Identifiers and Description

Gene Model Identifier

TTHERM_00426320

Standard Name

SKP1 (Skp1 homolog)

Aliases

PreTt14067 | 47.m00262 | p20

Description

Skp1 homolog; gene depletion induced telomere elongation; affinity purification enriched for SCF ubiquitin ligase components

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

Gene Ontology Annotations

Cellular Component

• SCF ubiquitin ligase complex (ISS) | GO:0019005 | Ref:17220281

Biological Process

• negative regulation of telomere maintenance (IDA) | GO:0032205 | Ref:17220281

Domains

• ( PF00651 ) BTB/POZ domain
• ( PF01466 ) Skp1 family, dimerisation domain
• ( PF03931 ) Skp1 family, tetramerisation domain

Gene Expression Profile

• Tetrahymena Functional Genomics Database:

Change in Gene Expression

TMHMM

TMHMM

Signal Peptide

Signal Peptide Present?: No
Presense Probability: 10.4%

TetraMine Data

TTHERM_00426320

WebApollo

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Tetrahymena Stock Center

No Data fetched for StockID

Homologs (v.2006 protein sequences)

Source	Identifier	Score	Description
Tetrahymena borealis	EI9_00167.1	2.9985100291019436e-113	suppressor-kinetochore protein 1 (167 aa)
Oxytricha	Contig20929.0.g68	2.000597631390999e-64	Skp1 family, dimerisation doma in
DictyBase	DDB_G0269230	9.000941515806455e-45	fpaA on chromosome: 1 position 3989908 to 3990396
WormBase	WBGene00004807	2.00017271388466e-38	locus:skr-1 status:Confirmed UniProt:G5ECU1 protein_id :CAB03110.1
SGD	YDR328C	7.002264059090237e-38	SKP1 Evolutionarily conserved kinetochore protein that is pa rt of multiple protein complex es, including the SCF ubiquiti n ligase complex, the CBF3 com plex that binds centromeric DN A, and the RAVE complex that r egulates assembly of the V-ATP ase
Stentor Coeruleus	SteCoe_6441	3.975449735908647e-31

General Information

No Data fetched for General Information

Associated Literature

1. Ref:17220281: Witkin KL, Prathapam R, Collins K (2007) Positive and negative regulation of Tetrahymena telomerase holoenzyme. Molecular and cellular biology 27(6):2074-83

Sequences

>TTHERM_00426320(coding)
ATGGATAAAGGTTCTACAAAGGTCAAATTATTGTCTCTTGAAAACGAAATTATTGAAGTT
GACGAAGAAGTCGCTAAGAAGTCATAGTTAATTAAAAATATGATTGAAGATACTGGAACT
GAAGATGATATTCCAATTCCAAATGTTAAGAAGGAGATTCTTTTAAAAATTTTAGAGTAC
TGCGAAAAGCACAAAAACGATAACCCACCTGAAATCGAAAAGCCATTAACCACCAGCAAT
TTAAGTGAATTAGTAGATCCATATGATGCTAAATTTATTGATATTGAAAATCTCGAATAA
CTCTTTGAAATTATATTAGCTGCTAACTATCTCGATATAAAATCTCTTCTTGACTTAGCT
TGCGCCAAAGTTGCTACTCTTATCAAGAACAAAACTCCTGATGAAATCAGAAAAACTTTC
AACATTCCTAACGACTTTACCCCTGAAGAAGAAGCTCAAATTAGAGAAGAAAATAAATGG
GCTGAAGAAGCCACTTCTTGA

>TTHERM_00426320(protein)
MDKGSTKVKLLSLENEIIEVDEEVAKKSQLIKNMIEDTGTEDDIPIPNVKKEILLKILEY
CEKHKNDNPPEIEKPLTTSNLSELVDPYDAKFIDIENLEQLFEIILAANYLDIKSLLDLA
CAKVATLIKNKTPDEIRKTFNIPNDFTPEEEAQIREENKWAEEATS

>TTHERM_00426320(gene)
ATGGATAAAGGTTCTACAAAGGTCAAATTATTGTCTCTTGAAAACGAAATTATTGAAGTA
ATTAATTAGTTTATTGATTGTTCATTCTTTGCTCATAATGAAGCAAGAGCTTTTTGAGAA
TTATTGTTATCATCATTCTGATGAATGATTAATTATTCATTCATTTAATATTTTTAATTA
ATTATAGGTTGACGAAGAAGTCGCTAAGAAGTCATAGTTAATTAAAAATATGATTGAAGG
TAAATTTATTTTATAGCAATAAATAAACAAAAGCAGCATAATAATAAAATATTTTGGTAA
TTTAAAGATACTGGAACTGAAGATGATATTCCAATTCCAAATGTTAAGAAGGAGATTCTT
TTAAAAATTTTAGAGTACTGCGAAAAGCACAAAAACGATAACCCACCTGAAATCGAAAAG
CCATTAACCACCAGCAATTTAAGTGAATTAGTAGATCCATATGATGCTAAATTTATTGAT
ATTGAAAATCTCGAATAACTCTTTGAAATTATATTAGCTGCTAACTATCTCGATATAAAA
TCTCTTCTTGACTTAGCTTGCGCCAAAGTTGCTACTCTTATCAAGAGTAAGATCAGAAAA
TTAAATAGCTTTTTTGTTTGTTTTCTATGCATGCATTTTATTCTATATTAATTTAACTTC
GCAAGAAAAACGACTATTTCATTAATGTTTTTTTGCAAAAATCTAACCAAAATGCATTAT
AAAAAGAGCTACTAAATGCATATTAGTTGACTTTTTCATTAATATATTTACTTATTTTAA
CTTATAATAGACAAAACTCCTGATGAAATCAGAAAAACTTTCAACATTCCTAACGACTTT
ACCCCTGAAGAAGAAGCTCAAATTAGAGAAGAAAATAAATGGGCTGAAGAAGCCACTTCT
TGA