Identifiers and Description

Gene Model Identifier

TTHERM_00678260

Standard Name

TFA (Tetrahymena homolog of the liver F-Antigen)

Aliases

PreTt07590 | 102.m00110 | 3730.m00037

Description

TFA 4-hydroxyphenylpyruvate dioxygenase; Homolog of vertebrate liver F-antigen; constituent of the intracellular membrane network; associated with membranes of the Golgi apparatus and transport vesicles

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• Golgi apparatus (IDA) | GO:0005794 | Ref:1469718
• Golgi-associated vesicle (IDA) | GO:0005798 | Ref:1469718

Molecular Function

• 4-hydroxyphenylpyruvate dioxygenase activity (IEA) | GO:0003868

Biological Process

• Golgi vesicle transport (IEP) | GO:0048193 | Ref:1469718
• aromatic amino acid family metabolic process (IEA) | GO:0009072

Domains

• ( PF00903 ) glyoxalase family protein
• ( TIGR00068 ) lactoylglutathione lyase
• ( TIGR03081 ) methylmalonyl-CoA epimerase
• ( TIGR01263 ) 4-hydroxyphenylpyruvate dioxygenase

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.2%

TetraMine Data

TTHERM_00678260

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_16390.1	9.997093137033517e-262	4-hydroxyphenylpyruvate dioxyg enase (434 aa)
Oxytricha	Contig5080.0.g13	2.000147820282363e-173	Glyoxalase/Bleomycin resistanc e protein/Dioxygenase superfam ily
WormBase	WBGene00001993	9.996149531968772e-161	locus:hpd-1 4-hydroxyphenylp yruvate dioxygenase status:C onfirmed UniProt:Q22633 pr otein_id:CAA90315.1
DictyBase	DDB_G0277511	2.998986826334339e-156	hpd on chromosome: 2 position 8032660 to 8033990
Stentor Coeruleus	SteCoe_22285	6.542840619051457e-69

General Information

No Data fetched for General Information

Associated Literature

1. Ref:1469718: Hummel R, Nørgaard P, Andreasen PH, Neve S, Skjødt K, Tornehave D, Kristiansen K (1992) Tetrahymena gene encodes a protein that is homologous with the liver-specific F-antigen and associated with membranes of the Golgi apparatus and transport vesicles. Journal of molecular biology 228(3):850-61

Sequences

>TTHERM_00678260(coding)
ATGAGTGAAAATAAAGATCACGTTGTTGTTGGATACACTGAAAAGCCTGTTGGTGAAAGA
CCTACTGGTGGTAAGTTCTTAGGTTATGATCACTTACATTTCTGGGTTGGTAATGCCAAG
CAAGCTGCAGGATGGTACACTTCTCGTTTTGGTTTCGAATACTATGCTTACAAGGGTTTG
GAAACTGGTAGCAGAGAAGTTGCAACTCACGTTGTCCGTAATAAATAAGGTGTCACTTTA
GCCTTCAGTACTCCCTATGGAAACGACAAGGACAACTAAAGGGAAATGAACTAACATTAA
AGTTTACACGGTGATGGTGTTAAGGATGTCGCTTTTGCTGTTGAAGACTGTCACTCTATT
TACAACAAGGCTATCTAAAGAGGTGCCAAGTGTGCTTATCCTCCTCAAGATTTGAAGGAC
GAACATGGTAGTGTCACTATTGCTGCAGTCCACACTTATGGTGAAGTTATTCACACATTT
ATCCAAAGAAATGACTATAAAGGTTTCTTCATGCCTGGATTTGTTGCTCACCCCTTAAAG
GACCCCCTTAACAATGTTCTTCCTGACATCAGCTACAACTATGTAGATCATATTGTTGGT
AACCAACCTGATAACATGATGACCTCTGCTGCTGACTGGTATGAAAAGACTTTGGACTTC
CACAGATTCTGGTCTGTTGATGACAGCATGATCCACACTGAATTCTCTTCCTTAAGATCT
ATTGTCATGACTGACTACGATTAAAAGATTAAAATGCCCATTAACGAACCTGCTGATGGA
AAGAGAAAATCATAAATCTAAGAATATATTGATTTCTATGCTGGCCCTGGTGTATAACAC
ATTGCCTTGAATACAAGTGATGTAATCAACACTGTCGAAGGTCTTAGAGCTAGAGGTGTT
GAATTTTTATCTATTCCTACTTCCTATTATGATAATCTCAGAAAGGCTCTTACTGCATAG
ACTTCTATCACTGTTAAGGAAGATCTTGATGTCTTACAAAAGAACCATATTTTAGTTGAT
TATGATGAAAAGGGTTACCTCTTATAAATCTTCACCAAGCCTGTTGAAGATAGACCTACT
CTCTTCTACGAAATCATTCAAAGAAATAACCATTAAGGATTCGGTGCTGGTAACTTCAAG
TCCTTGTTTGTCTCTTTGGAACTTGAATAAGAAAAGAGAGGAAACCTTACTGAAATTGTC
AAGAACATCTATTGA

>TTHERM_00678260(protein)
MSENKDHVVVGYTEKPVGERPTGGKFLGYDHLHFWVGNAKQAAGWYTSRFGFEYYAYKGL
ETGSREVATHVVRNKQGVTLAFSTPYGNDKDNQREMNQHQSLHGDGVKDVAFAVEDCHSI
YNKAIQRGAKCAYPPQDLKDEHGSVTIAAVHTYGEVIHTFIQRNDYKGFFMPGFVAHPLK
DPLNNVLPDISYNYVDHIVGNQPDNMMTSAADWYEKTLDFHRFWSVDDSMIHTEFSSLRS
IVMTDYDQKIKMPINEPADGKRKSQIQEYIDFYAGPGVQHIALNTSDVINTVEGLRARGV
EFLSIPTSYYDNLRKALTAQTSITVKEDLDVLQKNHILVDYDEKGYLLQIFTKPVEDRPT
LFYEIIQRNNHQGFGAGNFKSLFVSLELEQEKRGNLTEIVKNIY

>TTHERM_00678260(gene)
ATGAGTGAAAATAAAGATCACGTTGTTGTTGGATACACTGAAAAGCCTGTTGGTGAAAGA
CCTACTGGTGGTAAGTTCTTAGGTTATGATCACTTACATTTCTGGGTTGGTAATGCCAAG
CAAGCTGCAGGATGGTACACTTCTCGTTTTGGTTTCGAATACTATGCTTACAAGGGTTTG
GAAACTGGTAGCAGAGAAGTTGCAACTCACGTTGTCCGTAATAAATAAGGTGTCACTTTA
GCCTTCAGTACTCCCTATGGAAACGACAAGGACAACTAAAGGGAAATGAACTAACATTAA
AGTTTACACGGTGATGGTGTTAAGGATGTCGCTTTTGCTGTAATTTTAATTATCTAAATT
CTTTATCATAAATTAAAAAAGAAAAGCTAATGAAAAAATGATAATTTAACTTATATTTTA
TTAATAAGGTTGAAGACTGTCACTCTATTTACAACAAGGCTATCTAAAGAGGTGCCAAGT
GTGCTTATCCTCCTCAAGATTTGAAGGACGAACATGGTAGTGTCACTATTGCTGCAGTCC
ACACTTATGGTGAAGTTATTCACACATTTATCCAAAGAAATGACTATAAAGGTTTCTTCA
TGCCTGGATTTGTTGCTCACCCCTTAAAGGACCCCCTTAACAATGTTCTTCCTGACATCA
GCTACAACTATGTAGATCATATTGTTGGTAACCAACCTGTAAGATTAAATTTAAAAAAAA
TATTTTGAAGGAATAATTAATTCAGTAAAAAAAATGTTTAAATGGCTATCTTATAAGTAA
TCTACTACAAAACTCCCATCAAAGATGAAGAAATTTATTATTAAAGACAAATAGAACTTA
ATAAATACTTAAAAATAGCAAATAAAATCAATTTTAGAAATATTCTAAACATTTCTCTAG
AAAAAGTAAAAAAGAATAGCCATAAATTCAAGCGAGTAGTTAGTCATTCATAAATTTGAT
TAAAATACAAAAAGAGCAAATTTATAATTAAATAAATTAATTAATTAAATAGATGTATGT
ATTTAATAAAATGCTCATATTTTGTTTATTATAAATAGGATAACATGATGACCTCTGCTG
CTGACTGGTATGAAAAGACTTTGGACTTCCACAGATTCTGGTCTGTTGATGACAGCATGA
TCCACACTGAATTCTCTTCCTTAAGATCTATTGTCATGACTGACTACGATTAAAAGATTA
AAATGCCCATTAACGAACCTGCTGATGGAAAGAGAAAATCATAAATCTAAGAATATATTG
ATTTCTATGCTGGCCCTGGTGTATAACACATTGCCTTGAATACAAGTGATGTAATCAACA
CTGTCGAAGGTCTTAGAGCTAGAGGTGTTGAATTTTTATCTATTCCTACTTCCTATTATG
ATAATCTCAGAAAGGCTCTTACTGCATAGACTTCTATCACTGTTAAGGAAGATCTTGATG
TCTTACAAAAGAACCATATTTTAGTTGATTATGATGAAAAGGGTTACCTCTTATAAATCT
TCACCAAGCCTGTTGAAGATAGGTAAAAGATTTACTTCATTTATTATTTAGTTTTTAATT
TAGATTAGACTTTGAAATTCATCAAACTTTTCTGATGAATCTTCGAACAATTTTGATCAA
ACTAAACTTTTTCTAATATTTTTAATTAATTAATAAAAATAGACCTACTCTCTTCTACGA
AATCATTCAAAGAAATAACCATTAAGGATTCGGTGCTGGTAACTTCAAGTCCTTGTTTGT
CTCTTTGGAACTTGAATAAGAAAAGAGAGGAAACCTTACTGAAATTGTCAAGAACATCTA
TTGA