Identifiers and Description

Gene Model Identifier

TTHERM_00548030

Standard Name

SMPD1 (SphingoMyelinase PhophoDiesterase 1)

Aliases

PreTt15052 | 71.m00179 | 3729.m00056

Description

Endonuclease/Exonuclease/phosphatase family protein; cleaves sphingomyelin into cermaide and phosphocholine, second messengers for apoptosis

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• cytoplasm (IDA) | GO:0005737 | Ref:SUPR000294
• macronucleus (IDA) | GO:0031039 | Ref:SUPR000294

Domains

• ( TIGR03395 ) sphingomyelin phosphodiesterase
• ( PF03372 ) endonuclease/exonuclease/phosphatase family

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.7%

TetraMine Data

TTHERM_00548030

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_17053.1	9.997093137033517e-262	endonuclease/Exonuclease/phosp hatase (498 aa)
Oxytricha	Contig19618.0.g4	4.000010081770683e-74	Endonuclease/Exonuclease/phosp hatase family
DictyBase	DDB_G0288017	1.999534248571833e-46	DDB_G0288017 on chromosome: 5 position 978356 to 979732
Stentor Coeruleus	SteCoe_2706	1.4251640827409352e-21
WormBase	WBGene00012105	0.000019995566179747357	Putative neutral sphingomyelin ase status:Confirmed UniPr ot:O45870 protein_id:CAB0488 5.2

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00548030(coding)
ATGAAGACATAAGATTTTAAATCCAACCAAAAATCTGGCGATATTGAATCACAAATGCCT
AAATAAGGTTAGAAGGAACAAAGATCAAATAAGGAAAATTCACCTGAAAGATCGTAGCAA
AATATTTCAACGAGCTCAAACAATATTGATAAAATAAACAATACTTTAAATAGCTCGAAT
TTTGAAATTGGAGACAGATTGCCAATGCAAAAAATCTAAGTTATAAAATAAAATTCATCA
CCAAAGAACAACGTTATCTCTAATTATTTAAGCTAAGGAATTAGGTCTGTTCGTGTTCTC
ACTTATAACATCTTTCTAAGACCTCCACCAATCAAGAACAATAAAGACGACTACAAAAAT
GAGAGAACTAAGCTTTTTCTCAATTCAATAAGTGACTTTGATATTGTTTGTCTTTAGGAA
TTGTTTGGTTTTCTCAACCAACGCAAACACAAAATTATATTCAATGCTATGAAACAAGGA
TTCTTCTATCATGCAACATCACCTTCTCCTTCCTTTTTTAGCTCCTACTTGGTAGATGGA
GGATTAGTAACAATTTCTAGATTTCCCATCATAGAAAAGTCGTACAGACCTTTTAAATAT
GGAGTCCTCTCAGATAATTTATCATAGAAGGGTGTTCTATACACAAAAATTTAAGCAAAC
GATTCGTATATTCATCTTTTTAACACACATCTTCAAGCTAGTTACGTAGGTGCTGAAAAT
AATGTGAAAGCTACAGTTATCACAAGAGTAGACCAACTTATTTTGATAAAAGACTTCATA
AAAGAATAAGTAAAAAAGCACAGAGAAAAGGAGAGTGATATTATTATGATTTGTGGTGAT
TTCAATGTTAATGCTCGTCCCTAAACTTATCCTATTCATTATTTAAATGATGTTCCTGAT
ATTTAAGAATATATCAGAAAAATAAACCCAAAAGAATTTAGTGAGTATGACATCCTTAGA
TACATTCTATCTGACTTTGAAAGTATAGAATTCATAGATACATTAAGGAGAAAATTTAAA
GGTGAGTCTCCCATTACTTATGCCGATACTTACATTGATAGGGAAACTTAATAAGAACTA
CCAATGGAAGAGGCTCTAACAATAAAAGAGGATTTACTCCAAAAATCATGCTTAGACTAT
ATTATTCAATTGAAAATTCCGATTGAAGCAAAAGAAGTATAAGAAAATAACAACAACAAC
AACAATAACAACGAAAATGAAGAAGATGATATTGAAGAATTCAAAATGAAAAAATCAAAT
GCGCAATCTCAAAGTGGATTTGTTTTTGATTACGAATAAGTTTTCTTAGAAAAATTCTTT
GTAAAAAACTAACCATTTACATAGTTAAGCGATCATTATGGTGTTTACACAACCCTGAGA
TACGTAAATGTAAACTAAAAAAGTAGTTTCCAATTTAAAGAGTCTGTTATATCTTCTTAG
GATAAAAAAAATATAGATAATAAAAATTAGCACAGCTTTAACAATGCAAGTTTGAATGAA
TGA

>TTHERM_00548030(protein)
MKTQDFKSNQKSGDIESQMPKQGQKEQRSNKENSPERSQQNISTSSNNIDKINNTLNSSN
FEIGDRLPMQKIQVIKQNSSPKNNVISNYLSQGIRSVRVLTYNIFLRPPPIKNNKDDYKN
ERTKLFLNSISDFDIVCLQELFGFLNQRKHKIIFNAMKQGFFYHATSPSPSFFSSYLVDG
GLVTISRFPIIEKSYRPFKYGVLSDNLSQKGVLYTKIQANDSYIHLFNTHLQASYVGAEN
NVKATVITRVDQLILIKDFIKEQVKKHREKESDIIMICGDFNVNARPQTYPIHYLNDVPD
IQEYIRKINPKEFSEYDILRYILSDFESIEFIDTLRRKFKGESPITYADTYIDRETQQEL
PMEEALTIKEDLLQKSCLDYIIQLKIPIEAKEVQENNNNNNNNNENEEDDIEEFKMKKSN
AQSQSGFVFDYEQVFLEKFFVKNQPFTQLSDHYGVYTTLRYVNVNQKSSFQFKESVISSQ
DKKNIDNKNQHSFNNASLNE

>TTHERM_00548030(gene)
ATGAAGACATAAGATTTTAAATCCAACCAAAAATCTGGCGATATTGAATCACAAATGCCT
AAATAAGGTTAGAAGGAACAAAGATCAAATAAGGAAAATTCACCTGAAAGATCGTAGCAA
AATATTTGTAAATCCATATTATATTTTTCACTGAAATGACATAGTAAATTTGAGATAACA
TTATTTTTAATCCTTTTTTATTGAAAAAACAAAAAGCAACGAGCTCAAACAATATTGATA
AAATAAACAATACTTTAAATAGCTCGAATTTTGAAATTGGAGACAGATTGCCAATGCAAA
AAATCTAAGTTATAAAATAAAATTCATCACCAAAGAACAACGTTATCTCTAATTATTTAA
GCTAAGGAATTAGGTCTGTTCGTGTTCTCACTTATAACATCTTTCTAAGACCTCCACCAA
TCAAGAACAATAAAGACGACTACAAAAATGAGAGAACTAAGCTTTTTCTCAATTCAATAA
GTGACTTTGATATTGTTTGTCTTTAGGAATTGTTTGGTTTTCTCAACCAACGCAAACACA
AAATTATATTCAATGCTATGAAACAAGGATTCTTCTATCATGCAACATCACCTTCTCCTT
CCTTTTTTAGCTCCTACTTGGTAGATGGAGGATTAGTAACAATTTCTAGATTTCCCATCA
TAGAAAAGTCGTACAGACCTTTTAAATATGGAGTCCTCTCAGATAATTTATCATAGAAGG
GTGTTCTATACACAAAAATTTAAGCAAACGATTCGTATATTCATCTTTTTAACACACATC
TTCAAGCTAGTTACGTAGGTGCTGAAAATAATGTGGTAAGAGACTATATTAAACAATATT
TATACTAACTAATTAATTAAAAGCATACTATAAAATTAATTAATTTTCATTCATATTACA
CTAAAATTGATAAACAAAATATATTTAAGCATCATTTTTCTTTTCCAAAATTATTAGAAA
GCTACAGTTATCACAAGAGTAGACCAACTTATTTTGATAAAAGACTTCATAAAAGAATAA
GTAAAAAAGCACAGAGAAAAGGAGAGTGATATTATTATGATTTGTGGTGATTTCAATGTT
AATGCTCGTCCCTAAACTTATCCTATTCATTATTTAAATGATGTTCCTGATATTTAAGTA
ACAAAATTATAATAAACCTTTCTTACTAGAAACATTACAATGTTTAACCTAAAAATAAAA
GGAATATATCAGAAAAATAAACCCAAAAGAATTTAGTGAGTATGACATCCTTAGATACAT
TCTATCTGACTTTGAAAGTATAGAATTCATAGATACATTAAGGGTAATTCAAAAAATTTA
TTTTCAATTAATCAATTTAATTTGATTTCGATTTAAAAATTTTTTTTTTTAAACTAATTT
TTGATTATATGTAAATTATCAAATAGAGAAAATTTAAAGGTGAGTCTCCCATTACTTATG
CCGATACTTACATTGATAGGGAAACTTAATAAGAACTACCAATGGAAGAGGCTCTAACAA
TAAAAGAGGATTTACTCCAAAAATCATGCTTAGACTATATTATTCAATTGAAAATTCCGA
TTGAAGCAAAAGAAGTATAAGAAAATAACAACAACAACAACAATAACAACGAAAATGAAG
AAGTAAGATAATAAATAATACATTTGCTACTAAATTATAATTATTAGAATGCGACAGTTT
CTTGAATTTTATTTTTATCAAATTAAAATAGGATGATATTGAAGAATTCAAAATGAAAAA
ATCAAATGCGCAATCTCAAAGTGGATTTGTTTTTGATTACGAATAAGTTTTCTTAGAAAA
ATTCTTTGTAAAAAACTAACCATTTACATAGTTAAGCGATCATTATGGTGTTTACACAAC
CCTGAGATACGTAAATGTAAACTAAAAAAGTAGTTTCCAATTTAAAGAGTCTGTTATATC
TTCTTAGGATAAAAAAAATATAGATAATAAAAATTAGCACAGCTTTAACAATGCAAGTTT
GAATGAATGA