Identifiers and Description

Gene Model Identifier

TTHERM_00575350

Standard Name

TBP1 (TATA-Binding Protein )

Aliases

PreTt28925 | 77.m00137 | TATA-binding protein | 3812.m02620

Description

TATA-binding protein; component of the basal transcription apparatus; found in macronuclei throughout life cycle, but only found in micronuclei early in conjugation

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• micronucleus (IDA) | GO:0031040 | Ref:8264641
• macronucleus (IDA) | GO:0031039 | Ref:8264641

Molecular Function

• obsolete RNA polymerase II transcription factor activity (IEA) | GO:0003702
• DNA binding (IEA) | GO:0003677

Biological Process

• regulation of transcription, DNA-templated (IEA) | GO:0006355
• transcription, DNA-templated (IEP) | GO:0006351 | Ref:8264641
• transcription initiation from RNA polymerase II promoter (IEA) | GO:0006367

Domains

No Data fetched for Domains

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.2%

TetraMine Data

TTHERM_00575350

WebApollo

Fullscreen View

Tetrahymena Stock Center

• ( SD02729 ) Macronucleus: Partial Neo KO of TBP1

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_04002.1	8.000194140818961e-170	TATA-box binding protein (246 aa)
SGD	YER148W	5.0002513615276457e-88	SPT15 TATA-binding protein, ge neral transcription factor tha t interacts with other factors to form the preinitiation com plex at promoters, essential f or viability
DictyBase	DDB_G0275617	5.998372506255629e-88	tbpA on chromosome: 2 position 6092208 to 6093026
WormBase	WBGene00006542	2.0000012618802033e-84	locus:tbp-1 TATA-box-binding protein status:Confirmed UniProt:P32085 protein_id:CC D69071.1
Oxytricha	Contig262.1.g32	6.999281070199524e-80	Transcription factor TFIID (or TATA-binding protein, TBP)
Stentor Coeruleus	SteCoe_11068	8.985825944049381e-37

General Information

No Data fetched for General Information

Associated Literature

1. Ref:9115421: Tsukiyama T, Wu C (1997) Chromatin remodeling and transcription. Current opinion in genetics & development 7(2):182-91
2. Ref:8756729: Shen X, Gorovsky MA (1996) Linker histone H1 regulates specific gene expression but not global transcription in vivo. Cell 86(3):475-83
3. Ref:7579709: Lu MJ, Mpoke SS, Dadd CA, Allis CD (1995) Phosphorylated and dephosphorylated linker histone H1 reside in distinct chromatin domains in Tetrahymena macronuclei. Molecular biology of the cell 6(8):1077-87
4. Ref:8264641: Stargell LA, Gorovsky MA (1994) TATA-binding protein and nuclear differentiation in Tetrahymena thermophila. Molecular and cellular biology 14(1):723-34
5. Ref:8177745: Liu X, Gorovsky MA (1993) Mapping the 5' and 3' ends of Tetrahymena thermophila mRNAs using RNA ligase mediated amplification of cDNA ends (RLM-RACE). Nucleic acids research 21(21):4954-60

Sequences

>TTHERM_00575350(coding)
ATGAGCAGCGATAAAACATCTCAGCAGACTTTTAAGTTAGCACCAAACAATAGCGTCGCT
TAGAGCAATAGCATAGACCAAAATAAAAATAAAAACAATATCCTTAGCACTATAGAAACG
ATGGATAAGAGCATAAGTGAAGATTTATACCCAAAATTGTAGAATATTGTTTCCACTGTA
AATCTTAGTACAAAATTAGATTTAAAGCAAATAGCTCTTAGAGCCAGAAATGCTGAATAC
AATCCTAAAAGATTTGCTGCAGTAATTATGAGATTGAGAGATCCTAAAACTACAGCTCTG
ATTTTTGCTTCTGGTAAAATGGTGTGTACGGGTGCAAAAACAGAAGAAGATTCTAATAGA
GCTGCAAGAAAGTATGCTAAGATTATCTAAAAAATAGGTTTCCCCGTACAGTTCAAAGAT
TTTAAAATATAAAATATAGTAGGATCGACTGATGTAAAATTCCCCATCAATCTTGACCAT
CTTGAATAAGACCATAAAAAGTTCGTTTAGTATGAACCTGAAATTTTCCCTGGCTTGATT
TATCGTGAATTTAATACAAAAATAGTTCTCTTAATCTTCGTATCAGGTAAAATTGTACTG
ACAGGTGCAAAAACTAGAGAAAATATTAACAAAGCTTTCTAAAAAATATATTGGGTTTTG
TACAATTACTAGAAAAAAGACTATAGAGGTGCAAATCTTCATAATTAAAATTTAAATATT
AAACCTAGTATAAAAAATTGA

>TTHERM_00575350(protein)
MSSDKTSQQTFKLAPNNSVAQSNSIDQNKNKNNILSTIETMDKSISEDLYPKLQNIVSTV
NLSTKLDLKQIALRARNAEYNPKRFAAVIMRLRDPKTTALIFASGKMVCTGAKTEEDSNR
AARKYAKIIQKIGFPVQFKDFKIQNIVGSTDVKFPINLDHLEQDHKKFVQYEPEIFPGLI
YREFNTKIVLLIFVSGKIVLTGAKTRENINKAFQKIYWVLYNYQKKDYRGANLHNQNLNI
KPSIKN

>TTHERM_00575350(gene)
ATGAGCAGCGATAAAACATCTCAGCAGACTTTTAAGTTAGCACCAAACAATAGCGTCGCT
TAGAGCAATAGCATAGACCAAAATAAAAATAAAAACAATATCCTTAGCACTATAGAAACG
ATGGATAAGAGCATAAGTGAAGATTTATACCCAAAATTGTAGAATATTGTTTCCACTGTA
AATCTTAGTACAAAATTAGATTTAAAGCAAATAGCTCTTAGAGCCAGAAATGCTGAATAC
AATCCTAAAAGATTTGCTGCAGTAATTATGAGATTGAGAGATCCTAAAACTACAGCTCTG
ATTTTTGCTTCTGGTAAAATGGTGTGTACGGGTGCAAAAACAGAAGAAGATTCTAATAGA
GCTGCAAGAAAGTATGCTAAGATTATCTAAAAAATAGGTTTCCCCGTACAGTTCAAAGAT
TTTAAAATATAAAATATAGTAGGATCGACTGATGTAAAATTCCCCATCAATCTTGACCAT
CTTGAATAAGACCATAAAAAGTTCGTTTAGTATGAACCTGAAATTTTCCCTGGCTTGATT
TATCGTGAATTTAATACAAAAATAGTTCTCTTAATCTTCGTATCAGGTAAAATTGTACTG
ACAGGTGCAAAAACTAGAGAAAATATTAACAAAGCTTTCTAAAAAATATATTGGGTTTTG
TACAATTACTAGAAAAAAGACTATAGAGGTGCAAATCTTCATAATTAAAATTTAAATATT
AAACCTAGTATAAAAAATTGA