Identifiers and Description

Gene Model Identifier

TTHERM_00218760

Standard Name

TEB1 (TElomerase DNA Binding subunit 1; also known as Telomerase- (or TERT-) associated protein of 82 kDa )

Aliases

PreTt22303 | 18.m00329 | 3701.m00089

Description

Telomerase holoenzyme subunit p82; essential gene; knockdown induces telomere shortening, a heterotrimer of telomerase

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• telomerase holoenzyme complex (IDA) | GO:0005697 | Ref:27895115

Biological Process

• telomerase holoenzyme complex assembly (IDA) | GO:1905323 | Ref:27895115

Domains

• ( PF08792 ) A2L zinc ribbon domain
• ( PF01336 ) OB-fold nucleic acid binding domain
• ( PF08646 ) Replication factor-A C terminal domain
• ( TIGR00617 ) replication factor-a protein 1 (rpa1)
• ( TIGR00161 ) conserved hypothetical protein TIGR00161

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10%

TetraMine Data

TTHERM_00218760

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_06651.1	9.997093137033517e-262	hypothetical protein (690 aa)
Oxytricha	Contig13699.0.g10	0.00008003872323201264	Replication factor-A C termina l domain
SGD	YAR007C	0.00020003864201578029	RFA1 Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved si ngle-stranded DNA binding prot ein involved in DNA replicatio n, repair, and recombination

General Information

No Data fetched for General Information

Associated Literature

1. Ref:27895115: Upton HE, Chan H, Feigon J, Collins K (2017) Shared Subunits of Tetrahymena Telomerase Holoenzyme and Replication Protein A Have Different Functions in Different Cellular Complexes. The Journal of biological chemistry 292(1):217-228
2. Ref:25225329: Upton HE, Hong K, Collins K (2014) Direct single-stranded DNA binding by Teb1 mediates the recruitment of Tetrahymena thermophila telomerase to telomeres. Molecular and cellular biology 34(22):4200-12
3. Ref:23918804: Hong K, Upton H, Miracco EJ, Jiang J, Zhou ZH, Feigon J, Collins K (2013) Tetrahymena telomerase holoenzyme assembly, activation, and inhibition by domains of the p50 central hub. Molecular and cellular biology 33(19):3962-71
4. Ref:20363756: Min B, Collins K (2010) Multiple mechanisms for elongation processivity within the reconstituted tetrahymena telomerase holoenzyme. The Journal of biological chemistry 285(22):16434-43

Sequences

>TTHERM_00218760(coding)
ATGAAATTAACTAAAGGTGGGTCGTATATACTTAAAAAAGTGGACAGAAAATAGTTTTAT
TAAGATGAAGAAATAGTCATGTAAATAAAAAAAATACTTGGTTAAAAAACTACAGATTGC
AAACAATACATAAAATGTGAGTGTATAGATGGTTTGGGAGATGAAGCATTGATTTACTTT
GAGATGCTTGCTAATTAAAATCAGCATTTACAAAAAAACGATGTCATAATGATTTAAGAT
TATTTAAATGATAAAACATAAAACGACAAAATAGTTGTTTTAGTTACAAGGTTTTAATTT
TGTAAAGCCAGTCATGTTTAGCCTAAAACCGCCCAAAAAGAATCCATATAACTATTAAAT
ACTGAAAAAACAATAATTTAAAAGAGTAAAATTACTAAAAATCCAGCTGAAGAAGTTTTA
AAATTTATAGAAGTAAACGAAAAAGATAATAGTTCAAACAGTGAAGATATGATAATTGAA
TAGTAGAAATAAGAAATTAAGAATAATTAAAAAGAAAAACAAAGTATAAATGGATTTAAT
TTGGAAGATAGCTATTCAAATATTTCTGATATTACTAATTTTGGAGGGAAATCTAATTTT
AATATTGGATCACTTTCTGATTAACTTAGTAAATAGACACTGCTAATTTCTTAGTTGTAA
GTAGGTAAAAATAGATTTTCTTTTAAGTTCGAAGGAAGAGTTGTATATAAAAGTAGTACA
TTCCAGAATTAGCAAGACTCTAAGTATTTTTTCATCACAGCATAAGACGCTAATAATTAA
GAAATTAATTTGTCTTTTTGGCAAAAAGTTGATTAAAGCTATTAAACTTTGAAAGTAGGA
TAATATTATTACTTTATAGGAGGAGAAGTTAAATAGTTCAAAAATAATCTAGAATTAAAA
TTTAAGTTTGGAGACTACTAAATAATTCCTAAAGAGACTCTTTCTGCGAATTATGTATAA
CCTTTGGCATTACAACCTTCAAAATAATTTGGAAATGACTCAATAGGAGACTCTGATTAT
TCTATTCATAATTTAATTGAAAAGGAGGAAAGCATCGCTTAAAAGGGCTATAATGGATAA
AAGAATAATAAATATAGATAAAATAACAATAATAGCAAGCATACACTCTTAATATCTGAA
GTATTAAAAACTTCTAAATAATATTTATCAGTATTAGCATAAGTTGTTGATATTCAAAGT
TCAGATAAAAATATAAGATTAAAAATATGTGATAATAGCTGTAATTAAGAACTCAAAGTA
GTCATTTTTCCAGATTTATGCTATGAGTGGAGAGATAAATTTAGTATAAATAAATGGTAT
TATTTTAATGAGTTTGTTAGATAAATTTATAATGATGAAGTTTAGTTGAAAAATAACATT
CATTCTTCAATTAAAGAATCTGATGATTAAAGAAAAGTTATTACTTATAATTAAGAATAG
GGTGTTTTTAAAAAATCAATCTCAATTAATAGCAATGATAGTTTTGAAATTAAGCCTAAA
ATTTCATATAAAAACAATTCTAACTAAGAATAAAGGATTTATTCTTCAATTGAAGAAATA
ATCTAATAAGCATAGGCTTCAGAAATAGGTCAAAAAAAAGAATTCTATGTTTATGGAAAC
TTAGTTTCAATATAGATGAAAAATAAGCTTTATTATTATAGGTGTACTTGTTAGGGTAAG
TCAGTCTTAAAATATCACGGAGATTCATTTTTTTGTGAAAGTTGCTAGTAGTTCATAAAT
CCTTAGGTGCATTTGATGCTTAGAGCATTTGTTTAAGATTCTACAGGGACAATTCCTGTT
ATGATTTTCGATCAGCAGTCAAGCCAACTTATCAACTAAATTGATCCATCAATTCATGTC
TAAGAAGCAGGTTAATATGTTAAAAATTGTATTGAAAATGGATAAGAAGAAATTATAAGA
TAGTTATTTAGTAAATTAGACTTTGCTAGATTTATATTTGAAATTTAATTTGAAAATAAA
GAATTTAATAACGAATAAGAGATAGCATACAAAGTATTAAAAATTGAAAAAGAAAATATT
AAAGAAGAATCTAAATATCTACTAAAAAAGTTAGAGCACTTAATAAACAATAATCAAAAT
AACTGA

>TTHERM_00218760(protein)
MKLTKGGSYILKKVDRKQFYQDEEIVMQIKKILGQKTTDCKQYIKCECIDGLGDEALIYF
EMLANQNQHLQKNDVIMIQDYLNDKTQNDKIVVLVTRFQFCKASHVQPKTAQKESIQLLN
TEKTIIQKSKITKNPAEEVLKFIEVNEKDNSSNSEDMIIEQQKQEIKNNQKEKQSINGFN
LEDSYSNISDITNFGGKSNFNIGSLSDQLSKQTLLISQLQVGKNRFSFKFEGRVVYKSST
FQNQQDSKYFFITAQDANNQEINLSFWQKVDQSYQTLKVGQYYYFIGGEVKQFKNNLELK
FKFGDYQIIPKETLSANYVQPLALQPSKQFGNDSIGDSDYSIHNLIEKEESIAQKGYNGQ
KNNKYRQNNNNSKHTLLISEVLKTSKQYLSVLAQVVDIQSSDKNIRLKICDNSCNQELKV
VIFPDLCYEWRDKFSINKWYYFNEFVRQIYNDEVQLKNNIHSSIKESDDQRKVITYNQEQ
GVFKKSISINSNDSFEIKPKISYKNNSNQEQRIYSSIEEIIQQAQASEIGQKKEFYVYGN
LVSIQMKNKLYYYRCTCQGKSVLKYHGDSFFCESCQQFINPQVHLMLRAFVQDSTGTIPV
MIFDQQSSQLINQIDPSIHVQEAGQYVKNCIENGQEEIIRQLFSKLDFARFIFEIQFENK
EFNNEQEIAYKVLKIEKENIKEESKYLLKKLEHLINNNQNN

>TTHERM_00218760(gene)
AATAAATTAGCCAGTTTTTTGCAAAATTTTCAAAAACAAATATCTAAAAAGATAAATAGA
TAAAATTTAATTTTTTGTTTGGTAGAAATTACTATAATTCTAACAAACTAAAATAAAAAA
CAATTTACATTTTTTACTTTTAGATATAAAAACAAATCATAAATTAAAAGAAATTTTTCA
AGATAAAGTAAAAACTTTAAAACAATATTTTAAAGCCACTCCTAAATTTTAAAAGAAATG
AAATTAACTAAAGGTGGGTCGTATATACTTAAAAAAGTGGACAGAAAATAGTTTTATTAA
GATGAAGAAATAGTCATGTAAATAAAAAAAATACTTGGTTAAAAAACTACAGATTGCAAA
CAATACATAAAGTAATCAAAATATATAACTTATCTAAAAAGAAAACAAATTGAGAATAAA
AAAAATACAAATATAGATGTGAGTGTATAGATGGTTTGGGAGATGAAGCATTGATTTACT
TTGAGATGCTTGCTAATTAAAATCAGCATTTACAAAAAAACGATGTCATAATGATTTAAG
ATTATTTAAATGATAAAACATAAAAGTAAACTTTTAATATTAAAATGAGATAACAAAATT
AATAAATATTTTTAAAAATCAAGCGACAAAATAGTTGTTTTAGTTACAAGGTTTTAATTT
TGTAAAGCCAGTCATGTTTAGCCTAAAACCGCCCAAAAAGAATCCATATAACTATTAAAT
ACTGAAAAAACAATAATTTAAAAGAGTAAAATTACTAAAAATCCAGCTGAAGAAGTAATT
AGTAGCTTATTTGCAAAGCTGAATGAATATATTATTTTTACATTGAATATATTATTTTTA
CGAAATATTTTAGGTTTTAAAATTTATAGAAGTAAACGAAAAAGATAATAGTTCAAACAG
TGAAGATATGATAATTGAATAGTAGAAATAAGAAATTAAGAATAATTAAAAAGAAAAACA
AAGTATAAATGGTATTATTTATTTATTTATTAATCAATCTATCAATAATTTAATTTGAAA
ATTTTGAGTGAAAAATCCTTGATAAATTTTTTGAACCACTTAGAATTTCTTTGAATATGA
TTTTTTTGTTTTTGATTAGGATTTAATTTGGAAGATAGCTATTCAAATATTTCTGATATT
ACTAATTTTGGAGGGAAATCTAATTTTAATATTGGATCACTTTCTGATTAACTTAGTAAA
TAGACACTGCTAATTTCTTAGTTGTAAGTAGGTAAAAATAGATTTTCTTTTAAGTTCGAA
GGAAGAGTTGTATATAAAAGTAGTACATTCCAGAATTAGCAAGACTCTAAGTATTTTTTC
ATCACAGCATAAGACGCTAATAATTAAGAAATTAATTTGTCTTTTTGGCAAAAAGTTGAT
TAAAGCTATTAAACTTTGAAAGTAGGATAATATTATTACTTTATAGGAGGAGAAGTTAAA
TAGTTCAAAAATAAGTTAATTTATTTCTTTTTTTTTTTTAATTTAAATAAAATTTTATAT
TATAAAAATAGTCTAGAATTAAAATTTAAGTTTGGAGACTACTAAATAATTCCTAAAGAG
ACTCTTTCTGCGAATTATGTATAACCTTTGGCATTACAACCTTCAAAATAATTTGGAAAT
GACTCAATAGGAGACTCTGATTATTCTATTCATAATTTAATGTAAAAGTATTTATTAAAA
TCAATTTGTTTTGATATTTTTATGAACTTTTTTATAGTGAAAAGGAGGAAAGCATCGCTT
AAAAGGGCTATAATGGATAAAAGAATAATAAATATAGATAAAATAACAATAATAGCAAGC
ATACACTCTTAATATCTGAAGTATTAAAAACTTCTAAATAATATTTATCAGTATTAGCAT
AAGTTGTTGTAAGATAATTACTAAGAGGTTTATATGTAGGTATTAATATGTATTTTATTT
TAAATGAATAGGATATTCAAAGTTCAGATAAAAATATAAGATTAAAAATATGTGATAATA
GCTGTAATTAAGAACTCAAAGTAGTCATTTTTCCAGATTTATGCTATGAGTGGAGAGATA
AATTTAGTATAAATAAATGGTATTATTTTAATGAGTTTGTTAGATAAATTTATAATGATG
AAGTTTAGTTGAAAAATAACATTCATTCTTCAATTAAAGAATCTGATGATTAAAGAAAAG
TTATTACTTATAATTAAGAATAGGGTGTTTTTAAAAAATCAATCTCAATTAATAGCAATG
ATAGTTTTGAAATTAAGCCTAAAATTTCATATAAAAACAATTCTAACTAAGAATAAAGGA
TTTATTCTTCAATTGAAGAAATAATCTAATAAGCATAGGCTTCAGAAATAGGTCAAAAAA
AAGAATTCTATGTTTATGGAAACTTAGTTTCAATATAGATGAAAAATAAGCTTTATTATT
ATAGGTGTACTTGTTAGGGTAAGTCAGTCTTAAAATATCACGGAGATTCATTTTTTTGTG
AAAGTTGCTAGTAGTTCATAAATCCTTAGGTGCATTTGATGCTTAGAGCATTTGTTTAAG
ATTCTACAGGGACAATTCCTGTTATGATTTTCGATCAGCAGTCAAGCCAACTTATCAACT
GTAAATTTTTTTGGAAAAAATTAAATAAATTCATAAAATATTTGTTAAATAGAAATTGAT
CCATCAATTCATGTCTAAGAAGCAGGTTAATATGTTAAAAATTGTATTGAAAATGGATAA
GAAGAAATTATAAGATAGTTATTTAGTAAATTAGACTTTGCTAGATTTATATTTGAAATT
TAATTTGAAAATAAAGAATTTAATAACGAATAAGAGATAGCATACAAAGTATTAAAAATT
GAAAAAGAAAATATTAAAGAAGAATCTAAATATCTACTAAAAAAGTTAGAGCACTTAATA
AACAATAATCAAAATAACTGA