGTCATTCCTGGACCT
ATGTTGGCTCACAAGGGTGAAGAAGAAGGTATTGCTGCTGTTGAATATATTGCTGGAAAG
GGTGGTCATGTTAATTACGATGCTATTCCTAGTGTTATCTATACCCATCCTGAAGTTGCT
TGGGTCGGAAAGACTGAATAAGAACTTAAGGCTGCCAATATTAAGTACAACAAGGGTTCT
TTCCCCATGCTTGCTAACTCTAGAGCTAAAGCTAACAACGACTACGATGGTTTAATTAAG
ATCTTAACTGAAAAGGATACTGATAAACTCTTGGGTGTCCATATTATGAATGCATAAGCT
GGTGAATTAATCGGTGAAGCTACTTTAGCCGTCGAATATGGTGCTGCTGCTGAAGATATA
GGTAGAACTTGCCACGCTCATCCTACTATTTCTGAAGCTCTTAAAGAAGCTTGCATGGCT
GCTTATGACAAGCCCATCCACTTCTGA

>TTHERM_00043870(protein)
MFKTFVPTRNLTHSLRQLFSTSTQYDVVVIGGGPGGYVAAIKAGQLGLKTACVEKRGSLG
GTCLNVGCIPSKALLNISQKYYDASKHYKELGIEVEGVKMNWAQAQTKKAETVTGLTRGI
ESLFKKNKVDYFVGTGRLNDKNTIGINLNNGTQQVINSKNIIIATGSEPTPFPGLNFDEK
VIISSTGALSLPQIPKKLIVIGAGVIGLEMGSVYQRLGTQVTVIEFADQICPFLDTDVAK
AFQQSLKKQGLQILTGHKVVSGQNFGTHGSVVVEPVKGGPSQTFEADHILVSTGRRPYVD
GLNAKEIGIEFDNKNRIITNSHLQTNIPNIYAIGDVIPGPMLAHKGEEEGIAAVEYIAGK
GGHVNYDAIPSVIYTHPEVAWVGKTEQELKAANIKYNKGSFPMLANSRAKANNDYDGLIK
ILTEKDTDKLLGVHIMNAQAGELIGEATLAVEYGAAAEDIGRTCHAHPTISEALKEACMA
AYDKPIHF

>TTHERM_00043870(gene)
ATGTTCAAAACTTTTGTTCCTACTAGAAATCTTACCCATAGTCTTAGATAATTGTTCTCC
ACTAGCACTCAATATGATGTCGTCGTTATTGGTGGTGGTCCTGGTGGTAATAATCCTAAT
TATTTAATCAAAATTTTATACAATACAGCTTCTTCTCCTTCTTTTCGCTTTAAAGCAGTA
GCATTTCAGAGGTTATTCATGAAAACTTTGATTATTTAAAAACTGAGAAAAATTCACATA
GTTAAGCAAATATTCTATAAGAGTTGATCAAATATAAAAGATGCGTACTAAATTAAATTA
CAGTTTGTCTTAAAATATGCCTATAGCTAAGGATAATTTCAAATTATGTTCAATAGCTTT
AAGATAGAAGGAGAAGCAAGTGTTTATAGCTGATATAGCTAAAATTAAGAAAAATAGGTT
TATTTAATTATATTATAAATATAAAAGGTTACGTAGCTGCCATTAAGGCTGGTTAATTAG
GCTTAAAGACCGCTTGTGTTGAAAAGAGAGGTTCTTTGGGTGGTACCTGCTTAAATGTTG
GTTGCATTCCTTCAAAGGCTCTCTTAAACATCTCTTAAAAATATTATGATGCTTCCAAGC
ACTACAAAGAACTTGGTATCGAAGTTGAAGGTGTTAAAATGAATTGGGGTAAAATATTAA
ATTCTTTTTATTTTCATCCTCTTAAGAAAAAAAATTTTATCCACCAAAAATGATTTTTTA
CTCAAAATAAATACTTTTTTTTAATTGAATGCTTTTGTTTCAAACATCTAGCTGTTAGCA
AAATAATTTATTATAACTAAAATATATCTAATAAATAGCTCAAGCTTAAACAAAGAAGGC
TGAAACAGTTACTGGTTTGACCAGAGGTATCGAAAGTCTCTTCAAGAAGAATAAGGTTGA
CTACTTTGTTGGTACTGGTAGACTAAATGACAAGAACACTATTGGTATTAATCTTAACAA
TGGTACTTAGTAGGTTATTAACTCCAAGAACATTATTATTGCTACTGGATCTGAACCTAC
TCCTTTCCCTGGTCTCAACTTCGACGAAAAGGTTATCATCTCTTCAACTGGTAAAATAAA
AGATTTGTGGAAATTTATTTATTTACTTAAGCTATAATGAATTTTGTAGATTGATTAGCA
AATAAATAAATAAATAACAAGATTAGATAAGATTTATAAAAAGATATTTAATGAATGAAA
TAAATTGATTAGTAGCACTATTTAATTAATAAATAAAGCAAATTTTTTATCTTTCAATTT
ATCAAGAAATTTCTCAAAATTTTATTTGATGCTTCAATAATTTTTAAGGATTCTGATCTA
ATCTACTTAATTAATTAATTTATTTATTTATTGTATTATTCGAATCTCCTTTTAATCATT
TTATCATTTTACTATTACTTTAATACAGGTGCTCTCTCTTTACCCTAGATCCCTAAGAAA
TTAATCGTTATTGGTGCTGGTGTTATTGGTTTAGAAATGGGTTCTGTTTACCAAAGATTA
GGTACTCAAGTTACTGTCATTGAATTTGCTGATTAAATTTGCCCTTTCCTTGATACTGAT
GTTGCTAAGGCTTTCCAATAGAGCTTAAAGAAATAAGGTTTACAAATTTTGACTGGCCAT
AAGGTTGTTTCTGGTTAAAACTTCGGTACTCACGGTAGCGTAGTTGTTGAACCTGTTAAG
GGAGGTCCATCTTAGACCTTTGAAGCTGATCATATTTTAGTTTCTACAGGTCGTAGACCT
TATGTTGATGGCTTAAATGCTAAGGAAATCGGTATTGAGTTTGACAACAAAAATAGAATC
ATCACTAACTCCCACTTACAAACCAACATTCCCAATATTTATGCCATAGGTGATGTCATT
CCTGGACCTATGTTGGCTCACAAGGGTGAAGAAGAAGGTATTGCTGCTGTTGAATATATT
GCTGGAAAGGGTGGTCATGTTAATTACGATGCTATTCCTAGTGTTATCTATACCCATCCT
GAAGTTGCTTGGGTCGGAAAGACTGAATAAGAACTTAAGGCTGCCAGTAAATATTATTTT
TATTATTAATTTAAAATTAAATTAATCTAAATATTTAAACCAAATTTAATAGATATTAAG
TACAACAAGGGTTCTTTCCCCATGCTTGCTAACTCTAGAGCTAAAGCTAACAACGACTAC
GATGGTTTAATTAAGATCTTAACTGAAAAGGATACTGATAAACTCTTGGGTGTCCATATT
ATGAATGCATAAGCTGGTGAATTAATCGGTGAAGCTACTTTAGCCGTCGAATATGGTGCT
GCTGCTGAAGATATAGGTAGAACTTGCCACGCTCATCCTACTATTTCTGAAGCTCTTAAA
GAAGCTTGCATGGCTGCTTATGACAAGCCCATCCACTTCTGA