Identifiers and Description

Gene Model Identifier

TTHERM_00997620

Standard Name

TER1 (Tetrahymena Endoplasmic reticulum Retrieval receptor)

Aliases

PreTt24987 | 188.m00063

Description

Putative ER-retrevial receptor; transcription of TER1 induced following exocytosis; may be cargo protein of dense core secretory granules

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Biological Process

• protein retention in ER lumen (ISS) | GO:0006621 | Ref:12456006
• vesicle organization (IEP) | GO:0016050 | Ref:12456006

Domains

• ( PF04193 ) PQ loop repeat
• ( PF00810 ) ER lumen protein retaining receptor

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 37%

TetraMine Data

TTHERM_00997620

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_17840.1	4.001709789838121e-126	hypothetical protein (218 aa)
Oxytricha	Contig16185.0.g84	1.9991517704232713e-32	ER lumen protein retaining rec eptor
Stentor Coeruleus	SteCoe_1721	1.9287498479639178e-22
DictyBase	DDB_G0272124	0.000000000003001226732525078	kdelr on chromosome: 2 positio n 1376821 to 1377729
WormBase	WBGene00001331	0.000000000008998169033602767	locus:erd-2 ER lumen protein retaining receptor status:C onfirmed UniProt:P48583 pr otein_id:CAA90056.2
SGD	YBL040C	0.00000019998969434520019	ERD2 HDEL receptor, an integra l membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a r ole in maintenance of normal l evels of ER-resident proteins

General Information

No Data fetched for General Information

Associated Literature

1. Ref:12707780: Petcherskaia M, McGuire JM, Pherson JM, Kirk KE (2003) Loss of cap structure causes mitotic defect in Tetrahymena thermophila telomerase mutants. Chromosoma 111(7):429-37
2. Ref:12456006: Haddad A, Bowman GR, Turkewitz AP (2002) New class of cargo protein in Tetrahymena thermophila dense core secretory granules. Eukaryotic cell 1(4):583-93
3. Ref:10518620: Hargrove BW, Bhattacharyya A, Domitrovich AM, Kapler GM, Kirk K, Shippen DE, Kunkel GR (1999) Identification of an essential proximal sequence element in the promoter of the telomerase RNA gene of Tetrahymena thermophila. Nucleic acids research 27(21):4269-75

Sequences

>TTHERM_00997620(coding)
ATGGAGCTAGTACTTTTATTATTCTTATTAGGATACGTAATTTAAGATGCAGGCTGCGTA
ATTTTACTTCTAAGAATATTGAAGCAAAGGTCTGTTGATGGTTTATCTCTTTAATCCCAA
GTTATGTACGGATTAGGAACATTAATGAGAGTAATCTACACTTTCGATACAAGACTAAGC
AATTACACAATTGTATTTGTTGAAATGATGGTTGCTGTTTTACTCCACATAGGCATACTT
TATGGTTTCTTCAAGTACAGATACACTCAAACTTCAGATATTTAATCTCCTTTAATTAGC
TGGAAAACAATAATACCCGTATGTTCAGTTTTAGCTTACTTTTTCCATCCAGGTGAATAG
TATGAATATCTACAAATTTTAGTATCTCTATCCATGTTTATTGAAGCAGTAGGTCTCCTA
CCATAAATTTATGTAAATCGCAAGCAAGGACGTGTAGAATATGAATTAGGAAAATATCTC
ATTTTTATGGTTGCAAGCAGAATAGCAAGATTAGCATTTTGGTTTGTAATGTATAGAATG
GGTGATTAAAATATTGAATTGATGGTTGCTGATATTGTTCATACAGTTCTTCTTGCAGAT
TTTGCAATTCTTTTTATTAAAAACAAAGGCAAAGAAGTTATCTTAGTAATTTGA

>TTHERM_00997620(protein)
MELVLLLFLLGYVIQDAGCVILLLRILKQRSVDGLSLQSQVMYGLGTLMRVIYTFDTRLS
NYTIVFVEMMVAVLLHIGILYGFFKYRYTQTSDIQSPLISWKTIIPVCSVLAYFFHPGEQ
YEYLQILVSLSMFIEAVGLLPQIYVNRKQGRVEYELGKYLIFMVASRIARLAFWFVMYRM
GDQNIELMVADIVHTVLLADFAILFIKNKGKEVILVI

>TTHERM_00997620(gene)
ATGGAGCTAGTACTTTTATTATTCTTATTAGGATACGTAATTTAAGATGCAGGCTGCGTA
ATTTTACTTCTAAGAATATTGAAGCAAAGGTCTGTTGATGGTTTATCTCTTTAATCCCAA
GTTATGTACGGATTAGGAACATTAATGAGAGTAATCTACACTTTCGATACAAGACTAAGC
AATTACACAATTGTATTTGTTGAAATGATGGTTGCTGTTTTACTCCACATAGGCATACTT
TATGGTTTCTTCAAGTACAGATACACTCAAACTTCAGATATTTAATCTCCTTTAATTAGC
TGGAAAACAATAATACCCGTATGTTCAGTTTTAGCTTACTTTTTCCATCCAGGTGAATAG
TATGAATATCTACAAATTTTAGTATCTCTATCCATGTTTATTGAAGCAGTAGGTCTCCTA
CCATAAATTTATGTAAATCGCAAGCAAGGACGTGTAGAATATGAATTAGGAAAATATCTC
ATTTTTATGGTTGCAAGCAGAATAGCAAGATTAGCATTTTGGTTTGTAATGTATAGAATG
GGTGATTAAAATATTGAATTGATGGTTGCTGATATTGTTCATACAGTTCTTCTTGCAGAT
TTTGCAATTCTTTTTATTAAAAACAAAGGCAAAGAAGTTATCTTAGTAATTTGA